Gynecologic Cancer

Gynecologic Cancer

Study Finds Ixabepilone Plus Bevacizumab Active in Platinum-Resistant or Recurrent Ovarian Cancer

The addition of bevacizumab to ixabepilone could be a promising treatment strategy for a group of patients with cancer currently lacking therapeutic options, according to data presented during the

The ASCO Post
Efficacy and Safety of Tisotumab Vedotin in Previously Treated Recurrent or Metastatic Cervical Cancer

This study evaluates the efficacy and safety of tisotumab vedotin, a tissue factor-directed antibody–drug conjugate, in this patient population.

The Lancet Oncology
In Gynecologic Cancers, Who Can Safely Undergo Fertility-Sparing Surgery?

Traditional surgeries for gynecologic cancers can be lifesaving, but for younger women they can also cause infertility or induce surgical menopause.

Oncology Times - Latest Articles

Adjuvant Therapy Benefit Questioned in POLE-Mutated Endometrial Cancer

An individual patient data meta-analysis failed to demonstrate that receipt of adjuvant therapy provided a clear benefit for women with POLE-mutated endometrial cancer.

Cancer Therapy Advisor
Outcomes With MRI-Based Image-Guided Adaptive Brachytherapy for Locally Advanced Cervical Cancer

In this study, Pötter et al find that MRI-based image-guided adaptive brachytherapy is associated with a high rate of long-term local disease control and...

The ASCO Post
Tisotumab for Advanced Cervical Cancer Awaiting Approval

Tisotumab vedotin, an investigational antibody drug conjugate directed against tissue factor, has shown promise for patients with recurrent or metastatic cervical cancer.

Secondary Cytoreduction Followed By Chemotherapy Versus Chemotherapy Alone in Platinum-Sensitive Relapsed Ovarian Cancer (SOC-1)

Study investigators assess the efficacy of secondary cytoreduction plus chemotherapy versus chemotherapy alone in this patient population.

The Lancet Oncology
Genome-Wide Association Study of Variants Linked to Cervical Preinvasive and Invasive Disease

Bowden et al identify six independent variants among the PAX8, CLPTM1L, and HLA genes that are associated with risk for invasive cervical cancer or cervical intraepitheli

The ASCO Post
Curcumin Anti‐Tumor Effects on Endometrial Cancer With Focus on its Molecular Targets

This reviews covers studies concerned with the anti-tumor effects of curcumin on endometrial cancer.

Cancer Cell International
Overexpression of Nucleolin is a Potential Prognostic Marker in Endometrial Carcinoma

This study examines the expression of NCL in endometrial carcinoma tissues and its associations with patient outcomes.

Cancer Management and Research
Lenvatinib/Pembrolizumab Improves Survival in Advanced Endometrial Cancer

The combination of lenvatinib, a multikinase inhibitor of VEGFR1, VEGFR2, and VEGFR3 kinases, and pembrolizumab significantly improved multiple outcomes compared with standard single-agent CT in...

The ASCO Post
Patients With Ovarian Cancer Face an Increased Risk of Mental Illness

Women diagnosed with ovarian cancer were more than three times more likely than the general public to be diagnosed with anxiety, depression, and adjustment disorder...

The ASCO Post
Ovarian Cancer Prevention: How Patients Decide on Surgery

Patients consider the risk of cancer and menopause, as well as other factors, when making decisions about ovarian cancer prevention surgery, according to a small study.

Overall Survival With Olaparib vs Placebo Maintenance in Patients With Platinum-Sensitive Relapsed Ovarian Cancer and BRCA1/2 Mutation

The phase III SOLO2/ENGOT-Ov21 trial has shown a large numeric but statistically nonsignificant improvement in the secondary endpoint of overall survival with olaparib tablet maintenance therapy vs

The ASCO Post
Significance of EZH2 Expression in Endometrial Cancer

To identify new targets, researchers have explored the relevance of epigenetic modifiers in cancer therapeutics. One such potential candidate is enhancer of zeste homolog 2 (EZH2). 

Oncology Times - Latest Articles
Frailty May Impact Surgical Outcomes in Patients With Ovarian Cancer

Frailty may be a better predictor of poor surgical outcomes in patients with ovarian cancer than age, according to two studies reported at the SGO 2021 Virtual Annual Meeting on Women’s Cancer.

The ASCO Post
Hormonal IUD May Be a Potential Nonsurgical Treatment for Early Endometrial Cancer or Precancer

An intrauterine device, or IUD, that releases the hormone levonorgestrel appears to be an effective treatment for endometrial precancer and early-stage endometrial cancer. 

The ASCO Post
MRI-Guided Adaptive Brachytherapy in Locally Advanced Cervical Cancer (EMBRACE-I)

This study reports on EMBRACE-I, which aims to evaluate local tumor control and morbidity after chemoradiotherapy and MRI-based IGABT.

The Lancet Oncology
Phase III ARIEL4 Trial Confirms Benefit of Rucaparib in BRCA-Mutated Relapsed Ovarian Cancer

In patients with BRCA-mutated, advanced, relapsed ovarian cancer, treatment with the PARP inhibitor rucaparib led to a significant improvement in progression-free survival compared with...

The ASCO Post
Olaparib Tablets as Maintenance Therapy in Patients With Platinum-Sensitive Relapsed Ovarian Cancer and a BRCA1/2 Mutation

The aim of this final analysis is to investigate the effect of olaparib on overall survival.

The Lancet Oncology
Niraparib Plus Bevacizumab Shows Clinical Benefit in Patients With Advanced Ovarian Cancer

The addition of niraparib maintenance to first-line platinum-based chemotherapy with bevacizumab demonstrated clinical benefit in patients with advanced ovarian cancer.

The ASCO Post
The Impact of Pegylated Liposomal Doxorubicin in Recurrent Ovarian Cancer

The aim of the present meta-analysis is to further update the role of PLD in the treatment of recurrent ovarian cancer.

Journal of Ovarian Research
Nomograms to Predict the Density of Tumor-Infiltrating Lymphocytes in Patients With High-Grade Serous Ovarian Cancer

Study investigators explore the association of TILs with clinicopathological characteristics and blood indicators, and to develop nomograms to predict the density of TILs in patients with high-grad

Frontiers in Oncology
Gene Expression Profile Association With Poor Prognosis in Epithelial Ovarian Cancer Patients

Here, study investigators perform gene expression profiling of different subtypes of ovarian cancer to evaluate its association with patient overall survival and aggressive forms of the disease.

Scientific Reports
A Prospective Study of the Adaptive Changes in the Gut Microbiome During Standard-of-Care Chemoradiotherapy for Gynecologic Cancers

The purpose of this prospective study is to identify changes in the diversity and composition of the gut microbiome during and after pelvic CRT.

Serum Free Amino Acid Profiling in Differential Diagnosis of Ovarian Tumors

Serum free amino acid profiles are investigated to identify potential novel biomarkers of ovarian cancer and assess their performance in ovarian tumor differential diagnosis.

International Journal of Environmental Research and Public Health
Increased HSF1 Promotes Infiltration and Metastasis in Cervical Cancer via Enhancing MTDH-VEGF-C Expression

The purpose of this study is to explore the molecular mechanism of promoting cervical cancer by HSF1 in vivo and in vitro.

OncoTargets and Therapy
Prognostic Significance of the Expression of Metastasis-Associated in Colon Cancer-1 in Gynecologic Cancers and Breast Cancer

The aim of this systematic review and meta-analysis is to determine the prognostic significance of MACC1 expression in gynecologic cancers and breast cancer.

Exosome-Mediated Transfer of CD44 From High-Metastatic Ovarian Cancer Cells Promotes Migration and Invasion of Low-Metastatic Ovarian Cancer Cells

This study investigates the detailed roles and mechanisms of tumor-derived exosomes in progression and metastasis of ovarian cancer in vitro.

Prognostic Significance of Survivin Expression in Patients with Ovarian Carcinoma

The aim of this study is to assess the clinical and prognostic significance of expression survivin in patients with ovarian cancer.

Silencing of PTPN18 Induced Ferroptosis in Endometrial Cancer Cells Through p-P38-Mediated GPX4/xCT Down-Regulation

PTPN18 was found to be up-regulated in endometrial cancer tissues and a high level of PTPN18 promoted proliferation and metastasis of EC cells.

Cancer Management and Research
Circular RNAs: A Promising Biomarker for Endometrial Cancer

This review describes the biogenesis, function and characteristics of circRNAs, and the circRNAs with potential influence and clinical significance on the development of EC are summarized.

Cancer Management and Research
The Role of an Immune Signature for Prognosis and Immunotherapy Response in Endometrial Cancer

This study identifies an immune-related gene signature to predict the OS and response to immune checkpoints inhibitors in patients with endometrial cancer.

American Journal of Translational Research
Long-Term Quality of Life and Sexual Function of Elderly People With Endometrial or Ovarian Cancer

This study describes and compares according to age long-term HRQoL, sexual function, and social deprivation of adults with either EC or OC.

Health and Quality of Life Outcomes
Utility of Adjuvant Whole Abdominal Radiation Therapy in Ovarian Clear Cell Cancer: A Pragmatic Cohort Study of Women With Classic Immuno-Phenotypic Signature

This study evaluates the initial experience and clinical utility of first-line adjuvant intensity-modulated whole abdominal radiation therapy in women with OCCC referred to an academic center.

Radiation Oncology
Practice Patterns and Results of Tumor and Germline Genetic Evaluation of Women With Endometrial Cancer in South Louisiana

Study objectives are to describe rates of MMRd or MSI-H EC tumors, the prevalence of LS, the practice patterns of EC genetic evaluation and adherence to NCCN guidelines, and to...

Gynecology Oncology Reports
CDCA8, Targeted by MYBL2, Promotes Malignant Progression and Olaparib Insensitivity in Ovarian Cancer

This study concludes high CDCA8 expression is involved in the tumorigenesis, aggressiveness and chemoresistance of ovarian cancer.

American Journal of Cancer Research
Pharmacological Prophylaxis and Personal Protective Equipment Practices in Gynecological Cancer Surgery During COVID-19 Pandemic

The aim of this study is to assess PPE practices during surgery on COVID-19 negative gynecological cancer patients and use of pharmacologic prophylaxis by clinicians practicing gynecologic oncology

Indian Journal of Gynecologic Oncology
PRSS1 Upregulation Predicts Platinum Resistance in Ovarian Cancer Patients

Study investigators conduct in-depth explorations on PRSS1's platinum response to ovarian cancer through tissue and cytological experiments.

Frontiers in Cell and Developmental Biology
Cervical Cancer Care: Focusing on Disparities in Appalachia

While recent decades have seen a decline in cervical cancer incidence and mortality, some populations—such as women who live in the Appalachian region—still suffer disproportionately from...

Oncology Times - Latest Articles
Pembrolizumab in Vaginal and Vulvar Squamous Cell Carcinoma: A Case Series From a Phase II Basket Trial

This study presents a case series of patients with vaginal or vulvar SCC who were treated with single-agent pembrolizumab as part of a phase II basket clinical trial to evaluate efficacy and safety

Scientific Reports
Evaluation of FGFR1 as a Diagnostic Biomarker for Ovarian Cancer Using TCGA and GEO Datasets

This study aims to identify different expression patterns of genes related to FGFR1 and the usefulness of FGFR1 as diagnostic biomarker for ovarian cancer.

Targeting Dopamine Receptor D2 as a Novel Therapeutic Strategy in Endometrial Cancer

This study investigates the anti-tumorigenic effect of ONC201 in endometrial cancer cell lines and a genetically engineered mouse model of endometrial cancer.

The Role of Metformin in Ovarian Cancer: Does Metformin Increase Survival in Ovarian Neoplasm?

This review highlights the function of metformin as an antineoplastic agent in OC and its effect on overall survival, progress-free survival, and recurrence-free survival. 

Extracellular miRNAs as Predictive Biomarkers for Glypican-3-Derived Peptide Vaccine Therapy Response in Ovarian Clear Cell Carcinoma

The purpose of this study was to explore circulating biomarkers using pre-treatment serum samples from a GPC3 peptide vaccine clinical trial in order to predict response to vaccine therapy.

Brain Metastases from Uterine Cervical and Endometrial Cancer

This review investigates the prevalence, clinical characteristics, clinical presentation, diagnosis, treatment, and prognosis of patients with brain metastases from uterine...

Identification of Novel lncRNAs in Ovarian Cancer and Their Impact on Overall Survival

Study investigators aim to identify lncRNA sequences that are associated with high grade serous ovarian cancer and assess their impact on overall survival.

International Journal of Molecular Sciences
Phytochemicals in Gynecological Cancer Prevention

This literature review summarizes the current knowledge on the phytochemicals with proven antitumor activity, emphasizing their effectiveness and mechanism of action in gynecological cancer.

International Journal of Molecular Sciences
A Retrospective Study of Internal Small Bowel Herniation Following Pelvic Lymphadenectomy for Gynecologic Carcinomas

The aim of the study is to investigate the incident and etiology of internal hernias beneath the skeletonized pelvic structure following pelvic lymphadenectomy.

Scientific Reports
Dosimetric Predictors of Nephrotoxicity in Patients Receiving Extended-Field Radiation Therapy for Gynecologic Cancer

Study investigators sought dosimetric predictors of a decreasing estimated glomerular filtration rate in gynecological oncology patients receiving extended-field radiation therapy.

Association of a Novel Endometrial Cancer Biomarker Panel With Prognostic Risk, Platinum Insensitivity, and Targetable Therapeutic Options

Therefore, this study aims to assess pivotal molecular parameters that differentiate clinical outcomes in high- and low-risk endometrial cancer.

GYNOCARE Update: Modern Strategies to Improve Diagnosis and Treatment of Rare Gynecologic Tumors—Current Challenges and Future Directions

 Currently, gynecologic cancer research, due to distinct scientific and technological challenges, is lagging behind.

A Quality Improvement Pathway to Rapidly Increase Telemedicine Services in a Gynecologic Oncology Clinic During the COVID-19 Pandemic With Patient Satisfaction Scores and Environmental Impact

The primary goal was to convert 50% of all outpatient encounters during the COVID-19 pandemic to telemedicine within one week.

GSG2 Promotes Development and Predicts Poor Prognosis of Ovarian Cancer

In this study, immunohistochemical analysis is used to detect GSG2 expression in ovarian cancer tissues and corresponding normal tissues. 

Prognostic Significance of Bone Marrow FDG Uptake in Patients With Gynecological Cancer

Study investigators examine the prognostic significance and the underlying mechanism of increased BM 2-(18F) fluoro-2-deoxy-D-glucose as a tracer (FDG)-uptake in patients with gynecological cancer.

Scientific Reports
Risk Reclassification of Patients with Endometrial Cancer Based on Tumor Molecular Profiling: First Real World Data

This retrospective, monocentric study investigates the clinical feasibility of molecular profiling and its potential impact on treatment decisions.

Adjuvant Sequential Chemoradiation Affords Superior DFS Benefit Versus CCRT, RT in Early-Stage Cervical Cancer

Sequential chemoradiation was found to result in longer DFS and a lower risk for cancer death compared with concurrent chemoradiation or RT alone in the postoperative...

Cancer Therapy Advisor
Evaluation of the Potential of Pap Test Fluid and Cervical Swabs to Serve as Clinical Diagnostic Biospecimens For the Detection of Ovarian Cancer by Mass Spectrometry-Based Proteomics

This study is the first step in determining the feasibility of using the liquid-based Pap test or a cervical swab for the detection of ovarian cancer protein biomarkers.

Exploring the Potential of Drug Response Assays for Precision Medicine in Ovarian Cancer

This review highlights several drug-response assays developed in ovarian cancer and discussed the current challenges and future prospects of these assays in the...

International Journal of Molecular Sciences
Calreticulin—Multifunctional Chaperone in Immunogenic Cell Death: Potential Significance as a Prognostic Biomarker in Ovarian Cancer Patients

This study reviews the physiological functions of CRT and its involvement in the immunogenic cell death appearance in malignant disease.

Mithramycin and Analogs for Overcoming Cisplatin Resistance in Ovarian Cancer

This article summarizes recent clinical developments related to mithramycin and postulates a role for the use of mithramycin, or its analog, in the treatment of platinum-resistant ovarian cancer.

Therapeutic Potential of Natural Products in Treatment of Cervical Cancer

In this study, anti-cancerous natural products against cervical cancer are collected using Pubmed and Google Scholar, published within three years.

CRNDE Contributes Cervical Cancer Progression by Regulating miR-4262/ZEB1 Axis

This study examines the functional role of CRNDE in cervical cancer, as it remains poorly explored.

The Prognostic Value of DNA Methylation, Post-Translational Modifications and Correlated with Immune Infiltrates in Gynecologic Cancers

This study depicts the prognostic landscape of gynecological cancers from the perspective of DNA methylation, alternative splicing and polyadenylation events...

Calculating the Dose of Cisplatin That is Actually Utilized in Hyperthermic Intraperitoneal Chemotherapy Among Ovarian Cancer Patients

Hyperthermic intraperitoneal chemotherapy is an important treatment for ovarian cancer. This study explores how much cisplatin is actually utilized and its prognostic influence.

Choline Kinase Alpha Impairment Overcomes TRAIL Resistance in Ovarian Cancer Cells

ChoKα/CHKA overexpression and hyper-activation sustain altered choline metabolism conferring the cholinic phenotype to epithelial ovarian cancer...

A Comparative Study of Methods for Determining Intravoxel Incoherent Motion Parameters in Cervix Cancer

This study compares different fitting methods for determining IVIM parameters and to determine whether the use of different fitting methods would affect...

Current Ovarian Cancer Maintenance Strategies and Promising New Developments

This review will focus on current frontline ovarian cancer treatment as well molecularly based approaches to ovarian cancer management.

Cervical Cancer: Epidemiology, Risk Factors and Screening

Although cervical cancer threatens female health, it could be the first cancer that would be eliminated by human beings with comprehensive preventive and control strategy.

Identification of Hub Genes as Potential Prognostic Biomarkers in Cervical Cancer Using Comprehensive Bioinformatics Analysis and Validation Studies

This study examines the microarray datasets using comprehensive bioinformatics tools and identified novel biomarkers associated with the prognosis of patients with cervical cancer.

Reflections on the Role of Malat1 in Gynecological Cancer

Malat1, as one of the most extensively studied ncRNAs, is believed to be not only a potential biomarker for disease diagnosis and prognosis, but also a candidate drug target for...

Carboplatin Sensitivity in Epithelial Ovarian Cancer Cell Lines: The Impact of Model Systems

Epithelial ovarian cancer is the most lethal gynecologic malignancy in North America, underscoring the need for the development of new therapeutic strategies for...

Early Clearance of Serum HE4 and CA125 in Predicting Platinum Sensitivity and Prognosis in Epithelial Ovarian Cancer

The objectives of this study are to assess the clinical value of early clearance of HE4 and CA125 for platinum sensitivity and prognosis in patients with ovarian cancer.

Microscopic Peritoneal Residual Disease after Complete Macroscopic Cytoreductive Surgery for Advanced High Grade Serous Ovarian Cancer

The aim of this study is to assess and quantify the prevalence of residual mPM after complete macroscopic CRS in patients with advanced high-grade serous ovarian cancer.

DACH1 Mutation Frequency in Endometrial Cancer is Associated With High Tumor Mutation Burden

This study utilizes the Oncology Research Information Exchange Network Avatar database to determine the frequency of DACH1 mutations in patients with endometrial cancer...

Inflammatory Proteins HMGA2 and PRTN3 as Drivers of Vulvar Squamous Cell Carcinoma Progression

This study aims to advance the understanding of vulvar squamous cell carcinoma biology by recognizing biological pathways that drive the progression of this disease.

Pegylated Liposomal Doxorubicin in Patients With Epithelial Ovarian Cancer

This study evaluates the efficacy and safety of PLD in treating of in patients who experience epithelial ovarian, fallopian tubal, and peritoneal cancer progression...

Advanced Cervical Cancer in Young Women: Imaging Study of Late and Very Late Radiation-Related Side Effects After Successful Treatment by Combined Radiotherapy

Radical combined radiotherapy is a standard treatment for advanced cervical cancer.

Lower dietary mineral intake is significantly associated with cervical cancer risk in a population-based cross-sectional study

Population-based studies investigating the association between dietary mineral intake and risk of cervical intraepithelial neoplasia or cervical cancer in Chinese women are few.

Roles and Mechanisms of the Long Noncoding RNAs in Cervical Cancer

This review summarizes the current literature regarding the knowledge known about the roles and mechanisms of the lncRNAs in cervical neoplasia.

International Journal of Molecular Sciences
New novel non-MHC genes were identified for cervical cancer with an integrative analysis approach of transcriptome-wide association study

Although genome-wide association studies have successfully identified multiple genetic variants associated with cervical cancer, the functional role of those variants is not well understood.

Screening for the prevention and early detection of cervical cancer: protocol for systematic reviews to inform Canadian recommendations

This study's purpose is to inform recommendations by the Canadian Task Force on Preventive Health Care on screening in primary care for the prevention and early detection of cervical cancer by...

Postoperative Adjuvant Chemotherapy Improved the Prognosis in Locally Advanced Cervical Cancer Patients With Optimal Response to Neoadjuvant Chemotherapy

Few studies investigated the effectiveness of adjuvant chemotherapy in patients with optimal response to neoadjuvant chemotherapy, and an optimal number of treatment...

Frontiers in Oncology
Association of Neoadjuvant Chemotherapy With Overall Survival in Women With Metastatic Endometrial Cancer

The objective of this study is to determine the use of and outcomes associated with NACT for women with stage IV endometrial cancer.

Challenges Posed by Embryonic and Anatomical Factors in Systematic Lymphadenectomy for Endometrial Cancer

The present review summarizes the current evidence on the role of lymph node surgery in endometrial cancer, focusing on the embryological, anatomical, and technical aspects.

Ovarian Cancer and Pregnancy—A Current Problem in Perinatal Medicine: A Comprehensive Review

The aim of this review is to bring ovarian cancer as a complication of pregnancy to the attention of doctors and other medical professionals who have to cope with these rare cases.

Matrix Drug Screen Identifies Synergistic Drug Combinations to Augment SMAC Mimetic Activity in Ovarian Cancer

Recurrent ovarian cancer is difficult to treat due to the development of chemotherapy resistance. This resistance develops through multiple mechanisms to include the avoidance...

Gynecologic Oncology Sub-Specialty Training in Ghana: A Model for Sustainable Impact on Gynecologic Cancer Care in Sub-Saharan Africa

 In Ghana, most women with gynecological malignancies present with advanced-stage disease when treatment is less effective.

Emerging Targets of Immunotherapy in Gynecologic Cancer

Immune targets can be divided into stimulating and inhibiting molecules according to their function after receptor–ligand binding.

Propensity score-matched analysis of systemic chemotherapy versus salvage hysterectomy for persistent cervical cancer after definitive radiotherapy/concurrent chemoradiotherapy

This study evaluated oncologic outcomes of patients who were treated with salvage HT, compared to systemic CT for persistent cervical cancer after definitive RT/ CCRT.

BMC Cancer
Association of the hOGG1 Ser326Cys polymorphism with gynecologic cancer susceptibility: a meta-analysis

Investigators performed a comprehensive meta-analysis to precisely estimate of the impact of the hOGG1 Ser326Cys polymorphism on gynecologic cancer susceptibility. 

Short- and long-term outcomes for single-port risk-reducing salpingo-oophorectomy with and without hysterectomy for women at risk for gynecologic cancer.

This study examines the outcomes after single-port risk-reducing salpingo-oophorectomy with or without hysterectomy for reduction of ovarian, breast, or endometrial cancer risk.

International Journal of Gynecological Cancer
Sources of palliative care knowledge among patients with advanced or metastatic gynecologic cancer.

The objective of this study was to identify sources used by patients with advanced or metastatic gynecologic cancer to learn about palliative care and...

Journal of Pain and Symptom Management
The caring experience and supportive care needs of male partners for women with gynecologic cancer: a qualitative literature review.

The objective of the study was to systematically review male partners' caring experience and supportive care needs when for women with gynecologic cancer.

Journal of Clinical Nursing
Hydronephrosis in Patients With Cervical Cancer is an Indicator of Poor Outcome

This study shows that cervical cancer with hydronephrosis may have a higher morbidity and mortality than cervical cancer without hydronephrosis.

An increase in multi-site practices: The shifting paradigm for gynecologic cancer care delivery.

The purpose of this study was to assess whether the number of practice sites per gynecologic oncologist and geographic access to GOs has changed over time.

Gynecologic Oncology
TWIST1 expression and clinical significance in type I endometrial cancer and premalignant lesions

The aim of this study was to assess the correlation of TWIST1 expression with clinical parameters and the prognosis of type I endometrial cancer.

Obesity in Gynecologic Oncology

Studies have provided solid evidence for an independent, linear, positive correlation between a pathologically increased body mass index and the probability of developing endometrial...

Integrin-Linked Kinase Is a Novel Therapeutic Target in Ovarian Cancer

The objective of this study is to identify and validate novel therapeutic target(s) in ovarian cancer.

Adapting and avoiding coping strategies for women with ovarian cancer during the COVID-19 pandemic

This study aim to assess coping strategies employed by women with ovarian cancer during the COVID-19 pandemic.

Evaluating the effect of a group pre-treatment chemotherapy psycho-education session for chemotherapy-naive gynecologic cancer patients and their caregivers.

The objective was to evaluate the effects of a pre-chemotherapy education class on chemotherapy-naïve patients diagnosed with gynecologic cancer and their informal caregivers.

Gynecologic Oncology
COVID-19 outcomes of patients with gynecologic cancer in New York City.

Characterization of COVID-19 infection in patients with gynecologic cancer is important for guiding decision making regarding critical care and anticancer treatment because the...

GOG 244 - The Lymphedema and Gynecologic cancer (LeG) study: The impact of lower-extremity lymphedema on quality of life, psychological adjustment, physical disability, and function.

This prospective cooperative group study demonstrated LLE symptoms were associated with poorer outcomes on PRO/QOL measures.

Gynecologic Oncology
Emergency department utilization by patients with gynecologic cancer in the United States.

The objective of this study was to differentiate how patients with gynecologic cancers use emergency care, and to assess the characteristics associated with potentially avoidable treat-and-release

International Journal of Gynecological Cancer
Predictors of Response to Immune Checkpoint Inhibition in a Real World Gynecologic Cancer Population

This retrospective study aimed to identify prognostic factors associated with improved overall response rate and progression free survival in gynecologic cancer patients receiving at least two cycl

Gynecologic oncology reports
Cancer awareness in the general population varies with sex, age and media coverage: A population-based survey with focus on gynecologic cancers

This study employed a research-purpose population-based citizen panel to assess how often people recall gynecologic cancers compared to other cancer types and to explore the relative importance...<

European Journal of Obstetrics &amp
Panorama of Gynecologic Cancer in Brazil

This article describes the incidence, morbidity, and mortality of women in Brazil affected with GC between the years of 2000 and 2017.

JCO Global Oncology
Patterns of social media use and associations with psychosocial outcomes among breast and gynecologic cancer survivors

We sought to characterize the use of social media (SM) among breast and gynecologic cancer survivors, as well associations between patterns SM psychosocial outcomes.

Journal of Cancer Survivorship
Can Fried Frailty Score predict postoperative morbidity and mortality in gynecologic cancer surgery? Results of a prospective study.

The aim of this study is to evaluate the predictive ability of Fried Frailty Score for surgical outcomes in patients undergoing gynecologic cancer surgery.

Journal of Geriatric Oncology
Using the Risk Assessment Index to predict mortality and quality of life in breast and gynecologic cancer patients.

To aid oncologists in identifying patients with highest risk for adverse outcomes, the study investigated the RAI, a validated tool used to assess frailty in patients prior to elective surgery.

Journal of Clinical Oncology
Role of vaginal brachytherapy boost following adjuvant external beam radiotherapy in cervical cancer: Turkish Society for Radiation Oncology Gynecologic Group Study (TROD 04-002).

The aim of this study was to assess the impact of the addition of vaginal brachytherapy boost to adjuvant external beam radiotherapy on oncological outcomes and toxicity in patients with...

International Journal of Gynecological Cancer
Undergoing active treatment for gynecologic cancer during COVID-19: A qualitative study of the impact on healthcare and social support.

This qualitative study captured the perspectives of women undergoing active treatment for gynecologic malignancy at an academic medical center.

Gynecologic oncology reports
Provision of smartphones in a symptom monitoring program of gynecologic and breast cancer patients during active therapy.

With advances in technology, smartphones are being used for multiple research and clinical care functions. However, not all patients have these devices, leading to disparities in participation.

Journal of Clinical Oncology
Characteristics of immediate hypersensitivity reaction to paclitaxel-based chemotherapy in gynecologic cancer patients.

This study's objective was to investigate the incidence, patterns, and risk factors for paclitaxel-related IHRs and management of IHRs in gynecologic malignancy patients.

Asian Pacific Journal of Allergy and Immunology
Increased ultrasonographic endometrial thickness is associated with poor survival in patients with endometrial cancer: An Israel gynecologic oncology group study.

The authors aimed to assess the association of pre-operatively evaluated ultrasonographic endometrial thickness with outcomes of patients with endometrial cancer.

Diet and gut microbiome interactions in gynecologic cancer.

This study explores the mechanisms by which alterations in the gut and reproductive tract microbiome contribute to carcinogenesis focusing on obesity, hyperestrogenism, inflammation and...

Gynecologic Oncology
Clinical implications of plasma circulating tumor DNA in gynecologic cancer patients.

This study describes the molecular landscape identified on ctDNA, ctDNA concordance with tissue‐based analysis, and factors associated with OS in gynecologic cancer patients with ctDNA analysis.

Molecular Oncology
Gynecologic cancer surveillance in the era of SARS-CoV-2 (COVID-19).

The SARS-CoV-2 (COVID-19) pandemic has significantly impacted the management of patients with gynecologic cancers.

International Journal of Gynecological Cancer
Prophylactic Gynecologic Surgery at Time of Colectomy Benefits Women with Lynch Syndrome and Colon Cancer: A Markov Cost-Effectiveness Analysis.

This study aimed to compare the cost, quality of life, and likelihood of being alive and free from colon, endometrial, and ovarian cancer between operative choices for patients with Lynch syndrome

Diseases of The Colon &amp
Oncology Drug Reference Sheet: Rucaparib
Oncology Nursing Society
Gynecologic Cancer Patients at No Greater Risk of Dying From COVID-19
Oncology Times - Latest Articles

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