Ovarian Cancer

Ovarian Cancer

Bevacizumab in Advanced Ovarian Cancer: Phase III Trial Finds More Is Not Better

In advanced ovarian cancer, the duration of maintenance bevacizumab should remain 15 months, according to the European multicenter phase III ENGOT/GCIG trial.

The ASCO Post
Multi-Omics Profiling Identifies Risk Hypoxia-Related Signatures for Ovarian Cancer Prognosis

Hypoxia is a driver of the malignant progression in ovarian cancer, which results in poor prognosis.

Frontiers in Immunology

Identification of a Novel Tumor Microenvironment Prognostic Signature for Advanced-Stage Serous Ovarian Cancer

In our study, investigators constructed a prognostic 11-gene signature for advanced serous ovarian cancer from tumor microenvironment-related genes through lasso regression. 

Avelumab Alone or in Combination With Chemotherapy versus Chemotherapy Alone in Platinum-Resistant or Platinum-Refractory Ovarian Cancer

Study investigators report results of avelumab alone or avelumab plus PLD compared with PLD alone in patients with platinum-resistant or platinum-refractory ovarian cancer.

The Lancet Oncology
Could Risk-Based Triage System Alter Surgical Practice in Ovarian Cancer?

A simple, risk-assessment algorithm may change practice when it comes to selecting patients with advanced ovarian cancer who can tolerate complex primary debulking surgery...

The ASCO Post
Combination of Gene Set Signatures Correlates With Response to Nivolumab in Platinum-Resistant Ovarian Cancer

Based on a previous phase II clinical trial of anti-PD-1 antibody nivolumab for platinum-resistant ovarian cancer, investigators aim to identify the biomarkers predictive of response.

Scientific Reports
BRCA Genetic Test and Risk-Reducing Salpingo-Oophorectomy for Hereditary Breast and Ovarian Cancer

The BRCA genetic test and HRD test are used as a companion diagnosis before starting PARP inhibitor treatment.

PHGDH Is Upregulated at Translational Level and Implicated in Platin-Resistant in Ovarian Cancer Cells

Platinum-based chemotherapy is the first line option for ovarian cancer.

Frontiers in Oncology
Association of Salpingectomy With Delayed Oophorectomy Versus Salpingo-oophorectomy With Quality of Life in BRCA1/2 Pathogenic Variant Carriers

This study seeks to answers the question: What is the menopause-related quality of life in carriers of the BRCA1/2 pathogenic variant after salpingectomy with delayed oophorectomy compared with the

JAMA Oncology
Phase III ARIEL4 Confirms Rucaparib’s Benefit in BRCA-Mutated Relapsed Ovarian Cancer

In patients with BRCA-mutated, advanced, relapsed ovarian cancer, treatment with the PARP inhibitor rucaparib leads to a significant improvement in PFS compared with standard-of-care CT.

The ASCO Post
Analysis of Autophagy-Related Signatures Identified Two Distinct Subtypes for Evaluating the Tumor Immune Microenvironment and Predicting Prognosis in Ovarian Cancer

This study constructs an autophagy-related prognostic indicator, and identifies two promising targets in ovarian cancer. 

Frontiers in Oncology
Genetic Alterations and Their Therapeutic Implications in Epithelial Ovarian Cancer

Genetic alterations for epithelial ovarian cancer are insufficiently characterized.

BMC Cancer
Relationship Between Germline BRCA Pathogenic Variants and Diminished Ovarian Reserve

Turan et al find the presence of germline BRCA pathogenic variants is associated with diminished ovarian reserve in young women, particularly in those diagnosed with breast cancer and...

The ASCO Post
Structured Palliative Care Referrals in Recurrent Ovarian Cancer

Researchers find that implementation of a structured palliative care process is feasible, according to a pilot study of patients with recurrent ovarian cancer.

Oncology Times - Latest Articles
Cellular Mechanism of Gene Mutations and Potential Therapeutic Targets in Ovarian Cancer

This review illustrates recent advances in identifying ovarian cancer gene mutations, including those of TP53, BRCA1/2, PIK3CA, and KRAS genes.

Cancer Management and Research
The Prognostic and Predictive Role of Somatic BRCA Mutations in Ovarian Cancer

The aim of this study is to explore the prognostic and predictive role of sBRCA mutations as compared to gBRCA mutations in patients who were also tested for CNVs.

Immune-Checkpoint Inhibitors in Platinum-Resistant Ovarian Cancer

The aim of this review is to describe the immunobiology of ovarian cancer and likely benefit from immunotherapy, discuss clinical trial data and biomarkers that warrant further exploration...

Secondary Cytoreduction Followed By Chemotherapy Versus Chemotherapy Alone in Platinum-Sensitive Relapsed Ovarian Cancer

Study investigators assess the efficacy of secondary cytoreduction plus chemotherapy versus chemotherapy alone in this patient population.

The Lancet Oncology
Overall Survival With Olaparib vs Placebo Maintenance in Patients With Platinum-Sensitive Relapsed Ovarian Cancer and BRCA1/2 Mutation

The phase III SOLO2/ENGOT-Ov21 trial has shown a large numeric but statistically nonsignificant improvement in the secondary endpoint of overall survival with olaparib tablet maintenance therapy...

The ASCO Post
Frailty May Impact Surgical Outcomes in Patients With Ovarian Cancer

Frailty may be a better predictor of poor surgical outcomes in patients with ovarian cancer than age, according to two studies reported at the SGO 2021 Virtual Annual Meeting on Women’s Cancer.

The ASCO Post
Phase III ARIEL4 Trial Confirms Benefit of Rucaparib in BRCA-Mutated Relapsed Ovarian Cancer

In patients with BRCA-mutated, advanced, relapsed ovarian cancer, treatment with the PARP inhibitor rucaparib led to a significant improvement in progression-free survival compared with...

The ASCO Post
Olaparib Tablets as Maintenance Therapy in Patients With Platinum-Sensitive Relapsed Ovarian Cancer and a BRCA1/2 Mutation

The aim of this final analysis is to investigate the effect of olaparib on overall survival.

The Lancet Oncology
Niraparib Plus Bevacizumab Shows Clinical Benefit in Patients With Advanced Ovarian Cancer

The addition of niraparib maintenance to first-line platinum-based chemotherapy with bevacizumab demonstrated clinical benefit in patients with advanced ovarian cancer.

The ASCO Post
The Impact of Pegylated Liposomal Doxorubicin in Recurrent Ovarian Cancer

The aim of the present meta-analysis is to further update the role of PLD in the treatment of recurrent ovarian cancer.

Journal of Ovarian Research
Nomograms to Predict the Density of Tumor-Infiltrating Lymphocytes in Patients With High-Grade Serous Ovarian Cancer

Study investigators explore the association of TILs with clinicopathological characteristics and blood indicators, and to develop nomograms to predict the density of TILs in patients with high-grad

Frontiers in Oncology
Gene Expression Profile Association With Poor Prognosis in Epithelial Ovarian Cancer Patients

Study investigators perform gene expression profiling of different subtypes of ovarian cancer to evaluate its association with patient overall survival and aggressive forms of the disease.

Scientific Reports
Exosome-Mediated Transfer of CD44 From High-Metastatic Ovarian Cancer Cells Promotes Migration and Invasion of Low-Metastatic Ovarian Cancer Cells

This study investigates the detailed roles and mechanisms of tumor-derived exosomes in progression and metastasis of ovarian cancer in vitro.

Journal of Ovarian Research
Prognostic Significance of Survivin Expression in Patients with Ovarian Carcinoma

The aim of this study is to assess the clinical and prognostic significance of expression survivin in patients with ovarian cancer.

Journal of Clinical Medicine
Combination of Immune-Related Genomic Alterations Reveals Immune Characterization and Prediction of Different Prognostic Risks in Ovarian Cancer

With the highest case-fatality rate among women, the molecular pathological alterations of ovarian cancer are complex, depending on the diversity of genomic alterations.

Frontiers in Cell and Developmental Biology
PAX8 and MECOM Are Interaction Partners Driving Ovarian Cancer

Comprehensive genomic screens furthermore indicate an additional oncogenic role for PAX8 in renal and ovarian cancers.

Nature Communications
Intersection of DNA Repair Pathways and the Immune Landscape Identifies PD-L2 as a Prognostic Marker in Epithelial Ovarian Cancer

Study investigators examine the interaction between DNA repair proteins and immune biomarkers and their association with survival in 181 cases of epithelial ovarian carcinoma. 

Atezolizumab, Bevacizumab, and Chemotherapy for Newly Diagnosed Stage III or IV Ovarian Cancer

This study evaluates the addition of the humanized monoclonal PD-L1 antibody, atezolizumab, to platinum-based chemotherapy and bevacizumab in newly diagnosed stage III or IV ovarian cancer.

Journal of Clinical Oncology

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