Distinct Associations of NEDD4L Expression With Genetic Abnormalities and Prognosis in Acute Myeloid Leukemia

Researchers systemically determined NEDD4L expression with its clinical significance in AML by both public data and research cohorts. 

Cancer Cell International
Ibrutinib Protects T-Cells in Patients With CLL From Proliferation-Induced Senescence

The impact of first and second generation clinically available BTKi on t-cell function in vitro was explored and the effects  translated to changes in post-proliferation t-cell exhaustion... 

Journal of Translational Medicine
Transcription Factor MEF2D is Required for the Maintenance of MLL-Rearranged Acute Myeloid Leukemia

Scientists suggest that MEF2D plays a critical role in MLL-r AML and uncover the MEF2D-CEBPE axis as a crucial transcriptional mechanism regulating leukemia cell self-renewal... 

Blood Advances

A Pilot Study of High-Intensity Interval Training in Older Adults With Treatment Naïve Chronic Lymphocytic Leukemia

A 12-week supervised HIIT intervention combined with muscle endurance-based resistance training was implemented in older adults with treatment naïve CLL to monitor physical fitness... 

Scientific Reports
CLL Treatment May Increase Risk of Death From COVID-19

Patients with chronic lymphocytic leukemia and COVID-19 have a higher risk of death if they have received CLL treatment, according to a retrospective analysis published in Leukemia.

Cancer Therapy Advisor
m6A Regulator-Mediated Methylation Modification Patterns and Tumor Microenvironment Infiltration Characterization in Acute Myeloid Leukemia

Researchers combined the genome data from 255 AML specimens to thoroughly assess the m6A modification profile and correlate m6A modification patterns with TME infiltrative cell features.

Frontiers in Oncology
Discovery of Putative Tumor Suppressors From CRISPR Screens Reveals Rewired Lipid Metabolism in Acute Myeloid Leukemia Cells

Researchers demonstrate a systematic approach to identify proliferation suppressors, which are highly enriched for tumor suppressor genes, and define a network of 145 such genes in 22 modules. 

Nature Communications
Measurable Residual Disease Dynamics and Extended Follow-up in CLL14 Trial of Venetoclax/Obinutuzumab in Previously Untreated Chronic Lymphocytic Leukemia

Researchers find venetoclax plus obinutuzumab was associated with higher rates of undetectable MRD and prolonged MRD doubling time vs chlorambucil plus obinutuzumab at 3 months... 

The ASCO Post
Lin28A/CENPE Promoting the Proliferation and Chemoresistance of Acute Myeloid Leukemia

Lin28A/CENPE has enhanced the proliferation and chemoresistance of AML, and could be a prospective candidate for AML treatment.

Frontiers in Oncology
MRD Assessment Can Guide Treatment Discontinuation in CLL/SLL

MRD assessment can be used to guide treatment discontinuation in patients with CLL/SLL, according to phase 2 results published in the Journal of Clinical Oncology.

Hematology Advisor
PTPN11 Mutations Lead to Worse Survival Outcomes in Patients With Acute Myeloid Leukemia

In patients with AML, the presence of mutations of the tyrosine-protein phosphatase nonreceptor type 11 (PTPN11) gene was found to be a prognostic factor for poor survival...

Hematology Advisor
Addition of Enasidenib to Azacitidine in Newly Diagnosed IDH2-Mutant Acute Myeloid Leukemia

An interim analysis of the AG221-AML-005 trial showed the addition of the oral mutant IDH2 protein inhibitor enasidenib to azacitidine significantly improved overall response rate in patients...

The ASCO Post
Monitoring Clonal Evolution in Patients With Acute Myeloid Leukemia

Researchers developed a method, called CombiFlow, for processing expression data from plasma membrane-related protein markers examined in patients with AML. 

Hematology Advisor
T and B Cell Abnormalities, Pneumocystis Pneumonia, and Chronic Lymphocytic Leukemia Associated With an AIOLOS Defect in Patients

Researchers find AIOLOS plays a key role in T and B cell development in humans, and the particular gene variant described is strongly associated with immunodeficiency and likely malignancy.

Journal of Experimental Medicine
The Hydropathy Index of the HCDR3 Region of the B-Cell Receptor Identifies Two Subgroups of IGHV-Mutated Chronic Lymphocytic Leukemia Patients With Distinct Outcome

The hydropathy index of the BCR of tumor cells from 138 CLL patients were investigated alongside the potential association with other features of the disease, including the BCR mutational status...

Frontiers in Oncology
Genome-Wide Association Study Identifies Susceptibility Loci for Acute Myeloid Leukemia

Scientists conducted three genome-wide association studies with participants of European ancestry, with replication in a fourth study to report identification of risk loci for AML... 

Nature Communications
Blast Cells Surviving Acute Myeloid Leukemia Induction Therapy are in Cycle With a Signature of FOXM1 Activity

In vivo chemoresistant blasts were characterized by studying the transcriptional and genetic features of blasts from before and shortly after induction chemotherapy using paired samples...

BMC Cancer
Enhancing Therapeutic Efficacy of Double Negative T Cells against Acute Myeloid Leukemia Using Idelalisib

Scientists characterize the in vivo persistence of DNTs in PDX models to improve the efficacy and durability of DNT-mediated activity with PI3Kδ inhibition. 

Activation of Vitamin D Receptor Pathway Enhances Differentiating Capacity in Acute Myeloid Leukemia with Isocitrate Dehydrogenase Mutations

This study demonstrates 2-HG specifically activates vitamin D receptor in IDH mutant AML cells leading to increased sensitivity to the combination of vitamin D (or VDR agonist) and...

FDA Grants Orphan Drug Designation to LAVA-051 for CLL

LAVA-051, a bispecific antibody that activates the immune system to attack CD1d-expressing cancer cells, was given orphan drug designation from the FDA. 

Runt-Related Transcription Factor 3 Promotes Acute Myeloid Leukemia Progression

RUNX3 was discovered as an oncogene overexpressed in AML cells, and Runx3 knockdown suppressed AML progression by inducing DNA damage and apoptosis.

Frontiers in Oncology
The Multi-Omic Prognostic Model of Oxidative Stress-Related Genes in Acute Myeloid Leukemia

This study aims to contribute to the prognosis or monitoring of AML, as well as to clinical therapeutic decision-making, which may provide new evidence for the management of the disease.

Frontiers in Oncology

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