Prostate Cancer

Prostate Cancer

Addition of Ipatasertib to Abiraterone Plus Prednisolone Improves Radiographic Progression–Free Survival in Metastatic Castration-Resistant Prostate Cancer With PTEN Loss

A phase III trial found that the addition of the AKT inhibitor ipatasertib to abiraterone and prednisolone produced a significant improvement in radiographic progression-free survival... 

The ASCO Post
Alpha-L-Fucosidase Has Diagnostic Value in Prostate Cancer With “Gray-Zone PSA” and Inhibits Cancer Progression via Regulating Glycosylation

This study explores the diagnostic value of AFU in PCa patients with “gray-zone PSA” and the correlation between AFU expression and clinicopathological characteristics of PCa patients.

Frontiers in Oncology
Discovery Proteomics Defines Androgen-Regulated Glycoprotein Networks in Prostate Cancer Cells, as Well as Putative Biomarkers of Prostatic Diseases

Researchers discover that androgens elicited dose-dependent changes in the expression of glycoprotein networks related to cell growth and differentiation in PCa cells. 

Scientific Reports

TMPRSS4 Promotes Cancer Stem–Like Properties in Prostate Cancer Cells Through Upregulation of SOX2 by SLUG and TWIST1

Study authors investigated whether TMPRSS4 confers cancer stem–like properties to prostate cancer cells and characterized the underlying mechanisms.

Journal of Experimental & Clinical Cancer Research
Exploration of the Tumor Mutational Burden as a Prognostic Biomarker and Related Hub Gene Identification in Prostate Cancer

Investigators examined the correlations of the tumor mutational burden with clinical prognosis and antitumor immunity in prostate cancer, and compared the gene sets of high-TMB and...

Technology in Cancer Research & Treatment
CD8-Positive T Cells and CD204-Positive M2-like Macrophages Predict Postoperative Prognosis of Very High-Risk Prostate Cancer

This study investigated the clinical, pathological and immunological significance of the tumor immune microenvironment of very high-risk prostate cancer with seminal vesicle invasion.

Scientific Reports
Association of Treatment Modality, Functional Outcomes, and Baseline Characteristics With Treatment-Related Regret Among Men With Localized Prostate Cancer

Treatment-related regret is common among patients with localized prostate cancer, and rates appear to differ among treatment approaches associated with outcomes and patient expectations.

JAMA Oncology
No Survival Benefit but Improved Secondary Endpoints With Radiotherapy Plus Androgen Suppression in Intermediate-Risk Prostate Cancer

The phase III RTOG 0815 study finds both dose-escalated RTand short-course ADT improve outcomes in intermediate-risk prostate cancer. 

The ASCO Post
Urine Test for Prostate Cancer Signals Amount of Aggressive Tumor

A potential new urine biomarker for prostate cancer not only spots the presence of aggressive tumors, it also indicates the amount of these tumors, according to a recent report.

Protocol for GET FIT Prostate: A Randomized, Controlled Trial of Group Exercise Training for Fall Prevention and Functional Improvements During and After Treatment for Prostate Cancer

This trial compared the relative efficacy of strength training versus tai ji quan training against each other and to a stretching control group on falls, frailty, and physical functioning...

Type of Treatment, Symptoms and Patient Satisfaction Play an Important Role in Primary Care Contact During Prostate Cancer Follow-Up

This study investigates factors associated with GP contact during follow-up of prostate cancer survivors, such as patient, treatment and symptom variables, and satisfaction with GPs.

BMC Family Practice
Findings Support Targeted PSA Screening for Prostate Cancer

Patients with pathogenic variants in MSH2 and MSH6 have a significantly higher incidence of prostate cancer than do patients without these variants... 

Cancer Therapy Advisor
HYPORT in Prostate Cancer: New Standard After Surgery?

The long-term side effects of HYPORT for prostate cancer are similar to those of conventional radiotherapy, a new study concludes.

ASTRO: Long-Term AEs Similar for Shorter-Course RT After Prostatectomy

For patients who undergo prostatectomy for prostate cancer, hypofractionated postoperative prostate bed radiotherapy is similar to conventionally fractionated postoperative radiotherapy with...

Cancer Therapy Advisor
Study Zeros in on Why Men Abandon Prostate Cancer Active Surveillance

The appearance of higher-risk tumor features often triggers the conversion from active surveillance or watchful waiting of prostate cancer to treatment, a new study finds. 

Cancer Therapy Advisor
Doctors Disagree With Update to NCCN Guidelines for Prostate Cancer

The National Comprehensive Cancer Network recently updated its guidelines for the treatment of prostate cancer, and one change has some physicians concerned. 

Cancer Therapy Advisor
PIM1 Phosphorylation of the Androgen Receptor and 14-3-3 ζ Regulates Gene Transcription in Prostate Cancer

This research works to indicate a coordinated response in which PIM1 phosphorylation of AR and 14-3-3 ζ alters AR-dependent gene expression.

Communications Biology
Optimization of Training and Measurement Protocol for eNose Analysis of Urine Headspace Aimed at Prostate Cancer Diagnosis

Scientists describe the approach aimed at improving the experimental protocol for eNose application for PCa diagnosis through exploring the effects of the portion of urine analysed...

Scientific Reports
In Nonmetastatic Castration-Sensitive Prostate Cancer, Abiraterone Added to Androgen-Deprivation Therapy Improves Survival

According to a primary analysis of two comparisons from the STAMPEDE trial, adding two years of AAP to androgen-deprivation therapy improves metastasis-free survival and overall survival.

The ASCO Post
Prostate Cancer Observation Varies With MRI, Genomic Testing Availability

The availability of prostate MRI and genomic testing is associated with increased adoption of observation rather than treatment as an initial management strategy for localized prostate cancer.

Cancer Therapy Advisor
Detecting and Grading Prostate Cancer in Radical Prostatectomy Specimens Through Deep Learning Techniques

This study aims to evaluate the ability of deep learning algorithms to detect and grade prostate cancer in radical prostatectomy specimens.

Small Extracellular Vesicle-Derived microRNAs Stratify Prostate Cancer Patients According to Gleason Score, Race and Associate with Survival of African American and Caucasian Men

Researchers determine the diagnostic and prognostic utility of sEV-associated miRs in identifying aggressive PCa in African American and Caucasian men.

A Multi-Modal, Physician-Centered Intervention to Improve Guideline-Concordant Prostate Cancer Imaging

Research describes and analyzes the implementation of the PCIS intervention to determine the effect of a physician-focused behavioral intervention on VHA prostate cancer imaging use. 

Targeted Prostate Cancer Screening Could Benefit Men With Inherited Cancer Syndrome

Men who inherit an increased risk of cancer through "Lynch syndrome" could benefit from regular PSA testing from age 40 to detect early signs of prostate cancer.

Medical Xpress
Androgen Deprivation Therapy and Excess Mortality in Men With Prostate Cancer During the Initial Phase of the COVID-19 Pandemic

This study's aim was to estimate the impact of ADT on mortality from COVID-19 in men with prevalent prostate cancer by comparing all-cause mortality in the spring of 2020 to that in previous years.

Artificial Intelligence Combined With Big Data to Predict Lymph Node Involvement in Prostate Cancer

Scientists use machine learning to create a more accurate preoperative prediction of LNI in PCa, which would improve clinical treatment and follow-up strategies of this disease.

Frontiers in Oncology
Nomogram Incorporating Contrast-Enhanced Ultrasonography Predicting Time to the Development of Castration-Resistant Prostate Cancer

Scientists build and validate a nomogram incorporating the clinicopathologic characteristics and the parameters of CEUS to predict the time to CRPC after ADT.

Clinical Medicine Insights: Oncology
Reciprocal Deregulation of NKX3.1 and AURKA Axis in Castration-Resistant Prostate Cancer and NEPC Models

Researchers uncover a reciprocal loop between AURKA and NKX3.1 in CRPC and NEPC cells. 

Journal of Biomedical Science
Minimally Important Differences for the EORTC QLQ-C30 in Prostate Cancer Clinical Trials

This study estimates the MID for interpreting group-level change over time, both within a group and between groups, for the EORTC QLQ-C30 scores in patients with prostate cancer.

BMC Cancer
Stroma-Derived Extracellular Vesicle mRNA Signatures Inform Histological Nature of Prostate Cancer

Research presents a characterisation of normal vs disease-associated prostate stromal cell EVs, highlighting several differences in the encapsulated EV RNA cargo.

Journal of Extracellular Vesicles
Magnetic Resonance Imaging of PSMA-Positive Prostate Cancer by a Targeted and Activatable Gd(III) MR Contrast Agent

Research finds a targeted and activatable MR contrast agent that can be systemically administered in vivo to highlight PSMA+ prostate tumors...

Surgery vs Radiation May Lower Risk of Death From High-Risk Prostate Cancer

A new study finds that radical prostatectomy is associated with improved cancer-specific survival compared with external beam radiation therapy among men with high-risk prostate cancer.

Cancer Therapy Advisor
Androgen Signaling Inhibitors Appear More Effective in Luminal mCRPC

Among patients with mCRPC, androgen signaling inhibitors may be more beneficial for patients with luminal tumors than for those with basal tumors.

Cancer Therapy Advisor

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