Colorectal Cancer

Colorectal Cancer

FOCUS4-C Trial: Hint of Activity Reported With Adavosertib in Metastatic Colorectal Cancer

The novel WEE1 inhibitor adavosertib, given after induction chemotherapy, yielded a 65% reduction in the risk of disease progression or death compared with active monitoring in patients...

The ASCO Post
US Multisociety Task Force on Colorectal Cancer  Releases Updated Screening Recommendations

The US Multisociety Task Force on CRC has updated its CRC screening recommendations, specifically on when to start and when to stop screening in average-risk individuals.

The ASCO Post
Genetic Differences May Partly Explain Racial/Ethnic Disparities in Early-Onset Colorectal Cancer

Genomic patterns in patients with early-onset CRC vary by race and ethnicity, according to a presentation at the 2021 AACR Virtual Special Conference: Colorectal Cancer.

Cancer Therapy Advisor

Polygenic Risk Score Across Distinct Colorectal Cancer Screening Outcomes

Researchers elucidate the utility of the PRS as a second test after a FIT positive result to indicate or prioritize a colonoscopy.

BMC Medicine
Do Presenting Symptoms, Use of Pre-Diagnostic Endoscopy and Risk of Emergency Cancer Diagnosis Vary by Comorbidity Burden and Type in Patients With Colorectal Cancer?

Cancer patients often have pre-existing comorbidities, which can influence timeliness of cancer diagnosis thus, researchers examined symptoms, investigations and EP risk among CRC patients...

British Journal of Cancer
Sampling Error in the Diagnosis of Colorectal Cancer is Associated With Delay to Surgery

Researchers measure the rates and predictors of sampling errors for biopsies of colorectal cancers at lower endoscopy, and to determine whether these events lead to a delay in surgical care...

Surgical Endoscopy
New Study Uses Artificial Intelligence to Detect Colorectal Cancer

A Tulane University researcher has found that artificial intelligence can accurately detect and diagnose colorectal cancer from tissue scans as well or better than pathologists...

Medical Xpress
Vitamin D Status May Play a Pivotal Role in Colon Cancer Prevention

New research shows that women who consume higher levels of vitamin D have a reduced risk of developing early-onset colorectal cancer, compared with those who have lower levels.

Molecular Differences Between Lymph Nodes and Distant Metastases Compared With Primaries in Colorectal Cancer Patients

Scientists compared lymph nodes and distant metastases to evaluate whether molecular differences exist between these metastatic sites and primary tumors.

npj precision oncology
MYSM1 Inhibits Human Colorectal Cancer Tumorigenesis by Activating miR-200 Family Members/CDH1 and Blocking PI3K/AKT Signaling

New research suggests that MYSM1 might be a potential therapeutic and prognostic target for CRC.

Journal of Experimental & Clinical Cancer Research
The Role of PDGFRA as a Therapeutic Target in Young Colorectal Cancer Patients

An analysis of 49 CRC patients was conducted to understand the molecular characteristics of young patients through a whole-exome and RNA sequencing with tumor and matched normal samples.

Journal of Translational Medicine
Prognostic Value of a Novel Biomarker Combining DNA Ploidy and Tumor Burden Score for Initially Resectable Liver Metastases From Patients With Colorectal Cancer

The prognostic value of DNA ploidy, stroma fraction and nucleotyping of initially resectable liver metastases from patients with CRLM is examined by researchers. 

Cancer Cell International
Impact of Nutritional Status and Body Composition on Postoperative Outcomes After Pelvic Exenteration for Locally Advanced and Locally Recurrent Rectal Cancer

Risk factors, including nutritional status and body composition were determined for postoperative morbidity and survival after pelvic exenteration in patients with LARC or LRRC.

BJS Open
Survival Similar for Younger and Older Patients With Metastatic Colorectal Cancer, Study Finds

Despite increased activity and more intensive treatment for younger patients with colorectal cancer, researchers found that their survival compared to older patients was the same. 

Medical Xpress
Associations Between Hepatitis B Virus Infection and Risk of Colorectal Cancer

Researchers work to determine the relationship between HBV infection and new-onset CRC as research concerning the effect of HBV infection on the risk of CRC is rare and inconsistent.

BMC Cancer
Proteomics-Based Identification of Candidate Exosomal Glycoprotein Biomarkers and Their Value for Diagnosing Colorectal Cancer

Researchers screen for differences in glycoproteins associated with tumor-derived exosomes and validate their clinical value to serve as liquid biopsy biomarkers to diagnose early CRC.

Frontiers in Oncology
Blood Microbiota Diversity Determines Response of Advanced Colorectal Cancer to Chemotherapy Combined With Adoptive T Cell Immunotherapy

This study explored the effect of blood microbiota on clinical efficacy, represented by PFS and OS, of combined CT and adoptive cellular therapy in advanced colon cancer patients.

Inhibitory Immune Checkpoints PDCD-1 and LAG-3 Hypermethylation May Reduce the Risk of Colorectal Cancer

This study investigated the effect of PDCD-1LAG-3 methylation statuses in peripheral blood leukocytes on colorectal cancer risk.

Molecular Medicine
COVID-19 Lockdown May Be Associated With Higher Tumor Burden in Newly Diagnosed Patients With Metastatic Colorectal Cancer

Investigators found that tumor burden assessed as plasma ctDNA was significantly higher among patients with newly diagnosed metastatic colorectal cancer screened for a clinical trial...

The ASCO Post
Role of Phenotypes of Circulating Tumor Cells in the Diagnosis and Treatment of Colorectal Cancer

The aim of this study was to investigate the relationship between circulating tumor cells and their subpopulations and colorectal cancer. 

Cancer Management and Research
The Clinical Significance of Mesenteric Lymphocytes in Human Colorectal Cancer

Study investigators examine the immune landscape of the mesentery, particularly the role of lymphocytes and its association with the clinicopathological characteristics of colorectal cancer.

Frontiers in Oncology
Identification of the Effects of Chondroitin Sulfate on Inhibiting CDKs in Colorectal Cancer Based on Bioinformatic Analysis and Experimental Validation

In the present study, the importance of cyclin-dependent kinases on the occurrence of CRC is identified by data mining of The Cancer Genome Atlas and Gene Expression Omnibus.

Frontiers in Oncology
Tripartite Motif Protein 6 Promotes Colorectal Cancer Cell Migration and Metastasis via SOCS2-STAT3 Signaling

In this study, investigators use CRC cell lines with TRIM6 knockdown and overexpression to investigate the function of TRIM6 in CRC metastasis.

Frontiers in Oncology
Low-Dose Apatinib Combined With S-1 in Refractory Metastatic Colorectal Cancer

The aim of this prospective, single-arm, multicenter, phase 2 study is to assess the efficacy and safety of low-dose apatinib combined with S-1 in the treatment of refractory mCRC.

Frontiers in Oncology
Japanese Study Examines How Intervention Encourages Screening for Colorectal Cancer Among Patients With Schizophrenia

Researchers from Okayama University, Japan, conducted a randomized trial to assess the benefits of interventions for early cancer screening in patients with schizophrenia.

The ASCO Post
Liquid Biopsy Is Changing Colon Cancer Management

The measurement of circulating tumor DNA is changing the way gastrointestinal cancers are managed, according to Dr Bassel F. El-Rayes.

The ASCO Post
Identification and Verification of HCAR3 and INSL5 as New Potential Therapeutic Targets of Colorectal Cancer

This study identifies novel biomarkers related to the pathogenesis of CRC based upon a bioinformatics analysis, and further verifies the biomarkers in clinical tumor samples and CRC cell lines.

World Journal of Surgical Oncology
Nestin Expression as a Diagnostic and Prognostic Marker in Colorectal Cancer and Other Tumors

This literature focuses on nestin as a new biomarker of possible clinical importance in the early diagnosis and monitoring of cancer.

Clinical Medicine Insights: Oncology
Colorectal Polyps Often Recur After Incomplete Resection

A new study indicates that incomplete resection, compared with complete resection, substantially increases the likelihood that a polyp will be found during follow-up colonoscopy.

Detection of Molecular Residual Disease Using Personalized Circulating Tumor DNA Assay in Patients With Colorectal Cancer Undergoing Resection of Metastases

This study evaluates the prognostic value of ctDNA, correlating MRD status postsurgery with clinical outcomes by using a personalized and tumor-informed ctDNA assay.

JCO Precision Oncology
Downregulated ARID1A by miR-185 Is Associated With Poor Prognosis and Adverse Outcomes in Colon Adenocarcinoma

This study aims to explore ncRNA-dependent mechanism that regulates ARID1A expression in COAD regarding miR-185.

Frontiers in Oncology
The Survival Effect of Radiotherapy on Stage II/III Rectal Cancer in Different Age Groups

This study investigates whether radiotherapy exhibits disparate effects in different age groups of patients with stage II/III rectal cancer.

Frontiers in Oncology
Gankyrin as Potential Biomarker for Colorectal Cancer With Occult Liver Metastases

In this study, the expression of Gankyrin in colorectal cancer patients with liver metastases is investigated to determine its prognosis value.

Frontiers in Oncology

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