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Researchers Look at Access to Essential Cancer Drugs on a Global Scale

A recent study in The Lancet Oncology looked at whether the cancer therapeutics in the Essential Medicines List were aligned with the needs of oncologists worldwide.

The ASCO Post
11/25/2021
Stereotactic Ablative Radiotherapy Shows Long-Term Benefit in Operable Early NSCLC

Stereotactic ablative radiotherapy appeared as effective as surgery among patients with operable early-stage non-small cell lung cancer, according to new study results.

Healio
11/23/2021

Head And Neck Cancer

Including Dental Professionals in the Multidisciplinary Treatment Team of Head and Neck Cancer Patients Improves Long-Term Oral Health Status

Researchers look at oral health status, dental care behaviours, and OHRQoL ≥ 6 months after cancer therapy in HNSCC patients...

Clinical Oral Investigations
11/18/2021
Patient-Reported Outcomes and Complications During Head and Neck Cancer Radiotherapy Before versus During the COVID-19 Pandemic

Researchers compare PROs and complications during H&N radical radiotherapy for patients undergoing treatment to assess the rate of treatment-related complications.

Supportive Care in Cancer
11/26/2021
COL5A1 Serves as a Biomarker of Tumor Progression and Poor Prognosis and May Be a Potential Therapeutic Target in Gliomas

Researchers investigated the expression levels of COL5A1 in gliomas with different grades or pathological types based on public data and clinical samples.

Frontiers in Oncology
11/16/2021
Disparities in Reported Testing for 1p/19q Codeletion in Oligodendroglioma and Oligoastrocytoma Patients

Researchers evaluate disparities in reported testing for 1p/19q codeletion among oligodendroglioma and oligoastrocytoma patients before and after the guidelines.

Frontiers in Oncology
11/09/2021
AATF is Overexpressed in Human Head and Neck Squamous Cell Carcinoma and Regulates STAT3/Survivin Signaling

Researchers explore the expression pattern and biological roles of AATF in head and neck squamous cell carcinoma tissues and cell lines.

Dovepress
11/09/2021
Quality of Life and Health-Related Utility After Trans-Oral Surgery for Head and Neck Cancers

Researchers assess utility coefficients of health states following trans-oral robotic surgery and trans-oral laser microsurgery for head and neck cancer. 

Health and Quality of Life Outcomes
11/03/2021

FDA Approvals

FDA Approves Keytruda for Adjuvant Treatment of Renal Cell Carcinoma

The FDA expanded the approval of pembrolizumab to include adjuvant treatment of certain patients with renal cell carcinoma.

Healio
11/18/2021
FDA Grants Orphan Drug Designation to DF1001 for Esophageal Cancer

The FDA granted orphan drug designation to DF1001, a HER2-targeted natural killer cell engager therapy, for treatment of esophageal cancer.

Healio
11/21/2021
FDA Grants Fast Track Designation to Arfolitixorin for Metastatic Colorectal Cancer

The FDA granted fast track designation to arfolitixorin, a stabilized and biologically active pure form of folate, for treatment of patients with metastatic colorectal cancer. 

Healio
11/29/2021
FDA Approves Pafolacianine to Identify Ovarian Cancer Lesions During Surgery

Imaging drug pafolacianine, a targeted fluorescent imaging agent that that illuminates ovarian cancer intraoperatively, has been approved to help surgeons identify ovarian cancer lesions easier. 

Healio
11/30/2021
FDA Approves Sirolimus Protein-Bound Particles for Malignant Perivascular Epithelioid Cell Tumor​

The FDA approved sirolimus protein-bound particles for injectable suspension for adult patients with locally advanced unresectable or metastatic malignant perivascular epithelioid cell tumor. 

Oncology Times - Latest Articles
11/23/2021

Oncology

The use of Hericium erinaceus and Trametes versicolor extracts in supportive treatment in oncology.

Substances available in nature with potential therapeutic effects are the subject of research that raises tremendous hopes for new challenges medicine.

Acta Pharmaceutica
03/01/2021
Selecting Image-Guided Surgical Technologies in Oncology: A Surgeon's Perspective.

This study aimed to select the most promising IG technology per oncologic indication.

Journal of Surgical Research
01/01/2021
Development and Optimization of Clinical Informatics Infrastructure to Support Bioinformatics at an Oncology Center.

Translational bioinformatics for therapeutic discovery requires the infrastructure of clinical informatics.

Methods of Molecular Biology
01/01/2021
Pharmacogenomics in Pediatric Oncology: Mitigating Adverse Drug Reactions While Preserving Efficacy

Major developments in drugs such as thiopurines and optimization in clinical trial protocols for treating cancer in children have led to a remarkable improvement in survival, from approximately...<

Annual Review of Pharmacology and Toxicology
01/06/2021
Review of Oncology and Transplant Literature for the Management of Hepatic and Pancreatic Resections in Jehovah's Witnesses.

Jehovah's Witnesses undergoing liver or pancreas surgery represent a unique medical and ethical challenge.

Cancer medicine journal
04/01/2021

Lung Cancer

Cold and Heterogeneous T Cell Repertoire is Associated With Copy Number Aberrations and Loss of Immune Genes in Small-Cell Lung Cancer

Researchers depict the immunogenomic ITH architecture of SCLC and compare these LS-SCLCs with localized NSCLCs to assess the impact of immunogenomic attributes on patient survival.

Nature Communications
11/17/2021
m6A Regulator Expression Profile Predicts the Prognosis, Benefit of Adjuvant Chemotherapy, and Response to Anti-PD-1 Immunotherapy in Patients With Small-Cell Lung Cancer

This research works to advance the ability to create individualized therapy regimens and guide SCLC prognostication.

BMC Medicine
11/22/2021
Real-World Effectiveness of Second-Line Afatinib versus Chemotherapy for the Treatment of Advanced Lung Squamous Cell Carcinoma in Immunotherapy-Naïve Patients

The efficacy of second-line afatinib versus chemotherapy in patients with advanced lung SCC who progressed after first-line chemotherapy was investigated in this study. 

BMC Cancer
11/15/2021
Cost-Effectiveness Analysis of Pembrolizumab plus Chemotherapy as First-Line Therapy for Extensive-Stage Small-Cell Lung Cancer

This study aims to assess the cost-effectiveness of adding pembrolizumab to standard first-line etoposide-platinum for patients with ES-SCLC from the US payer perspective.

PLOS ONE
11/15/2021
2021 State of Lung Cancer Report Finds Survival Has Increased but Remains Significantly Lower for People of Color

The new State of Lung Cancer report reveals that the 5-year survival rate for lung cancer increased from 14.5% nationally to 23.7%, yet remains significantly lower among communities of color.

The ASCO Post
11/19/2021

Immuno Oncology

Comprehensive Transcriptomic Analysis Reveals the Role of the Immune Checkpoint HLA-G Molecule in Cancers

The aim of this study is to systematically identify the roles of checkpoint HLA-G molecules across various types of cancer.

Frontiers in Immunology
07/01/2021
Cardiovascular Risks Associated With Checkpoint Inhibitors and CAR T-Cell Therapy

Leveraging the immune system to treat cancer, however, also increases the potential for serious off-target effects.

The ASCO Post
04/10/2021
Role of Immunotherapy in Localized Muscle Invasive Urothelial Cancer

Study investigators report results from clinical trials using single agent ICI, ICI/ICI and ICI/chemo combination therapies in the neoadjuvant setting for non-metastatic MIBC. 

Therapeutic Advances in Medical Oncology
09/22/2021
Immunotherapy Combination Confers Durable Benefit in Advanced Renal Cell Carcinoma

First-line nivolumab plus ipilimumab conferred greater long-term clinical benefit than sunitinib for patients with advanced renal cell carcinoma, according to new study results. 

Healio
11/16/2021
Response Endpoints Deemed ‘Poor Surrogates’ for Overall Survival in Trials of Immune Checkpoint Inhibitors

Tumor response endpoints are “poor surrogate endpoints” for OS in trials of immune checkpoint inhibitors, according to research published in JCO Precision Oncology.

Cancer Therapy Advisor
08/05/2021
SSTP1, a Host Defense Peptide, Exploits the Immunomodulatory IL6 Pathway to Induce Apoptosis in Cancer Cells

Researchers suggests that identification of the membrane targets for the promising anticancer HDPs might lead to the identification of new drugs for targeted therapy.

Frontiers in Immunology
11/19/2021

Gastrointestinal Cancer

Ripretinib Trial Misses Primary Endpoint for Patients With Gastrointestinal Stromal Tumor

Ripretinib failed to prolong PFS compared with sunitinib among patients with GIST who received prior treatment with imatinib, according to results of the phase 3 INTRIGUE study...

Healio
11/05/2021
Effect of KLF17 Overexpression on Epithelial–Mesenchymal Transition of Gastric Cancer Cells

This study investigated KLF17 expression in normal and gastric cancer tissues and cell lines.

Journal of International Medical Research
11/05/2021
Impact of COVID-19 Pandemic on Gastrointestinal Cancer Diagnosis and Resection

This study works to determine the demographic, histopathologic and clinical characteristics of cancer patients most impacted by COVID-19.

ScienceDirect
11/23/2021
The Long-Term Survival Outcomes of Gastric Cancer Patients With Total Intravenous Anesthesia or Inhalation Anesthesia

This study compares outcomes of gastric cancer patients after surgery with TIVA or IHA to explore the relationship between anesthesia and survival outcomes in those patients. 

BMC Cancer
11/10/2021
Multiscale Heterogeneity in Gastric Adenocarcinoma Evolution is an Obstacle to Precision Medicine

Using multiregional whole-exome sequencing, scientists investigate the effect of somatic evolution on intratumoral heterogeneity to shed light on the evolutionary biology of GC.

Genome Medicine
11/08/2021

Skin Cancer

Treatment Sequence Impacts Survival in BRAF-Mutant Metastatic Melanoma

Treatment sequence can impact survival in patients with BRAF V600-mutant metastatic melanoma, according to results from the phase 3 DREAMseq trial.

Cancer Therapy Advisor
11/18/2021
‘Better Biomarkers are Needed’ as Treatment Options for Advanced Melanoma Increase

Approvals of BRAF-targeted therapies and immune checkpoint inhibitors have greatly expanded the melanoma treatment landscape during the past decade. 

Healio
11/15/2021
Immunotherapy Before Targeted Therapy Extends OS in Metastatic Melanoma

Patients with BRAF V600 mutation-positive metastatic melanoma who received an immune checkpoint inhibitor combination followed by targeted therapy survived longer...

Healio
11/16/2021
Prognosis for Cutaneous Melanoma by Clinical and Pathological Profile

Demographic and clinical-pathological variables are analyzed to measure their impact on patient survival in this cohort of CMM patients.

Frontiers in Oncology
11/16/2021
Achieving Integrated Self-Directed Cancer Aftercare for Melanoma

To support survivors, the ASICA intervention was developed to prompt and improve TSSE performance, with subsequent reporting of concerns and submission of skin photos to a DNP.

BMC Cancer
11/13/2021

Gynecologic Cancer

Identification of Hub Genes Correlated With Poor Prognosis for Patients With Uterine Corpus Endometrial Carcinoma by Integrated Bioinformatics Analysis and Experimental Validation

The present study aimed to identify potential key molecules with prognostic significance by bioinformatic methods and to improve our understanding of the genetic landscape of UCEC. 

Frontiers in Oncology
11/19/2021
Hexokinases 2 Promoted Cell Motility and Distant Metastasis by Elevating Fibronectin Through Akt1/p-Akt1 in Cervical Cancer Cells

Researchers find exogenous expression of HK2 activated Akt1 in cervical cancer cells, subsequently enhances cell motility and tumor metastasis...

Cancer Cell International
11/10/2021
Insulin Resistance and Metabolic Syndrome Increase the Risk of Relapse For Fertility Preserving Treatment in Atypical Endometrial Hyperplasia and Early Endometrial Cancer Patients

Researchers conducted a retrospective study to investigate the relationship between metabolic features and recurrent events of preservative therapy for AEH and early EC patients.

Frontiers in Oncology
11/30/2021
Single-Cell RNA Sequencing Reveals Multiple Pathways and the Tumor Microenvironment Could Lead to Chemotherapy Resistance in Cervical Cancer

Scientists comprehensively analyze cells from pretreated and chemoresistant cervical cancer tissues to generate a molecular census of cell populations.

Frontiers in Oncology
11/26/2021
Patient Perspectives and Experiences of the Rapid Implementation of Digital Consultations During COVID-19 — A Qualitative Study Among Women With Gynecological Cancer

This study explores the experiences and perspectives of patients with gynecological cancer whose outpatient appointments were re-scheduled to digital consultations during the COVID-19 pandemic.

Supportive Care in Cancer
11/18/2021
Spotlight
Children With Cancer and COVID: Most Do Well, Which Ones Don't?

A new study that followed 131 children with cancer who were infected with SARS-CoV-2 shows that most (79%) did well and had only asymptomatic or mild disease.

Medscape
11/16/2021

News

CDK4/6 Inhibitors Combined With Fulvestrant for Hormone Receptor–Positive, HER2-Negative Advanced Breast Cancer: FDA Analysis of Overall Survival

Dr Jennifer Gao and colleagues found the addition of CDK4/6 inhibitor treatment to fulvestrant resulted in a consistent OS benefit vs placebo plus fulvestrant in patients with HR+...

The ASCO Post
12/09/2021
10916
Large-Scale Genomic Sequencing Reveals Adaptive Opportunity of Targeting Mutated-PI3Kα in Early and Advanced HER2+ Breast Cancer

Study authors characterized the adaptive roles of PI3Kα mutations among HER2+ tumor progression.

Clinical and Translational Medicine
12/04/2021
10913
John Leonard, MD, Discusses the Lymphoma Treatment Landscape

Dr John P. Leonard discusses the complex landscape and management of patients with lymphoma, as well as hot topics in hematologic malignancies, including the use of monsunetuzumab therapy.

Oncology Learning Network
12/04/2021
10909
Addition of Ipatasertib to Abiraterone Plus Prednisolone Improves Radiographic Progression–Free Survival in Metastatic Castration-Resistant Prostate Cancer With PTEN Loss

A phase III trial found that the addition of the AKT inhibitor ipatasertib to abiraterone and prednisolone produced a significant improvement in radiographic progression-free survival... 

The ASCO Post
11/25/2021
10862
m6A Regulator Expression Profile Predicts the Prognosis, Benefit of Adjuvant Chemotherapy, and Response to Anti-PD-1 Immunotherapy in Patients With Small-Cell Lung Cancer

This research works to advance the ability to create individualized therapy regimens and guide SCLC prognostication.

BMC Medicine
11/22/2021
10863
Impact of COVID-19 Pandemic on Gastrointestinal Cancer Diagnosis and Resection

This study works to determine the demographic, histopathologic and clinical characteristics of cancer patients most impacted by COVID-19.

ScienceDirect
11/23/2021
10864

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