Solid Tumors

Solid Tumors

Assessing the Safety of a Novel OX40 Agonist in Advanced Solid Tumors

Recently published data shows that BMS-986178, an investigational OX40 agonist, appears to be safe to use as monotherapy or in combination with immune checkpoint inhibitors in the treatment...

Oncology Times - Latest Articles
PD-1 Immunobiology in Glomerulonephritis and Renal Cell Carcinoma

The expression and function of PD-1 molecules on immune and kidney parenchymal cells are reviewed in the healthy kidney, PD-1 immunotherapy-induced nephrotoxicity, glomerulopathies and RCC.

BMC Nephrology
Safety and Activity of Vandetanib in Combination With Everolimus in Patients With Advanced Solid Tumors

Study investigators determine the safety, maximum tolerated dose, recommended phase II dose, and dose-limiting toxicities of VAN + EV in patients with advanced solid cancers and the effect of...


Updated Outcomes for Patients With Metastatic Nonseminomatous Germ Cell Tumors and Development of New Prognostic Model

Dr Silke Gillessen and colleagues in the IGCCCG Update Consortium analyze outcomes in a more contemporary cohort of men with metastatic nonseminomatous germ cell tumors.

The ASCO Post
Morning (vs Evening) Dosing and Better Survival in Glioblastoma

Timing could make a difference: new results suggest that patients with glioblastoma who took temozolomide in the morning rather than the evening showed an improved overall survival.

Benefit–Risk Summary of Nivolumab for the Treatment of Patients with Unresectable Advanced, Recurrent, or Metastatic Esophageal Squamous Cell Carcinoma After Prior Fluoropyrimidine‐ and Platinum‐Based Chemotherapy

The study demonstrates a significant improvement in overall survival with an estimated median OS of 10.9 months in the nivolumab arm compared with 8.4 months in the chemotherapy arm.

Prognostic Nomogram for Predicting Long-Term Cancer-Specific Survival in Patients With Lung Carcinoid Tumors

The current study establishes a nomogram model for predicting cancer-specific survival in patients with lung carcinoid tumors.

BMC Cancer
Differential Impact of ALK Mutations in Neuroblastoma

The tyrosine kinase receptor ALK can be abnormally activated in neuroblastoma, and somatic ALK mutations occur in 6%-10% of patients.

Molecular Genetics of Follicular-Derived Thyroid Cancer

This review summarizes the current literature on the molecular landscape of follicular-derived thyroid tumors.

Hypoxia-Induced Cancer Cell Responses Driving Radioresistance of Hypoxic Tumors: Approaches to Targeting and Radiosensitizing

The present review article helps clarify two intriguing points: why hypoxia-adapted cancer cells turn out radioresistant and how they can be rendered more radiosensitive.

Ablative Radiation Extends Life in Unresectable Pancreatic Cancer

For patients with inoperable pancreatic cancer, higher dose ablative radiation after chemotherapy induction may extend life.

Integrative Molecular Characterization of Sarcomatoid and Rhabdoid Renal Cell Carcinoma

Study investigators evaluate multiple clinical trial and real-world cohorts of S/R RCC to characterize their molecular features, clinical outcomes, and immunologic characteristics.

Nature Communications
Atezolizumab’s Indication in Previously Treated Metastatic Bladder Cancer Is Withdrawn

Genentech announced on March 8 the company is voluntarily withdrawing the U.S. indication for atezolizumab in patients with prior platinum-treated metastatic urothelial carcinoma.

The ASCO Post
The Potential Role of MR Based Radiomic Biomarkers in the Characterization of Focal Testicular Lesions

The purpose of this study is to investigate the performance of MRI-based Radiomics signatures for the preoperative prediction of testicular neoplasm histology.

Scientific Reports
MRI-Based Radiomics Approach for Differentiation of Hypovascular Non-Functional Pancreatic Neuroendocrine Tumors and Solid Pseudopapillary Neoplasms of the Pancreas

This study aims to investigate the value of radiomics parameters derived from contrast enhanced MRI in differentiation of hypo-NF-pNETs and solid pseudopapillary neoplasms of the pancreas.

BMC Medical Imaging
Hypofractionated Low-Dose Radiotherapy Combined with Immune Checkpoint Inhibition in Metastatic Solid Tumors

This retrospective cohort study includes 32 patients with metastatic solid tumors treated with hypofractionated radiotherapy combined with an immune checkpoint inhibitor.

OncoTargets and Therapy
Ureteral Urothelial Carcinoma With Squamous Cell Carcinoma and Sarcomatoid Carcinoma Differentiation

Herein is a case of ureteral urothelial carcinoma with squamous cell carcinoma and sarcomatoid carcinoma differentiation and rapid ileal metastasis.

BMC Surgery
Diffusion Histology Imaging Differentiates Distinct Pediatric Brain Tumor Histology

While conventional MRI has been widely adopted for examining pediatric high-grade brain tumors clinically, accurate neuroimaging detection and differentiation of tumor histopathology...

Scientific Reports
Promising Molecular Targets for the Targeted Therapy of Biliary Tract Cancers

In this article, a comprehensive review is conducted to examine potential molecular targets for BTC targeted therapy and their mechanisms.

OncoTargets and Therapy
Centromere Protein U Enhances the Progression of Bladder Cancer by Promoting Mitochondrial Ribosomal Protein s28 Expression

This study investigates further the expression of two candidate genes, centromere protein U and mitochondrial ribosomal protein s28 to better understand their role in bladder cancer pathogenesis.

Korean Journal of Physiology Pharmacology
Systematic Identification of Key Functional Modules and Genes in Esophageal Cancer

Differential expression genes and weighted gene co-expression network analysis are important methods to screen the core genes as bioinformatics methods.

Cancer Cell International
Volume-Based Algorithm of Lung Dose Optimization in Novel Dynamic Arc Radiotherapy for Esophageal Cancer

This study aims to develop a volume-based algorithm that can rapidly optimize rotating gantry arc angles and predict the lung V5 preceding the treatment planning.

Scientific Reports
Classification of Paediatric Brain Tumours by Diffusion Weighted Imaging and Machine Learning

This study set out to determine if apparent diffusion coefficients can discriminate between posterior fossa brain tumours on a multicentre basis.

Scientific Reports
Biodegradable Polymeric Nanoparticles for Drug Delivery to Solid Tumors

This review examines the use of polymeric nanoparticles as drug delivery systems of anticancer compounds, their physico-chemical properties and their ability to be...

Frontiers in Pharmacology
Targeting MYCN in Molecularly Defined Malignant Brain Tumors

This review discusses efforts made to circumvent the difficulty of targeting MYCN specifically by using direct or indirect measures to treat MYCN-driven brain tumors.

Frontiers in Oncology
Next Generation Imaging Techniques to Define Immune Topographies in Solid Tumors

At present there is no unified and integrated understanding about the role played by different postulated models of immune exclusion in human solid tumors.

Frontiers in Immunology
Diagnosis of Lynch Syndrome and Strategies to Distinguish Lynch-Related Tumors from Sporadic MSI/dMMR Tumors

This review addresses the hallmarks of LS and present recent advances in diagnostic and screening strategies to identify LS patients. 

Immune Checkpoint Inhibitors for the Treatment of Bladder Cancer

This review examines relevant clinical trial results with immune checkpoint inhibitors in patients with metastatic urothelial cancer.

Primary Tumors From Mucosal Barrier Organs Drive Unique Eosinophil Infiltration Patterns and Clinical Associations

This study conducts a comprehensive analysis of multiple primary tumors from distinct anatomical sites using a standardized method.

Safety and Survival Rates Associated With Ablative Stereotactic Radiotherapy for Patients With Oligometastatic Cancer

This study aims to answer the question is stereotactic ablative radiotherapy safe and clinically beneficial in the management of oligometastatic cancer.

JAMA Oncology
Clinically Useful Biomarkers in Metastatic Renal Cell Carcinoma

Unique to clear cell RCC is early and near ubiquitous inactivation of the von Hippel-Lindau gene, rendering RCC responsive to inhibition of the vascular endothelial growth factor pathway.

Oncology Times - Latest Articles
Which Patients With Kidney Cancer Are Likely to Respond to ICI?

Several factors associated with a diminished response to immune checkpoint inhibitor drugs among patients with metastatic ccRCC have been identified.

Stratification of Hepatocellular Carcinoma Risk Following HCV Eradication or HBV Control

Hepatocellular carcinoma incidence has dramatically decreased in patients infected with HCV and HBV due to the widespread use of highly effective antiviral agents.

Predictive Factors for Pancreatic Cancer and Its Early Detection Using Special Pancreatic Ultrasonography in High-Risk Individuals

This study aims to analyze the predictive factors of neoplastic progression in patients at high risk for pancreatic cancer and examined the efficiency of surveillance using...

Lymph Node Ratio Rather Than Positive Lymph Node Counts Has Better Prognostic Value in Patients With Testicular Germ Cell Tumors

The current study seeks to analyze and compare the prognostic value of lymph node ratio as well as positive lymph node counts to understand its clinical significance in testicular germ cell tumors.

Promoterless Transposon Mutagenesis Drives Solid Cancers via Tumor Suppressor Inactivation

Cancer gene discovery from end-stage solid tumors in these studies performed by this study's labs and others has found few proto-oncogenic insertions.

Primary Ovarian Angiosarcoma: A Rare and Recognizable Ovarian Tumor

The diagnosis of primary angiosarcoma of ovary is still a challenge as it has no specific clinical symptoms and is easily confused with other malignant neoplasms in morphology.

Antibody–Drug Conjugates in Solid Tumors: A Look Into Novel Targets

This review aims at providing a summary of the technology behind these compounds and at presenting the latest ADCs approved in solid tumors...

Immune Cell Engagers in Solid Tumors: Promises and Challenges of the Next Generation Immunotherapy

In the landscape of cancer immunotherapy, immune cell engagers are rapidly emerging as a feasible and easy-to-deliver alternative to adoptive cell therapy for the...

CAR T Cells in Solid Tumors: Challenges and Opportunities

The pivotal challenges in the field of solid tumor CAR T cell therapy can be summarized in three major parts: recognition, trafficking, and surviving in the tumor.

Potential Biomarkers of Childhood Brain Tumor Identified by Proteomics of Cerebrospinal Fluid From Extraventricular Drainage

Study investigators analyze the proteome of waste CSF from extraventricular drainage from 29 children bearing different brain tumors and 17 controls needing EVD insertion for unrelated causes.

Scientific Reports
TACTICS: TACE Plus Sorafenib Improves PFS in Unresectable HCC

Combining transcatheter arterial chemoembolization therapy with sorafenib improved PFS, but not OS, when compared with TACE alone in patients with unresectable HCC.

Hypoxia-Induced Therapy Resistance: Available Hypoxia-Targeting Strategies and Current Advances in Head and Neck Cancer

This study provides an overview of three main strategies to target tumor hypoxia: HIF-inhibitors, hypoxia-activated prodrugs and anti-angiogenic agents, and summarizes the clinical advances...

Translational Oncology
Consumer-Grade Electroencephalography Devices as Potential Tools for Early Detection of Brain Tumors

In support of this paradigm in neuro-oncology, the achievement of gross total surgical resection in younger patients with GBM shows favorable outcomes compared to instances where...

A Novel Therapeutic Approach for Colorectal Cancer Stem Cells: Blocking the PI3K/Akt Signaling Axis With Caffeic Acid

This study finds caffeic acid effectively suppresses self-renewal capacity, stem-like characteristics, and migratory capacity of CD44+ and CD133+ colorectal CSCs in vitro and in vivo.

Circulating Exosomal miRNAs as Biomarkers for the Diagnosis and Prognosis of Colorectal Cancer

This study reports the potential of circulating exosomal miRNAs to act as biomarkers for the diagnosis and prognosis of CRC.

International Journal of Molecular Sciences
Non-Invasive Assessment of Telomere Maintenance Mechanisms in Brain Tumors

Most tumors including low-grade oligodendrogliomas use TERT expression for telomere maintenance while astrocytomas use the ALT pathway.

Studies on the Safety and Efficacy of Pyrotinib in the Treatment of HER2- Positive Advanced Solid Tumors Excluding Breast Cancer

This pilot study investigates the safety and efficacy of pyrotinib in HER2-positive non-breast advanced solid tumors.

Iodine-Related Attenuation in Contrast-Enhanced Dual-Energy Computed Tomography in Small-Sized Solid-Type Lung Cancers is Associated With the Postoperative Prognosis

This study examines the correlation between iodine-related attenuation in contrast-enhanced DE-CT and postoperative prognosis of surgically resected solid-type small-sized lung cancers.

Aberrant Factors of Fibrinolysis and Coagulation in Pancreatic Cancer

This review provides a brief highlight of existing studies that the fibrinolysis and coagulation systems were activated in pancreatic cancer patients...

Autophagy-Mediated Tumor Cell Survival and Progression of Breast Cancer Metastasis to the Brain

This review outlines the molecular mechanisms underlying autophagy-mediated breast cancer cell survival and metastasis to the brain.

Dysphagia and its Impact on the Quality of Life of Head and Neck Cancer Patients: Institution-Based cross-sectional study

Impaired swallowing is a primary medical concern in HNC patientsThis cross-sectional study aimed to assess swallowing function and its impact on QoL.

Utilization of Circulating Cell-Free DNA Profiling to Guide First-Line Chemotherapy in Advanced Lung Squamous Cell Carcinoma

This study investigates the predictive and monitoring role of circulating cell-free DNA profiling for the outcome of first-line chemotherapy in patients with advanced lung squamous cell carcinoma.<

Anti-Stem Cell Property of Pterostilbene in Gastrointestinal Cancer Cells

This study examined the potential mechanism of this contrasting effect of PTE using three gastrointestinal cancer cell lines, namely CT26, HT29, and MKN74.

International Journal of Molecular Sciences
NDRG1 Expression Is an Independent Prognostic Factor in Inflammatory Breast Cancer

This study found that the level of expression of NDRG1 in tumor tissues predicts the survival outcome of patients with IBC.

Gene and Protein Expression of mTOR and LC3 in Hepatocellular Carcinoma, Colorectal Liver Metastasis and “Normal” Liver Tissues

The physiological role of autophagy in the progression of liver diseases is still debated.

Artificial Intelligence in Medical Imaging and Its Application in Sonography for the Management of Liver Tumor

This study summarizes AI development in medical images with challenges to task setting, data curation, and focus on the application of AI for the managements of liver tumor...

Frontiers in Oncology
Integrative Analysis of Long Extracellular RNAs Reveals a Detection Panel of Noncoding RNAs for Liver Cancer

Among other developments, study investigators use machine learning models to identify a signature of 3 noncoding RNAs for the detection of liver cancer.

Fentanyl Inhibits Lung Cancer Viability and Invasion via Upregulation of miR-331-3p and Repression of HDAC5

The current study aimes to investigate the effects and the mechanisms underlying the effects of fentanyl on NSCLC.

Estrogen-induced circRNA, circPGR, functions as a ceRNA to promote estrogen receptor-positive breast cancer cell growth by regulating cell cycle-related genes

Estrogen and estrogen receptor-regulated gene transcriptional events have been well known to be involved in ER-positive breast carcinogenesis.

Uncovering Emperature‐Dependent Extracellular Vesicle Secretion in Breast Cancer

Pathological studies in breast cancer have implied that temperature is associated with disease progression.

Breast Cancer During Pregnancy: A Marked Propensity to Triple-Negative Phenotype

This study reviews recent progress in understanding the development of breast cancer during pregnancy and their unique subtype of triple negative which is the...

Frontiers in Oncology
Efficacy of Local Treatments for Hepatocellular Carcinoma Involving the Inferior Vena Cava and/or Right Atrium

The most commonly involved major vessel is the portal vein; however, approximately 4% of patients with HCC have inferior vena cava and/or right atrium invasion.

Roles of Lysyl Oxidase Family Members in the Tumor Microenvironment and Progression of Liver Cancer

Study investigators review the clinical value and novel biological roles of LOX family members in tumor progression and the TME of liver cancers.

International Journal of Molecular Sciences
Evaluation of Variant Frequency in SARS-CoV-2 Infection-Related Genes Utilizing Lung Cancer Genomic Database

Study investigators analyzed the coding variants of ACE2 and TMPRSS2 and their allele frequencies in 350 Japanese patients with advanced-stage lung cancer using whole-exome...

Microphthalmia-Associated Transcription Factor-Dependent Melanoma Cell Adhesion Molecule Activation Promotes Peritoneal Metastasis of Ovarian Cancer

This study investigates the function of microphthalmia-associated transcription factor, which contributes to the development of melanoma, in epithelial ovarian cancer. 

International Journal of Molecular Sciences
Immunohistochemical Analysis of PGC-1α and ERRα Expression Reveals Their Clinical Significance in Human Ovarian Cancer

The purpose of this study was to investigate whether the PGC-1α/ERRα axis could serve as an effective prognostic marker in ovarian cancer. 

Obesity Epidemic—The Underestimated Risk of Endometrial Cancer

This work provides an overview of pathophysiological interactions and pathways in obese women initiating tumorigenesis.

The Added Value of CA125 Normalization Before Interval Debulking Surgery to the Chemotherapy Response Score for the Prognostication of Ovarian Cancer patients Receiving Neoadjuvant Chemotherapy for Advanced Disease

Investigators studied whether CA125 normalization following neoadjuvant chemotherapy can complement the chemotherapy response system in the prognostication of patients with tubo-ovarian HGSC.

Bioinformatics Analysis of Key Genes and Pathways of Cervical Cancer

The purpose of this study is to find new genes that can be used as potential biomarkers for the prognosis of cervical cancer.

Alterations in Urobiome in Patients With Bladder Cancer and Implications for Clinical Outcome: A Single-Institution Study

This study was performed to characterize the alterations in urobiome and explore its implications of clinical outcome in male patients with bladder cancer.

A Noninvasive Assessment of Tumor Proliferation in Lung cancer Patients using Intravoxel Incoherent Motion Magnetic Resonance Imaging

Ki-67 is a nuclear antigen widely used in routine pathologic analyses as a tumor cell proliferation marker for lung cancer.

Herbal Medicines for Anorexia in Lung Cancer

This review discusses with the clinical evidence of herbal medicine use for reducing anorexia in lung cancer patients.

CAFs affect the proliferation and treatment response of head and neck cancer spheroids during co-culturing in a unique in vitro model

This study aims to create a biologically relevant HNSCC in vitro model consisting of both tumor cells and CAFs cultured in 3D to establish predictive biomarkers for treatment response...

Tumor Mutation Burden, Immune Cell Infiltration, and Construction of Immune-Related Genes Prognostic Model in Head and Neck Cancer

This study aimed to investigate the TMB and immune cell infiltration in these patients and construct an immune-related genes prognostic model.

The Detection of Plasma Soluble Podoplanin of Patients with Breast Cancer and Its Clinical Signification

This study investigates the clinical significance of plasma soluble PDPN levels in patients with breast cancer and its significance in the diagnosis and metastasis.

MYC dysfunction modulates stemness and tumorigenesis in breast cancer

Study investigators found that the expression of MYC varies in different subtypes of breast cancer, with relatively high frequency in TNBC.

Putting the BRK on Breast Cancer: From Molecular Target to Therapeutics

This review highlights recent advances in BRK biology in contributing to the “hallmarks of cancer”, as well as BRK's therapeutic significance.

Microbiome Related Cytotoxically Active CD8+ TIL Are Inversely Associated With Lung Cancer Development

This study evaluated the effect of inhalation of bronchoalveolar fluid in the lung cancer cell growth.

Frontiers in Oncology
Cerebrospinal Fluid Penetration and Combination Therapy of Entrectinib for Disseminated ROS1/NTRK-Fusion Positive Pediatric High-Grade Glioma

Targeting oncogenic fusion-genes in pediatric high-grade gliomas with entrectinib has emerged as a highly promising therapeutic approach.

Pregnancy‐specific glycoprotein 9 acts as both a transcriptional target and a regulator of the canonical TGF‐β/Smad signaling to drive breast cancer progression

This study reports PSG9 expression levels were elevated in tumor tissues and plasma specimens from breast cancer patients, and were associated with poor prognosis.

Mechanisms of Resistance to Chemotherapy in Breast Cancer and Possible Targets in Drug Delivery Systems

This systematic review aims to bring the molecular mechanisms involved in BC chemoresistance and extract from the previous literature information regarding the use of nanoparticles...

Primary and Acquired Resistance to Immunotherapy in Lung Cancer: Unveiling the Mechanisms Underlying of Immune Checkpoint Blockade Therapy

Immuno-oncology has redefined the treatment of lung cancer, with the ultimate goal being the reactivation of the anti-tumor immune response.

Salivary Metabolic Profile of Patients with Lung Cancer, Chronic Obstructive Pulmonary Disease of Varying Severity and Their Comorbidity: A Preliminary Study

The aim of the work was to study the features of the salivary biochemical composition in the combined pathology of lung cancer and chronic obstructive pulmonary disease of varying severity.

Systemic and intravesical adoptive cell therapy of tumor-reactive T cells can decrease bladder tumor growth in vivo

The therapeutic armamentarium of bladder cancer has been recently enriched with the introduction of new therapies including ICIs, receptor TKIs and antibody drug conjugates...

Neuroendocrine and Aggressive-Variant Prostate Cancer

This review provides an overview of neuroendocrine prostate cancer focusing on the AVPC subtype and we approach current treatment options as well as ongoing research efforts.

The efficacy and safety of sunscreen use for the prevention of skin cancer

Several well-conducted randomized controlled trials with long follow-up showed that sunscreen use reduces the risk of squamous cell and melanoma skin cancers.

Identification of Incidental Skin Cancers Among Adults Referred to Dermatologists for Suspicious Skin Lesions

The findings of this study suggest that total body skin examinations may be useful for detecting incidental skin cancers and that patients with suspicious index lesions should be prioritized.

Development and Validation of an Immune-Related Gene Pair Signature in Skin Cutaneous Melanoma

In this study, investigators established a prognostic immune-related gene pair signature for predicting the survival of SKCM patients.

Molecular Alterations in Metastatic Ovarian Cancer From Gastrointestinal Cancer

This article provides new insights into the metastatic pathway and generates novel therapeutic targets for effective treatment and satisfactory outcomes in GIC patients.

Frontiers in Oncology
Evolving Role of Artificial Intelligence in Gastrointestinal Endoscopy

This review discusses AI and associated various technological terminologies, evolving role in gastrointestinal endoscopy, and future possibilities.

Liquid Biomarkers for Pediatric Brain Tumors: Biological Features, Advantages and Perspectives

This review summarizes current knowledge on liquid biopsy markers and technologies in pediatric brain tumors, their advantages and drawbacks...

Autoantibodies against tumor-associated antigens in sputum as biomarkers for lung cancer

This study provides the first evidence that sputum TAAbs could be used as biomarkers for the early detection of lung cancer.

Translational Oncology
Integrative multi-omics analysis of muscle-invasive bladder cancer identifies prognostic biomarkers for frontline chemotherapy and immunotherapy

Only a subgroup of patients with muscle-invasive bladder cancer are responders toward cisplatin-based chemotherapy and PD-L1 blockade immunotherapy.

A novel imaging based Nomogram for predicting post-surgical biochemical recurrence and adverse pathology of prostate cancer from pre-operative bi-parametric MRI

Study investigators developed and validated an integrated radiomic-clinicopathologic nomogram for post-surgical bRFS and adverse pathology prediction in men with prostate cancer.

Diagnostic value of microRNA-25 in patients with non-small cell lung cancer in Chinese population

This meta-analysis aims to explore diagnostic value of miR-25 in NSCLC in Chinese population.

CD44 in Ovarian Cancer Progression and Therapy Resistance—A Critical Role for STAT3

This review summarizes currently available evidence about functional crosstalk between CD44 and STAT3 in human malignancies with an emphasis on ovarian cancer.

Frontiers in Oncology
Updates and New Options in Advanced Epithelial Ovarian Cancer Treatment

Although primary epithelial ovarian cancer is still treated with a combination of surgery and systemic therapy, more complex surgical procedures and novel therapeutics have emerged...

Progress of Artificial Intelligence in Gynecological Malignant Tumors

The purpose of this paper is to describe the progress of AI in gynecological malignant tumors and discuss some problems in its application.

Perceptions of care after end-of-treatment among younger women with different gynecologic cancer diagnoses

The aim of this study was to explore how care following end-of-treatment was perceived by women treated for different gynecologic cancer diagnoses during younger adulthood.

Unplanned hospitalizations in patients with locoregionally advanced head and neck cancer treated with (chemo)radiotherapy with and without prophylactic percutaneous endoscopic gastrostomy

Current studies about percutaneous endoscopic gastrostomy tube placement report equivalent patient outcomes with prophylactic PEG tubes versus common nutritional support. 

Comparison of Tumor Infiltrating Lymphocyte Density with Histopathological Parameters and Effect on Prognosis in Head and Neck Squamous Cell Cancers

The study aims to determine the ratio of the TIL in the tumor microenvironment in squamous cell carcinoma of H&N and its effect on prognosis using histopathological parameters.

Hypofractionated chemoradiation for head and cancer: Data from the PET NECK trial

There has been increased interest in hypofractionated accelerated chemoradiation for head and neck cancer during the recent first peak of the COVID-19 pandemic.

Oral Oncology
Improving quality of life through the routine use of the patient concerns inventory for head and neck cancer patients

The patient concerns inventory is a prompt list allowing head and neck cancer patients to discuss issues that otherwise might be overlooked. 

Bone marrow mesenchymal stem cells interact with head and neck squamous cell carcinoma cells to promote cancer progression and drug resistance

This study demonstrated that the recognized recruitment of MSC to tumors could impart multiple protumorigenic properties including chemotherapy resistance like that observed...

Urinary charged metabolite profiling of colorectal cancer using capillary electrophoresis-mass spectrometry

To understand the metabolomic profiles of different stages of CRC, study investigators conducted metabolomic profiling of urinary samples. 

Scientific Reports
New fecal bacterial signature for colorectal cancer screening reduces the fecal immunochemical test false-positive rate in a screening population

This work aimed to develop a new, noninvasive CRC screening tool based on fecal bacterial markers capable of decreasing FIT false-positive rates in a FIT-positive population.

The Intestinal Microbiota and Colorectal Cancer

The roles for intestinal microorganisms that initiated and facilitated the CRC process are becoming increasingly clear.

Frontiers in Immunology
Depressed Colorectal Cancer: A New Paradigm in Early Colorectal Cancer

This study hypothesized that depressed colorectal neoplasms have unique clinicopathological features different that are different from those of protruded and flat colorectal neoplasms.

Clinical and translational gastroenterology

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