Colorectal Cancer

Colorectal Cancer

The Survival Effect of Radiotherapy on Stage II/III Rectal Cancer in Different Age Groups

This study investigates whether radiotherapy exhibits disparate effects in different age groups of patients with stage II/III rectal cancer.

Frontiers in Oncology
Gankyrin as Potential Biomarker for Colorectal Cancer With Occult Liver Metastases

In this study, the expression of Gankyrin in colorectal cancer patients with liver metastases is investigated to determine its prognosis value.

Frontiers in Oncology
Task Force Finalizes New Colorectal Cancer Screening Recommendation

The US Preventive Services Task Force has published a final recommendation statement calling for individuals to get their first CRC screening at age 45 instead of waiting until age 50.

Oncology Times - Latest Articles

Benefits From Moving More, Sitting Less for CRC Survivors

A study shows that CRC survivors experienced better quality of life and less fatigue if they engaged in more moderate to vigorous physical activity and reduced their sedentary behavior.

Better Responses to Hepatic Arterial Infusion Therapy Among Patients With KRAS Wild-Type Metastatic Colorectal Cancer

Patients with CRC and unresectable liver metastases and KRAS wild-type disease experienced better responses to hepatic arterial infusion pump CT than did patients with KRAS mutations...

The ASCO Post
Is There a Link Between Use of Antibiotics and Early-Onset Colorectal Cancer?

Study findings presented by Perrott et al at the ESMO World Congress on Gastrointestinal Cancer showed that the use of antibiotics may be linked to colon tumor formation across all patient age grou

The ASCO Post
Poorer Survival in CRC With Obesity: Is Chemo Dose Too Low?

Patients with CRC who are also obese have poorer survival than those who are not obese. A new study suggests that they may be receiving a lower cumulative dose of adjuvant CT...

Predicting Treatment Response of Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer Using Amide Proton Transfer MRI Combined With Diffusion-Weighted Imaging

This study evaluates amide proton weighted MRI combined with diffusion-weighted imaging in predicting NCRT response in patients with locally advanced rectal cancer.

Frontiers in Oncology
Development and Validation of a Prognostic Nomogram for Colorectal Cancer Patients With Synchronous Peritoneal Metastasis

In this study, investigators aim to use a multicenter data to identify the factors associated with S-PM of CRC to construct a nomogram for predicting the overall survival of these patients.

Frontiers in Oncology
Early-Onset CRC Associated With Longer Survival

Individuals diagnosed with primary CRC at less than 50 years of age have better survival outcomes than individuals diagnosed at 51-55 years, based on data from more than 750,000 patients.

CRC Mortality Risk Correlates With Adenoma Detection Rate

Low adenoma detection rates are associated with a greater risk of death in CRC patients, especially among those with high-risk adenomas, based on a review of more than 250,000 colonoscopies.

PDE2 Inhibits PKA-Mediated Phosphorylation of TFAM to Promote Mitochondrial Ca2+-Induced Colorectal Cancer Growth

In this study, the regulatory effects of mitochondrial Ca2+ on PDE2/cAMP/PKA axis and the phosphorylation of mitochondrial TFAM as well as the growth of CRC cells are systematically investigated.

Frontiers in Oncology
Alkylating Signature in Colorectal Cancer Linked to High Red Meat Intake

According to the study’s results, high red meat consumption may cause alkylating damage in colon cells that lead to cancer-causing mutations in KRAS and PIK3CA genes...

The ASCO Post
The Novel Curcumin Derivative 1g Induces Mitochondrial and ER-Stress-Dependent Apoptosis in Colon Cancer Cells by Induction of ROS Production

In the present study, the novel curcumin derivative, 1g, is found to inhibit tumor growth in colon cancer cells both in vitro and in vivo. 

Frontiers in Oncology
Perioperative Systemic Therapy for Patients With Resectable Colorectal Peritoneal Metastases

Rovers et al find the addition of perioperative systemic therapy to CRS-HIPEC is feasible and safe for the treatment of patients with resectable colorectal peritoneal metastases.   

The ASCO Post
LncRNA DLEU1 Contributes to the Growth and Invasion of Colorectal Cancer via Targeting miR-320b/PRPS1

Here, the level of DLEU1 in CRC tissues is investigated by qRT-PCR.

Frontiers in Oncology
Standard Multigene Testing Could Detect More Hereditary Cancer Syndromes in Patients With Colorectal Cancer

Up to 38.6% of people with colon cancer who have a hereditary cancer syndrome could have their conditions remain undetected with current universal tumor-screening methods...

The ASCO Post
USPSTF Issues New Recommendation Statement on Colorectal Cancer Screening

The USPSTF has recommended that individuals at average risk for the disease begin screening exams at age 45 instead of the traditional age of 50.

The ASCO Post
Trastuzumab Deruxtecan-nxki in HER2-Positive Metastatic Colorectal Cancer

In the phase II DESTINY-CRC01 trial, Dr Siena and colleagues find that trastuzumab deruxtecan-nxki produces durable responses in patients with previously treated HER2+ metastatic..

The ASCO Post
Addition of Celecoxib to Standard Adjuvant Therapy in Stage III Colon Cancer

The phase III CALGB/SWOG 80702 trial has shown no DFS benefit with the addition of the cyclooxygenase 2 inhibitor celecoxib to standard adjuvant therapy in patients with stage III colon cancer.

The ASCO Post
Early-Onset Colorectal Cancer — Are Sugary Drinks to Blame?

High consumption of sugar-sweetened beverages in adolescence and young adulthood could partially explain the recent rapid rise in EO-CRC—at least in women, according to the authors...

MRI Radiomics Signature as a Potential Biomarker for Predicting KRAS Status in Locally Advanced Rectal Cancer Patients

The purpose of this study is to analyze the association between T2 MRI radiomics features and KRAS status in LARC patients.

Frontiers in Oncology
KRAS Mutational Regression Is Associated With Oligo-Metastatic Status and Good Prognosis in Metastatic Colorectal Cancer

The present study analyzes the mutational trajectories of KRAS in a well-characterized cohort of CRC patients who developed poly- or oligo-metastatic disease.

Frontiers in Oncology
Is It Time for Universal Genetic Testing in Colorectal Cancer?

Universal multigene panel testing of colorectal cancer patients can detect heritable mutations that would not have been discovered with guideline-based testing, according to new research.

Prospective Experimental Treatment of Colorectal Cancer Patients Based on Organoid Drug Responses

The first prospective clinical trial that leverages tumor organoids to guide experimental treatment decisions.

How Antibiotics & the Microbiome May Play a Role in Colon Cancer

For at least a decade, evidence has been accumulating about the association between antibiotic use and increased risk for colorectal cancer.

Oncology Times - Latest Articles
Patients of Different Races With Early-Onset Colorectal Cancer Exhibit Distinct Genetic Features

Racial differences in genetic mutations were observed among patients with early-onset colorectal cancer, according to data presented by Dr Holowatyj during the virtual AACR Annual

The ASCO Post
FDA Approves First AI Device to Detect Colon Lesions

The FDA  announces its first-ever approval of an artificial intelligence device to help find colon lesions during colonoscopy.

Liver Transplant Emerges for Hepatic Mets in Colorectal Cancer

Liver transplant might be the next big thing for extensive hepatic metastases in colorectal cancer.

Comparing Metabolomics Profiles in Various Types of Liquid Biopsies Among Screening Participants With and Without Advanced Colorectal Neoplasms

Analysis of metabolomics has been suggested as a promising approach for early detection of colorectal cancer and advanced adenomas. 

Recent Updates on the Significance of KRAS Mutations in Colorectal Cancer Biology

This literature covers the diverse nature of the effects of KRAS mutations on age-related CRC development.

WNT5a in Colorectal Cancer: Research Progress and Challenges

In patients with colorectal cancer, WNT5a triggers a variety of downstream signaling pathways, which mainly affect the migration and invasion of tumor cells.

Cancer Management and Research
Future Prospects of Colorectal Cancer Screening: Characterizing Interval Cancers

This review provides a comprehensive overview of the epidemiological, clinical, and molecular characteristics of interval colorectal cancers.


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