Lung Cancer

Lung Cancer

Immune Microenvironment Signatures as Biomarkers to Predict Early Recurrence of Stage Ia-b Lung Cancer

This study aims to identify immune-related biomarkers that might predict tumor recurrence in stage Ia-b NSCLC within 40 months after curative resection.

Frontiers in Oncology
BMI May Not Be Best Obesity Indicator to Assess Risk for Lung Cancer

New research published in the Journal of Thoracic Oncology suggests the method used to calculate how obesity is measured may affect whether it is considered a risk factor for lung cancer.

Oncology Times - Latest Articles
Nivolumab Plus Ipilimumab vs Nivolumab for Previously Treated Patients With Stage IV Squamous Cell Lung Cancer

Combination therapy with nivolumab and ipilimumab is currently only indicated as first-line therapy in patients with advanced non–small-cell lung cancer.

JAMA Oncology

Comprehensive Dissection of Treatment Patterns and Outcome for Patients With Metastatic Large-Cell Neuroendocrine Lung Carcinoma

Study investigators retrospectively analyze all patients with metastatic large-cell neuroendocrine lung carcinoma in the records of a large German academic center since 2010.

Frontiers in Oncology
The Effect of Smoking Status on Efficacy of Immune Checkpoint Inhibitors in Metastatic Non–Small-Cell Lung Cancer

Study investigators examine whether or not smoking status can effect efficacy of ICIs in metastatic non–small-cell lung cancer. 

Missing Protein in SCLC May Explain Poor Response to Immunotherapies

A new study reveals that a key surface protein, NKG2DL (natural killer group 2, member D ligand), that typically triggers an immune response is missing in most SCLC tumors.

Oncology Times - Latest Articles
Are Patients With Primary Lung Cancer Detected by Low-Dose CT at Reduced Risk of Brain Metastases?

Patients with primary lung cancer detected using low-dose computed tomography screening may be at reduced risk for developing brain metastases after diagnosis, according to a study published...

The ASCO Post
First-Line Chemo-Immunotherapy for Extensive-Stage Small-Cell Lung Cancer: A United States-Based Cost-Effectiveness Analysis

This study aims to assess the cost-effectiveness of two recently approved first-line chemo-immunotherapies for patients with extensive-stage small-cell lung cancer in the United States.

Frontiers in Oncology
Nivolumab/Ipilimumab Improves Overall Survival vs Chemotherapy in First-Line Treatment for Unresectable Malignant Pleural Mesothelioma

A prespecified interim analysis in the phase III CheckMate 743 trial has shown improved OS with first-line nivolumab/ipilimumab vs platinum-based CT in unresectable malignant pleural mesothelioma.<

The ASCO Post
Pathogenic Role of Epstein–Barr Virus in Lung Cancers

In this article, investigators review the current understanding of the EBV-LC association and the etiological role of EBV in lung carcinogenesis.

Alterations of the Platelet Proteome in Lung Cancer: Accelerated F13A1 and ER Processing as New Actors in Hypercoagulability

In order to comprehensively investigate the biochemical changes in platelets from cancers with high risk of thrombosis, investigators examine the platelet proteome of brain and lung cancer patients

The Role of Radiomics in Lung Cancer: From Screening to Treatment and Follow-Up

This review identifies important recent publications to be synthesized into a comprehensive review of the current status of radiomics in lung cancer at each step of the patients’ care.

Frontiers in Oncology
Targeting Hyperactive TGFBR2 for Treating MYOCD Deficient Lung Cancer

Further analysis reveals that MYOCD potently inhibits stemness of lung cancer stem cells.

​​Set of Genetic Markers in Lung Cancer Identified

Investigators at Wake Forest School of Medicine have identified a set of new genetic markers that could potentially lead to new personalized treatments for lung cancer.

Oncology Times - Latest Articles
Map of Early-Stage Lung Cancer Sheds Light on Tumor Development

Researchers at The University of Texas MD Anderson Cancer Center have developed a first-of-its-kind spatial atlas of early-stage lung cancer and surrounding normal lung tissue...

Oncology Times - Latest Articles
Evaluation of Cell Surface Vimentin Positive Circulating Tumor Cells as a Diagnostic Biomarker for Lung Cancer

This study aims to determine whether cell surface vimentin positive CTCs could be used as a biomarker for lung cancer as well.

Frontiers in Oncology
Understanding Socioeconomic Disparities in Lung Cancer Care

A recent study finds that sociodemographic factors such as race, marital, income, and insurance status are associated with disparities in the receipt of lung cancer treatment, per findings...

Oncology Times - Latest Articles
The Impact of the COVID-19 Pandemic on Lung Cancer Screening

According to Dr. Norman Sharpless, the decrease in low-dose CT scanning for lung nodules and subsequent increased number of suspicious pulmonary nodules have become particularly alarming.

Oncology Times - Latest Articles
The Incidence and Risk Analysis of Lung Cancer Development in Patients with Chronic Obstructive Pulmonary Disease: Possible Effectiveness of Annual CT-Screening

This study examines the incidence of lung cancer and the lung cancer mortality rate in Japanese COPD patients, as well as factors that are associated with the development of lung cancer in COPD pat

Optimal Treatment Strategies for Stage I Non–Small-Cell Lung Cancer in Veterans With Pulmonary and Cardiac Comorbidities

Study investigators use use simulation modeling to assess projected outcomes associated with different management strategies of Veterans with stage I NSCLC with COPD and/or CAD.

Single-Cell Sequencing, an Advanced Technology in Lung Cancer Research

This review summarizes lung cancer research using SCS and their research achievements.

OncoTargets and Therapy
Severity of COVID-19 in Patients With Lung Cancer: Evidence and Challenges

This review summarizes available evidence regarding the direct and indirect impact of the COVID-19 pandemic on lung cancer care and patients.

Journal for ImmunoTherapy of Cancer
GOECP/SEOR Radiotherapy Guidelines for Small-Cell Lung Cancer

These guidelines emphasize treatment fields, radiation techniques, fractionation, concomitant treatment, and the optimal timing of Ch and radiotherapy.

RNA-Based Therapies: A Cog in the Wheel of Lung Cancer Defense

This article describes the current understanding of various aspects of RNA-based therapeutics, including modern platforms, modifications, and combinations with chemo-/immunotherapies...

Molecular Cancer
Non-Coding RNAs in Cancer Diagnosis and Therapy: Focus on Lung Cancer

This review is structured to provide an overview of non-coding RNAs in cancer biology, diagnostics, and therapeutics, focusing on lung cancer.

Some Patients With Lung Cancer Report Feeling Uninformed About Their Disease, Uninvolved With Their Treatment

More than 1 in 10 patients with lung cancer do not know what type of tumor they have, according to data from a 17-country study carried out by the GLCC presented at the European Lung Cancer Virtual

The ASCO Post
Neoadjuvant Atezolizumab in Stage IB/IIIB Resectable Lung Cancer

Neoadjuvant atezolizumab is well-tolerated by patients with stage IB-IIIB lung cancer, according to the primary analysis of the Lung Cancer Mutation Consortium (LCMC) 3 study.

Oncology Times - Latest Articles
Nivolumab and Ipilimumab as Maintenance Therapy in Extensive-Disease Small-Cell Lung Cancer

CheckMate 451, a double-blind phase III trial, evaluated nivolumab plus ipilimumab and nivolumab monotherapy as maintenance therapy following first-line chemotherapy for ED-SCLC.

Journal of Clinical Oncology
Successful Bronchial Arterial Infusion Chemotherapy Combined With Radiotherapy for an Endobronchial Metastasis After Resection of Small Cell Lung Cancer

Bronchial arterial infusion chemotherapy has been reported to be an effective treatment option for centrally located early‐stage SCC and has a favorable response rate for patients with...

Respirology Case Reports
Improving Social Support to Increase QoL in Lung Cancer Patients

The purpose of this study is to analyze original papers in order to determine whether an increase in social support is important in improving QoL for lung cancer patients. 

Cancer Management and Research
Tackling Drug Resistance in EGFR Exon 20 Insertion Mutant Lung Cancer

This literature reviews the current understanding of the mechanisms of resistance to these compounds, which include on-target EGFR secondary mutations, compensatory bypass pathway...

Pharmacogenomics and Personalized Medicine
Expression of Inflammatory Interleukins and Selected miRNAs in Non-Small Cell Lung Cancer

Study investigators examine the mRNA expression of interleukins IL-1β, IL-6, IL-17 and miR-9, miR-122 as potential useful biomarkers of NSCLC.

Scientific Reports
Quantitative Assessment of CD200 and CD200R Expression in Lung Cancer

This study uses quantitative immunofluorescence to characterize the CD200/CD200R immune checkpoint in lung cancer. 


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