Chronic ITP

Chronic ITP

Platelet Desialylation and TFH Cells–The Novel Pathway of Immune Thrombocytopenia

This review discusses platelet clearance and production, especially the role of the anti-GPIbα antibody and desialylation in the pathophysiology of ITP and therapy for this disease.

Experimental Hematology & Oncology
Imbalance of T Lymphocyte Subsets in Adult Immune Thrombocytopenia

This work is to further clarify the relationship between T cell immune dysfunction and the pathogenesis of ITP.

International Journal of General Medicine
Emerging Therapies in Immune Thrombocytopenia

Beyond the inhibition of the autoimmune response, new TPO-RAs that stimulate platelet production have been developed.

Journal of Clinical Medicine

Misdiagnosed Thrombocytopenia in Children and Adolescents: Analysis of the Pediatric and Adult Registry on Chronic ITP

Misdiagnosed primary ITP in children is rare in the international prospective Pediatric and Adult Registry on Chronic ITP.

Blood Advances
Impact of Eradication Therapy of Helicobacter Pylori in Children With Chronic Immune Thrombocytopenic Purpura

The study examines the prevalence of H. pylori among chronic ITP children and to investigate the impact of treatment of H. pylori infection on platelet count response.

Eltrombopag for Post-Transplant Thrombocytopenia: Results of Phase II Randomized Double-Blind Placebo-Controlled Trial

Prolonged thrombocytopenia occurs in up to 37% of patients after HSCT and is associated with adverse prognosis and increased risk of bleeding.

Chronic Immune Thrombocytopenia and Hashimoto’s Hypothyroidism in an Adolescent: Presentation and Implications

Presented here is a case of a 14-year-old female diagnosed with immune thrombocytopenia.

Thrombotic Thrombocytopenic Purpura: Pathophysiology, Diagnosis, and Management

TTP is a rare thrombotic microangiopathy characterized by microangiopathic hemolytic anemia, severe thrombocytopenia, and ischemic end organ injury due to microvascular platelet-rich thrombi.

Journal of Clinical Medicine
The Association of Lymphocyte Phenotypes and Outcomes After Discontinuing Eltrombopag in Immune Thrombocytopenia

This study examines the phenotypes of lymphocytes in ITP to clarify whether they predict outcomes after the discontinuation of eltrombopag.

Comparison of Clinical Efficacy of Laparoscopic Splenectomy Versus Open Splenectomy for Idiopathic Thrombocytopenic Purpura

The purpose of this study is to compare the clinical efficacy of laparoscopic splenectomy and open splenectomy in the treatment of Idiopathic thrombocytopenic purpura.

ITP in Children: Shifting Management Strategies?

The optimal approach to managing children newly diagnosed with this disease remains controversial.

MedPage Today
Antimicrobial Prophylaxis in Patients With Immune Thrombocytopenia Treated With Rituximab

The aim of this study is to describe the use of primary anti-infective prophylaxis in common clinical practice in patients affected by ITP and treated with RTX. 

Annals of Hematology
Evolving Treatment Modalities for Immune Thrombocytopenia in Adults

Study investigators review the newer approaches in the treatment of ITP.

Journal of Community Hospital Internal Medicine Perspectives
Co-Inhibition of the Immunoproteasome Subunits LMP2 and LMP7 Ameliorates Immune Thrombocytopenia

This study found that the expression of the immunoproteasome catalytic subunit, LMP2, was significantly upregulated in peripheral blood mononuclear cells of active ITP patients...

Frontiers in Immunology

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