Head And Neck Cancer

Head And Neck Cancer

Molecular Interplays Between Cell Invasion and Radioresistance That Lead to Poor Prognosis in Head-Neck Cancer

In this study, investigators hypothesize that HNC cells might exhibit a cross-phenotypic attribute between cell invasion and radioresistance.

Frontiers in Oncology
Predictive Value of Skeletal Muscle Mass in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma Patients Treated With Immune Checkpoint Inhibitors

Study investigators evaluate the impact of skeletal muscle index on prognosis and immune-related adverse events in a cohort of recurrent/metastatic HNSCC treated with ICIs.

Frontiers in Oncology
Systematic Analysis of Survival-Associated Alternative Splicing Signatures in Thyroid Carcinoma

Study investigators use TCGA to generate AS maps in patients with thyroid cancer.

Frontiers in Oncology

Patterns of Technology Use Among Patients With Head and Neck Cancer and Implications for Telehealth

The objective of this study is to describe baseline technology use within the head and neck cancer population prior to the COVID-19 pandemic.

OTO Open
Human Adipose-Derived Stem/Stromal Cells Promote Proliferation and Migration in Head and Neck Cancer Cells

Although clinical studies on the subject of oncological safety are still needed, these findings emphasize the importance of complete tumor removal before ASCs are used in the head and neck.

Saliva Test to Detect HPV-Associated Throat Cancer

A novel saliva test has been shown to detect HPV-associated oropharyngeal squamous cell carcinoma with high accuracy in a small study.

Fluorescein-Guided Panendoscopy for Head and Neck Cancer Using Handheld Probe-Based Confocal Laser Endomicroscopy

Confocal laser endomicroscopy has the potential for a rapid and histological assessment in the head and neck operating room.

Frontiers in Oncology
Further Understanding of the Immune Microenvironment in Head and Neck Squamous Cell Carcinoma: Implications for Prognosis

Investigators review the literature on the tumor microenvironment as a key player in tumor growth and anti-cancer treatment responses in head and neck cancer.

Cancer Management and Research
Portrait of DNA Methylated Genes Predictive of Poor Prognosis in Head and Neck Cancer and the Implication for Targeted Therapy

Investigators conduct a systematic review to assess whether DNA hypermethylated genes are predictive of high risk of developing HNC and/or impact on survival and outcomes in non-HPV/non-tobacco/non

Scientific Reports
Masticatory Muscle Index for Indicating Skeletal Muscle Mass in Patients With Head and Neck Cancer

Investigators examine whether masticatory SMI measurements based on head and neck CT scans can be used to conduct sarcopenia assessments by evaluating whether M-SMI is correlated with L3-SMI.

Pembrolizumab Plus Cetuximab in Recurrent or Metastatic Head and Neck Cancer

Dr Sacco and colleagues find the combination of pembrolizumab and cetuximab produces durable responses in patients with recurrent or metastatic HNSCC who had received no prior PD-1

The ASCO Post
Pembrolizumab Plus Cetuximab in Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

Given each drug's single agent activity and unique mechanism of action, this study aims to evaluate the anti-tumour activity of PD-1 blockade with EGFR inhibition in recurrent or metastatic HNSCC.<

The Lancet Oncology
Research Progress of circRNAs in Head and Neck Cancers

In this study, the generation, characteristics, and functions of circRNAs, along with their regulatory mechanisms in head and neck cancers are summarized.

Frontiers in Oncology
The Potential of MET Immunoreactivity for Prediction of Lymph Node Metastasis in Early Oral Tongue Squamous Cell Carcinoma

Since MET is a known orchestrator of invasive tumor growth, study investigators examine its association with LNM in early oral tongue squamous cell carcinoma.

Frontiers in Oncology
Neck Dissections Based on Sentinel Lymph Node Navigation Versus Elective Neck Dissections in Early Oral Cancers

This study aims to compare patients with early oral cavity squamous cell carcinoma treated with traditional elective neck dissection with those managed by sentinel lymph node biopsy using...

Journal of Clinical Oncology
Low-Dose Radiation Shows Promise for HPV-Related Throat Cancer

A radiation dose that is less than half of the standard treatment is a promising option for some patients with HPV-positive throat cancer, according to findings from a recent study.

Oncology Times - Latest Articles
Negative Results When Immunotherapy Was Added Onto Radiation

The early halt of a phase 3 trial of avelumab plus CRT for the treatment of squamous cell head and neck cancer raises a question: does combining a checkpoint inhibitor with RT hurt patients?

New Database of HPV-Negative Head & Neck Carcinomas Unveiled

New research clarifies the contributions of genes, proteins, and signaling pathways associated with HPV-negative head and neck squamous cell carcinomas.

Oncology Times - Latest Articles
Tipifarnib for Patients With Advanced HRAS-Mutant Head and Neck Cancer and High Variant Allele Frequency

In a phase II trial, Ho et al finds that tipifarnib produces a high response rate among patients with recurrent or metastatic HNSCC with HRAS mutations and high variant allele frequency.

The ASCO Post
Cetuximab, Docetaxel, and Cisplatin versus Platinum, Fluorouracil, and Cetuximab as First-Line Treatment in Patients With Recurrent or Metastatic Head and Neck Squamous-Cell Carcinoma

Results from a phase 2 trial of the TPEx chemotherapy regimen show promising results, with a median overall survival of 14·0 months in first-line recurrent or metastatic HNSCC.

The Lancet Oncology
Electrochemotherapy in the Treatment of Head and Neck Cancer: Current Conditions and Future Directions

This review describes current knowledge and data on the use of ECT in various forms of HNCs across different clinical settings, with attention to future clinical and research perspectives.

Single-Cell Deconvolution of Head and Neck Squamous Cell Carcinoma

This study finds that higher proportions of a class of immune cells (tumor-infiltrating regulatory T-cells) are associated with improved survival in head and neck cancer. 

The Role of Anti-EGFR Agents in the Era of Immunotherapy

This review focuses on the current role of anti-EGFR therapies in HNCs, underlying available clinical data and mechanisms of resistance, and highlight future perspectives regarding...

Therapeutic Advances in Medical Oncology
A Principal Component of Quality of Life Measures Is Associated with Survival for Head and Neck Cancer Patients Treated with Radiation Therapy

The relationship between post-treatment recovery of HRQOL and outcome in head and neck cancer is not well characterized. 

Immune-Related Mutational Landscape and Gene Signatures: Prognostic Value and Therapeutic Impact for Head and Neck Cancer

This review summarizes more recent efforts to elucidate immune-related mutational landscapes and gene expression signatures by integrative analysis of multi-omics data...

Effect of Acupuncture in Pain Management of Head and Neck Cancer Radiotherapy

This prospective randomized open-label trial evaluates the role of acupuncture in the treatment of pain related to curative and adjuvant (chemo)radiotherapy of head and neck cancer.

Journal of Clinical Medicine
Identification of Four Key Prognostic Genes and Three Potential Drugs in Human Papillomavirus Negative Head and Neck Squamous Cell Carcinoma

This study examines the identification of biomarkers for HPV-positive and HPV-negative HNSCCs.

Cancer Cell International
The Hidden Curve Behind COVID-19 Outbreak: The Impact of Delay in Treatment Initiation in Cancer Patients and How to Mitigate the Additional Risk of Dying—The Head and Neck Cancer Model

Study investigators analyze the impact on global cancer mortality considering the decline in oncology care during the COVID-19 outbreak using head and neck cancer as a model.

FGF19/FGFR4 Signaling Axis Confines and Switches the Role of Melatonin in Head and Neck Cancer Metastasis

As there is no consensus about the effective dosages of melatonin in cancer management, it is imperative to fully understand the dose-dependent responsiveness of cancer cells...

Perioperative Mortality of Head and Neck Cancers

Most clinical studies of head and neck cancers focus on the prognosis of patients with head and neck cancer, but perioperative mortality is rarely mentioned.

BMC Cancer
Precision Medicine Approaches to Overcome Resistance to Therapy in Head and Neck Cancers

This review outlines the mechanisms of resistance to the therapeutic strategies currently used in HNSCC, discusses combination treatment strategies to overcome them, and...

Frontiers in Oncology
Taking a Step Down on the Reconstruction Ladder for Head and Neck Reconstruction During the COVID-19 Pandemic

The objective of this study is to share the experience and approach towards head and neck reconstruction during the COVID-19 pandemic in Pakistan.

BMC Surgery
Aurora Kinases Shed Light on Resistance to EGFR Inhibition in Head and Neck Cancer

Joo-leng and colleagues examine acquired resistance to gefitinib, an EGFR-tyrosine kinase inhibitor in multiple EGFR wild-type HNSCC cell lines.


source list reference