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Quality of surgical care can impact survival in patients with bladder cancer after robot-assisted radical cystectomy: results from the International Robotic Cystectomy Consortium

Using a validated quality score, we investigated the impact of surgical factors on the overall survival, recurrence-free survival and disease-specific survival in patients with locally advanced...<

African Journal of Urology
12/01/2020
Evaluation of the Relationship of Glasdegib Exposure and Safety End Points in Patients With Refractory Solid Tumors and Hematologic Malignancies.

The relationship between glasdegib exposure and adverse event cluster terms of clinical concern was explored in this analysis.

The Journal of Clinical Pharmacology
09/24/2020

Head And Neck Cancer

Molecular margins in head and neck cancer: Current techniques and future directions

Complete tumor extirpation with clear surgical margins remains a central tenet of oncologic head and neck surgery.

Oral Oncology
11/01/2020
Comprehensive Geriatric Assessment: A Case Report on Personalizing Cancer Care of an Older Adult Patient With Head and Neck Cancer.

Understanding multidimensional screening and assessment is key to optimizing cancer care in older adults.

Clinical Journal of Oncology Nursing
10/01/2020
Toxicity syndrome and early competing deaths in head-and-neck cancer undergoing radiation therapy: Observation and hypothesis.

Radiotherapy and/or CRT is the mainstay for treatment of LAHNC. Sepsis remains a poorly understood and unrecognized event in cancer.

Medical Hypotheses
10/01/2020
Evaluation of antioxidant network proteins as novel prognostic biomarkers for head and neck cancer patients.

The purpose of this retrospective case study is to identify potential prognostic biomarkers in patients with HNSCC including APE1, NRF2 and PPARGC1A, SOD3 and DCN (antioxidant proteins).

Oral Oncology
12/01/2020
STAT3 as a predictive biomarker in head and neck cancer: A validation study.

LAHNSCC treatment consists of radiotherapy (RT) alone or CCRT. CCRT is accompanied by substantially more toxicity than RT alone.

Pathology Research and Practice
11/01/2020
Evaluation of patient specific care needs during treatment for head and neck cancer.

This study aimed to evaluate potential correlations between patient specific care needs, regarding...

Oral Oncology
11/01/2020

FDA Approvals

Comparison of FDA accelerated vs regular pathway approvals for lung cancer treatments between 2006 and 2018.

The aim of this study is to compare FDA Accelerated vs Regular Pathway approvals and BTD for lung cancer treatments between 2006 and 2018 regarding...

PLOS ONE
07/24/2020
Timing of US Food and Drug Administration (FDA) cancer drug approvals relative to publication of clinical trial results.

Publication of clinical trial results in peer reviewed literature is essential to inform clinicians regarding the use of new anti-cancer treatments, which often have a low therapeutic ratio...

Journal of Clinical Oncology
05/20/2020
FDA and EMA Approvals of New Breast Cancer Drugs-A Comparative Regulatory Analysis.

This study examines new drug approvals for breast cancer by the FDA and the EMA, based on an analysis of regulatory documents from both agencies for the period from 1995 to 2018.

Cancers
02/13/2020
Predicting Regulatory Product Approvals Using a Proposed Quantitative Version of FDA's Benefit-Risk Framework to Calculate Net-Benefit Score and Benefit-Risk Ratio.

Approval of regulated medical products in the USA is based upon a rigorous review benefits and risks as performed by US FDA staff scientists summarized descriptive qualitative format called...

Therapeutic Innovation &amp
07/08/2020
FDA Approvals and Consensus Guidelines for Botulinum Toxins in the Treatment of Dystonia.

In 2016, the American Academy of Neurology (AAN) published practice guidelines for botulinum toxin (BoNT) in treatment blepharospasm, cervical dystonia, adult spasticity, and headache.

Toxins
05/17/2020

Oncology

Validation of local p16 testing for determination of human papilloma virus status eligibility on a low risk oropharyngeal cancer trial - A Trans-Tasman Radiation Oncology Group study.

This study investigates whether local p16 screening, by immunohistochemistry (IHC), has high positive predictive value (PPV) for HPV status in a good prognosis HPV positive OPSCC population...

Oral Oncology
11/01/2020
Development and Optimization of Clinical Informatics Infrastructure to Support Bioinformatics at an Oncology Center.

Translational bioinformatics for therapeutic discovery requires the infrastructure of clinical informatics.

Methods of Molecular Biology
01/01/2021
Pharmacogenomics in Pediatric Oncology: Mitigating Adverse Drug Reactions While Preserving Efficacy

Major developments in drugs such as thiopurines and optimization in clinical trial protocols for treating cancer in children have led to a remarkable improvement in survival, from approximately...<

Annual Review of Pharmacology and Toxicology
01/06/2021
Review of Oncology and Transplant Literature for the Management of Hepatic and Pancreatic Resections in Jehovah's Witnesses.

Jehovah's Witnesses undergoing liver or pancreas surgery represent a unique medical and ethical challenge.

Cancer medicine journal
04/01/2021
The use of Hericium erinaceus and Trametes versicolor extracts in supportive treatment in oncology.

Substances available in nature with potential therapeutic effects are the subject of research that raises tremendous hopes for new challenges medicine.

Acta Pharmaceutica
03/01/2021
Development and Optimization of Clinical Informatics Infrastructure to Support Bioinformatics at an Oncology Center.

Translational bioinformatics for therapeutic discovery requires the infrastructure of clinical informatics.

Methods of Molecular Biology
01/01/2021

Lung Cancer

Continuous Versus 1-Year Fixed-Duration Nivolumab in Previously Treated Advanced Non–Small-Cell Lung Cancer: CheckMate 153

This study presents an exploratory analysis of CheckMate 153, a largely community-based phase IIIb/IV study, to evaluate the impact of 1-year fixed-duration...

Journal of Clinical Oncology
10/07/2020
Fucoxanthin extracted from Laminaria Japonica inhibits metastasis and enhances the sensitivity of lung cancer to Gefitinib.

The aim of this study was to demonstrate the effects of Fucoxanthin, a major active component extracted from Laminaria japonica on metastasis and Gefitinib sensitivity in...

Journal of Ethnopharmacology
01/30/2021
Surface plasmon resonance signal enhancement based on erlotinib loaded magnetic nanoparticles for evaluation of its interaction with human lung cancer cells

In the present study, signal enhancement of erlotinib conjugated magnetic nanoparticles compared to erlotinib was evaluated...

Optics and Laser Technology
01/01/2021
Targeted Delivery of Quercetin by Nanoparticles Based on Chitosan Sensitizing Paclitaxel-Resistant Lung Cancer Cells to Paclitaxel

This study explores whether QUE could reverse the resistance of NSCLC to paclitaxel-based therapy.

Materials Science and Engineering: C
02/01/2021
A k-NN Method for Lung Cancer Prognosis with the Use of a Genetic Algorithm for Feature Selection

In this paper, a k-Nearest-Neighbors technique, for which a genetic algorithm is applied for the efficient feature selection to reduce the dataset dimensions and enhance the classifier pace...

Expert Systems With Applications
02/01/2021
Polydopamine nanoparticles-assisted impedimetric sensor towards label-free lung cancer cell detection

Herein, this study demonstrated the first evaluation of the PDA NPs for the electrochemical determination of lung cancer cells.

Materials Science and Engineering: C
02/01/2021

Immuno Oncology

Design considerations for phase I/II dose finding clinical trials in Immuno-oncology and cell therapy

Immuno-oncology and cell therapy, the frontier of cancer treatment, is a rapidly developing area that brings new opportunities to patients.

Contemporary Clinical Trials
09/01/2020
Epigenetic Regulation of the Non-Coding Genome: Opportunities for Immuno-Oncology

The contribution of the non-coding genome to disease and its therapeutic potential have been largely unexplored. Recently, several epigenetic drugs developed for cancer treatment described...

Epigenomes
09/10/2020
Concepts in immuno-oncology: tackling B cell malignancies with CD19-directed bispecific T cell engager therapies.

The B cell surface antigen CD19 is a target for treating malignancies, such as precursor acute lymphoblastic leukemia and non-Hodgkin lymphoma.

Annals of Hematology
08/27/2020
TEPI-2 and UBI: designs for optimal immuno-oncology and cell therapy dose finding with toxicity and efficacy.

Conventional dose finding designs in oncology drug development target on the identification of maximum tolerated (MTD), with assumption that MTD has...

Journal of Biopharmaceutical Statistics
09/20/2020
Abstract 3402: BCAT1 as a druggable target in immuno-oncology

To better understand the role of BCAT1 in cancer, this study examines its gene expression at the single cell level (scRNAseq) in specimens obtained from lung, colorectal, breast, and ovarian cancer

Cancer Research
08/15/2020
Immuno-oncology cell therapy branches out

Optimization of CAR-T cell technology and application other immune types such as NK cells are tackling the efficacy, cost logistical challenges therapies for cancer....

Biopharma Dealmakers
09/01/2020

Gastrointestinal Cancer

All in the Levels- Programmed Death-Ligand 1 Expression as a Biomarker for Immune Checkpoint Inhibitor Response in Gastrointestinal Cancer Patients.

ICIs benefit patients with rare subsets of GI cancer. Significant interest exists to identify predictive biomarkers that may increase the applicability of ICI therapy for these patients.

Oncologist
09/18/2020
Therapeutic Applications of Human and Bovine Colostrum in the Treatment of Gastrointestinal Diseases and Distinctive Cancer Types: The Current Evidence

The incidence of gastrointestinal disorders and cancers is escalating all over the world. 

Frontiers in Pharmacology
09/11/2020
Postoperative Onset and Detection of SARS-CoV-2 in Surgically Resected Specimens From Gastrointestinal Cancer Patients With Pre/Asymptomatic COVID-19

The study's objective is to describe the epidemiologic features and clinical courses of gastrointestinal cancer patients with pre/asymptomatic COVID-19 and to explore evidence of SARS-CoV-2 in the

Annals of Surgery
10/14/2020
Patient-reported outcomes (PROs) in older adults with gastrointestinal (GI) cancer undergoing surgery.

Older adults with GI cancer often experience poor surgical outcomes, yet little is known about their PROs, such as physical function, quality of life, and physical and psychological symptom burden.

Journal of Clinical Oncology
10/08/2020
Clinical practice guideline for endoscopic resection of early gastrointestinal cancer.

Although surgery was the standard treatment for early gastrointestinal cancers, endoscopic resection is now a cancers without regional lymph node metastasis.

Intestinal Research
10/13/2020
Economic Impact of the Introduction of Outpatient Medical Specialist Care (ASV) of Gastrointestinal Cancer Patients from a German Hospital Management Perspective.

The treatment of cancer patients in Germany is characterized by sectoral separation of the in- and outpatient care accompanied by 2 separate reimbursement systems. 

Onkologie
09/21/2020

Skin Cancer

The Impact of Notch Signaling for Carcinogenesis and Progression of Nonmelanoma Skin Cancer: Lessons Learned from Cancer Stem Cells, Tumor Angiogenesis, and Beyond

Since many decades, nonmelanoma skin cancer (NMSCs) is the most common malignancy worldwide.

Advances in Experimental Medicine and Biology
01/01/2021
Reconfigurable Vivaldi THz antenna based on graphene load as hyperbolic metamaterial for skin cancer spectroscopy

Demand for an antenna with high gain and directivity for medical sensing is necessary so the Vivaldi antenna in the THz spectrum with reconfigurable characteristics is a proper solution.

Optics Communications
02/01/2021
In situ implantable three-dimensional extracellular matrix bioactive composite scaffold for postoperative skin cancer therapy

Despite drastic improvements in surgical excision techniques, tumor recurrence has remained a significant problem over the past decades.

Chemical Engineering Journal
11/15/2020
Injectable multi-responsive micelle/nanocomposite hybrid hydrogel for bioenzyme and photothermal augmented chemodynamic therapy of skin cancer and bacterial infection

Activatable theranostic strategy with high specificity and sensitivity for simultaneous skin cancer therapy anti-infection remains a major challenge.

Chemical Engineering Journal
01/15/2021
FDA Updates Hydrochlorothiazide Label for Nonmelanoma Skin Cancer

HCTZ is associated with an increased risk of nonmelanoma skin cancer, and patients who take the drug should limit sun exposure and undergo regular skin cancer screening.

Medscape
FDA: Small Risk of Skin Cancer With Hydrochlorothiazide Use
Cancer Therapy Advisor

Gynecologic Cancer

Sources of palliative care knowledge among patients with advanced or metastatic gynecologic cancer.

The objective of this study was to identify sources used by patients with advanced or metastatic gynecologic cancer to learn about palliative care and...

Journal of Pain and Symptom Management
09/22/2020
Short- and long-term outcomes for single-port risk-reducing salpingo-oophorectomy with and without hysterectomy for women at risk for gynecologic cancer.

This study examines the outcomes after single-port risk-reducing salpingo-oophorectomy with or without hysterectomy for reduction of ovarian, breast, or endometrial cancer risk.

International Journal of Gynecological Cancer
09/18/2020
The caring experience and supportive care needs of male partners for women with gynecologic cancer: a qualitative literature review.

This study's objective is to systematically review male partners’ caring experience and supportive care needs when caring for women with gynaecologic cancer.

Journal of Clinical Nursing
09/19/2020
The caring experience and supportive care needs of male partners for women with gynecologic cancer: a qualitative literature review.

The objective of the study was to systematically review male partners' caring experience and supportive care needs when for women with gynecologic cancer.

Journal of Clinical Nursing
09/19/2020
Prophylactic Gynecologic Surgery at Time of Colectomy Benefits Women with Lynch Syndrome and Colon Cancer: A Markov Cost-Effectiveness Analysis.

This study aimed to compare the cost, quality of life, and likelihood of being alive and free from colon, endometrial, and ovarian cancer between operative choices for patients with Lynch syndrome

Diseases of The Colon &amp
10/01/2020
Oncology Drug Reference Sheet: Rucaparib
Oncology Nursing Society
Spotlight
Much is left unspoken: Self-reports from families in pediatric oncology.

The aim of this study was to explore how families in pediatric oncology experienced illness‐related information and communication with professionals and within the family.

Pediatric Blood &amp
09/25/2020

News

Fucoxanthin extracted from Laminaria Japonica inhibits metastasis and enhances the sensitivity of lung cancer to Gefitinib.

The aim of this study was to demonstrate the effects of Fucoxanthin, a major active component extracted from Laminaria japonica on metastasis and Gefitinib sensitivity in...

Journal of Ethnopharmacology
01/30/2021
371
Surface plasmon resonance signal enhancement based on erlotinib loaded magnetic nanoparticles for evaluation of its interaction with human lung cancer cells

In the present study, signal enhancement of erlotinib conjugated magnetic nanoparticles compared to erlotinib was evaluated...

Optics and Laser Technology
01/01/2021
4158
Discrepancies between genitourinary cancer patients' and clinicians' characterization of the Eastern Cooperative Oncology Group performance status.

This study was designed to describe the patient‐reported performance status and the provider‐reported PS.

Cancer
10/02/2020
4085
A comparison of general, genitourinary, bowel, and sexual quality of life among long term survivors of prostate, bladder, colorectal, and lung cancer.

A comparison of general, genitourinary, bowel, and sexual quality of life among long term survivors of prostate, bladder, colorectal, and lung cancer.

Journal of Geriatric Oncology
07/29/2020
4088
The scope, presentation, and management of genitourinary complications in patients presenting with high-grade urethral complications after radiotherapy for prostate cancer.

The objective of this study is to describe the presentation, scope, and management of genitourinary complications in patients referred for high-grade urethral complications or sphincter weakness incontinence after prostate RT.

Cuaj-canadian Urological Association Journal
07/17/2020
4156
Assessing Genitourinary Cancer Clinical Trial Accrual Sufficiency Using Archived Trial Data

Clinical trials often fail to reach their anticipated end points, most frequently because of poor accrual.

JCO clinical cancer informatics
07/15/2020
4157

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A perspective on HPK1 as a novel immuno-oncology drug target.
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Racial and Socioeconomic Disparities After Surgical Resection for Rectal Cancer.
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Surgical or imaging lymph node assessment in locally advanced cervical cancer: a systematic review and meta-analysis.
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