Colorectal Cancer

Colorectal Cancer

Addition of Celecoxib to Standard Adjuvant Therapy in Stage III Colon Cancer

The phase III CALGB/SWOG 80702 trial has shown no DFS benefit with the addition of the cyclooxygenase 2 inhibitor celecoxib to standard adjuvant therapy in patients with stage III colon cancer.

The ASCO Post
Early-Onset Colorectal Cancer — Are Sugary Drinks to Blame?

High consumption of sugar-sweetened beverages in adolescence and young adulthood could partially explain the recent rapid rise in EO-CRC—at least in women, according to the authors...

MRI Radiomics Signature as a Potential Biomarker for Predicting KRAS Status in Locally Advanced Rectal Cancer Patients

The purpose of this study is to analyze the association between T2 MRI radiomics features and KRAS status in LARC patients.

Frontiers in Oncology

FDA Approves First AI Device to Detect Colon Lesions

The FDA  announces its first-ever approval of an artificial intelligence device to help find colon lesions during colonoscopy.

KRAS Mutational Regression Is Associated With Oligo-Metastatic Status and Good Prognosis in Metastatic Colorectal Cancer

The present study analyzes the mutational trajectories of KRAS in a well-characterized cohort of CRC patients who developed poly- or oligo-metastatic disease.

Frontiers in Oncology
Is It Time for Universal Genetic Testing in Colorectal Cancer?

Universal multigene panel testing of colorectal cancer patients can detect heritable mutations that would not have been discovered with guideline-based testing, according to new research.

How Antibiotics & the Microbiome May Play a Role in Colon Cancer

For at least a decade, evidence has been accumulating about the association between antibiotic use and increased risk for colorectal cancer.

Oncology Times - Latest Articles
Prospective Experimental Treatment of Colorectal Cancer Patients Based on Organoid Drug Responses

The first prospective clinical trial that leverages tumor organoids to guide experimental treatment decisions.

Patients of Different Races With Early-Onset Colorectal Cancer Exhibit Distinct Genetic Features

Racial differences in genetic mutations were observed among patients with early-onset colorectal cancer, according to data presented by Dr Holowatyj during the virtual AACR Annual

The ASCO Post
Liver Transplant Emerges for Hepatic Mets in Colorectal Cancer

Liver transplant might be the next big thing for extensive hepatic metastases in colorectal cancer.

Comparing Metabolomics Profiles in Various Types of Liquid Biopsies Among Screening Participants With and Without Advanced Colorectal Neoplasms

Analysis of metabolomics has been suggested as a promising approach for early detection of colorectal cancer and advanced adenomas. 

Recent Updates on the Significance of KRAS Mutations in Colorectal Cancer Biology

This literature covers the diverse nature of the effects of KRAS mutations on age-related CRC development.

WNT5a in Colorectal Cancer: Research Progress and Challenges

In patients with colorectal cancer, WNT5a triggers a variety of downstream signaling pathways, which mainly affect the migration and invasion of tumor cells.

Cancer Management and Research
Future Prospects of Colorectal Cancer Screening: Characterizing Interval Cancers

This review provides a comprehensive overview of the epidemiological, clinical, and molecular characteristics of interval colorectal cancers.

Comprehensive Analysis of Mutational and Clinicopathologic Characteristics of Poorly Differentiated Colorectal Neuroendocrine Carcinomas

This study aims to investigate clinicopathologic characteristics of colorectal NECs and elucidate genomic differences and similarities between colorectal NECs and colorectal adenocarcinomas.

Scientific Reports
CDC42EP3 Promotes Colorectal Cancer Through Regulating Cell Proliferation, Cell Apoptosis and Cell Migration

The objective of this study is to investigate whether CDC42EP3 has regulatory effects in CRC.

Cancer Cell International
The Roadmap of Colorectal Cancer Screening

This review provides an overview of CRC screening globally and the most recent approaches aimed at improving accuracy and participation in CRC screening, while also considering...

Using CT Colonography as a Noninvasive Colorectal Cancer Screening Test for Advanced Neoplasia

According to a report published by Pickhardt et al, compared with multitarget stool DNA and fecal immunochemical tests, CT colonography using a polyp size threshold ≥ 10 mm most effectively...

The ASCO Post
CRC Screening to Start at Age 45: ACG Update

CRC screening is now recommended for average-risk individuals starting at age 45 years, according to the American College of Gastroenterology's updated guidelines.

Machine Learning Algorithms to Define Colorectal Cancer Risk Factors

Researchers from the University of Florida are using machine learning algorithms to help identify new risk factors to explain early onset of colorectal cancer among patients under 50 years old.

Oncology Times - Latest Articles
Genome-Wide Analysis Identifies Critical DNA Methylations Within NTRKs Genes in Colorectal Cancer

The following study investigates the methylation and expression profiles and prognostic value of NTRKs gene in colorectal cancer.

Journal of Translational Medicine
Understanding Cell‐Cell Communication and Signaling in the Colorectal Cancer Microenvironment

This article aims to review the current in vitro and in vivo mono‐cellular and multi‐cellular cultures models of colorectal cancer, and to explore how they can be used for single‐

Clinical and Translational Medicine
Identification of Key Genes Involved in Tumor Immune Cell Infiltration and Cetuximab Resistance in Colorectal Cancer

This study intends to identify genes that play essential roles in cetuximab resistance and tumor immune cell infiltration.

Cancer Cell International
Neoadjuvant Chemoradiotherapy for Patients With Unresectable Radically Locally Advanced Colon Cancer

The goal of this study is to evaluate the treatment outcomes and toxicity of NACRT followed with surgery and adjuvant chemotherapy in patients with unresectable radically LACC.

BMC Cancer
Nuclear TEAD4 with SIX1 Overexpression is an Independent Prognostic Marker in the Stage I–III Colorectal Cancer

In this study, the regulation, function and prognostic significance of TEAD4 and its new direct target gene SIX1 in CRC progression are evaluated using human tissues, molecular and cell biology.

Cancer Management and Research
Effects of Antithrombotic Drugs on the Results of Fecal Immunochemical Test in Colorectal Neoplasms Screening

The aim of this study is to clarify the effect of antithrombotic agents on FIT accuracy in screening for colorectal neoplasms.

Scientific Reports
Epigenetic Landscape of Liquid Biopsy in Colorectal Cancer

This study summarizes current knowledge of the most relevant epigenetic mechanisms associated with cancer development and progression, and the implications of their deregulation in cancer cells...<

Frontiers in Cell and Developmental Biology
Risk of Colorectal Cancer in Patients With Attention-Deficit Hyperactivity Disorder

The association between ADHD and the risk of developing CRC is, as yet, to be investigated, and therefore, this nationwide, cohort study examines the association in patients from Taiwan.

The Protein Secretome Is Altered in Rectal Cancer Tissue Compared to Normal Rectal Tissue, and Alterations in the Secretome Induce Enhanced Innate Immune Responses

Study investigators profile the inflammatory protein secretome of normal and malignant rectal tissue pre- and post-radiation in human ex vivo explant models and examine the...

Comparison of Proteomic Technologies for Blood-Based Detection of Colorectal Cancer

Blood-based protein biomarkers are increasingly being explored as supplementary or efficient alternatives for population-based screening of colorectal cancer.

International Journal of Molecular Sciences
Long Noncoding RNA JAKMIP2-AS1 Promotes the Growth of Colorectal Cancer and Indicates Poor Prognosis

The aim of this study is to examine the expression pattern of JAKMIP2-AS1 in colorectal cancer and evaluate its biological role and clinical significance in tumor progression.

Monoclonal Antibodies and CAR T Cells in the Treatment of Colorectal Cancer

Besides common therapeutic approaches, such as surgery, chemotherapy, and radiotherapy, novel therapeutic approaches, including immunotherapy, have been an advent in CRC treatment.

Clinical Perspectives on Liquid Biopsy in Metastatic Colorectal Cancer

This review examines the clinical prospects of liquid biopsy in metastatic colorectal cancer, specifically with regard to the recently discovered various biomarkers identified on liquid biopsy.

Evaluation of Prognostic Factors and Clinicopathological Patterns of Recurrence After Curative Surgery for Colorectal Cancer

This study's focus is on the evaluation of potential prognostic factors for timing and patterns of recurrence in order to plan tailored follow-up programs.

Second Primary Malignancies in Colorectal Cancer Patients

The aim of this retrospective analysis is to identify SPMs in colorectal cancer patients in a single-institution cohort, describe the most frequent SPMs in colorectal cancer patients...

Scientific Reports
Comprehensive Landscape and Future Perspectives of Circular RNAs in Colorectal Cancer

This review discusses dysregulation, functions and clinical significance of circRNAs in CRC and the molecular mechanisms by which circRNAs exert their functions and how their expression is regulate

A Qualitative Transcriptional Signature for the Risk Assessment of Precancerous Colorectal Lesions

The developed incidence risk score could well predict the incidence risk of precancerous colorectal lesions and has value in clinical application.

Duration of Adjuvant Doublet Chemotherapy in Patients With High-Risk Stage II Colorectal Cancer

As oxaliplatin results in cumulative neurotoxicity, reducing treatment duration without loss of efficacy would benefit patients and healthcare providers.


Journal of Clinical Oncology
Evaluation of Wavelength Ranges and Tissue Depth Probed by Diffuse Reflectance Spectroscopy for Colorectal Cancer Detection

Investigators evaluate the diagnostic capabilities of diffuse reflectance spectroscopy for CRC detection by building 6 classification models based on support vector machines.

Scientific Reports
Maintaining Standards in Colorectal Cancer Surgery During the Global Pandemic

This study assesses the response and short-term outcomes from elective colorectal cancer surgery during the pandemic at study investigators' respective institution. 

Metachronous Advanced Neoplasia After Submucosal Invasive Colorectal Cancer Resection

This study assesses the occurrence of metachronous AN following SM-CRC resection.

Scientific Reports
Comparison of Long-term Outcomes Between Lynch Syndrome and Sporadic Colorectal Cancer

This study aims to compare the long-term outcomes between patients with LS and SCRC.

BMC Cancer
Prognostic Significance of Preoperative Lymphocyte-to-C-Reactive Protein Ratio in Patients with Non-Metastatic Colorectal Cancer

The inflammatory indexes are attracting increasing attention as a prognostic predictor for colorectal cancer.

The Evolutionary Landscape of Treatment for BRAFV600E Mutant Metastatic Colorectal Cancer

This review presents current therapies specifically headed to BRAFV600E mutant mCRC and systematically reviews ongoing clinical trials identifying different approaches under investigations

Role of gut microbiome in regulating the effectiveness of metformin in reducing colorectal cancer in type 2 diabetes

This study tries to find the common grounds of initiation of T2DM and CRC and the reason why metformin reduces the risk of CRC in patients with T2DM.

Evaluation of Productivity Losses Due to Premature Mortality from Colorectal Cancer

The purpose of this study is to assess the productivity losses from premature deaths due to colorectal cancer over a ten year period (2008–2017).

Immune Landscape and Prognostic Immune-Related Genes in KRAS-Mutant Colorectal Cancer Patients

KRAS mutation-mediated regulation of immunophenotype and immune pathways in CRC remains to be elucidated.

Defining Eligible Patients for Allele-Selective Chemotherapies Targeting NAT2 in Colorectal Cancer

This study recently identified a subset of CRC patients who are heterozygous for a wild-type and a low activity allele but lack the wild-type allele in their tumors due to loss of...

Scientific Reports
Bacteria‐Derived Ferrichrome Inhibits Tumor Progression in Sporadic Colorectal Neoplasms and Colitis‐Associated Cancer

This study investigates the anti-tumor effects of ferrichrome on precancerous conditions and cancer cells associated with sporadic as well as colitis-associated CRC.

Resolving the Paradox of Colon Cancer Through the Integration of Genetics, Immunology, and the Microbiota

While colorectal cancers are paradigmatic tumors invaded by effector memory lymphocytes, the mechanisms accounting for the relative resistance of MSI negative CRC to immunogenic cell...

Frontiers in Immunology
Mechanisms of Immunosuppression in Colorectal Cancer

More emerging studies are exploring immunotherapy for solid cancers, including colorectal cancer.

Colorectal Cancer Screening and Surveillance for Non-Hereditary High-Risk Groups—Is It Time for a Re-Think?

An individual’s risk of developing CRC is multi-factorial with known risk factors including increasing age, male sex, family history of CRC and raised body mass index.

Efficacy of Chinese herbal injections combined with fluoropyrimidine and oxaliplatin-based chemotherapy for advanced colorectal cancer

Chinese herbal injections, as an important part of TCM, have been widely applied as adjunctive treatments to chemotherapy in patients with advanced CRC. 

USP43 directly regulates ZEB1 protein, mediating proliferation and metastasis of colorectal cancer

This study examines the biological role of USP43 in colorectal cancer.

Development and Validation of a Lifestyle-Based Model for Colorectal Cancer Risk Prediction: The LiFeCRC Score

Study investigators develop and validate a lifestyle-based CRC risk prediction algorithm in an asymptomatic European population.

A New Method for the Detection of Colorectal Cancer and the Precancerous Lesions: Occult Blood Testing Combination with Promoter Methylation in the Fecal Sample

This study establishes a possibilities screening method for detecting CRC and precancerous lesions and evaluate its detection performance in the Chinese population. 

Molecular Targets in Precision Chemoprevention of Colorectal Cancer: An Update from Pre-Clinical to Clinical Trials

This study discusses precursor-lesion specific targets of CRC and the current status of pre-clinical studies regarding clinical interventions and combinations for better efficacy and safety...

International Journal of Molecular Sciences
An insight into small extracellular vesicles: Their roles in colorectal cancer progression and potential clinical applications

Recent evidence from CRC has revealed that sEVs contribute to tumorigenesis, progression, and drug resistance, and serve as a tool for “liquid biopsy” and a drug delivery system for therapy.

LAD1 expression is associated with the metastatic potential of colorectal cancer cells

To determine the relationship of LAD1 with colorectal cancer progression, this study explored the effect of LAD1 loss on the malignant features of colorectal cancer cells.

BMC Cancer
Exosomal miR-193a and let-7g accelerate cancer progression on primary colorectal cancer and paired peritoneal metastatic cancer

This study confirmed the possibility of using this as a diagnostic and prognostic marker for colorectal cancer by measuring the expression levels of exosomal miR-193a and let-7g in blood.

Translational Oncology
Sexual Dimorphism in Colon Cancer

This study critically reviews recent clinical and molecular insights into sexual dimorphism of CRC biology modulated by the tumor microenvironment, estrogen, Wnt/β-catenin signalling...

Frontiers in Oncology
Portal Vein Thrombosis in Metastatic Colorectal Cancer During FOLFIRI-bevacizumab Chemotherapy Successfully Treated with Apixaban

Portal vein thrombosis (PVT) while using an angiogenesis inhibitor is relatively rare. 

Internal Medicine
Lymphocyte-White Cell Ratio Is a Novel Marker of Morbidity Following Colorectal Cancer Surgery

A preoperative marker for morbidity in patients with colorectal cancer would help to risk stratify patients and allow for timely intervention to avert poor outcomes.

Journal of Surgical Research
Educational inequalities and regional variation in colorectal cancer survival in Finland

This study investigated the impact of education on CRC survival by using both individual and area-based information on education.

Cancer Epidemiology
Effect of pristimerin on apoptosis through activation of ROS/ endoplasmic reticulum (ER) stress-mediated noxa in colorectal cancer.

This study aimed to investigate the mechanisms of pristimerin-induced apoptosis against CRC in vitro and in vivo.

Management of pain in colorectal cancer patients.

This review focuses on the pathophysiology of CRC-related pain and discusses currently applied pain management. 

Critical Reviews in Oncology Hematology
Role of enterocyte-specific gene polymorphisms in response to adjuvant treatment for stage III colorectal cancer.

This study examined the clinical significance of single-nucleotide polymorphisms in enterocyte-related genes MS4A12 and CDX2 in response to adjuvant treatment for...

Pharmacogenetics and Genomics
An effective approach to the early diagnosis of colorectal cancer based on three-dimensional fluorescence spectra of human blood plasma.

This study examined a combination strategy of Tchebichef image moments coupled with partial least squares-discriminate analysis was proposed for the detection of CRC from three classes.

Journal of Pharmaceutical and Biomedical Analysis
Effect of the isoflavone corylin from cullen corylifolium on colorectal cancer growth, by targeting the STAT3 signaling pathway.

The purpose of this study was to analyze the antitumor activity of corylin in CRC and to elucidate its molecular mechanisms of action.

Modeling cancer clinical trials using HL7 FHIR to support downstream applications: A case study with colorectal cancer data

This study successfully identified 62 discrete items from a preliminary survey of 43 base questions in four CRFs used in colorectal cancer clinical trials, in which...

International Journal of Medical Informatics
Deterministic Arterial Input Function selection in DCE-MRI for automation of quantitative perfusion calculation of colorectal cancer.

This study examined the development of a deterministic algorithm for automated detection of the Arterial Input Function in DCE-MRI of colorectal cancer.

Magnetic Resonance Imaging
Diagnostic role of circulating MiR-21 in colorectal cancer: a update meta-analysis.

MicroRNA-21 is an oncogenic miRNA that modulates the expression of multiple cancer-related target genes.

Annals of Medicine
Reproducibility of Computed Tomography perfusion parameters in hepatic multicentre study in patients with colorectal cancer

The goal of this study is to set up a new approach aiming at achieving multicentre reproducibility of blood flow values in liver.

Biomedical Signal Processing and Control
Quantitative characterization of the colorectal cancer in a rabbit model using high-frequency endoscopic ultrasound.

Colonoscopy accompanied with biopsy works as the routine endoscopic strategy for the diagnosis of colorectal cancer in clinic; however, the colonoscopy is limited to the tissue surface.

NF-κB2 and RELB offer prognostic information in colorectal cancer and NFKB2 rs7897947 represents a genetic risk factor for disease development.

This study focused on NF-κB2 and RELB of the alternative pathway of NF-κB, which remains largely underexplored in colorectal cancer.

Translational Oncology
NIR promotes progression of colorectal cancer through regulating RB.

Here, the authors report that NIR promotes progression of colorectal cancer through regulating RB function.

Biochimica et Biophysica Acta
Pectin co-functionalized Dual Layered Solid Lipid Nanoparticle made by soluble curcumin for the targeted potential treatment of colorectal cancer

The investigation is to increase the cytotoxicity of soluble curcumin by loading it onto pectin and skimmed milk powder dual layered solid lipid nanoparticles.

Carbohydrate Polymers
Emerging roles for HMGA2 in colorectal cancer.

In this review, the authors address the roles of HMGA2 in the oncogenic networks of CRC based on recent advances. 

Translational Oncology
The meiosis-specific cohesin component stromal antigen 3 promotes cell migration and chemotherapeutic resistance in colorectal cancer.

This study evaluated the prognostic impact and role of STAG3 in CRC. Analysis of 172 CRC surgical specimens revealed that high STAG3 expression was associated with poor prognosis.

Cancer Letters
Effect of ginger extracts on colorectal cancer HCT-116 cell line in the expression of MMP-2 and KRAS

The aim of this study was to compare the effects of ethanol and aqueous fresh ginger rhizome extracts on some types of secondary metabolites and radical-scavenging activity.

Gene Reports
Assessing Knowledge and Perceptions of Colorectal Cancer Screening in Armenia.

This study seeks to evaluate knowledge of and attitudes toward CRC and screening programs in Armenia.

Journal of Surgical Research
DNA integrity index as a potential molecular biomarker in colorectal cancer

The purpose of this study was to assess the clinical utility of the DII as a potential biomarker for colorectal cancer in 90 colorectal cancer patients, 30 patients with...

Egyptian Journal of Medical Human Genetics
The targeted delivery of interleukin-12 to the carcinoembryonic antigen increases the intratumoral density of NK and CD8 T cell in an immunocompetent mouse model of colorectal cancer.

The recent success achieved by immune checkpoint inhibitors in the field of immuno-oncology has been less evident for treatment metastatic colorectal cancer patients. 

Journal of gastrointestinal oncology
The expression patterns of NBAT1 and CASC15 are associated with colorectal cancer

In this study, NBAT1 and CASC15 LncRNAs were selected according to review literature and their expression levels were compared in 75 colorectal cancer and adjacent normal tissues

Gene Reports
Accuracy of 18F-FDG PET/CT in monitoring therapeutic response and detection of loco-regional recurrence and metastatic deposits of colorectal cancer in comparison to CT

The study shows the role of PET/CT in monitoring response to therapy in colorectal cancer as well as detection of loco-regional recurrence and metastatic deposits hence guiding...

Egyptian Journal of Radiology and Nuclear Medicine
Low expression of adenomatous polyposis coli 2 correlates with aggressive features and poor prognosis in colorectal cancer.

This study investigated the clinical value of APC2 dysregulation in the prognosis of CRC.

Bioengineered bugs
Effects of postoperative adjuvant chemotherapy and palliative chemotherapy on the gut microbiome in colorectal cancer.

This purpose of this study was to explore the effect of chemotherapy on the gut bacteria and fungi in CRC.

Microbial Pathogenesis
Simultaneous Versus Staged Resection of Colorectal Cancer Liver Metastasis: A Retrospective Single-Center Study.

For patients with colorectal cancer and synchronous liver metastasis, either a simultaneous, or a two-staged resection of the primary tumor and the liver metastases is possible.

Journal of Surgical Research
Retinoic acid core-shell lipoplexes for the treatment of colorectal cancer

The aim of the present research work was to formulate lipid-complexed with DNA using cationic lipid in the form of lipoplexes of retinoic acid on colorectal cancer cell lines.

Colloids and Surfaces A: Physicochemical and Engineering Aspects
FDG-PETCT versus contrast-enhanced computed tomography in diagnosis of post-therapeutic colorectal cancer recurrence and metastases

This study was designed to assess the role of 18F-FDG CT was able to detect additional/CT in posttherapeutic surveillance of colorectal cancer patients as compared...

Egyptian Journal of Radiology and Nuclear Medicine
Development of a dual-energy spectral CT based nomogram for the preoperative discrimination of mutated and wild-type KRAS in patients with colorectal cancer

The purpose of this study was to develop a dual-energy spectral CT nomogram for the preoperative identification of KRAS mutation in patients with CRC.

Clinical Imaging
Role of Cyclooxygenase-2 in colorectal cancer patients.

Cyclooxygenase-2 (COX-2) is an inducible enzyme which triggers the biosynthesis of prostaglandins.

Frontiers in Bioscience
Diagnosis Setting and Colorectal Cancer Outcomes: The Impact of Cancer Diagnosis in the Emergency Department.

The rate of diagnosis of colorectal cancer (CRC) in the emergency department (ED), its characteristics, and its effect on outcomes have been poorly described.

Journal of Surgical Research
A combined FAK, c-MET, and MST1R three-protein panel risk-stratifies colorectal cancer patients.

This study examined the protein expression of FAK, c-MET, and MST1R levels in a well-annotated cohort of 330 colorectal cancer patients. 

Translational Oncology
Central Venous Catheter Insertion in Colorectal Cancer Patients, PICC or PC?
Oncology Nurse Advisor
Biological Agents Plus Chemo for Elderly Colorectal Cancer Patients
Oncology Times - Latest Articles
Daiichi Sankyo Begins Trial for HER3-Directed Agent in Colorectal Cancer Patients
Precision Oncology News
HalioDx, FFCD Collaborate for Phase II Metastatic Colorectal Cancer Trial
Precision Oncology News
CRC Risk: Raised by Meat/Alcohol, Lowered by Aspirin/NSAIDs
Comparison of Colorectal and Endometrial Microsatellite Instability Tumor Analysis and Premm5 Risk Assessment for Predicting Pathogenic Germline Variants on Multigene Panel Testing
ASCO: Journal of Clinical Oncology: Table of Contents
Severe proteinuria during the administration of bevacizumab plus mFOLFOX6 in a colorectal cancer patient after kidney transplantation: a case report

Bevacizumab (BEV) leads to proteinuria and renal damage. It is not clear whether the administration of immunosuppressive drugs after transplantation affects safety BEV administration.

Journal of Pharmaceutical Health Care and Sciences
Distinct epigenetic features of tumor-reactive CD8 T cells in colorectal cancer patients revealed by genome-wide DNA methylation analysis

Tumor-reactive CD8 tumor-infiltrating lymphocytes (TILs) represent a subtype of T cells that can recognize and destroy tumor specifically.

Genome Biology
Portal Vein Thrombosis in Metastatic Colorectal Cancer During FOLFIRI-bevacizumab Chemotherapy Successfully Treated with Apixaban

Portal vein thrombosis (PVT) while using an angiogenesis inhibitor is relatively rare.

Internal Medicine

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