ASCO GU Recap: Groundbreaking Studies and Exciting Developments in Genitourinary Cancers

Janssen Presents First-ever Results from Dual Bispecific Combination Study Showing 96 Percent Overall Response Rate in Patients With Relapsed or Refractory Multiple Myeloma

Phase 1 Trial of KN046, a Novel Bispecific Antibody Targeting PD-L1 and CTLA-4 in Patients With Advanced Solid Tumors

HD201 Comparable to Referent Trastuzumab for HER2-Positive Breast Cancer

Preclinical Characterization and Phase 1 Trial Results of INBRX-109, a Third-generation, Recombinant, Humanized, Death Receptor 5 Agonist Antibody, in Chondrosarcoma

IMscin001 Part 2: A Randomised Phase 3, Open-label, Multicentre Study Examining the Pharmacokinetics, Efficacy, Immunogenicity, and Safety of Atezolizumab Subcutaneous versus Intravenous in Previously Treated Locally Advanced or Metastatic NSCLC

Menstrual Suppression in the Myelosuppressed: A Retrospective Cohort Study

Camrelizumab Plus Apatinib and Temozolomide as First-line Treatment in Patients With Advanced Acral Melanoma

ASCO GU Recap: Groundbreaking Studies and Exciting Developments in Genitourinary Cancers

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Mar, 16, 2023

The 2023 ASCO Genitourinary Cancers Symposium took place February 16-18, 2023, in San Francisco, California. Catch up on groundbreaking developments from the meeting on Aggrego Oncology.

Atezolizumab in the Treatment of Locally Advanced or Metastatic Urothelial Carcinoma: Results from the Phase 3 IMvigor130 Study

Two abstracts presented at the 2023 ASCO Genitourinary Cancers Symposium shared results from the IMvigor130 study evaluating atezolizumab in the treatment of locally advanced or metastatic urothelial carcinoma (mUC). The phase 3 IMvigor trial studied atezolizumab both in combination with platinum/gemcitabine as a first-line treatment, and as a monotherapy in place of chemotherapy.

Nivolumab Demonstrates Durable Clinical Success in High-Risk Muscle-Invasive Urothelial Carcinoma

Extended follow-up results from the phase 3 CheckMate 274 trial demonstrate that nivolumab continued to improve disease-free survival (DFS), non-urothelial tract recurrence-free survival (RFS), and distant metastasis-free survival (DMFS) vs placebo in patients with high-risk muscle invasive urothelial carcinoma after radical resection.

Radiolabeled 89Zr-DFO-girentuximab Demonstrates Accuracy for Identifying Clear Cell Renal Cell Carcinoma

According to findings from the ZIRCON trial, radiolabeled 89Zr-DFO-girentuximab (TLX250-CDx) PET/CT is well tolerated and can accurately and noninvasively identify clear cell renal carcinoma in imaging.

Rucaparib Improves OS in Metastatic Castration-Resistant Prostate Cancer

Interim results of the phase 3 TRITON3 study demonstrated that rucaparib improved overall survival (OS) vs physician’s choice of therapy (docetaxel, abiraterone, or enzalutamide) in patients with chemotherapy-naïve metastatic castration-resistant prostate cancer.

Darolutamide Plus ADT With Docetaxel Provides New Standard of Care for Patients With mHSPC

According to findings from the phase 3 ARASENS study, the overall survival (OS) benefits of early treatment intensification with darolutamide plus androgen-deprivation therapy among patients with metastatic hormone sensitive prostate cancer were similar regardless of whether patients had high- or low-volume, or high- or low-risk disease.

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