Gastrointestinal Cancer

Gastrointestinal Cancer

Retrieval of 30 Lymph Nodes Is Mandatory for Selected Stage II Gastric Cancer Patients

This study aims to explore the impact of retrieving 30 or more lymph nodes on the survival of stage II cancer patients.

Frontiers in Oncology
HER2 Expression, Test Deviations, and Their Impact on Survival in Metastatic Gastric Cancer

The multicenter VARIANZ study aims to investigate the background of response and resistance to trastuzumab in mGC.

Journal of Clinical Oncology
Ten-Year Outcomes With Neoadjuvant Chemoradiotherapy Plus Surgery vs Surgery Alone for Esophageal Cancer

This 10-year follow-up of the Dutch CROSS trial shows a continued OS benefit with neoadjuvant chemoradiotherapy plus surgery vs surgery alone in patients with locally advanced resectable esophageal

The ASCO Post

Adjuvant Nivolumab Practice-Changing in Resected Gastroesophageal Cancer

A “significant and clinically meaningful” improvement of disease-free survival is observed in a Phase III trial among patients who already had their esophageal or gastroesophageal cancers treated w

Oncology Times - Latest Articles
Andecaliximab Disappoints in Advanced Gastric Cancer

Adding andecaliximab to first-line treatment with modified oxaliplatin, leucovorin, and fluorouracil (mFOLFOX6) provides no survival benefit in patients with advanced HER2-negative gastric...

Zolbetuximab Plus EOX Versus EOX Alone for First-Line Treatment of Advanced CLDN18.2-Positive Gastric and Gastro-Oesophageal Adenocarcinoma

This phase II study evaluates clinical outcomes of zolbetuximab + EOX versus EOX alone in advanced CLDN18.2+ gastric cancer.

Annals of Oncology
Anesthesiologist Volume and Adverse Short-Term Outcomes After Complex Surgery for Gastrointestinal Cancer

Hallet et al find that higher anesthesiologist volume is associated with reduced risk of short-term adverse postoperative outcomes in patients undergoing complex surgery for gastrointestinal cancer

The ASCO Post
Addition of Neoadjuvant FOLFIRINOX to Preoperative Chemoradiotherapy in Locally Advanced Rectal Cancer

The UNICANCER-PRODIGE 23 trial has shown intensification of preoperative therapy with FOLFIRINOX prior to chemoradiotherapy results in improved disease-free survival in...

The ASCO Post
FDA Grants Breakthrough Therapy Designation to Bemarituzumab for Gastric Cancers

The FDA grants breakthrough therapy designation to bemarituzumab for use with CT as first-line treatment of certain patients with GI cancers, according to the agent’s manufacturer.

The Importance of Addressing the Burden of Stomach Cancer

Ongoing efforts to improve early detection, as well as continued treatment advancements, are crucial to address stomach cancer around the world.

Oncology Times - Latest Articles
MicroRNAs as Predictive Biomarkers of Resistance to Targeted Therapies in Gastrointestinal Tumors

The aim of this review is to summarize the major studies that have investigated the role of microRNAs as mediators of resistance to targeted therapies currently in use in GI neoplasms...

Exploring the Attitudes of Health Professionals Providing Care to Patients Undergoing Treatment for Upper Gastrointestinal Cancers to Different Models of Nutrition Care Delivery

This study aims to explore the perspectives of health professionals on providing nutrition care to upper gastrointestinal cancer patients by electronic methods to allow the future scaling-up of acc

Effects of Cooperative Nursing and Patient Education on Postoperative Infection and Self-Efficacy in Gastrointestinal Tumors

This study aims to explore the effect of cooperative nursing care management/self-efficacy education on postoperative infection and self-efficacy in gastrointestinal tumor surgery patients.

World Journal of Clinical Cases
KK-LC-1 May be an Effective Prognostic Biomarker for Gastric Cancer

This study detects the expression of  KK-LC-1 in gastric cancer specimens and analyze the associations between KK-LC-1 expression and clinicopathological parameters and clinical prognosis.

BMC Cancer
Circulating Hybrid Cells May Help to Monitor Treatment Response in Patients With Rectal and Esophageal Cancers

An analysis of 58 peripheral blood specimens from patients with rectal and esophageal cancers demonstrates that circulating hybrid cells may be a novel, noninvasive biomarker with potential for...<

The ASCO Post
Oral Microbiota and Helicobacter Pylori in Gastric Carcinogenesis: What Do We Know and Where Next?

This study reviews the investigations done on oral microbiota and analyze various lines of evidence regarding the role of oral microbiota in gastric cancer, to date.

BMC Microbiology
Laparoscopic vs. Open Surgery for Gastrointestinal Stromal Tumors of Esophagogastric Junction

This study compares the efficacy of laparoscopic surgery and the open procedure for EGJ-GIST through the propensity score weighting method.

Chinese Journal of Cancer Research
Progress in GI Cancers 2021: ASCO Clinical Cancer Advance

The American Society of Clinical Oncology has singled out progress against gastrointestinal cancers driven by molecular profiling as its clinical advance of the year.

Oncology Times - Latest Articles
Hepatitis B Virus Reactivation in Gastrointestinal Stromal Tumor Patients Treated With Imatinib

This study aims to review the possible mechanism of HBVr induced by imatinib and explore appropriate measures for patient management and monitoring.

Frontiers in Oncology
Impact of Metabolism-Related Mutations on the Heart Rate of Gastric Cancer Patients After Peritoneal Lavage

During surgery for gastric cancer, peritoneal lavage using warm distilled water can cause temporary hemodynamic changes.

World Journal of Clinical Cases
Evaluation of Blood Supply with Indocyanine Green Fluorescence in Resection for Concurrent Gastric and Pancreatic Cancer

Study investigators present a rare case of concurrent resection of pancreatic and gastric cancer in which indocyanine green fluorescence was used to evaluate the remnant stomach.

Gastrointestinal Stromal Tumor With Multisegmental Spinal Metastases as First Presentation

The most common sites of metastasis are the liver and peritoneum, whereas spinal metastases from gastrointestinal stromal tumor are extremely rare.

Risk of Gastrointestinal Cancer in Patients With an Elevated Level of Gamma-Glutamyltransferase

The aim of this study is to assess the relationship between GGT level and risk of GI cancer, and the contribution of the interaction of hyperglycemia with elevated GGT level...

A Universal Molecular Prognostic Score for Gastrointestinal Tumors

This study concludes that mPS_colon is a universal prognostic classifier for patients with GI cancers and that it should prove informative for optimization of personalized therapy for such patients

Methyladenosine Modification in RNAs: Classification and Roles in Gastrointestinal Cancers

This review highlights the multitude of epigenetic changes of RNA methlyadenosine modifications in gene expression, and their roles in GIC tumorigenesis, progression, and...

Frontiers in Oncology
Epidemiology, Diagnosis, Staging and Multimodal Therapy of Esophageal and Gastric Tumors

Future directions for diagnosis of esophageal and gastric malignancies are evolving rapidly and will involve advances in endoscopic and endosonographic techniques including...

Challenges in Crohn’s Disease Management after Gastrointestinal Cancer Diagnosis

This review provides a comprehensive overview of the current evidence for an adequate diagnostic pathway and medical and surgical management of CD patients after gastrointestinal cancer onset.

Sex Differences in the Incidence of Obesity-Related Gastrointestinal Cancer

This systematic review aims to understand why sex disparities in obesity are associated with sex differences in the incidence of gastrointestinal cancers.

International Journal of Molecular Sciences
Identification of Genes Universally Differentially Expressed in Gastric Cancer

These universal DEGs may be of special importance to gastric cancer diagnosis and treatment targets, and they may make it easier to study the molecular mechanisms underlying GC.

Myeloid-Derived Suppressor Cells in Gastrointestinal Cancers

In patients with GI malignancies, MDSCs can lead to the suppression of T cells and natural killer cells. 

Clinicopathological Characteristics and Outcomes of Gastrointestinal Stromal Tumors With High Progranulin Expression

Little is known about the clinicopathological features of patients with gastrointestinal stromal tumors with regard to PGRN expression.

Ripretinib in Gastrointestinal Stromal Tumor: The Long-Awaited Step Forward

This study provides a critical review on the preclinical and clinical development of ripretinib in GIST.

Gastrointestinal Stromal Tumors (GISTs): Novel Therapeutic Strategies with Immunotherapy and Small Molecules

The purpose of this review is to present alternative approaches for the treatment of the GIST patients, such as combinations of immunotherapy and novel inhibitors with traditional therapies.

International Journal of Molecular Sciences
Association Between Inflammation and Function of Cell Adhesion Molecules Influence on Gastrointestinal Cancer Development

Gastrointestinal cancer is highly associated with inflammatory processes inducing the release of cytokines from cancer or immune cells, including interferons, interleukins...

Prognostic Value of Low MicroRNA-34a Expression in Human Gastrointestinal Cancer

This study summarizes the predictive role of miR-34a for survival in patients with gastrointestinal cancers.

BMC Cancer
Preceding Endoscopic Submucosal Dissection in Submucosal Invasive Gastric Cancer Patients Does Not Impact Clinical Outcomes

This study aims to evaluate the specific influence of endoscopic submucosal dissection on the prognosis of patients with T1b2 gastric cancer.

Scientific Reports
Predicting Postoperative Peritoneal Metastasis in Gastric Cancer With Serosal Invasion Using a Collagen Nomogram

Accurate prediction of peritoneal metastasis for gastric cancer with serosal invasion is crucial in clinic.

Advances in the Surgical Management of Gastric and Gastroesophageal Junction Cancer

This review summarizes the current standard of surgical care for gastroesophageal junction and gastric cancer as well as highlights recent and upcoming advances to the field.

microRNAs Promoting Growth of Gastric Cancer Xenografts and Correlation to Clinical Prognosis

This review focuses on the role of microRNAs with documented efficacy in preclinical xenograft models with respect to growth of human gastric cancer cells.

A Novel Prognosis Marker Based on Combined Preoperative Carcinoembryonic Antigen and Systemic Inflammatory Response for Resectable Gastric Cancer

Carcinoembryonic antigen is one of the important indexes for the diagnosis and prognosis of gastrointestinal cancer.

Preoperative Improvement in Physical Function by Comprehensive Rehabilitation Leads to Decreased Postoperative Complications in Gastrointestinal Cancer Patients

This study investigates how baseline laboratory data and changes in physical function due to preoperative rehabilitation training in GIC patients can influence the frequency of PCs.

Emerging roles of RNA methylation in gastrointestinal cancers

Accumulating evidences indicate that RNA methylation is essential for many biological functions, and its dysregulation is associated with human cancer progression, particularly in GI cancers.

Downregulation of CDH11 Promotes Metastasis and Resistance to Paclitaxel in Gastric Cancer Cells

This study explores the mechanisms that mediate PTX-resistance and metastasis in GC with peritoneal metastasis.

A non-lab nomogram of survival prediction in home hospice care patients with gastrointestinal cancer

This study aimed to develop a gastrointestinal cancer-specific non-lab nomogram predicting survival time in home-based hospice.

BMC Palliative Care
Nano drug delivery systems in upper gastrointestinal cancer therapy

This review aims to provide an overview of novel approaches and perspectives on nanoparticle drug delivery systems for gastrointestinal carcinomas.

Cross-testing of major molecular markers indicates distinct pathways of tumorigenesis in gastric adenocarcinomas and synchronous gastrointestinal stromal tumors

Small subtype of the gastrointestinal stromal tumor is usually asymptomatic and is frequently found incidentally in association with gastric adenocarcinoma.

Scientific Reports
An immune checkpoint score system for prognostic evaluation and adjuvant chemotherapy selection in gastric cancer

The study established a comprehensive immune scoring system based on 6 immunosuppressive ligands using the LASSO method to improve prognostic accuracy and provide an...

Nomogram to Predict Preoperative Occult Peritoneal Metastasis of Gastrointestinal Stromal Tumors (GIST) Based on Imaging and Inflammatory Indexes

Preoperative imaging examination is the primary method for diagnosing metastatic gastrointestinal stromal tumor, but it is associated with a high rate of missed diagnosis.

A Novel Kindred with Familial Gastrointestinal Stromal Tumors Caused by a Rare KIT Germline Mutation (N655K): Clinico-Pathological Presentation and TKI Sensitivity

This study reported the identification of a novel kindred affected by familial GIST caused by a KIT germline mutation in exon 13 (N655K).

Upper Gastrointestinal Cancer Management in the COVID-19 Era: Risk of Infection, Adapted Role of Endoscopy, and Potential Treatment Algorithm Alterations

The safety of upper gastrointestinal cancer patients in the SARS-CoV-2 outbreak is extremely important and most surgeons need to establish a contingency management.

A novel nomogram for predicting liver metastasis in patients with gastrointestinal stromal tumor: a SEER-based study

The present study aimed at developing and validating nomogram to predict LIM in patients with GIST, thus helping clinical diagnosis and treatment.

BMC Surgery
High Prevalence of Gastrointestinal Manifestations of COVID-19 Infection in Hospitalized Patients With Cancer.

This study sought to characterize the GI manifestations of coronavirus disease-19 in oncology patients.

Journal of Clinical Gastroenterology
Gastrointestinal Nematode-Derived Antigens Alter Colorectal Cancer Cell Proliferation and Migration through Regulation of Cell Cycle and Epithelial-Mesenchymal Transition Proteins.

As the global incidences of colorectal cancer rises, there is a growing importance in understanding interaction between external factors, such as common infections, on initiation and...

International Journal of Molecular Sciences
Biochemical parameters and nutritional status of surgical patients with gastrointestinal cancer: a literature review.

This is an integrative literature review with the objective of identifying the relationship between biochemical parameters and the nutritional status of surgical patients with GI cancer.

Revista do Colégio Brasileiro de Cirurgiões
Gastrointestinal events with PARP inhibitors in cancer patients: A meta-analysis of phase II/III randomized controlled trials.

This authors conducted this meta-analysis of RCTs to fully investigate the incidence and the relative risk of GI events in cancer patients receiving PARP inhibitors.

Journal of Clinical Pharmacy and Therapeutics
Effect of an Evidence-Based Nutrition Care Pathway for Cancer Patients Undergoing Gastrointestinal and Pelvic Surgery.

This study reports on the development, implementation and evaluation of an evidence-based nutrition care pathway for lower gastrointestinal and pelvic cancer patients.

Nutrition and Cancer
Does Family History of Cancer Influence Undergoing Screening and Gastrointestinal Investigations

The objectives of the study were to compare sociodemographic characteristics, history of GI investigations and Helicobacter pylori eradication, and modifiable cancer risk factors...

Journal of Gastrointestinal and Liver Diseases
MCM family in gastrointestinal cancer and other malignancies: From functional characterization to clinical implication.

This review summarizes the current knowledge on the oncogenic role of MCM proteins and highlights their clinical implications in various malignancies, especially in GI cancers.

Biochimica et Biophysica Acta
Use and Outcomes of Epidural Analgesia in Upper Gastrointestinal Tract Cancer Resections.

This study aims to use the American College of Surgeons NSQIP to study the utilization and outcomes of EA in open upper GI tract cancer resections.

Journal of Surgical Research
Early change in peripheral CD4 T cells associated with clinical outcomes of immunotherapy in gastrointestinal cancer.

Biomarkers for immune checkpoint inhibitors are limited in gastrointestinal cancer.

Frailty screening for predicting rapid functional decline, rapid progressive disease, and shorter overall survival in older patients with gastrointestinal cancer receiving palliative chemotherapy - a prospective, clinical study

This prospective study examined the value of frailty screening to predict rapid functional decline, rapid progressive disease and shorter overall survival in older patients with gastrointestinal...

Journal of Geriatric Oncology
Metformin and Gastrointestinal Cancer Development in Newly Diagnosed Type 2 Diabetes: A Population-Based Study in Korea.

This study aimed to investigate the association between metformin use and stomach, colon, liver, and pancreatic cancer development among patients with newly diagnosed, drug-naïve type 2 diabetes.

Clinical and translational gastroenterology
Limited usefulness of serum carcinoembryonic antigen and carbohydrate antigen 19-9 levels for gastrointestinal and whole-body cancer screening.

This study aimed to examine the diagnostic performance of these serum markers in multiple-organ cancer screening.

Scientific Reports
Dose–Volume and Radiobiological Model-Based Comparative Evaluation of the Gastrointestinal Toxicity Risk of Photon and Proton Irradiation Plans in Localized Pancreatic Cancer Without Distant Metastasis

The purpose of this study was to investigate the potential of 3D-passive scattering proton beam therapy in limiting GI organ at risk toxicity in localized pancreatic cancer based on dosimetric data

Frontiers in Oncology
Managing a gastrointestinal oncology practice in Japan during the COVID-19 pandemic: single institutional experience in The Cancer Institute Hospital of Japanese Foundation for Cancer Research

In this article, the authors outlined the decisions made regarding the practice of gastrointestinal oncology in our institution during the COVID pandemic.

International Journal of Clinical Oncology
Opioid-induced constipation in patients with cancer pain in Japan (OIC-J study): a post hoc subgroup analysis of patients with gastrointestinal cancer

An observational study of opioid-induced constipation in Japanese patients with cancer included 212 patients with various tumor types.

International Journal of Clinical Oncology
EVs as Potential New Therapeutic Tool/Target in Gastrointestinal Cancer and HCC

For more than a decade, extracellular vesicles (EVs) have been in focus of science.

Newly established gastrointestinal cancer cell lines retain the genomic and immunophenotypic landscape of their parental cancers.

Human cancer cell lines are frequently used as model systems to study molecular mechanisms and genetic changes in cancer.

Scientific Reports
mRNA vaccine–induced neoantigen-specific T cell immunity in patients with gastrointestinal cancer

Here, validated, defined neoantigens, predicted neoepitopes, and mutations of driver genes were concatenated into a single mRNA construct to vaccinate patients with metastatic...

Journal of Clinical Investigation
The Association of Lymphotoxin-Beta Receptor With the Subsequent Diagnosis of Incident Gastrointestinal Cancer: Results From the Dallas Heart Study

Lymphotoxin-beta receptor is an immunological protein associated with inflammation, and from preclinical studies is implicated in tumorigenesis.

Journal of gastrointestinal oncology
Gastrointestinal metastatic breast cancer unmasked by anticoagulation

This study discusses the challenges associated with the diagnosis and management of breast cancer metastatic to the GI tract revealed by need for anticoagulation due to concurrent cancer-associated

Current Problems in Cancer: Case Reports
BReast CAncer ( BRCA ) gene mutations as an emerging biomarker for the treatment of gastrointestinal malignancies

This study discusses the risks and incidence of individual GI cancers seen with BRCA mutations, highlight tumor biology and provide a comprehensive review of the available preclinical and

Chinese clinical oncology
Evaluation of the usefulness of upper gastrointestinal endoscopy and the ValsamouthⓇ by an otolaryngologist in patients with Hypopharyngeal cancer.

The aim of this retrospective study is to evaluate the usefulness of upper gastrointestinal endoscopy and the ValsamouthⓇ by an otolaryngologist in patients with...

Auris Nasus Larynx
Opioid-induced constipation in patients with cancer pain in Japan (OIC-J study): a post hoc subgroup analysis of patients with gastrointestinal cancer

An observational study of opioid-induced constipation in Japanese patients with cancer included 212 patients with various tumor types.

International Journal of Clinical Oncology
Pharmacodynamic biomarkers in metronomic chemotherapy: multiplex cytokine measurements in gastrointestinal cancer patients

Metronomic chemotherapy has shown promising antitumor activity in a number of malignancies. 

Clinical and Experimental Medicine
The association of polypharmacy with functional status impairment, frailty, and health-related quality of life in older adults with gastrointestinal malignancy: Results from the Cancer and Aging Resilience Evaluation (CARE) registry.

The study's objective was to examine the prevalence of polypharmacy and its association with functional status impairments, frailty, and health-related quality of life in older adults with GI malig

Journal of Clinical Oncology
Π-conjugated polymeric micelles potentiate docetaxel therapy in advanced-stage gastrointestinal cancer

This study shows that Π electron-stabilized polymeric micelles based on PEG-b-p(HPMAm-Bz) can be loaded highly efficiently with docetaxel and potentiate chemotherapy...

EVs as Potential New Therapeutic Tool/Target in Gastrointestinal Cancer and HCC

For more than a decade, extracellular vesicles (EVs) have been in focus of science. 

Patient experiences of the urgent cancer referral pathway-Can the NHS do better? Semi-structured interviews with patients with upper gastrointestinal cancer.

In England, cancer waiting time targets are currently not being met.

Health Expectations
Clinical utility of circulating tumor DNA sequencing in advanced gastrointestinal cancer: SCRUM-Japan GI-SCREEN and GOZILA studies.

Comprehensive genomic profiling enables biomarker detection in advanced solid tumors.

Nature Medicine
Therapeutic Applications of Human and Bovine Colostrum in the Treatment of Gastrointestinal Diseases and Distinctive Cancer Types: The Current Evidence

The incidence of gastrointestinal disorders and cancers is escalating all over the world. 

Frontiers in Pharmacology
Postoperative Onset and Detection of SARS-CoV-2 in Surgically Resected Specimens From Gastrointestinal Cancer Patients With Pre/Asymptomatic COVID-19

The study's objective is to describe the epidemiologic features and clinical courses of gastrointestinal cancer patients with pre/asymptomatic COVID-19 and to explore evidence of SARS-CoV-2 in the

Annals of Surgery
Patient-reported outcomes (PROs) in older adults with gastrointestinal (GI) cancer undergoing surgery.

Older adults with GI cancer often experience poor surgical outcomes, yet little is known about their PROs, such as physical function, quality of life, and physical and psychological symptom burden.

Journal of Clinical Oncology
Clinical practice guideline for endoscopic resection of early gastrointestinal cancer.

Although surgery was the standard treatment for early gastrointestinal cancers, endoscopic resection is now a cancers without regional lymph node metastasis.

Intestinal Research
Economic Impact of the Introduction of Outpatient Medical Specialist Care (ASV) of Gastrointestinal Cancer Patients from a German Hospital Management Perspective.

The treatment of cancer patients in Germany is characterized by sectoral separation of the in- and outpatient care accompanied by 2 separate reimbursement systems. 

Perception of cancer in patients diagnosed with the most common gastrointestinal cancers.

Gastrointestinal cancers, including colorectal cancer, stomach cancer and pancreatic are among the most common cancers in Poland.

BMC Palliative Care
Use and Outcomes of Epidural Analgesia in Upper Gastrointestinal Tract Cancer Resections.

This study aims to use the American College of Surgeons National Surgical Quality Improvement Program (NSQIP) to study the utilization and outcomes of EA in open upper GI tract cancer resections.

Journal of Surgical Research
All in the Levels- Programmed Death-Ligand 1 Expression as a Biomarker for Immune Checkpoint Inhibitor Response in Gastrointestinal Cancer Patients.

ICIs benefit patients with rare subsets of GI cancer. Significant interest exists to identify predictive biomarkers that may increase the applicability of ICI therapy for these patients.


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