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Cutaneous Squamous-Cell Carcinoma

Cutaneous Squamous-Cell Carcinoma

Circulating Immunosuppressive Regulatory T Cells Predict Risk of Incident Cutaneous Squamous Cell Carcinoma

The aim of this study was to determine whether circulating Treg levels are associated with cuSCC development, particularly in the context of high UVR. 

Frontiers in Medicine
11/02/2021
Organ Transplant Recipients at Risk of Multiple Skin Cancers

Organ transplant recipients may be at risk of developing multiple skin cancers, according to a study published in JAMA Dermatology.

Cancer Therapy Advisor
11/01/2021
Photoplethysmography for Demarcation of Cutaneous Squamous Cell Carcinoma

Scientists present a video processing algorithm showing promising results encouraging further investigation to clarify how detailed distinctions can be made in cSCC. 

Scientific Reports
11/02/2021

c-FOS Drives Reversible Basal to Squamous Cell Carcinoma Transition

Using surface markers of resistant BCCs and patient single-cell and bulk transcriptomic data, researchers uncover the dynamic roadmap of BST.

Cell Reports
10/05/2021
Development and Characterization of Phasor-Based Analysis for FLIM to Evaluate the Metabolic and Epigenetic Impact of HER2 Inhibition on Squamous Cell Carcinoma Cultures

Researchers combined lifetime and phasor FLIM analysis to evaluate the influence of HER2 inhibition, a prevalent cancer biomarker, on both nuclear and cytoplasmic NAD(P)H of two SCC cultures.

Journal of Biomedical Optics
10/09/2021
Genomic Similarities in Actinic Keratosis and Cutaneous Squamous Cell Carcinoma Found

cSCC & AK, are highly similar at the genomic level in terms of tumor mutational burden, driver gene patterns & copy number aberrations, according to the largest AK genomic dataset to date. 

Dermatology Advisor
09/30/2021
FDG-PET/CT Imaging for Evaluating Durable Responses to Immune Check Point Inhibitors in Patients With Advanced Cutaneous Squamous Cell Carcinoma

Scientists compare CMR rates by FDG-PET and RECIST1.1 via CT or MRI in patients on cemiplimab for > 10 months.

Cancer Imaging
10/13/2021
Kinectin1 Depletion Promotes EGFR Degradation via the Ubiquitin-Proteosome System in Cutaneous Squamous Cell Carcinoma

Research expands the understanding of KTN1 function in protein degradation, which defines a new network of UPS in EGFR degradation in cSCC.

Cell Death & Disease
10/23/2021
Serum Sialylation Changes in Actinic Keratosis and Cutaneous Squamous Cell Carcinoma Patients

Scientists determined the serum levels of TSA, LSA, ST6GalI, and NEU3 in 40 patients with cSCC, 28 patients with AK, and 40 healthy subjects.

Journal of Personalized Medicine
10/15/2021
Serial Excision for Treatment of Non-Melanoma Skin Cancer

The objective of this study is to investigate outcomes of serial excision as an alternative excision modality for NMSC.

Plastic and Reconstructive Surgery-Global Open
06/10/2021
Expression Profiles of ASIC1/2 and TRPV1/4 in Common Skin Tumors

Study investigators examine the expression profiles of ASIC1, ASIC2, TRPV1 and TRPV4 in malignant melanoma, squamous cell carcinoma, basal cell carcinoma and in nevus cell nevi. 

International Journal of Molecular Sciences
06/02/2021
Effect of the COVID-19 Pandemic on Delayed Skin Cancer Services

Investigators aim to summarize evidenced-based recommendations for the surgical management and prioritization of three skin cancer categories during the COVID-19 pandemic.

Dermatologic Clinics
10/01/2021
Exosomal Circular RNA RNA-seq Profiling and the Carcinogenic Role of Exosomal circ-CYP24A1 in Cutaneous Squamous Cell Carcinoma

Based on RNA-seq, study investigators systematically uncover the expression and implication of exosomal circRNAs in cSCC.

Frontiers in Medicine
05/24/2021
Topical Arginase Inhibition Decreases Growth of Cutaneous Squamous Cell Carcinoma

This study demonstrates the therapeutic potential of transcutaneous arginase inhibition in cSCC.

Scientific Reports
05/24/2021
Reflectance Confocal Microscopy of Aging Skin and Skin Cancer

Skin aging is a complex process that causes morphologic variations. Some of these variations have been hypothesized to be involved in skin cancer development. 

05/20/2021
Delayed Response After Confirmed Progression and Other Unique Immunotherapy-Related Treatment Concepts in Cutaneous Squamous Cell Carcinoma

This study highlights treatment issues distinct to the management of the disease including expansion of the traditional concept of pseudoprogression and describes delayed responses after...

Frontiers in Oncology
04/15/2021
Possible Link Between High Risk SCC Tumors and Statins in Men

Adult men taking statins may be at greater risk for larger and more advanced CSCC tumors, according to study results presented at the AAD VMX 2021.

04/27/2021
Risk for Cutaneous Squamous Cell Carcinoma Increases With Age

Although the diagnosis of actinic keratosis has been associated with developing CSCC, patient age is shown to have a greater association with the long-term development of CSCC.

Cancer Therapy Advisor
04/15/2021
Cutaneous Squamous Cell Carcinoma Arising From the Ulcer of the Lesions of Dupuytren’s Disease on the Palm

This is a case of a 52-year-old female with squamous cell carcinoma arising from the ulcer of the lesions of Dupuytren’s disease on the left palm.

Frontiers in Oncology
03/25/2021
Small Molecules in the Treatment of Squamous Cell Carcinomas: Focus on Indirubins

This review discusses the genetic landscape of squamous cell carcinoma and the related to the potential targets of indirubin-based small molecules in cancer therapy.

Cancers
04/07/2021
Identification of a Gene Prognostic Signature for Oral Squamous Cell Carcinoma by RNA Sequencing and Bioinformatics

Study investigators aim to identify new biomarkers or potential therapeutic targets for OSCC.

BioMed Research International
04/01/2021
Nectin Cell Adhesion Molecule 4 (NECTIN4) Expression in Cutaneous Squamous Cell Carcinoma: A New Therapeutic Target?

The aim of this study is to determine the expression and function of NECTIN4 in cSCC.

Biomedicines
03/30/2021
Efficacy and Toxicity of Definitive ChemoRadiation and ImmunOtherapy in Locally and/or Regionally Advanced Unresectable Cutaneous Squamous Cell Carcinoma

This single arm phase 2 prospective study aims to investigate the combination of curative intent chemoradiation and durvalumab (anti-PD-L1 checkpoint inhibitor) for this patient cohort.

Radiation Oncology
04/09/2021
Growth and Viability of Cutaneous Squamous Cell Carcinoma Cell Lines Display Different Sensitivities to Isoform-Specific Phosphoinositide 3-Kinase Inhibitors

Study investigators determine the sensitivity of four patient-derived cSCC cell lines to isoform-specific PI3K inhibitors to start investigating their potential therapeutic value in cSCC.

International Journal of Molecular Sciences
03/30/2021
Mutually Exclusive Lymphangiogenesis or Perineural Infiltration in Human Skin Squamous-Cell Carcinoma

Although anti-PD-1 therapy is beneficial for some patients with advanced sSCC, a greater understanding of disease mechanisms is still needed to develop better therapies.

03/30/2021
Risk Prediction Model for Cutaneous Squamous Cell Carcinoma in Adult Cardiac Allograft Recipients

The aim of this study is to identify risk factors and predict the incidence of cSCC for heart transplant recipients.

03/18/2021
Cutaneous Squamous Cell Carcinoma in Patients With Hidradenitis Suppurativa

Cutaneous squamous cell carcinoma is a recognized but infrequent complication of hidradenitis suppurativa.

Cancers
03/08/2021
Cutaneous Squamous Cell Carcinoma in the Age of Immunotherapy

Expanded applications of programmed death-1 (PD-1) blockade therapies have revealed cSCC to be one of the most amenable targets.

Cancers
03/08/2021
Cutaneous Squamous Cell Carcinoma in Lynch Syndrome — An Overlooked Association

Study investigators report a case of CSCC occurring in a patient with Lynch syndrome and explore some of the characteristic features and significance of this association.

Cureus
02/25/2021
Managing Risk Factors & Timing of Subsequent Cutaneous Squamous Cell Carcinoma

Each year in the United States, at least 200,000 to 400,000 new cases of cSCC are expected, and disease-related death occurs in more than 3,000 people with cSCC. 

Oncology Times - Latest Articles
03/01/2021
High-Risk Cutaneous Squamous Cell Carcinomas: The Present and Future

There are several unanswered questions about cutaneous squamous cell carcinoma, including which patients should undergo nodal staging, who should be surgically treated with...

The ASCO Post
02/10/2021
CD8+CD103+ Tissue-Resident Memory T Cells Convey Reduced Protective Immunity in Cutaneous Squamous Cell Carcinoma

While several memory T-cell subtypes have been reported in inflammatory and neoplastic conditions, the proportional representation of the different subsets of memory T cells and...

01/21/2021
Gene Test Helps Inform Management of High-Risk SCC Patients

Emerging data support the clinical validity and use of DecisionDx-SCC as a prognostic 40-gene expression profile test for patients with high-risk SCC.

Medscape
02/01/2021

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