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Genitourinary Cancer

Genitourinary Cancer

Prognostic Value of Vascular-Expressed PSMA and CD248 in Urothelial Carcinoma of the Bladder

Researchers performed a bioinformatic analysis of CD248 and PSMA using the TCGA-BLCA dataset to explore the underlying mechanism of PSMA and CD248 in UCB progression.

Frontiers in Oncology
11/17/2021
CircTP63 Promotes Cell Proliferation and Invasion by Regulating EZH2 via Sponging miR-217 in Gallbladder Cancer

Scientists provided better understanding for the regulatory role of circRNAs in GBC progression to improve the diagnosis and therapies of GBC.

Cancer Cell International
11/17/2021
Transcriptome-Wide Map of N6-Methyladenosine Methylome Profiling in Human Bladder Cancer

MeRIP-seq and RNA-seq are used to research the difference of mRNA, lncRNA, and circRNA expression levels and m6A methylation levels between bladder cancer tissues and normal adjacent tissues.

Frontiers in Oncology
11/15/2021

Clinical Outcome of Laparoscopic Versus Robot-Assisted Radical Cystectomy for Patients With Bladder Cancer

With the development of minimally invasive surgery technology, researchers actively work to compare outcomes of bladder cancer patients receiving LRC or RARC treatment. 

 

BMC Surgery
11/02/2021
Development and Validation of a Novel Lipid Metabolism-Related Gene Prognostic Signature and Candidate Drugs for Patients With Bladder Cancer

This research explores the function and prognostic value of lipid metabolism-related genes in patients with bladder cancer.

Lipids in Health and Disease
10/27/2021
Impact of Immunohistochemistry-Based Subtyping of GATA3, CK20, CK5/6, and CK14 Expression on Survival After Radical Cystectomy for Muscle-Invasive Bladder Cancer

Scientists work to determine IHC markers or patterns that may predict prognosis in patients with MIBC through gene staining to test against clinical outcomes...

Scientific Reports
10/27/2021
LINC00958 Promotes Bladder Cancer Carcinogenesis by Targeting miR-490-3p and AURKA

Researchers sought to determine the role of the LINC00958-miR-490-3p-AURKA axis in bladder cancer and hypothesized that LINC00958 aggravates disease progression via the miR-490-3p-AURKA axis.

BMC Cancer
10/26/2021
Epigenetic Interplay Between Methylation and miRNA in Bladder Cancer: Focus On Isoform Expression

Researchers put forward a method to identify the effects of methylation and miRNA interaction associated with isoform expression and its further association to survival in bladder cancer patients. 

BMC Genomics
10/21/2021
Prognostic Value of Immune-Related lncRNA Pairs in Patients With Bladder Cancer

Research establishes a novel model to predict the efficacy of immunotherapy regardless of expression.

World Journal of Surgical Oncology
10/18/2021
Systemic Immune-Inflammation Index is a Promising Non-Invasive Biomarker for Predicting the Survival of Urinary System Cancers

This meta-analysis aimed to explore the prognostic significance of pre-treatment SII in tumours of the urinary system.

Annals of Medicine
10/14/2021
Evaluating the Impact of 18F-FDG-PET-CT on Risk Stratification and Treatment Adaptation for Patients With Muscle-Invasive Bladder Cancer (EFFORT-MIBC)

Researchers work to stratify patients and guide further treatment decisions in order to improve the outcome of patients with primary MIBC.

BMC Cancer
10/18/2021
Robotic-Assisted Radical Cystectomy Safe, Feasible for Octogenarians

Doctors compare mortality rates to find that RARC was associated with lower in-hospital mortality compared with open surgery even after controlling for patient and hospital characteristics.

Cancer Therapy Advisor
10/12/2021
A Retrospective Multicenter Comparison of Conditional Cancer-Specific Survival Between Laparoscopic and Open Radical Nephroureterectomy in Locally Advanced Upper Tract Urothelial Carcinoma

Scientists compare the CCSS between ONU and LNU in patients with advanced UTUC after adjusting for the differential baseline characteristics by using propensity score matching.

PLOS ONE
10/11/2021
Role of Hypermethylated-lncRNAs in the Prognosis of Bladder Cancer Patient

RRBS was conducted on five paired bladder cancer and normal adjacent tissues to screen for methylated-RNAs (including lncRNAs). 

Journal of International Medical Research
10/07/2021
Biological Functions and Clinical Significance of Long Noncoding RNAs in Bladder Cancer

This study summarizes the functions and mechanisms, and clinical significance of lncRNAs in the oncogenesis and malignancy of human BCa within the last 10 years.

Cell Death Discovery
10/05/2021
Quality of Life Among Germ-Cell Testicular Cancer Survivors: The Effect of Time Since Cancer Diagnosis

Research questions whether there are time-dependent effects of the disease and treatment on the age-adjusted QoL.

PLOS ONE
10/06/2021
Trends of Incidence and Prognosis of Upper Tract Urothelial Carcinoma

Scientists estimate the incidence of UTUC based on age, sex and primary site and to establish a reliable and practical nomogram based on significant clinical factors...

BJBMS
10/01/2021
The Clinical Implications and Molecular Mechanism of CX3CL1 Expression in Urothelial Bladder Cancer

Researchers evaluate the association between CX3CL1 and BCa and to investigate the underlying biological mechanisms involving CX3CL1 and its receptors in BCa.

Frontiers in Oncology
10/04/2021
Preoperative Aspartate Transaminase/Alanine Transaminase Ratio as a Prognostic Biomarker in Primary Non-Muscle-Invasive Bladder Cancer

Researchers evaluate the prognostic value of the AST/ALT ratio in primary NMIBC using PSM analysis.

BMC Urology
09/27/2021
Metformin and Sodium Dichloroacetate Effects on Proliferation, Apoptosis, and Metabolic Activity Tested Alone and in Combination in a Canine Prostate and a Bladder Cancer Cell Line

This study aimed to investigate the effect of metformin on the metabolic activity and cell proliferation of canine carcinoma-derived tumor cell lines.

PLOS ONE
09/27/2021
DD-MVAC vs Gemcitabine/Cisplatin for Muscle-Invasive Bladder Cancer

Scientists compare the efficacy of gemcitabine/cisplatin or dose-dense methotrexate, vinblastine, doxorubicin & dd-MVAC in patients with muscle-invasive bladder cancer. 

The ASCO Post
09/22/2021
High Expression of SLC16A1 as a Biomarker to Predict Poor Prognosis of Urological Cancers

This study provided a potential molecular mechanism of the key role of SLC16A1 in urological cancer.

Frontiers in Oncology
09/22/2021
Radical Cystectomy: Early-Stage Micropapillary Bladder Cancer Outcomes Similar to Late-Stage Conventional Urothelial Carcinoma

A study presented at the AUA 2021 Annual Meeting has found that among patients treated with radical cystectomy, those with cT1 micropapillary bladder cancer had similar or worse...

The ASCO Post
09/14/2021
M6A Classification Combined With Tumor Microenvironment Immune Characteristics Analysis of Bladder Cancer

This study aims to investigate the role of m6A modification in TME cell infiltration of bladder cancer.

Frontiers in Oncology
09/15/2021
Accelerated Approval Now Full for Pembro in Bladder Cancer

The new full approval is for pembroilizumab for first-line use for patients with locally advanced or metastatic urothelial carcinoma who are not eligible for any platinum-containing chemotherapy.

Medscape
09/01/2021
Effect of Cisplatin and Gemcitabine With or Without Berzosertib in Patients With Advanced Urothelial Carcinoma

Does inhibition of ataxia telangiectasia and Rad3 complement cisplatin-based chemotherapy for metastatic urothelial cancer?

JAMA Oncology
08/26/2021
Multi-Omics Analysis of the Expression and Prognosis for FKBP Gene Family in Renal Cancer

This study aims to examine FKBPs prognostic value and molecular mechanism in clear cell renal cell carcinoma.

Frontiers in Oncology
08/12/2021
Adjuvant Nivolumab Improves Disease-Free Survival in High-Risk Muscle-Invasive Urothelial Carcinoma

An interim analysis of the phase III CheckMate 274 trial has shown improved DFS with adjuvant nivolumab vs placebo among all patients and among those with tumor PD-L1 expression ≥ 1%.

The ASCO Post
08/10/2021
Integrated Analysis of a Competing Endogenous RNA Network Reveals a Prognostic lncRNA Signature in Bladder Cancer

This study study comprehensively analyzes the differentially expressed RNA and corresponding ceRNA network and constructs a potentially predictive tool for prognosis.

Frontiers in Oncology
08/02/2021
ctDNA Identifies Patients Who Benefit From Immunotherapy in MIUC

Among patients with muscle-invasive urothelial carcinoma, the presence of detectable ctDNA after surgery may identify those likely to benefit from adjuvant immunotherapy with the ICI atezolizumab.<

Medscape
07/14/2021
Reducing Immunotherapy Resistance in Prostate Tumors

Reprogramming immune cells inside tissues surrounding prostate tumors may improve response to checkpoint inhibitor therapy in patients, according to a new study.

Oncology Times - Latest Articles
07/05/2021
Adjuvant Radiation May Provide a Survival Benefit Over Salvage Radiation in High-Risk Prostate Cancer

Adjuvant RT after radical prostatectomy may offer greater benefit than early salvage RT in men with high-risk prostate cancer, according to results of a study published in the Journal of Clinical..

Cancer Therapy Advisor
07/01/2021
Adjuvant Versus Early Salvage Radiation Therapy for Men at High Risk for Recurrence Following Radical Prostatectomy for Prostate Cancer and the Risk of Death

Investigators evaluate the impact of adjuvant versus early sRT on all-cause mortality risk in men with adverse pathology defined as positive pelvic lymph nodes or pGleason score 8-10 prostate cance

Journal of Clinical Oncology
06/04/2021

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