Chronic ITP

Chronic ITP

SDF-1α Facilitates Mesenchymal Stem Cells to Induce Regulatory B Cell Differentiation from Patients With Immune Thrombocytopenia

B cells play a central role in the pathogenesis of ITP by participating in humoral immunity. The aim of the research is to provide a potential approach in the management of ITP.

Stem Cells International
Quantitative LC–MS/MS Uncovers the Regulatory Role of Autophagy in Immune Thrombocytopenia

In this study, investigators report the qualitative and quantitative profiles of the ITP proteome.

Cancer Cell International

Unexpected Thrombocytosis Could Flag Occult Cancer

A finding of thrombocytosis was associated with a greatly increased risk for some cancers up to 5 years later.

Effectiveness of Corticosteroids in the Treatment of Chemotherapy-Induced Thrombocytopenia

According to study results presented during ESMO Congress 2021, corticosteroids appeared to have a benefit in the treatment of mild to moderate CT-induced thrombocytopenia...

Hematology Advisor
Patients With Cancer and COVID-19 Face Increased Risk of Thromboembolic Events

Among patients with cancer, COVID-19 infection may lead to life-threatening thromboembolic events even after acute illness, necessitating risk prediction tools for TEs.

Hematology Advisor
Influence of Vincristine, Clinically Used in Cancer Therapy and Immune Thrombocytopenia, on the Function of Human Platelets

Due to its property of increasing platelet counts, vincristine is also used to treat patients with immune thrombocytopenia. 

Low-Dose Decitabine Modulates T-cell Homeostasis and Restores Immune Tolerance in Immune Thrombocytopenia

In this study, investigators analyze the effect of decitabine on T-cell subpopulations in ITP in vitro and in vivo.

Comparison of Splenectomy and Eltrombopag Treatment in the Second-Line Treatment of Immune Thrombocytopenic Purpura

In this study, investigators compare the efficiency and toxicities of splenectomy and eltrombopag as second-line treatments in ITP.

Romiplostim in Children With Newly Diagnosed or Persistent Primary Immune Thrombocytopenia

The data suggest that earlier treatment with romiplostim may help children to avoid the side effects associated with corticosteroid use and reduce the need for subsequent treatment.

Predictive Value of High ICAM-1 Level for Poor Treatment Response to Low-Dose Decitabine in Adult Corticosteroid Resistant ITP Patients

This study attempts to elucidate the correlation between endothelial dysfunction and disease severity of ITP and find related markers to predict response to low-dose decitabine treatment.

Frontiers in Immunology
Platelet Desialylation and TFH Cells–The Novel Pathway of Immune Thrombocytopenia

This review discusses platelet clearance and production, especially the role of the anti-GPIbα antibody and desialylation in the pathophysiology of ITP and therapy for this disease.

Experimental Hematology & Oncology
Imbalance of T Lymphocyte Subsets in Adult Immune Thrombocytopenia

This work is to further clarify the relationship between T cell immune dysfunction and the pathogenesis of ITP.

International Journal of General Medicine
Emerging Therapies in Immune Thrombocytopenia

Beyond the inhibition of the autoimmune response, new TPO-RAs that stimulate platelet production have been developed.

Journal of Clinical Medicine
Misdiagnosed Thrombocytopenia in Children and Adolescents: Analysis of the Pediatric and Adult Registry on Chronic ITP

Misdiagnosed primary ITP in children is rare in the international prospective Pediatric and Adult Registry on Chronic ITP.

Blood Advances
Impact of Eradication Therapy of Helicobacter Pylori in Children With Chronic Immune Thrombocytopenic Purpura

The study examines the prevalence of H. pylori among chronic ITP children and to investigate the impact of treatment of H. pylori infection on platelet count response.

Eltrombopag for Post-Transplant Thrombocytopenia: Results of Phase II Randomized Double-Blind Placebo-Controlled Trial

Prolonged thrombocytopenia occurs in up to 37% of patients after HSCT and is associated with adverse prognosis and increased risk of bleeding.

Chronic Immune Thrombocytopenia and Hashimoto’s Hypothyroidism in an Adolescent: Presentation and Implications

Presented here is a case of a 14-year-old female diagnosed with immune thrombocytopenia.

Thrombotic Thrombocytopenic Purpura: Pathophysiology, Diagnosis, and Management

TTP is a rare thrombotic microangiopathy characterized by microangiopathic hemolytic anemia, severe thrombocytopenia, and ischemic end organ injury due to microvascular platelet-rich thrombi.

Journal of Clinical Medicine
The Association of Lymphocyte Phenotypes and Outcomes After Discontinuing Eltrombopag in Immune Thrombocytopenia

This study examines the phenotypes of lymphocytes in ITP to clarify whether they predict outcomes after the discontinuation of eltrombopag.

Comparison of Clinical Efficacy of Laparoscopic Splenectomy Versus Open Splenectomy for Idiopathic Thrombocytopenic Purpura

The purpose of this study is to compare the clinical efficacy of laparoscopic splenectomy and open splenectomy in the treatment of Idiopathic thrombocytopenic purpura.

ITP in Children: Shifting Management Strategies?

The optimal approach to managing children newly diagnosed with this disease remains controversial.

MedPage Today
Antimicrobial Prophylaxis in Patients With Immune Thrombocytopenia Treated With Rituximab

The aim of this study is to describe the use of primary anti-infective prophylaxis in common clinical practice in patients affected by ITP and treated with RTX. 

Annals of Hematology
Evolving Treatment Modalities for Immune Thrombocytopenia in Adults

Study investigators review the newer approaches in the treatment of ITP.

Journal of Community Hospital Internal Medicine Perspectives
Co-Inhibition of the Immunoproteasome Subunits LMP2 and LMP7 Ameliorates Immune Thrombocytopenia

This study found that the expression of the immunoproteasome catalytic subunit, LMP2, was significantly upregulated in peripheral blood mononuclear cells of active ITP patients...

Frontiers in Immunology

source list reference

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