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Overcoming Resistance to Targeted Therapies in Chronic Lymphocytic Leukemia

Recent advances that have contributed to the understanding of resistance to targeted therapies in CLL are discussed in this study.

Blood Advances
01/12/2021
Long Term Results of Single-Fraction Carbon-Ion Radiotherapy for Non-small Cell Lung Cancer

This study suggests that single-fraction passive carbon-ion radiotherapy can serve as an alternate treatment for patients with early-stage non-small cell lung cancer...

Cancers
12/31/2020
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Head And Neck Cancer

Roles of the Wnt Signaling Pathway in Head and Neck Squamous Cell Carcinoma

This paper summarizes the groundbreaking discoveries and recent advances involving the Wnt signaling pathway and highlight the relevance of this pathway in head & neck squamous cell cancer.

01/05/2021
Reinforcing the Known Hygiene Practices for the Health Care Workers Along with Working Guidelines for Managing Head and Neck Cancer Patients in the COVID Era

Treatment for patients with cancer needs to be delivered despite the existing pandemic. This puts the health care workers at a higher risk to contract infection.

01/07/2021
Risk Factors for Osteoradionecrosis of the Jaw in Patients with Head and Neck Squamous Cell Carcinoma

This study evaluates factors associated with ORNJ in patients with HNSCC, focusing on jaw-related dose–volume histogram parameters.

01/05/2021
Comparison of Intrafractional Motion in Head and Neck Cancer Between Two Immobilization Methods During Stereotactic Ablative Radiation Therapy by CyberKnife

Maintaining immobilization to minimize spine motion is very important during salvage stereotactic ablative radiation therapy for recurrent head and neck cancer.

01/05/2021
A Pre-Operative Prognostic Score for the Selection of Patients for Salvage Surgery After Recurrent Head and Neck Squamous Cell Carcinomas

The present study is a single-center retrospective analysis of 164 patients treated with salvage surgery after recurrence of head and neck cancer.

Scientific Reports
01/12/2021
Diagnostic and Prognostic Value of FOXD1 Expression in Head and Neck Squamous Cell Carcinoma

FOXD1 was significantly upregulated in HNSCC and was a good diagnostic biomarker and an independent predictor of poor survival and low rate of recurrence-free survival...

01/01/2021

FDA Approvals

FDA Approves First and Only Treatment for AL Amyloidosis

The first and only treatment for a rare and often fatal blood cell disorder has been approved in the United States.

Medscape
01/20/2021
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FDA Approval of Immunotherapy Drugs Brings Hope to Mesothelioma Patients

The drugs—nivolumab and ipilimumab—have now been approved by the FDA for first-line treatment of adult patients who suffer from malignant pleural mesothelioma.

Oncology Times - Latest Articles
12/20/2020
The quality of reporting general safety parameters and immune-related adverse events in clinical trials of FDA-approved immune checkpoint inhibitors

This methodological review compared the quality of reporting of safety information and in particular, serious irAEs, in publications and ClinicalTrials.gov for all current FDA-approved ICIs.

BMC Cancer
11/23/2020
FOCR Meeting Highlights Modernization of Expedited FDA Drug Approvals

The Friends of Cancer Research held the first of a two-part virtual annual meeting, which focused on ways of updating expedited drug approvals at the FDA.

Oncology Times - Latest Articles
12/20/2020
A New Strategy in Treating Patients With CAR T-Cell Therapy

A novel “switchable” CAR T-cell therapy for blood cancers moved into early clinical trials recently after gaining Fast Track designation from the FDA. 

Oncology Times - Latest Articles
12/20/2020

Oncology

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Selecting Image-Guided Surgical Technologies in Oncology: A Surgeon's Perspective.

This study aimed to select the most promising IG technology per oncologic indication.

Journal of Surgical Research
01/01/2021
Pharmacogenomics in Pediatric Oncology: Mitigating Adverse Drug Reactions While Preserving Efficacy

Major developments in drugs such as thiopurines and optimization in clinical trial protocols for treating cancer in children have led to a remarkable improvement in survival, from approximately...<

Annual Review of Pharmacology and Toxicology
01/06/2021
Review of Oncology and Transplant Literature for the Management of Hepatic and Pancreatic Resections in Jehovah's Witnesses.

Jehovah's Witnesses undergoing liver or pancreas surgery represent a unique medical and ethical challenge.

Cancer medicine journal
04/01/2021
The use of Hericium erinaceus and Trametes versicolor extracts in supportive treatment in oncology.

Substances available in nature with potential therapeutic effects are the subject of research that raises tremendous hopes for new challenges medicine.

Acta Pharmaceutica
03/01/2021
Development and Optimization of Clinical Informatics Infrastructure to Support Bioinformatics at an Oncology Center.

Translational bioinformatics for therapeutic discovery requires the infrastructure of clinical informatics.

Methods of Molecular Biology
01/01/2021

Lung Cancer

Perspectives of Family Physicians Towards Access to Lung Cancer Screening for Individuals Living With Low Income

This study seeks to understand FPs perspectives on access to lung cancer screening for individuals living with low income in order to improve equity in access to LCS.

01/07/2021
An Update in Clinical Utilization of Photodynamic Therapy for Lung Cancer

Despite the clinical success reported, photodynamic therapy is still currently underutilized to treat lung cancer and other tumors.

01/01/2021
Comprehensive Perspective for Lung Cancer Characterisation Based on AI Solutions Using CT Images

This study explores the need to combine the information from tumors with other lung structures for the next generation of computer-aided decision, which could create...

12/31/2020
Current Lung Cancer Screening Guidelines May Miss High-Risk Population: A Real-World Study

Despite much research published on lung cancer screening, China has had no large-scale study on the missed diagnosis of lung cancer in a health examination population.

BMC Cancer
01/11/2021
Duration of Lead Time in Screening for Lung Cancer

Screening for lung cancer has used chest radiography, low dose computed tomography and sputum cytology.

01/06/2021
Bisphosphonates and Risk of Lung Cancer

This study conducts a meta-analysis to figure out the relationship between bisphosphonates and lung cancer.

01/08/2021

Immuno Oncology

PET Imaging Facilitates Antibody Screening for Synergistic Radioimmunotherapy With a 177Lu-Labeled αPD-L1 Antibody

The low response rate of immunotherapy, such as anti-PD-L1/PD-1 and anti-CTLA4, has limited its application to a wider population of cancer patients.

01/01/2021
Immunocyte Membrane-Coated Nanoparticles for Cancer Immunotherapy

This review shows the latest research progress, the advantages, the disadvantages, and the application of immunocyte membrane-coated nanoparticles in cancer immunotherapy.

Cancers
12/30/2020
The Microbiome and Its Implications in Cancer Immunotherapy

This review mainly focuses on various microbes and their association with different types of cancer, responses to immunotherapeutic modulation...

Molecules
01/03/2021
The evolving landscape of predictive biomarkers in immuno‐oncology with a focus on spatial technologies

This review aims to provide an overview of the current methodologies that are used to profile the TME, which may provide insights into the immunopathology associated...

11/22/2020
Society for Immunotherapy of Cancer Clinical Practice Guideline on Immunotherapy for the Treatment of Lymphoma

The recent development and clinical implementation of novel immunotherapies for the treatment of Hodgkin and non-Hodgkin lymphoma have improved patient outcomes across subgroups.

12/24/2020
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Gastrointestinal Cancer

Prognostic Value of Low MicroRNA-34a Expression in Human Gastrointestinal Cancer

This study summarizes the predictive role of miR-34a for survival in patients with gastrointestinal cancers.

BMC Cancer
01/14/2021
Preceding Endoscopic Submucosal Dissection in Submucosal Invasive Gastric Cancer Patients Does Not Impact Clinical Outcomes

This study aims to evaluate the specific influence of endoscopic submucosal dissection on the prognosis of patients with T1b2 gastric cancer.

Scientific Reports
01/13/2021
Predicting Postoperative Peritoneal Metastasis in Gastric Cancer With Serosal Invasion Using a Collagen Nomogram

Accurate prediction of peritoneal metastasis for gastric cancer with serosal invasion is crucial in clinic.

01/08/2021
Advances in the Surgical Management of Gastric and Gastroesophageal Junction Cancer

This review summarizes the current standard of surgical care for gastroesophageal junction and gastric cancer as well as highlights recent and upcoming advances to the field.

01/05/2021
microRNAs Promoting Growth of Gastric Cancer Xenografts and Correlation to Clinical Prognosis

This review focuses on the role of microRNAs with documented efficacy in preclinical xenograft models with respect to growth of human gastric cancer cells.

01/03/2021
A Novel Prognosis Marker Based on Combined Preoperative Carcinoembryonic Antigen and Systemic Inflammatory Response for Resectable Gastric Cancer

Carcinoembryonic antigen is one of the important indexes for the diagnosis and prognosis of gastrointestinal cancer.

01/01/2021

Skin Cancer

Non-Invasive Skin Sampling of Tryptophan/Kynurenine Ratio in Vitro Towards a Skin Cancer Biomarker

Non-invasive topical sampling of Trp/Kyn can therefore serve as a promising concept for skin cancer diagnostics.

Scientific Reports
01/12/2021
Treating Melanoma in Situ During a Pandemic with Telemedicine and a Combination of Imiquimod, 5-Fluorouracil, and Tretinoin

The recent COVID-19 pandemic has created a quandary for the physician in terms of evaluating and treating cutaneous skin cancers, particularly melanomas.

Dermatologic Therapy
01/17/2021
Metastatic Cutaneous Squamous Cell Carcinoma Involving the Parotid Gland: Experience Outside of the Sun Belt

This study characterizes a subset of patients with metastatic head and neck cutaneous squamous cell carcinoma in a tertiary North American center and describe oncologic...

01/08/2021
Skin Dendritic Cells in Melanoma Are Key for Successful Checkpoint Blockade Therapy

Immunotherapy with checkpoint inhibitors has shown impressive results in patients with melanoma, but still many do not benefit from this line of treatment.

01/06/2021
Ultradeep Sequencing Differentiates Patterns of Skin Clonal Mutations Associated With Sun-Exposure Status and Skin Cancer Burden

In ultraviolet radiation–exposed skin, mutations fuel clonal cell growth.

01/01/2021
Treatment of Non-melanoma Skin Cancers in the Absence of Mohs Micrographic Surgery

This study discusses the management of non-melanoma skin cancers in settings where Mohs micrographic surgery is not readily available.

12/22/2020

Gynecologic Cancer

Calculating the Dose of Cisplatin That is Actually Utilized in Hyperthermic Intraperitoneal Chemotherapy Among Ovarian Cancer Patients

Hyperthermic intraperitoneal chemotherapy is an important treatment for ovarian cancer. This study explores how much cisplatin is actually utilized and its prognostic influence.

01/08/2021
Choline Kinase Alpha Impairment Overcomes TRAIL Resistance in Ovarian Cancer Cells

ChoKα/CHKA overexpression and hyper-activation sustain altered choline metabolism conferring the cholinic phenotype to epithelial ovarian cancer...

01/04/2021
Evaluation of the Potential of Pap Test Fluid and Cervical Swabs to Serve as Clinical Diagnostic Biospecimens For the Detection of Ovarian Cancer by Mass Spectrometry-Based Proteomics

This study is the first step in determining the feasibility of using the liquid-based Pap test or a cervical swab for the detection of ovarian cancer protein biomarkers.

01/07/2021
A Comparative Study of Methods for Determining Intravoxel Incoherent Motion Parameters in Cervix Cancer

This study compares different fitting methods for determining IVIM parameters and to determine whether the use of different fitting methods would affect...

01/14/2021
Current Ovarian Cancer Maintenance Strategies and Promising New Developments

This review will focus on current frontline ovarian cancer treatment as well molecularly based approaches to ovarian cancer management.

01/01/2021
Cervical Cancer: Epidemiology, Risk Factors and Screening

Although cervical cancer threatens female health, it could be the first cancer that would be eliminated by human beings with comprehensive preventive and control strategy.

12/31/2020
Spotlight
COVID-19-Positive Cancer Patients Undergoing Active Anticancer Treatment

This study aims to describe the clinical characteristics and outcomes of patients diagnosed with COVID-19 whilst on anticancer treatment in a developing country.

12/24/2020

News

FDA Approves First and Only Treatment for AL Amyloidosis

The first and only treatment for a rare and often fatal blood cell disorder has been approved in the United States.

Medscape
01/20/2021
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Oncology Today With Dr Neil Love: Gastrointestinal Cancers Edition

A discussion of various treatments and therapies for gastric cancer, including HER2+ advanced gastric/GEJ cancer.

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Increasing Importance of HER2 and HER3 Testing in the Context of an Expanding Targeted Therapies Landscape for Breast, Gastrointestinal, Lung, and Other Cancers

Review evidence-based guidelines and expert recommendations regarding HER2 testing and interpretation of results in breast, gastric, colorectal, non–small cell lung, and other cancers.

05/11/2020
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Applying Probability Calibration to Ensemble Methods to Predict 2-Year Mortality in Patients With DLBCL

Study investigators develop a predictive model to predict the mortality hazard of DLBCL patients within 2 years of treatment.

01/07/2021
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Gene Expression Profiling-Based Risk Prediction and Profiles of Immune Infiltration in Diffuse Large B-Cell Lymphoma

Recent studies suggest that the immune microenvironment plays a role in treatment response prediction and survival in DLBCL.

01/07/2021
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Immune Reconstitution and Infectious Complications Following Axicabtagene Ciloleucel Therapy for Large B-Cell Lymphoma

This study evaluates the long-term course of hematologic recovery, immune reconstitution, and infectious complications in 41 patients with LBCL treated with axicabtagene ciloleucel at a single center.

Blood Advances
01/05/2021
7647

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Trending

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A Novel Immune Prognostic Index for Stratification of High-Risk Patients With Early Breast Cancer
Scientific Reports
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Long-Term Treatment Outcomes of Children and Adolescents With Lymphoblastic Lymphoma Treated With Various Regimens
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Non-Invasive Skin Sampling of Tryptophan/Kynurenine Ratio in Vitro Towards a Skin Cancer Biomarker
Scientific Reports