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Gastrointestinal Cancer

Gastrointestinal Cancer

Multiscale Heterogeneity in Gastric Adenocarcinoma Evolution is an Obstacle to Precision Medicine

Using multiregional whole-exome sequencing, scientists investigate the effect of somatic evolution on intratumoral heterogeneity to shed light on the evolutionary biology of GC.

Genome Medicine
11/08/2021
The Long-Term Survival Outcomes of Gastric Cancer Patients With Total Intravenous Anesthesia or Inhalation Anesthesia

This study compares outcomes of gastric cancer patients after surgery with TIVA or IHA to explore the relationship between anesthesia and survival outcomes in those patients. 

BMC Cancer
11/10/2021
Effect of KLF17 Overexpression on Epithelial–Mesenchymal Transition of Gastric Cancer Cells

This study investigated KLF17 expression in normal and gastric cancer tissues and cell lines.

Journal of International Medical Research
11/05/2021

Ripretinib Trial Misses Primary Endpoint for Patients With Gastrointestinal Stromal Tumor

Ripretinib failed to prolong PFS compared with sunitinib among patients with GIST who received prior treatment with imatinib, according to results of the phase 3 INTRIGUE study...

Healio
11/05/2021
Long Noncoding RNA SGO1-AS1 Inactivates TGFβ Signaling by Facilitating TGFB1/2 mRNA Decay and Inhibits Gastric Carcinoma Metastasis

Novel lncRNAs involved in the progression of GC were identified and explored for their regulatory mechanisms and clinical significance in GC.

Journal of Experimental & Clinical Cancer Research
10/28/2021
LINC00963/miR-4458 Regulates the Effect of Oxaliplatin in Gastric Cancer by Mediating Autophagic Flux Through Targeting of ATG16L1

Researchers hypothesized that LINC00963 might be involved in promoting oxaliplatin resistance in gastric cancer by inducing autophagy through targeting of ATG16L1.

Scientific Reports
10/25/2021
Comparison of Submucosal and Subserosal Approaches Toward Optimized Indocyanine Green Tracer-Guided Laparoscopic Lymphadenectomy for Patients With Gastric Cancer (FUGES-019): A Randomized Controlled Trial

Researchers compare the efficacy and ICG injection between the preoperative submucosal and intraoperative subserosal approaches for LN tracing during laparoscopic gastrectomy.

BMC Medicine
10/27/2021
Expression and Prognostic Potential of Ribosome 18S RNA m6A Methyltransferase METTL5 in Gastric Cancer

The protein expression of METTL5 was detected in GCTs and adjacent tissues by immunohistochemical staining to explore the correlation between the expression level of METTL5... 

Cancer Cell International
10/26/2021
pCLE Highlights Distinctive Vascular Patterns in Early Gastric Cancer and in Gastric Diseases With High Risk of Malignant Complications

The pCLE technique is used to examine the vasculature associated with endoscopically normal mucosa in lesions with malignant phenotype or increased risk of GC... 

Scientific Reports
10/26/2021
Similar Long-term Survival With Laparoscopic, Open Gastrectomy

Five-year overall survival after laparoscopic distal gastrectomy for locally advanced gastric cancer is on par with that of open surgery, according to new data from the Chinese CLASS-01 trial.

Medscape
10/22/2021
Long-Term Data Support Nivolumab Plus Chemotherapy but Not Nivolumab Plus Ipilimumab in Gastric Cancer

Longer follow-up data from the phase III CheckMate 649 trial support the use of nivolumab plus chemotherapy as a new standard first-line regimen in patients with advanced gastric cancer. 

The ASCO Post
10/25/2021
Gastric Cancer Stem Cells Survive in Stress Environments via Their Autophagy System

Scientists find cancer stem cells of GC might maintain their viability via the autophagy system, proving that autophagy inhibitors might be a promising therapeutic agent for GC.

Scientific Reports
10/19/2021
Effects and Prognostic Values of miR-30c-5p Target Genes in Gastric Cancer via a Comprehensive Analysis Using Bioinformatics

Potential diagnostic and prognostic values of miR-30c-5p target genes in gastric cancer by using a filtration step analysis and integrated bioinformatics tools are explored.

Scientific Reports
10/18/2021
Comprehensive Analysis of IGFBPs as Biomarkers in Gastric Cancer

This study aimed to explore IGFBPs and their prognostic value as markers in gastric cancer.

Frontiers in Oncology
10/21/2021
Peripheral Blood-Based DNA Methylation of Long Non-Coding RNA H19 and Metastasis-Associated Lung Adenocarcinoma Transcript 1 Promoters are Potential Non-Invasive Biomarkers for Gastric Cancer Detection

Bioinformatic analysis was utilized to verify the reported association between MALAT1 and H19 expression and the occurrence, development, and prognosis of GC. 

Cancer Control
10/06/2021
Circular RNA UBE2Q2 Promotes Malignant Progression of Gastric Cancer by Regulating Signal Transducer and Activator of Transcription 3-Mediated Autophagy and Glycolysis

Scienists proved that circUBE2Q2 is upregulated in GC tissues and cell lines, sponges miR-370-3p to activate the STAT3 pathway, and promotes tumor metastasis...

Cell Death & Disease
10/05/2021
Comparison of Long-Term Efficacy in S-1 and Capecitabine With Oxaliplatin as Adjuvant Chemotherapy for Patients With Gastric Cancer After Curative Surgery

Research compares the long-term survival rates of patients who received TS-1 or XELOX during adjuvant chemotherapy and clinical indications that could guide clinicians in selecting regimens.

Technology in Cancer Research & Treatment
10/04/2021
Phase II Feasibility Study of Adjuvant Chemotherapy with Docetaxel/Cisplatin/S-1 Followed by S-1 for Stage III Gastric Cancer

This phase II trial evaluates the feasibility, safety, and efficacy of postoperative adjuvant therapy with DCS following S-1 therapy in patients with stage IIIA, IIIB, and IIIC gastric cancer...

BMC Cancer
10/01/2021
Development of a Two-Circular RNA Panel as Potential Prognostic Biomarker for Gastric Cancer

Scientists attempted to screen circRNAs that can be used to predict postoperative recurrence and survival in patients with GC.

Journal of Translational Medicine
10/02/2021
Effect of Lockdown on Digestive System Cancer Care Among Older Patients During the First Wave of COVID-19

Scientists see if the effects of lockdown on cancer care and the short-term mortality rate in older patients differed when comparing the very oldest individuals with younger individuals.

Digestive and Liver Disease
10/03/2021
Expression of NEDD9 and Connexin-43 in Neoplastic and Stromal Cells of Gastric Adenocarcinoma

Researchers determine the expression of Cx43 and NEDD9 in node-positive and node-negative gastric cancer at gastrectomy tissue...

BJBMS
10/01/2021
RNF144A-AS1, a TGF-β1- and Hypoxia-Inducible Gene That Promotes Tumor Metastasis and Proliferation via Targeting the miR-30c-2-3p/LOX Axis in Gastric Cancer

This research intends to explore the function and characterize the underlying mechanism of long noncoding RNA RNF144A-AS1 in GC metastasis and outgrowth.

Cell & Bioscience
09/28/2021
Health Care Utilization Among Patients with Oesophageal and Gastric Cancer

Researchers describe individuals’ health care use from the time of treatment decision until death & investigate the impact of the initial treatment strategy and assignment of a CN...

BMC Health Services Research
09/27/2021
T Stage and Venous Invasion are Crucial Prognostic Factors for Long-Term Survival of Patients With Remnant Gastric Cancer

Researchers investigated the clinicopathological factors associated with the long-term outcomes of RGC.

World Journal of Surgical Oncology
09/27/2021
mGWAS Identification of Six Novel Single Nucleotide Polymorphism Loci With Strong Correlation to Gastric Cancer

Researchers combined genome-wide and metabolome-wide datasets generated from 233 GC patients and 233 healthy controls to identify the GC-associated mQTLs. 

Cancer & Metabolism
09/26/2021
Effect of Helicobacter Pylori on Plasma Metabolic Phenotype in Patients With Gastric Cancer

Scientists use Hp as the bacteria & host agents for increasing the risk of gastric cancer to find profound implications for earlier detection of early cancer...

Cancer Control
09/26/2021
Adding First-Line Nivolumab to Chemotherapy Improves Survival in Gastric, Gastroesophageal Junction, and Esophageal Adenocarcinomas

Scientists show that the addition of first-line nivolumab to chemotherapy resulted in improved overall and progression-free survival among patients...

The ASCO Post
09/25/2021
OTUB2 Facilitates Tumorigenesis of Gastric Cancer Through Promoting KDM1A-Mediated Stem Cell-Like Properties

Researchers demonstrate that OTUB2 may serve as a vital driver in GC tumorigenesis by enhancing KDM1A-mediated stem cell-like properties.

Frontiers in Oncology
09/27/2021
A Novel and Rapid Serum Detection Technology for Non-Invasive Screening of Gastric Cancer Based on Raman Spectroscopy Combined With Different Machine Learning Methods

In this study, scientists analyzed the differences in serum Raman spectra of GC patients and normal subjects, and explored the metabolic differences between them. 

Frontiers in Oncology
09/27/2021
Prediction of Locoregional Recurrence-Free Survival of Oesophageal Squamous Cell Carcinoma After Chemoradiotherapy Based on an Enhanced CT-Based Radiomics Model

Scientists establish a predictive model based on enhanced computed tomography examination, and evaluate its clinical value for detecting LRFS in cases of oesophageal squamous cell carcinoma.

Frontiers in Oncology
09/24/2021
Clinicopathological Characteristics and Response to Chemotherapy in Treatment-Naive Epstein–Barr Virus Associated Gastric Cancer

Scientists investigate the treatment response of chemotherapy both in advanced stage and metastatic EBVaGC.

Frontiers in Oncology
09/23/2021
Knockdown of m6A Reader IGF2BP3 Inhibited Hypoxia-Induced Cell Migration and Angiogenesis by Regulating Hypoxia Inducible Factor-1α in Stomach Cancer

The roles of IGF2BP3 in hypoxia-induced cell migration and angiogenesis together with its m6A-dependent targets were investigated in SC in vitro and in vivo.

Frontiers in Oncology
09/21/2021
CT Radiomics for the Preoperative Prediction of Ki67 Index in Gastrointestinal Stromal Tumors

This study establishes and verifies a radiomics model for the preoperative prediction of the Ki67 index of gastrointestinal stromal tumors.

Frontiers in Oncology
09/14/2021

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