Head And Neck Cancer

Head And Neck Cancer

Patient-Reported Outcomes and Complications During Head and Neck Cancer Radiotherapy Before versus During the COVID-19 Pandemic

Researchers compare PROs and complications during H&N radical radiotherapy for patients undergoing treatment to assess the rate of treatment-related complications.

Supportive Care in Cancer
COL5A1 Serves as a Biomarker of Tumor Progression and Poor Prognosis and May Be a Potential Therapeutic Target in Gliomas

Researchers investigated the expression levels of COL5A1 in gliomas with different grades or pathological types based on public data and clinical samples.

Frontiers in Oncology
Including Dental Professionals in the Multidisciplinary Treatment Team of Head and Neck Cancer Patients Improves Long-Term Oral Health Status

Researchers look at oral health status, dental care behaviours, and OHRQoL ≥ 6 months after cancer therapy in HNSCC patients...

Clinical Oral Investigations

AATF is Overexpressed in Human Head and Neck Squamous Cell Carcinoma and Regulates STAT3/Survivin Signaling

Researchers explore the expression pattern and biological roles of AATF in head and neck squamous cell carcinoma tissues and cell lines.

Disparities in Reported Testing for 1p/19q Codeletion in Oligodendroglioma and Oligoastrocytoma Patients

Researchers evaluate disparities in reported testing for 1p/19q codeletion among oligodendroglioma and oligoastrocytoma patients before and after the guidelines.

Frontiers in Oncology
Quality of Life and Health-Related Utility After Trans-Oral Surgery for Head and Neck Cancers

Researchers assess utility coefficients of health states following trans-oral robotic surgery and trans-oral laser microsurgery for head and neck cancer. 

Health and Quality of Life Outcomes
Health-Related Quality of Life With Pembrolizumab vs Chemotherapy for Advanced Esophageal Cancer

Health-related QoL was maintained with both pembrolizumab and chemotherapy in a phase III trial including patients with advanced esophageal cancer who underwent previous treatment.

The ASCO Post
An Alternative Immunotherapy Combination in Head & Neck Cancers

An immunotherapy combination could be better than standard extreme chemotherapy as first-line treatment for some patients with head and neck cancer, according to a major Phase III trial.

Oncology Times - Latest Articles
Primary Transoral Surgery and Reduced-Dose Adjuvant Radiation Therapy for HPV-Positive Locally Advanced Oropharyngeal Cancer

The ECOG-ACRIN E3311 trial has shown high progression-free survival rates and good functional outcomes in patients with intermediate-risk HPV, p16-positive locally advanced oropharyngeal cancer..

The ASCO Post
Prognostic Impact of Sarcopenia in Patients With Head and Neck Cancer Treated With Surgery or Radiation

Scientists compare the prognostic impact of sarcopenia in patients with head and neck cancer treated with surgery or radiation.

Cost-Utility of Two Minimally-Invasive Surgical Techniques for Operable Oropharyngeal Cancer: Transoral Robotic Surgery versus Transoral Laser Microsurgery

A comparative analysis of two minimally-invasive techniques is warranted for which researchers used a decision-analytic model for comparing TORS and TLM from the cost-utility point of view.

BMC Health Services Research
Extraoral Photobiomodulation for Prevention of Oral and Oropharyngeal Mucositis in Head and Neck Cancer Patients

A randomized, double-blind clinical trial aimed to evaluate the effect of extraoral PBM prophylactic delivery on OM, OM-related pain, QoL, and cancer safety outcomes in OOPSCC patients during RT.

Supportive Care in Cancer
BCAR3 Promotes Head and Neck Cancer Growth and is Associated With Poor Prognosis

BCAR3-related mRNAs were analyzed with GO and KEGG analyses, to show that BCAR3 is likely associated with many important biological functions, such as focal adhesion and actin regulation.

Cell Death Discovery
Spatial Heterogeneity of Immune Infiltration Predicts the Prognosis of Nasopharyngeal Carcinoma Patients

Scientists conduct the first study highlighting the important role of lymphocytes in predicting the prognosis of NPC patients from the perspective of spatial distribution.

New Approach of Prediction of Recurrence in Thyroid Cancer Patients Using Machine Learning

To combat the clinical difficulty of predicting disease recurrence and prognosis in patients undergoing thyroidectomy, researchers explore the use of inductive logic programming as a new algorithm.

SOD2 Enhancement by Long-Term Inhibition of the PI3K Pathway Confers Multi-Drug Resistance and Enhanced Tumor-Initiating Features in Head and Neck Cancer

Researchers developed PII3K inhibitor resistant cancer cells by prolonged culturing of cell lines with BEZ235, a dual PI3K and mTOR inhibitor.

International Journal of Molecular Sciences
Predicting Treatment Response in Head & Neck Squamous Cell Carcinoma

A novel test performed in the form of a liquid biopsy that looks for DNA shed by cancer cells in the individual's bloodstream for predicting treatment response has been developed by scientists. 

Oncology Times - Latest Articles
Identification of Immune Subtypes for Predicting the Prognosis of Patients in Head and Neck Squamous Cell Carcinoma

A series of bioinformatic approaches were used to identify HNSCC immune subtypes and investigate their underlying immune characteristics that detects potentially targetable ICB subtypes. 

Technology in Cancer Research & Treatment
Knowledge-Based Planning for Robustly Optimized Intensity-Modulated Proton Therapy of Head and Neck Cancer Patients

Doctors assess the performance of a proton-specific KBP model in the creation of robustly optimized IMPT plans for treatment of advanced head and neck cancer patients.

Frontiers in Oncology
A New Prognostic Score for Predicting Survival in Patients Treated With Robotic Stereotactic Radiotherapy for Brain Metastases

Independent pretreatment factors associated with overall survival are identified to create an easy-to-use prognostic score for patients with brain metastases irrespective of primary tumor location.

Scientific Reports
Detection of Inaccessible Head and Neck Lesions Using Human Saliva and Fluorescence Spectroscopy

Scientists use fluorescence spectroscopy from human saliva to help bridge gaps in head and neck cancer detection. 

Lasers in Medical Science
Swallowing, Nutritional Status, and Salivary Flow in Patients After Head and Neck Cancer Treatment

This study confirms the relationship between swallowing & nutritional status and how appropriate protein intake influences muscle activity during swallowing in head & neck cancer survivors.

Scientific Reports
Prognostic Utility of Pretreatment Neutrophil-Lymphocyte Ratio in Advanced Larynx Cancer

Scientists identify an optimal NLR cutoff point and examine the prognostic utility of this biomarker in patients with locoregionally advanced larynx cancer treated with curative intent.

Biomarker Insights
Influence of Modulation Factor on Treatment Plan Quality and Irradiation Time in Hippocampus-Sparing Whole-Brain Radiotherapy Using Tomotherapy

This research investigates if changing the MF in HS-WBRT, its possible to shorten the irradiation time while maintaining the quality of the radiotherapy plan.

Technology in Cancer Research & Treatment
Immunotherapy Combination Could Be Alternative to 'Extreme' Chemotherapy in Some Head and Neck Cancers

Nivolumab and Ipilimumab helped some patients with advanced head & neck cancer live longer, compared to standard treatment consisting of an aggressive cocktail of two chemotherapy drugs...

Medical Xpress
Effect of Programmed Death-Ligand 1 in Cancer-Associated Fibroblasts on Advanced Laryngeal Squamous Cell Carcinoma

Researchers explore the effect of programmed death-ligand 1 (PD-L1) in cancer-associated fibroblasts (CAFs) on advanced laryngeal squamous cell carcinoma (LSCC).

Technology in Cancer Research & Treatment
miR-17-5p Drives G2/M-Phase Accumulation by Directly Targeting CCNG2 and is Related to Recurrence of Head and Neck Squamous Cell Carcinoma

This study aims to clarify the role of miR-17-5p in the cell cycle process of HNSCC and the correlation with clinical characteristics of patients with HNSCC...

BMC Cancer
Short-Term Response Might Influence the Treatment-Related Benefit of Adjuvant Chemotherapy After Concurrent Chemoradiotherapy for Esophageal Squamous Cell Carcinoma Patients

Scientists decide to investigate the potential benefit of AC after CCRT for ESCC and to identify biomarkers predictive of a clinical benefit.

Radiation Oncology
Prognostic Association of Starvation-Induced Gene Expression in Head and Neck Cancer

Researchers placed HNSCC cells under serum-free conditions to induce growth retardation and autophagy, subjecting them to transcriptome analysis to investigate the dynamics of expression of genes

Scientific Reports
Analysis of T cell Receptor Clonotypes in Tumor Microenvironment Identifies Shared Cancer-Type-Specific Signatures

Scientists sought to determine the extent of shared TCR clonotypes in the intra-tumor microenvironment of two different head and neck cancer types: EBV-linked NPC and non-virally linked HNSCC.

Cancer Immunology, Immunotherapy
Nuclear HER3 Expression Improves the Prognostic Stratification of Patients With HER1 Positive Advanced Laryngeal Squamous Cell Carcinoma

Scientists conducted this retrospective observational study on two series of locoregionally advanced LSCC patients treated with BioRT with cetuximab and salvage or upfront surgery...

Journal of Translational Medicine
Low Expression of CIP4 in Predicting Worse Overall Survival: A Potential Biomarker for Laryngeal Cancer

Scientists examine the TCGA profile geared towards evaluating the potential prognostic value and clinical correlation of CIP4 expression in LC. 

DIAPH1 Promotes Laryngeal Squamous Cell Carcinoma Progression Through Cell Cycle Regulation

Researchers suggest that DIAPH1 influences the expression of genes in several signaling pathways and promotes LSCC progression by regulating the cell cycle.

Frontiers in Oncology

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