Hematologic Malignancies

Hematologic Malignancies

COVID-19 Vaccine Failure in Patients With Blood Cancers

COVID vaccines do not work well for patients with hematologic malignancies, new data suggest.

Brentuximab Vedotin Plus Chemotherapy in Newly Diagnosed Early-Stage Unfavorable-Risk Hodgkin Lymphoma

Kumar et al find that the combination of brentuximab vedotin with AVD is highly active in patients with newly diagnosed, early-stage, unfavorable-risk Hodgkin lymphoma and may permit the reduction.

The ASCO Post
Study Finds Tranexamic Acid Unable to Prevent Bleeding in Patients With Hematologic Malignancies

In the first trial to evaluate prophylactic antifibrinolytic therapy in patients with hematologic malignancies, tranexamic acid failed to reduce bleeding or the need for transfusion vs placebo. 

The ASCO Post

Rivaroxaban May Be Clinically Superior to LMWH in Patients With Cancer-Associated Thrombosis

Among patients with cancer-associated thrombosis, rivaroxaban may be superior to low-molecular-weight heparin for reducing all-cause mortality, although additional study is necessary...

Cancer Therapy Advisor
Small Study Explores CAR T-Cell Therapy for Relapsed or Refractory B-Cell Lymphoma

Bispecific anti-CD19/CD20 CAR T-cell therapy was well tolerated and showed signs of clinical efficacy in patients with relapsed/refractory B-cell lymphoma, according to phase I clinical trial data.

The ASCO Post
Burkitt Lymphoma: An International Prognostic Index

A global collaborative effort has led to the development and validation of a novel prognostic index specific for Burkitt lymphoma to aid risk stratification, interpretation of clinical trials...

Oncology Times - Latest Articles
Lymphoma Patients at Higher Risk of Death When Diagnosed With COVID-19

According to a retrospective study, lymphoma patients admitted to the hospital with severe COVID-19 and treated with B-cell depleting immunotherapy within the previous 12 months have nearly twice..

Oncology Times - Latest Articles
New ASH Guidelines: VTE Prevention and Treatment in Cancer Patients

New ASH guidelines "strongly recommend" using no thromboprophylaxis over using parenteral thromboprophylaxis in ambulatory patients receiving cancer CT who have low VTE risk.

Favorable Trisomies and ETV6-RUNX1 Predict Cure in Low-Risk B-Cell Acute Lymphoblastic Leukemia: Results From Children's Oncology Group Trial AALL0331

COG AALL0331 tests whether pegaspargase intensification on a low-intensity chemotherapy backbone would improve the CCR rate in a low-risk subset of children with standard-risk B-ALL.

Journal of Clinical Oncology
Cancer Survivorship in Hematologic Malignancies: Lifestyle Changes After Diagnosis

There is a paucity of data regarding changes made after a diagnosis of a hematologic malignancy.

Cancer medicine journal
Research Minute: The Latest Hematology/Oncology Research

This article takes a deeper look into the most recent developments in CML research and treatment. 

Oncology Times - Latest Articles
DNA Methylation and Cancer Incidence: Lymphatic–Hematopoietic versus Solid Cancers in the Strong Heart Study

This study evaluates the association of blood DNA methylation with lymphatic–hematopoietic cancers and, for comparison, with solid cancers.

Clinical Epigenetics
Management of Patients With Multiple Myeloma Beyond the Clinical-Trial Setting: Understanding the Balance Between Efficacy, Safety and Tolerability, and Quality of Life

This review assesses the current instruments, methodologies, and recent initiatives for analyzing the MM patient experience.

Blood Cancer Journal
Precision Medicine in Hematology 2021: Definitions, Tools, Perspectives, and Open Questions

Although the emerging roles of precision medicine and personalized medicine in hematology and oncology are clearly visible, several questions remain.

Assessment and Management of Cardiotoxicity in Hematologic Malignancies

The most studied drugs associated with cardiotoxicity are anthracyclines, but many new agents have demonstrated unexpected cardiotoxic effect, including those currently used in MM treatment...

Disease Markers
CD8 T Cells Compensate for Impaired Humoral Immunity in COVID-19 Patients With Hematologic Cancer

These observations have important implications for cancer and COVID-19-directed treatments, immunosuppressive therapies, and for understanding the role of B and T cells in acute COVID-19.

Hematopoietic Stem Cell Niche During Homeostasis, Malignancy, and Bone Marrow Transplantation

This study discusses how different components of the bone marrow niche, particularly non-hematopoietic and hematopoietic cells, regulate normal hematopoiesis, and...

Kinase Inhibitors Developed for Treatment of Hematologic Malignancies: Implications for Immune Modulation in COVID-19

Based on in vitro and clinical observations, this study deciphers the impact of the main TKIs approved or in late-stage development for the treatment of hematological malignancies, including...

Blood Advances
Degradation of BRD4—A Promising Treatment Approach Not Only for Hematologic But Also for Solid Cancer

Bromodomain and extra-terminal proteins are epigenetic readers that regulate gene expression and promote cancer evolution. 

Gut Microbiota Influence in Hematological Malignancies: From Genesis to Cure

This review summarizes the current knowledge of the role of the microbiota in modulating the immune system, its role in hematological malignancies, and its influence on different therapies...

International Journal of Molecular Sciences
Reinfection Versus Failure of Viral Clearance in a COVID-19 Patient with Hematologic Malignancy

There continues to be uncertainty whether contracting COVID-19 can impart immunity against reinfection, and, if so, how long the immunity lasts.

Immune Therapies for Hematologic Malignancies

The era of immunotherapy for hematologic malignancies began with the first allogeneic hematopoietic stem cell transplant study published by E. Donnall Thomas in 1957.

Hematopoietic versus Solid Cancers and T Cell Dysfunction: Looking for Similarities and Distinctions

This study aims to map areas of similarities and differences in solid versus hematopoietic malignancies, providing a high-level rather than a detailed perspective on T cell dysfunction in those tum

Treatment of Acute Leukemia During COVID-19

The risk of severe COVID-19 and mortality is markedly raised in patients with cancer, prompting several collaborative groups to issue guidelines to mitigate the risk of infection...

Clinical Significance of Occult Central Nervous System Disease in Adult Acute Lymphoblastic Leukemia

This study retrospectively evaluates the incidence of occult CNS disease and its impact on outcome in 240 adult patients with newly diagnosed ALL.

Alignment-Free Method for Functional Annotation of Amino Acid Substitutions: Application on Epigenetic Factors Involved in Hematologic Malignancies

Genes coding for epigenetic regulators have important roles in cancer pathogenesis and mutations in these genes show great potential as clinical biomarkers, especially in HMs.

Weathering the Storm: COVID-19 Infection in Patients with Hematological Malignancies

Owing to their immunosuppressive status, patients with hematological malignancies are at an increased risk of infection and have a worse prognosis than patients without HMs.

Mitochondrial Bioenergetics at the Onset of Drug Resistance in Hematological Malignancies

In hematological malignancies, there is a strong relationship between cellular metabolism, mitochondrial bioenergetics, interconnections with supportive microenvironment and drug resistance.

Frontiers in Oncology
Analysis of Risk Factors and Clinical Indicators in Bloodstream Infections Among Patients with Hematological Malignancy

The present study is aimed to describe the epidemiology, clinical indexes, and antibiotic use for in-hospital bloodstream infections of hematological malignancy patients.

Hematopoeitic Cell Transplantation and CAR T-Cell Therapy: Complements or Competitors?

The advent of both technologies revolutionized treatment of many hematologic malignancies, both offering the chance at sustained remissions for patients who would otherwise...

Frontiers in Oncology
Targeting Chromatin Complexes in Myeloid Malignancies and Beyond: From Basic Mechanisms to Clinical Innovation

This review summarizes some of the current concepts on the role epigenetic modifiers in malignant chromatin states with a specific focus on myeloid malignancies and...

Decisional involvement and information preferences of patients with hematologic malignancies

This study described and examined factors associated with preferences of patients with hematologic malignancies for decisional involvement, information sources, and presentation of information.

Blood Advances
Radioprotective Agents and Enhancers Factors. Preventive and Therapeutic Strategies for Oxidative Induced Radiotherapy Damages in Hematological Malignancies

The purpose of this review was to examine the data in the literature on the possible use of old and new substances to increase the efficacy of radiation treatment in hematological diseases...

CD123 as a Biomarker in Hematolymphoid Malignancies: Principles of Detection and Targeted Therapies

This review provides an overview of CD123 biology and in-depth discussion of clinical laboratory techniques used to determine CD123 expression in various hematolymphoid neoplasms.

Immunotherapy in Hematologic Malignancies: Emerging Therapies and Novel Approaches

In this review, immunotherapies for each type of hematologic malignancy will be introduced, and novel targets that are under investigation will be described.

International Journal of Molecular Sciences
Heterozygous germ line CSF3R variants as risk alleles for development of hematologic malignancies

Heterozygous pathogenic germ line CSF3R variants increase risk for developing both myeloid and lymphoid malignancies.

Blood Advances
Evaluation of the Relationship of Glasdegib Exposure and Safety End Points in Patients With Refractory Solid Tumors and Hematologic Malignancies.

The relationship between glasdegib exposure and adverse event cluster terms of clinical concern was explored in this analysis.

The Journal of Clinical Pharmacology
Haploidentical stem cell transplantation vs matched unrelated donor transplantation in adults with hematologic malignancies: a systematic review and meta-analysis.

Haploidentical hematopoietic stem cell transplantation and matched unrelated donor transplantation are two important options when a matched sibling donor is unavailable.

Total Hip Arthroplasty in Adolescents and Young Adults for Management of Advanced Corticosteroid-Induced Osteonecrosis Secondary to Treatment for Hematologic Malignancies

This study examined clinical outcomes of THA in adolescents and young adults treated for hematologic malignancies who developed advanced ONFH.

Journal of Arthroplasty
Discovery of CA-4948, an Orally Bioavailable IRAK4 Inhibitor for Treatment of Hematologic Malignancies

Small molecule potent IRAK4 inhibitors from a novel bicyclic heterocycle class were designed and synthesized based on hits identified Aurigene’s compound library.

ACS Medicinal Chemistry Letters
Revisiting Early Palliative Care for Patients With Hematologic Malignancies and Bone Marrow Transplant: Why the Delay?

The aim of this literature review is to analyze and discuss the possible barriers to care and delayed referrals for hematologic malignancies and bone marrow transplant patients.

Primary Palliative Care for Patients with Advanced Hematologic Malignancies: A Pilot Trial of the SHARE Intervention.

The objective of this study was to develop and pilot-test a nurse-led primary palliative care intervention for patients with advanced hematologic malignancies.

Journal of Palliative Medicine
Revisiting the treatment of anemia in the setting of chronic kidney disease, hematologic malignancies and cancer: perspectives with opinion and commentary.

A review of anemia in the context of chronic kidney disease, hematologic malignancies and cancer is presented with focus on the establishment of ESAs as integral in the treatment of anemia.

Expert Review of Hematology
Impact of a Clostridioides difficile testing computerized clinical decision support on an adult stem cell transplant and hematologic malignancies unit.

Clostridioides difficile infection rates in hospitalized hematopoietic stem cell transplant (HSCT) and hematologic malignancy (HM) patients are higher than the general population.

Biology of Blood and Marrow Transplantation
Multiple myeloma (MM) therapy within a Medicare-insured patient population: Role of care setting and oncologist sub-specialization in hematologic malignancies.

Dramatic increases in oncology practice consolidation with hospitals may affect care setting and whether patients see oncologists that specialize in their cancer, with downstream effects on...

Journal of Clinical Oncology
Acute Respiratory Failure Outcomes in Patients with Hematologic Malignancies and Hematopoietic Cell Transplant: A Secondary Analysis of the EFRAIM Study

Patients with allogeneic HCT who develop acute respiratory failure are perceived to have worse outcomes than autologous HCT and non-transplant patients with hematologic malignancy.

Biology of Blood and Marrow Transplantation
Effects of treatments on gonadal function in long-term survivors of pediatric hematologic malignancies: A cohort study.

This study aims to evaluate the prevalence of gonadal dysfunction and the most important associated risk factors in a cohort of hematologic malignancy survivors.

Pediatric Blood &amp
Strong association between herpes simplex virus-1 and chemotherapy-induced oral mucositis in patients with hematologic malignancies.

A link between oral cavity infections and CIOM in patients with hematological malignancies undergoing intensive chemotherapy or hematopoietic stem cell transplantation has been suggested.

The Korean Journal of Internal Medicine
Hematologic malignancies of the gastrointestinal luminal tract.

Hematologic malignancies include several lymphoproliferative and myeloproliferative disorders, many of which are frequently encountered in current health care settings.

Abdominal Radiology
Sex representation in clinical trials associated with FDA cancer drug approvals differs between solid and hematologic malignancies.

This study aimed to assess the...

Impact of a Clostridioides difficile testing computerized clinical decision support on an adult stem cell transplant and hematologic malignancies unit.

Clostridioides difficile infection rates in hospitalized HSCT and HM patients are higher than in the general population.

Biology of Blood and Marrow Transplantation
Germ cell tumors and associated hematologic malignancies evolve from a common shared precursor.

GCTs are the most common cancer in men between the ages of 15-40. While most patients are cured, those with disease arising in the mediastinum have distinctly poor outcomes.

Journal of Clinical Investigation
Hematologic malignancies of the gastrointestinal luminal tract.

Hematologic malignancies include several lymphoproliferative and myeloproliferative disorders, many of which are frequently encountered in current health care settings.

Abdominal Radiology

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