Genitourinary Cancer

Genitourinary Cancer

Healthy Lifestyle May Offset Genetic Risk in Prostate Cancer

Adhering to a healthy lifestyle may offset the heightened risk of lethal prostate cancer in patients with adverse genetic risk factors, according to results of a large U.S. study.

Second-Line FOLFOX Chemotherapy versus Active Symptom Control for Advanced Biliary Tract Cancer

The aim of this study is to determine the benefit derived from second-line FOLFOX chemotherapy in advanced biliary tract cancer.

The Lancet Oncology
BRG1 Knockdown Inhibits Proliferation Through Multiple Cellular Pathways in Prostate Cancer

Study investigators have probed the functions of BRG1 on a background of prostate cancer to investigate how BRG1 controls gene expression programmes and cancer cell behaviour.

Clinical Epigenetics

Relugolix As First Oral GnRH Antagonist Option for Prostate Cancer

The FDA recently approved relugolix, a GnRH receptor antagonist, for adults with advanced prostate cancer.

Oncology Times - Latest Articles
Seminal Vesicle-Sparing in Radical Cystectomy Shown to Improve Outcomes

Seminal vesicle sparing at radical cystectomy provides good oncologic outcomes and helps to preserve urinary continence and sexual function in well-selected patients with bladder cancer, a new stud

Cancer Therapy Advisor
LuPSMA Outperforms Cabazitaxel for Metastatic Castration-Resistant Prostate Cancer in Phase II Trial

Following disease progression on docetaxel, PSMA-targeted radionuclide therapy reduces the risk of disease progression or death by 37% vs cabazitaxel in men with mCRPC...

The ASCO Post
Relugolix As First Oral GnRH Antagonist Option for Prostate Cancer

The FDA recently approved relugolix, a gonadotropin-releasing hormone (GnRH) receptor antagonist, for adults with advanced prostate cancer. 

Oncology Times - Latest Articles
Comparison of Systemic Treatments for Metastatic Castration-Sensitive Prostate Cancer

This study seeks to answer the question surrounding the most effective systemic treatments for metastatic castration-sensitive prostate cancer.

JAMA Oncology
Nivolumab: First Adjuvant Immunotherapy to Show Survival Benefit in High-Risk Muscle-Invasive Urothelial Cancer

Adjuvant therapy with nivolumab, an anti–PD-1 immune checkpoint inhibitor, after radical surgery improved disease-free survival in high-risk muscle-invasive urothelial cancer regardless of PD-L1 st

The ASCO Post
MR-Guided Adaptive Radiotherapy for Bladder Cancer

This article examines the technical challenges of bladder radiotherapy and explore how magnetic resonance guided radiotherapy could be leveraged with the aim of improving bladder cancer patient out

Frontiers in Oncology
Prostate Cancer Radiotherapy: Increased Biochemical Control and Late Toxicity in Men With Medication Allergies

Given similarities in the mediators of medication allergy and tissue response to radiotherapy, study investigators assess whether outcomes following prostate radiotherapy differ in patients with MA

JNCI Cancer Spectrum
18F-Guided PET Radiotracing Boosts Survival After Prostate Cancer Relapse

Adding the 18F-fluciclovine PET radiotracer to help guide radiation treatments for recurrent prostate cancer can improve disease-free survival rates, results from a Phase III study show.

Oncology Times - Latest Articles
Vegetable Intake and the Risk of Bladder Cancer in the BLadder Cancer Epidemiology and Nutritional Determinants (BLEND) International Study

This research aims to elucidate the association between vegetable intake and bladder cancer risk by conducting a pooled analysis of data from prospective cohort studies.

BMC Medicine
Can Treatment for Prostate Cancer Affect Smell and Taste?

One in six men being treated for advanced prostate cancer reported experiencing a reduced sense of smell and taste, according to a study published by Alonzi et al. 

The ASCO Post
Radiotherapy of Oligometastatic Prostate Cancer: A Systematic Review

Due to improved imaging sensitivity, the term “oligometastatic” prostate cancer disease is diagnosed more often, leading to an increasing interest in metastasis-directed therapy.

Radiation Oncology
Cell-Free DNA Concentration and Fragment Size as a Biomarker for Prostate Cancer

This study investigates whether differences in cfDNA concentration and cfDNA fragment size could improve the sensitivity for detecting more advanced and aggressive prostate cancer.

Scientific Reports
The Prognostic Impact of Tumor Architecture for Upper Urinary Tract Urothelial Carcinoma: A Propensity Score-Weighted Analysis

This study examined the association of tumor architecture with cancer recurrence, metastasis, and cancer-specific survival in patients treated with radical nephroureterectomy for UTUC in Taiwan.

Frontiers in Oncology
A Bladder Cancer Patient-Derived Xenograft Displays Aggressive Growth Dynamics in vivo and in Organoid Culture

This study establishes the CoCaB 1 PDX and organoid system as companion representative tumor models for the development of novel bladder cancer therapies.

Scientific Reports
Mimickers of Urothelial Carcinoma and the Approach to Differential Diagnosis

A broad spectrum of lesions, including hyperplastic, metaplastic, inflammatory, infectious, and reactive, may mimic cancer all along the urinary tract.

Clinics and Practice
Identification of UBE2C as Hub Gene in Driving Prostate Cancer by Integrated Bioinformatics Analysis

The aim of this study is to identify novel genes in promoting primary prostate cancer progression and to explore its role in the prognosis of prostate cancer.

Effect of Prior Cancer on Survival Outcomes for Patients With Advanced Prostate Cancer

Whether a prior cancer history has an adversely impact on clinical outcomes for patients with advanced prostate cancer remains largely unknown.

BMC Urology
Urethral Cancer Managed With Phallus Preserving Surgery

This study describes a case of distal urethral carcinoma, which presented as a metastatic groin mass and identifying the primary lesion proved challenging.

Journal of Medical Case Reports
Identification of Lipidomic Profiles Associated With Drug-Resistant Prostate Cancer Cells

The association of circulating lipids with clinical outcomes of drug-resistant castration-resistant prostate cancer is not fully understood.

Lipids in Health and Disease
Liquid vs Tissue Biopsy in Prostate Cancer: Why Not Both?

The genomic landscape of circulating tumor DNA was comparable to the landscape of tissue biopsies in a large study of patients with metastatic castration-resistant prostate cancer. 

Pooled Analysis of Xpert Bladder Cancer Based on the 5 mRNAs for Rapid Diagnosis of Bladder Carcinoma

The purpose of this article is to review the accuracy of Xpert Bladder Cancer in the follow-up diagnosis of bladder cancer and evaluate the role...

Comparison of Functional and Oncological Outcomes of Innovative “Three-Port” and Traditional “Four-Port” Laparoscopic Radical Prostatectomy in Patients With Prostate Cancer

This study compares functional and oncological outcomes between innovative “three-port” and traditional “four-port” laparoscopic radical prostatectomy in patients with prostate cancer.

miRNAs and Biomarkers in Testicular Germ Cell Tumors: An Update

The purpose of this review is to collect all the studies executed on miRNAs that have a potential role as biomarkers for testicular tumors.

International Journal of Molecular Sciences
Age and Tumor Differentiation-Associated Gene Expression Based Analysis of Non-Familial Prostate Cancers

To investigate age-specific tumor associated gene signatures and their potential biomarkers for disease aggressiveness, this study highlights well and poorly differentiated tumor types of young and

Frontiers in Oncology
Interchangeability of Light and Virtual Microscopy for Histopathological Evaluation of Prostate Cancer

Virtual microscopy holds promise to reduce subjectivity as well as intra- and inter-observer variability for the histopathological evaluation of prostate cancer. 

Scientific Reports
Identifying the Need to Discuss Infertility Concerns Affecting Testicular Cancer Patients

The objective of this study is to evaluate the manner in which men with testicular cancer are counselled about implications on fertility and the possibility of semen preservation.

Maintaining Consistent Bladder Filling During External Beam Radiotherapy for Prostate Cancer

Radiation therapy for patients with prostate cancer is preferably provided with a full urinary bladder.

Experimental Models for Studying HPV-Positive and HPV-Negative Penile Cancer: New Tools for An Old Disease

The present review summarizes and discusses the available data concerning the pre-clinical models of penile cancer and their uses.

Establishment and Validation of a Novel Predictive Model to Quantify the Risk of Bone Metastasis in Patients With Prostate Cancer

This study aims to construct and validate a nomogram to quantify bone metastasis risk in patients with prostate cancer. 

The Expression of YWHAZ and NDRG1 Predicts Aggressive Outcome in Human Prostate Cancer

This study aims to identify molecular biomarkers that could improve risk prediction in prostate cancer.

Pathogenesis and Diagnosis of Genitourinary Cancer

These comprehensive innovative analyses have led to new molecular classification based on the genomic expression profiles and the discovery of potential diagnostic...

Cost-effectiveness of Prostate Radiation Therapy for Men With Newly Diagnosed Low-Burden Metastatic Prostate Cancer

This study seeks to answer the question for men with newly diagnosed, low-volume metastatic prostate cancer, if the addition of prostate radiation therapy to androgen deprivation is therapy cost-ef

Association of Caveolin-1 Expression With Prostate Cancer

This meta-analysis evaluates the prognostic value of caveolin-1 in prostate cancer, as well as ascertain the relationship between caveolin-1 expression and...

Frontiers in Oncology
Insights into Urological Cancer

Urological malignancies nowadays remain a hot topic of translational oncologic research. 

Comprehensive Integrative Profiling of Upper Tract Urothelial Carcinomas

Crosstalk between genetic, epigenetic, and immune alterations in upper tract urothelial carcinomas and their role in shaping muscle invasiveness and patient outcome are poorly understood.

Genome Biology
Imaging of Abdominal and Pelvic Infections in the Cancer Patient

This article reviews common, as well as less common, imaging manifestations of infections and their potential mimics in the abdomen and pelvis in cancer patients and...

Intraoperative Assessment and Postsurgical Treatment of Prostate Cancer Tumors Using Tumor-Targeted Nanoprobes

Successful visualization of prostate cancer tumor margins during surgery remains a major challenge.

Discovery of Extracellular Vesicles Derived miR-181a-5p in Patient's Serum as an Indicator for Bone-Metastatic Prostate Cancer

This study's purpose is to identify extracellular vesicle-delivered microRNAs in the patient's serum as indicators for bone-metastatic prostate cancer.

Fifteen-MiRNA-Based Signature Is a Reliable Prognosis-Predicting Tool for Prostate Cancer Patients

Recurrence is a major problem for prostate cancer patients, thus, identifying prognosis-related markers to evaluate clinical outcomes is essential.

Impact of Time to Castration Resistance on Cytoreductive Radiotherapy in Metastatic Castration-Resistant Prostate Cancer

This study aimed to identify the value of local radiotherapy and potential candidates for metastatic castration-resistant prostate cancer.

Frontiers in Oncology
Genitourinary Medical Oncology Expert Opinion Survey Regarding Treatment Management in COVID-19 Pandemic

The specific changes in the management of genitourinary cancers in different cancer centers due to COVID-19 are not known and some clinical scenarios remain controversial.

Bayesian Network Analysis of Open, Laparoscopic, and Robot-Assisted Radical Cystectomy for Bladder Cancer

Study investigators perform the direct and network meta-analysis to evaluate the safety and efficacy of robot-assisted versus laparoscopic versus open radical cystectomy for bladder cancer.

A Clinical Evaluation of Enzalutamide in Metastatic Castration-Sensitive Prostate Cancer: Guiding Principles for Treatment Selection and Perspectives on Research

This publication comprehensively analyzes the clinical evidence and guiding principles of enzalutamide use in castration-sensitive prostate cancer.

Epidemiology and survival outcome of adult kidney, bladder, and prostate rhabdomyosarcoma: A SEER database analysis

Study investigators perform an analysis of all adult RMS cases reported in SEER database to understand prognostic factors among kidney, bladder, and prostate RMS.

Early Salvage Radiotherapy Bests Adjuvant Treatment for Prostate Cancer

Adjuvant radiotherapy following radical prostatectomy does not improve event-free survival in men with localized or locally advanced prostate cancer and should not be considered...

Oncology Times - Latest Articles
Origin of Subsequent Malignant Neoplasms in Patients with History of Testicular Germ Cell Tumor

This study investigates the genetic landscape and cellular origins of cancers that develop later in life after treatment for TGCT and found evidence that a common progenitor cell...

A novel imaging based Nomogram for predicting post-surgical biochemical recurrence and adverse pathology of prostate cancer from pre-operative bi-parametric MRI

Investigators developed and validated an integrated radiomic-clinicopathologic nomogram for post-surgical biochemical recurrence free survival and adverse pathology prediction...

Integrative multi-omics analysis of muscle-invasive bladder cancer identifies prognostic biomarkers for frontline chemotherapy and immunotherapy

Only a subgroup of patients with muscle-invasive bladder cancer are responders toward cisplatin-based chemotherapy and PD-L1 blockade immunotherapy.

Evaluation of cytokine expression and circulating immune cell subsets as potential parameters of acute radiation toxicity in prostate cancer patients

The aim of research was to evaluate the possible clinical value of the associations between clinical, physical, and biological factors, and risk for development of acute radiotoxicity in patients..

Scientific Reports
Mobile Health App for Prostate Cancer Patients on Androgen Deprivation Therapy: Qualitative Usability Study

This study aimed to evaluate the usability and patient experience of a newly developed mHealth app among prostate cancer patients on ADT and physicians’ beliefs about the potential benefits of...

Genitourinary Syndrome of Menopause: Current Treatment Options in Breast Cancer Survivors – Systematic Review

Breast cancer survivors usually receive treatments which lead to persistent oestrogen suppression, which may cause atrophic vaginitis in a large proportion of these women. 

A Comparison of Genitourinary Society Pathology and International Society of Urological Pathology Prostate Cancer Guidelines.

In 2019, GUPS and ISUP held their own consensus conferences on prostate cancer grading, with separately published manuscripts.

European Urology
The Impact of the COVID-19 Pandemic on Genitourinary Cancer Care: Re-envisioning the Future.

The objective of this study was to provide an evidence-informed, expert-derived review of genitourinary cancer care moving forward following the initial COVID-19 pandemic.

European Urology
Pilot study of fractional CO2 laser therapy for genitourinary syndrome of menopause in gynecologic cancer survivors

This study evaluated the efficacy of fractional CO2 laser treatments in gynecologic cancer survivors with GSM.

Surgical Management of Genitourinary Cancer Liver Metastases.

Genitourinary cancers are common. Liver metastases from genitourinary uncommon

Surgical Oncology Clinics of North America
Common germline-somatic variant interactions in advanced urothelial cancer

The prevalence and biological consequences of deleterious germline variants in urothelial cancer are not fully characterized.

Blood pressure and bladder cancer risk in men by use of survival analysis and in interaction with NAT2 genotype, and by Mendelian randomization analysis

The association between blood pressure and bladder cancer risk remains unclear with confounding by smoking being of particular concern.

A review of current advancements and limitations of artificial intelligence in genitourinary cancers

In the realm of genitourinary cancers, AI has had particular success in improving the diagnosis and treatment of prostate, renal, and bladder cancers.

Management of urologic cancers during the pandemic and potential impact of treatment deferrals on outcomes

This study summarized the prepandemic literature on deferred surgery for GU cancers and risk of disease progression.

The Immune Microenvironment in Penile Cancer and Rationale for Immunotherapy

This review described the penile cancer microenvironment, and summarized the rationale for immunotherapy in penile cancer patients.

Discrepancies between genitourinary cancer patients' and clinicians' characterization of the Eastern Cooperative Oncology Group performance status.

This study was designed to describe the patient‐reported performance status and the provider‐reported PS.

Development and Validation of a Comprehensive Multivariate Dosimetric Model for Predicting Late Genitourinary Toxicity Following Prostate Cancer Stereotactic Body Radiotherapy.

This study sought to develop a multivariate model that predicts CTCAE late grade 2 or greater genitourinary toxicity by interrogating the entire DVH from a large cohort of prostate cancer...

Frontiers in Oncology
Landscape of somatic DNA damage repair (DDR) gene mutations in genitourinary cancer in China.

In this study, the authors assessed DDR GAs for better understanding therapeutic implications.

Journal of Clinical Oncology
Practice patterns related to prostate cancer grading: results of a 2019 Genitourinary Pathology Society clinician survey

This study's purpose was to survey urologic clinicians regarding interpretation of and practice patterns in relation to emerging aspects of prostate cancer grading, including...

Urologic Oncology-seminars and Original Investigations
Assessing Genitourinary Cancer Clinical Trial Accrual Sufficiency Using Archived Trial Data

Clinical trials often fail to reach their anticipated end points, most frequently because of poor accrual.

JCO clinical cancer informatics
Update on Circulating Tumor Cells in Genitourinary Tumors with Focus on Prostate Cancer.

Current developments in the treatment of genitourinary tumors underline unmet clinical need for biomarkers to improve decision-making a challenging setting.

A comparison of general, genitourinary, bowel, and sexual quality of life among long term survivors of prostate, bladder, colorectal, and lung cancer.

A comparison of general, genitourinary, bowel, and sexual quality of life among long term survivors of prostate, bladder, colorectal, and lung cancer.

Journal of Geriatric Oncology
The scope, presentation, and management of genitourinary complications in patients presenting with high-grade urethral complications after radiotherapy for prostate cancer.

The objective of this study is to describe the presentation, scope, and management of genitourinary complications in patients referred for high-grade urethral complications or sphincter weakness in

Cuaj-canadian Urological Association Journal
A competing risk analysis of death patterns in male genitourinary cancer.

This work is aimed to explore the death patterns among male genitourinary cancer patients due to other causes. The occurrence of death not related to cancer is defined as competing risk.

Cancer reports (Hoboken, N.J.)

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