Solid Tumors

Solid Tumors

FDA Grants Orphan Drug Status to Rivoceranib for Hepatocellular Carcinoma

The FDA granted orphan drug designation to rivoceranib, a small-molecule tyrosine kinase inhibitor that targets the VEGF receptor 2, for the treatment of hepatocellular carcinoma.

Eligibility Criteria May Hinder Black Patients in Pancreatic Cancer Trials

A simulated pancreatic cancer clinical trial screening process found black patients are significantly more likely than White patients to be excluded from clinical trials... 

Oncology Times - Latest Articles
Evorpacept Alone and Combined With Pembrolizumab or Trastuzumab for Advanced Solid Tumors

The phase I ASPEN-01 study finds evidence of activity of the CD47-blocking protein evorpacept in combination with pembrolizumab or trastuzumab for the treatment of advanced solid tumors.

The ASCO Post

Immunogenicity of COVID-19 Vaccination in Patients Receiving Systemic Therapy for Solid Tumors

Researchers found that the Moderna COVID-19 vaccine produced adequate antibody responses in a majority of patients receiving chemotherapy, immunotherapy, or chemoimmunotherapy for solid tumors...

The ASCO Post
DFS After First Nephrectomy Predicts OS in Localized Renal Cell Carcinoma

Post-nephrectomy recurrence appeared associated with shorter survival among patients with intermediate-high or high-risk renal cell carcinoma, according to new study results.

The Feasibility of Haar Feature-Based Endoscopic Ultrasound Probe Tracking for Implanting Hydrogel Spacer in Radiation Therapy for Pancreatic Cancer

A Haar feature-based method for tracking EUS probe location on diagnostic CT or MRI without external tracking hardware was developed to facilitate injecting hydrogel in designed injection points.

Frontiers in Oncology
Elevated Neddylation Pathway Promotes Th2 Cells Infiltration by Transactivating STAT5A in Hepatocellular Carcinoma

Researchers investigated the relationship between activated NEDD8-UBE2M-RBX1 axis and immune cell infiltration by analyzing mRNA transcriptome and clinical data of HCC samples from TCGA database.

Frontiers in Oncology
Eukaryotic Initiation Factor 2 Signaling Behind Neural Invasion Linked With Lymphatic and Vascular Invasion in Pancreatic Cancer

Scientists observed a 128-patient cohort undergoing surgery for early-stage PDAC to clarify what changes occurred alongside PNI in PDAC.

Scientific Reports
Multiparametric MRI for Assessment of Early Response to Neoadjuvant Sunitinib in Renal Cell Carcinoma

This research works to detect early response to sunitinib treatment in metastatic clear cell renal cancer using multiparametric MRI.

Akt-Mediated Ephexin1–Ras Interaction Promotes Oncogenic Ras Signaling and Colorectal and Lung Cancer Cell Proliferation

Research shows ephexin1 is overexpressed in both CRC and LC tissues and is associated with a poor prognosis, and provides evidence for the functional and clinical significance of Ephexin1...

Cell Death & Disease
Pancreatic Cancer Cells Render Tumor-Associated Macrophages Metabolically Reprogrammed by a GARP and DNA Methylation-Mediated Mechanism

PDA tumor cells, through direct cell–cell contact, induce DNA methylation and downregulation of a panel of glucose metabolism and OXPHOS genes selectively in M1-like macrophages...

Signal Transduction & Targeted Therapy
Timing of Toenail Collection and Concentrations of Metals in Pancreatic Cancer

The influence of specific time intervals between several clinical events and the collection of toenails upon concentrations of trace elements in patients with pancreatic cancer was analyzed. 

Exposure and Health
Bioinformatics Screening of Biomarkers Related to Liver Cancer

Scientists took original data was downloaded from the TCGA database, and the R software to screen the DEGs in the gene expression profile of liver cancer tissues and adjacent tissues. 

BMC Bioinformatics
A Immune-Related Signature Associated with TME Can Serve as a Potential Biomarker for Survival and Sorafenib Resistance in Liver Cancer

This research team worked to develop a robust TME-related prognostic signature that could independently predict both RFS and OS of LIHC. 

OncoTargets and Therapy
Tiny Worms Sniff Out Early-Stage Pancreatic Cancer

Early research shows C elegans are attracted to the odor certain chemicals give off that may include scents of human cancer cell secretions, cancer tissues, and urine from patients...

Evaluation of Preoperative Diagnostic Methods for Resectable Pancreatic Cancer

Researchers evaluate the diagnostic ability of EUS-FNA and its effect on the preoperative diagnosis, surgical outcome, and prognosis of pancreatic cancer.

BMC Gastroenterology
Targeting CDC7 Potentiates ATR-CHK1 Signaling Inhibition Through Induction of DNA Replication Stress in Liver Cancer

Researchers use integrated bioinformatics and functional genetics approaches to study the therapeutic options for the use of ATR or CHK1 inhibitors in liver cancer.

Genome Medicine
Hepatic Artery Infusion Pump Combined With Systemic Chemotherapy for Patients With Liver Metastases From Breast Carcinoma

The efficacy and safety of HAI combined with systemic chemotherapy in patients with breast carcinoma liver metastases is evaluated through this study. 

Technology in Cancer Research & Treatment
PKI-587 Enhances Radiosensitization of Hepatocellular Carcinoma by Inhibiting the PI3K/AKT/mTOR Pathways and DNA Damage Repair

Researchers evaluate the role of the dual PI3K/mTOR inhibitor, PKI-587, on radiosensitization of HCC and its possible mechanism. 

GNG7 and ADCY1 as Diagnostic and Prognostic Biomarkers for Pancreatic Adenocarcinoma Through Bioinformatic-Based Analyses

Researchers work to screen out the genes that have diagnostic and prognostic significance for PAAD through downloading the GSE55643 and GSE15471 mRNA expression profiles from the GEO database. 

Scientific Reports
Plasma Lipidomic Profiles of Kidney, Breast and Prostate Cancer Patients Differ From Healthy Controls

Lipidomic changes are investigated and visualized using various MDA tools, such as PCA, orthogonal projection to latent structures discriminant analysis, and ROC. 

Scientific Reports
The Mechanism of miR-141 Regulating the Proliferation and Metastasis of Liver Cancer Cells by Targeting STAT4

The expression of miRNA-141 in hepatocellular carcinoma cells & the effect of targeting STAT4 on the proliferation, migration, & invasion on those cells were detected using qRT-PCR, MTT.

Journal of Oncology
ctDNA Reduction After Tebentafusp Predicts OS in Uveal Melanoma

Reduction in circulating tumor DNA appeared correlated with longer OS among patients with previously treated metastatic uveal melanoma who received tebentafusp. 

ctDNA: An Emerging Neoadjuvant Biomarker in Resectable Solid Tumors

Scientists evaluate ctDNA as a tool capable of predicting complete pCR in LARC and MIBC, to focus on evaluating its response as a response biomarker in early-stage solid tumors. 

PLOS Medicine
Neoadjuvant Therapy for Pancreatic Cancer

 This research offers a state-of-the-art review on neoadjuvant treatments in the setting of pancreatic ductal adenocarcinoma.

Updates in Surgery
Clinical Impact of Pathogenic Germline Variants in Pancreatic Cancer

This study aimed to report the prevalence and outcomes of unselected PC patients with pathogenic/likely PGVs detected using a universal testing approach.

Clinical and translational gastroenterology
Novel Genomic Alteration in Superficial Esophageal Squamous Cell Neoplasms in Non-Smoker Non-Drinker Females

Researchers explore clinical characteristics and genomic alterations of the esophageal epithelium in patients with superficial ESCC with respect to risk factors.

Scientific Reports
Rising Rates of Esophageal Cancer in Young Adults; Lifestyle May Be to Blame

Increased rates of esophageal adenocarcinoma could reflect changes in lifestyle-related risk factors for the disease, with rises in unhealthy habits including smoking, poor diet...

Radioimmunotherapy for Solid Tumors: Spotlight on Glypican-1 as a Radioimmunotherapy Target

Research shows the current treatment paradigm for several solid tumors expressing GPC-1 & suggests the potential clinical utility of a GPC-1 directed radioimmunotherapy for these tumors.

Therapeutic Advances in Medical Oncology
The Clinical Significance of Preoperative Serum Fibrinogen Levels and Platelet Counts in Patients with Gallbladder Carcinoma

Scientists investigate the clinical significance of preoperative serum fibrinogen levels and platelet counts in GBC patients.

BMC Gastroenterology
Identification of Phosphoenolpyruvate Carboxykinase 1 as a Potential Therapeutic Target for Pancreatic Cancer

Scientists show that PCK1 is required for pancreatic cancer cell growth both in vitro and in vivo through this research study. 

Cell Death & Disease
Metabolic Syndrome and its Component Traits Present Gender-Specific Association with Liver Cancer Risk

Researchers explore the gender-specific effect and potential role of non-linear associations between MetS components and liver cancer risk.

BMC Cancer
Elevated Expression of Nuclear Receptor-Binding SET Domain 3 Promotes Pancreatic Cancer Cell Growth

Researchers show that long full-length NSD3 is overexpressed in pancreatic cancer.

Cell Death & Disease

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