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Downregulated Expression of CLEC9A as Novel Biomarkers for Lung Adenocarcinoma

This study aimed to reveal the role of CLEC9A in LUAD based on bioinformatics and cellular functional experiments.

Frontiers in Oncology
09/20/2021
Comprehensive Analysis of the Cancer Driver Genes in Breast Cancer Demonstrates Their Roles in Cancer Prognosis and Tumor Microenvironment

The purpose of this study was to identify the expression characteristics and prognostic value of cancer driver genes in breast cancer.

World Journal of Surgical Oncology
09/10/2021

Head And Neck Cancer

The Role of Akt in Acquired Cetuximab Resistant Head and Neck Squamous Cell Carcinoma

This study aims to characterize acquired cetuximab resistance mechanisms in HNSCC cell lines by protein phosphorylation profiling.

Frontiers in Oncology
09/10/2021
Upregulated Glycolysis Correlates With Tumor Progression and Immune Evasion in Head and Neck Squamous Cell Carcinoma

Here, study investigators perform a comprehensive analysis of the glycolytic activity in head and neck squamous cell carcinoma. 

Scientific Reports
09/07/2021
DIAPH1 Promotes Laryngeal Squamous Cell Carcinoma Progression Through Cell Cycle Regulation

Researchers suggest that DIAPH1 influences the expression of genes in several signaling pathways and promotes LSCC progression by regulating the cell cycle.

Frontiers in Oncology
09/22/2021
Cathepsins B, D, and G Are Expressed in Metastatic Head and Neck Cutaneous Squamous Cell Carcinoma

This study investigated the expression of cathepsins B, D and G and their localization in relation to the CSC subpopulations we have recently identified in mHNcSCC.

Frontiers in Oncology
09/21/2021
Evaluating Predictive Factors for Toxicities Experienced by Head & Neck Cancer Patients Undergoing Radiotherapy

The purpose of this study is to evaluate if HPV status serves as an independent predictor of early and late dysphagia outcomes when considered alongside standard patient characteristics...

Journal of Translational Medicine
09/07/2021
Different Primary Sites of Hypopharyngeal Cancer Have Different Lymph Node Metastasis Patterns: A Retrospective Analysis From Multi-Center Data

Scientists reassessed the features of the primary tumor (tumor size, primary location, and extent of invasion) and the involvement of lymph nodes at each level.

Frontiers in Oncology
09/20/2021

FDA Approvals

FDA clears IND application for CRISPR-edited T-cell receptor therapy to treat AML

The FDA cleared an investigational new drug application for NTLA-5001, a T-cell receptor T-cell therapy designed to treat adults with relapsed or refractory acute myeloid leukemia.

Healio
09/17/2021
FDA approves Tivdak for advanced cervical cancer

The FDA granted accelerated approval to tisotumab vedotin-tftv for certain women with advanced cervical cancer.

Healio
09/21/2021
FDA grants fast track designation to CAR macrophage cell therapy for HER2-positive tumors

The FDA granted fast track designation to CT-0508 for treatment of patients with solid tumors that overexpress human epidermal growth factor receptor 2.

Healio
09/22/2021
FDA Approves Cabozantinib for Patients With Previously Treated Radioactive Iodine–Refractory Differentiated Thyroid Cancer

The FDA approves cabozantinib for the treatment of adult and pediatric patients aged 12 years and older with locally advanced or metastatic differentiated thyroid cancer...

The ASCO Post
09/18/2021
FDA Approves Cabozantinib for Differentiated Thyroid Cancer

The FDA approves Cabozantinib, indicated for patients whose disease has progressed after they have received VEGFR-targeted therapy...

Medscape
09/22/2021

Oncology

Review of Oncology and Transplant Literature for the Management of Hepatic and Pancreatic Resections in Jehovah's Witnesses.

Jehovah's Witnesses undergoing liver or pancreas surgery represent a unique medical and ethical challenge.

Cancer medicine journal
04/01/2021
Selecting Image-Guided Surgical Technologies in Oncology: A Surgeon's Perspective.

This study aimed to select the most promising IG technology per oncologic indication.

Journal of Surgical Research
01/01/2021
Pharmacogenomics in Pediatric Oncology: Mitigating Adverse Drug Reactions While Preserving Efficacy

Major developments in drugs such as thiopurines and optimization in clinical trial protocols for treating cancer in children have led to a remarkable improvement in survival, from approximately...<

Annual Review of Pharmacology and Toxicology
01/06/2021
Development and Optimization of Clinical Informatics Infrastructure to Support Bioinformatics at an Oncology Center.

Translational bioinformatics for therapeutic discovery requires the infrastructure of clinical informatics.

Methods of Molecular Biology
01/01/2021
The use of Hericium erinaceus and Trametes versicolor extracts in supportive treatment in oncology.

Substances available in nature with potential therapeutic effects are the subject of research that raises tremendous hopes for new challenges medicine.

Acta Pharmaceutica
03/01/2021

Lung Cancer

Consolidation nivolumab and ipilimumab versus observation in limited-disease small cell lung cancer after chemo-radiotherapy

Scientists demonstrate superiority of consolidation combination immunotherapy versus observation after chemo-radiotherapy plus PCI.

Annals of Oncology
09/22/2021
The Prediction Potential of the Pretreatment Lung Immune Prognostic Index for the Therapeutic Outcomes of Immune Checkpoint Inhibitors in Patients With Solid Cancer

Scientists performed a systematic review and meta-analysis, to investigate the significance of the LIPI score as a predictive tool in solid cancer patients receiving ICIs treatment. 

Frontiers in Oncology
09/23/2021
Comparison of Clinical and Pathological Characteristics Between Extremely Multiple GGNs and Single GGN

Scientists aim to compare the clinical and pathological characteristics between patients undergoing surgery for extremely multiple ground-glass nodules (GGNs) and those for single GGN.

Frontiers in Oncology
09/21/2021
Downregulated Expression of CLEC9A as Novel Biomarkers for Lung Adenocarcinoma

This study aimed to reveal the role of CLEC9A in LUAD based on bioinformatics and cellular functional experiments.

Frontiers in Oncology
09/20/2021
Addition of Ramucirumab to Gemcitabine in Second-Line Treatment of Malignant Pleural Mesothelioma

Scientists find that the addition of ramucirumab to gemcitabine improved overall survival in the second-line treatment of malignant pleural mesothelioma.

The ASCO Post
09/21/2021
Clinical Utility of Circulating Tumor Cells in the Early Detection of Lung Cancer in Patients with a Solitary Pulmonary Nodule

Researchers investigate the potential of CTCs as a biomarker for early detection of lung cancer.

Prevention, Early Detection, and Interception
09/14/2021

Immuno Oncology

Standardization & Harmonization of Immuno-Oncology Toxicities

A report from the Association of Community Cancer Centers shows that IO treatment is increasingly being given to patients in community settings, not just in academic cancer centers.

Oncology Times - Latest Articles
04/05/2021
Immune Regulation of the cGAS-STING Signaling Pathway in the Tumor Microenvironment and Its Clinical Application

STING agonists, as novel agonists, are used in preclinical research and in the treatment of various tumors via clinical trials and have displayed attractive application prospects.

OncoTargets and Therapy
03/01/2021
mRNA in Cancer Immunotherapy: Beyond a Source of Antigen

Many novel immunotherapeutic strategies focus on the use of mRNA beyond its use as the source of tumor antigens. 

Molecular Cancer
03/03/2021
Comprehensive Transcriptomic Analysis Reveals the Role of the Immune Checkpoint HLA-G Molecule in Cancers

The aim of this study is to systematically identify the roles of checkpoint HLA-G molecules across various types of cancer.

Frontiers in Immunology
07/01/2021
Cardiovascular Risks Associated With Checkpoint Inhibitors and CAR T-Cell Therapy

Leveraging the immune system to treat cancer, however, also increases the potential for serious off-target effects.

The ASCO Post
04/10/2021
Response Endpoints Deemed ‘Poor Surrogates’ for Overall Survival in Trials of Immune Checkpoint Inhibitors

Tumor response endpoints are “poor surrogate endpoints” for OS in trials of immune checkpoint inhibitors, according to research published in JCO Precision Oncology.

Cancer Therapy Advisor
08/05/2021

Gastrointestinal Cancer

Neoadjuvant Chemotherapy Versus Direct Surgery for Locally Advanced Gastric Cancer With Serosal Invasion

This study examines patients with cT4NxM0 gastric cancer who underwent D2 gastrectomy.

Frontiers in Oncology
08/23/2021
CT Radiomics for the Preoperative Prediction of Ki67 Index in Gastrointestinal Stromal Tumors

This study establishes and verifies a radiomics model for the preoperative prediction of the Ki67 index of gastrointestinal stromal tumors.

Frontiers in Oncology
09/14/2021
Screening and Identification of Key Biomarkers of Gastric Cancer: Three Genes Jointly Predict Gastric Cancer

The differentially expressed genes between gastric cancer and adjacent normal tissues were detected to explore biomarkers that may play an important role in gastric cancer.

Frontiers in Oncology
08/17/2021
Clinicopathological Characteristics and Response to Chemotherapy in Treatment-Naive Epstein–Barr Virus Associated Gastric Cancer

Scientists investigate the treatment response of chemotherapy both in advanced stage and metastatic EBVaGC.

Frontiers in Oncology
09/23/2021
Knockdown of m6A Reader IGF2BP3 Inhibited Hypoxia-Induced Cell Migration and Angiogenesis by Regulating Hypoxia Inducible Factor-1α in Stomach Cancer

The roles of IGF2BP3 in hypoxia-induced cell migration and angiogenesis together with its m6A-dependent targets were investigated in SC in vitro and in vivo.

Frontiers in Oncology
09/21/2021

Skin Cancer

Immunotherapy Combo Checks Progression in Advanced Melanoma

Researchers have used two immunotherapy drugs to target and block different protein checkpoints, significantly increasing the time before melanoma progressed in new patients with...

Oncology Times - Latest Articles
07/05/2021
Bempegaldesleukin Plus Nivolumab in First-Line Metastatic Melanoma

This phase II cohort from PIVOT-02 study evaluates the CD122-preferential interleukin-2 pathway agonist bempegaldesleukin plus nivolumab in first-line metastatic melanoma.

Journal of Clinical Oncology
07/13/2021
PDCD1 Polymorphisms May Predict Response to Anti-PD-1 Blockade in Patients With Metastatic Melanoma

Investigators retrospectively analyze plasma DNA of patients with advanced melanoma treated with PD-1 antibodies, nivolumab or pembrolizumab, for five PD-1 genotype single nucleotide polymorphisms.

Frontiers in Immunology
06/09/2021
Optimizing Texting Interventions for Melanoma Prevention and Early Detection

Researchers establish the optimal text messaging intervention to achieve behavior change in young adults at risk of skin cancer.

Prevention, Early Detection, and Interception
09/01/2021
Digital Quantification of Tumor PD-L1 Predicts Outcome of PD-1-Based Immune Checkpoint Therapy in Metastatic Melanoma

Scientists investigate digital PD-L1 quantification versus physician PD-L1 quantification in pre-treatment tumor tissue...

Frontiers in Oncology
09/21/2021
Pituitary Adenylate Cyclase Activating Polypeptide Has Inhibitory Effects on Melanoma Cell Proliferation and Migration In Vitro

Researchers provide evidence that PACAP receptors are expressed by normal and malignant cutaneous pigment cells deriving from two different stages of malignancy and PACAP signalling...

Frontiers in Oncology
09/20/2021

Gynecologic Cancer

High Prevalence of Germline BRCA Mutations in Indian Women With Ovarian Cancer

Scientists found that Indian women with ovarian cancer not selected for study based on clinical factors had a high prevalence of germline pathogenic or likely pathogenic BRCA variants

The ASCO Post
09/10/2021
A SMYD3/ITGB6/TGFβ1 Positive Feedback Loop Promotes the Invasion and Adhesion of Ovarian Cancer Spheroids

This study found that SMYD3 and ITGB6 could promote the release and activation of latent TGFβ1 and increase the phosphorylation of Smad3 activated by TGFβ1 in ovarian cancer spheroids.

Frontiers in Oncology
09/21/2021
Comparison Between Laparoscopic and Robotic Surgery in Elderly Patients With Endometrial Cancer: A Retrospective Multicentric Study

The aim of this study was to evaluate the peri-operative and oncological outcomes of EEC patients who had undergone laparoscopic (LS) or robotic surgery (RS).

Frontiers in Oncology
09/22/2021
Integration of scRNA-Seq and Bulk RNA-Seq to Analyse the Heterogeneity of Ovarian Cancer Immune Cells and Establish a Molecular Risk Model

In this study, a series of tissue-specific clusters were constructed to predict immune cell compositions from two OC scRNA-seq datasets in the GEO database.

Frontiers in Oncology
09/21/2021
Identification and Experimental Validation of Immune-Associate lncRNAs for Predicting Prognosis in Cervical Cancer

This study aimed to identify an immune-related lncRNA signature for the prospective assessment of prognosis in CC patients.

OncoTargets and Therapy
09/07/2021
Spotlight
Teleoncology for Veterans With Cancer During the COVID-19 Pandemic

In a single-center study, investigators find an overall high level of satisfaction with teleoncology care during the COVID-19 pandemic among veterans with cancer in the US...

The ASCO Post
09/07/2021

News

Metastatic Castration-Resistant Prostate Cancer Remains Dependent on Oncogenic Drivers Found in Primary Tumors

Scientists question if targeted sequencing of hormone-sensitive primary PC identify drivers of metastasis that are targetable in advanced CRPC. 

Journal of Clinical Oncology
09/16/2021
10019
PTP4A3 Is a Prognostic Biomarker Correlated With Immune Infiltrates in Papillary Renal Cell Carcinoma

Scientists developed a comprehensive analysis across multiple databases to elucidate the role of PTP4A3 in ccRCC and pRCC & analyzed PTP4A3 and immune cell tumor infiltration (TIMER). 

Frontiers in Immunology
09/23/2021
10018
Detection of clonotypic DNA in the cerebrospinal fluid as a marker of central nervous system invasion in lymphoma

Researchers studied a NGS-based assay that detects tumor-derived DNA for clonotypic immunoglobulin gene rearrangements in the CSF of patients with lymphomas.

Blood Advances
09/22/2021
10016
Prediction of Biochemical Recurrence-Free Survival of Prostate Cancer Patients Leveraging Multiple Gene Expression Profiles in Tumor Microenvironment

In this study, the dataset from TCGA-PRAD project and the dataset E-MTAB-6128 were used to develop and validate a prognostic model...

Frontiers in Oncology
09/23/2021
10015
Optimizing Texting Interventions for Melanoma Prevention and Early Detection

Researchers establish the optimal text messaging intervention to achieve behavior change in young adults at risk of skin cancer.

Prevention, Early Detection, and Interception
09/01/2021
9941
Drug-Drug Interactions Between Palbociclib and Proton Pump Inhibitors May Significantly Affect Clinical Outcome of Metastatic Breast Cancer Patients

Re et al question the effect of co-administration of PPIs and palbociclib on progression-free survival (PFS) in metastatic breast cancer (mBC) patients.

ESMO Open
09/09/2021
9928

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