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All News


US Multisociety Task Force on Colorectal Cancer  Releases Updated Screening Recommendations

The US Multisociety Task Force on CRC has updated its CRC screening recommendations, specifically on when to start and when to stop screening in average-risk individuals.

The ASCO Post
11/15/2021
FDA Grants RMAT Designation to CRISPR-Edited CAR-T for Advanced B-Cell Malignancies

The FDA granted regenerative medicine advanced therapy designation to CTX110, a CAR T-cell therapy in development for treatment of relapsed or refractory B-cell malignancies.

Healio
11/29/2021
Doxorubicin/Adriamycin Monotherapy or Plus Ifosfamide in First-Line Treatment for Advanced Soft Tissue Sarcoma

Researchers conducted a pooled analysis to comprehensively compare the efficacy and tolerability between AI and ADM in patients with previously untreated ASTS.

Frontiers in Oncology
11/22/2021

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Content Feed

FOCUS4-C Trial: Hint of Activity Reported With Adavosertib in Metastatic Colorectal Cancer

The novel WEE1 inhibitor adavosertib, given after induction chemotherapy, yielded a 65% reduction in the risk of disease progression or death compared with active monitoring in patients...

The ASCO Post
11/10/2021
A Novel Germline Heterozygous BCL11B Variant Causing Severe Atopic Disease and Immune Dysregulation

Researchers work to classify germline BCL11B-dependent atopic disease as a novel primary atopic disorder.

Frontiers in Immunology
11/23/2021
FDA Approves Sirolimus Protein-Bound Particles for Malignant Perivascular Epithelioid Cell Tumor​

The FDA approved sirolimus protein-bound particles for injectable suspension for adult patients with locally advanced unresectable or metastatic malignant perivascular epithelioid cell tumor. 

Oncology Times - Latest Articles
11/23/2021
Indatuximab Ravtansine Has Encouraging Activity in Relapsed/Refractory Multiple Myeloma

Indatuximab ravtansine with lenalidomide or pomalidomide shows encouraging clinical activity for R/R MM, according to data from a phase 1/2a study published in the Lancet Haematology.

Hematology Advisor
11/23/2021
Children With Cancer and COVID: Most Do Well, Which Ones Don't?

A new study that followed 131 children with cancer who were infected with SARS-CoV-2 shows that most (79%) did well and had only asymptomatic or mild disease.

Medscape
11/16/2021
US Multisociety Task Force on Colorectal Cancer  Releases Updated Screening Recommendations

The US Multisociety Task Force on CRC has updated its CRC screening recommendations, specifically on when to start and when to stop screening in average-risk individuals.

The ASCO Post
11/15/2021
COL5A1 Serves as a Biomarker of Tumor Progression and Poor Prognosis and May Be a Potential Therapeutic Target in Gliomas

Researchers investigated the expression levels of COL5A1 in gliomas with different grades or pathological types based on public data and clinical samples.

Frontiers in Oncology
11/16/2021
'Remarkable' Results in Pediatric Acute Promyelocytic Leukemia

"Remarkable" results with a novel treatment regimen in pediatric acute promyelocytic leukemia have been reported by researchers at the National Cancer Institute.

Medscape
11/15/2021
Immunogenicity of SARS–CoV-2 Vaccines in Patients With Cancer

The CANVAX Cohort Study found that immunogenicity varied among vaccines and that both antibody concentrations and neutralization titers were lower than those in healthy controls. 

The ASCO Post
11/15/2021
Prognosis for Cutaneous Melanoma by Clinical and Pathological Profile

Demographic and clinical-pathological variables are analyzed to measure their impact on patient survival in this cohort of CMM patients.

Frontiers in Oncology
11/16/2021
Immunotherapy Combination Confers Durable Benefit in Advanced Renal Cell Carcinoma

First-line nivolumab plus ipilimumab conferred greater long-term clinical benefit than sunitinib for patients with advanced renal cell carcinoma, according to new study results. 

Healio
11/16/2021
Prognostic Value of Vascular-Expressed PSMA and CD248 in Urothelial Carcinoma of the Bladder

Researchers performed a bioinformatic analysis of CD248 and PSMA using the TCGA-BLCA dataset to explore the underlying mechanism of PSMA and CD248 in UCB progression.

Frontiers in Oncology
11/17/2021
Treatment Sequence Impacts Survival in BRAF-Mutant Metastatic Melanoma

Treatment sequence can impact survival in patients with BRAF V600-mutant metastatic melanoma, according to results from the phase 3 DREAMseq trial.

Cancer Therapy Advisor
11/18/2021
Fasting-Mimicking Diet Safe, May Benefit Patients on Anticancer Therapy

A cyclic, 5-day fasting-mimicking diet appeared safe and showed potential to improve outcomes among patients on anticancer therapy for different tumor types, according to new study results. 

Healio
11/17/2021
FDA Approves Keytruda for Adjuvant Treatment of Renal Cell Carcinoma

The FDA expanded the approval of pembrolizumab to include adjuvant treatment of certain patients with renal cell carcinoma.

Healio
11/18/2021
Neoadjuvant Regimens Best Standard Care in HER2+ Breast Cancer

Two neoadjuvant treatment regimens can improve pCR rates over standard care in patients with HER2-positive breast cancer, according to phase 2 results published in Nature Communications.

Cancer Therapy Advisor
11/17/2021
CEBPA-bZip Mutations Associated With Favorable Prognosis in Acute Myeloid Leukemia

CEBPA-bZip mutations, whether monoallelic or biallelic, are associated with favorable outcomes from AML, similar to those with CEBPA-dm, according to research published in Blood.

Hematology Advisor
11/19/2021
Alpha-L-Fucosidase Has Diagnostic Value in Prostate Cancer With “Gray-Zone PSA” and Inhibits Cancer Progression via Regulating Glycosylation

This study explores the diagnostic value of AFU in PCa patients with “gray-zone PSA” and the correlation between AFU expression and clinicopathological characteristics of PCa patients.

Frontiers in Oncology
11/22/2021
Long-Term Outcomes With Chemoradiotherapy Before vs After Chemotherapy in Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer

Long-term results of a German phase II trial showed similar disease outcomes, chronic toxicity, and QoL with chemoradiotherapy before vs after chemotherapy... 

The ASCO Post
11/22/2021
Study Finds Unique Genomic and Molecular Features in Young Adult Patients With Cancer

Young adults diagnosed with cancer may require different treatments than those received by older patients, according to a systematic comparison of the genomes of 14 different types of cancers...

The ASCO Post
11/23/2021
Pre-Existing Cardiovascular Disease Increases Risk of Atrial Arrhythmia and Mortality in Cancer Patients Treated With Ibrutinib

Researchers investigate the incidence of new-onset atrial fibrillation after ibrutinib initiation in patients with underlying CVD. 

Cardio-Oncology
11/19/2021
Impact of Chemotherapy and Radiotherapy on the Survival of Elderly Esophageal Cancer Patients Undergoing Surgery

 Researchers investigate the potential effect of CRT on the prognosis of esophageal cancer, a common and lethal carcinoma. 

BMC Gastroenterology
11/18/2021
Real-World Effectiveness of Second-Line Afatinib versus Chemotherapy for the Treatment of Advanced Lung Squamous Cell Carcinoma in Immunotherapy-Naïve Patients

The efficacy of second-line afatinib versus chemotherapy in patients with advanced lung SCC who progressed after first-line chemotherapy was investigated in this study. 

BMC Cancer
11/15/2021
Patient Perspectives and Experiences of the Rapid Implementation of Digital Consultations During COVID-19 — A Qualitative Study Among Women With Gynecological Cancer

This study explores the experiences and perspectives of patients with gynecological cancer whose outpatient appointments were re-scheduled to digital consultations during the COVID-19 pandemic.

Supportive Care in Cancer
11/18/2021
Acceptability and Appropriateness of a Clinical Pathway for Managing Anxiety and Depression in Cancer Patients

Scientists explore differences between trial arms (core versus enhanced) in these outcomes to determine whether implementation intensity impacts perceptions of the CP itself.

BMC Health Services Research
11/17/2021
Undertaking General Practice Quality Improvement to Improve Cancer Screening

A qualitative approach was used to interview 18 general practice staff and five Primary Health Network staff to understand their experiences with these quality improvement initiatives.

BMC Family Practice
11/17/2021
Discovery Proteomics Defines Androgen-Regulated Glycoprotein Networks in Prostate Cancer Cells, as Well as Putative Biomarkers of Prostatic Diseases

Researchers discover that androgens elicited dose-dependent changes in the expression of glycoprotein networks related to cell growth and differentiation in PCa cells. 

Scientific Reports
11/15/2021
New Resilience Instrument for Family Caregivers in Cancer

Scientists validate the 10-item Resilience Scale Specific to Cancer in FCs using multidimensional item response theory analysis.

Health and Quality of Life Outcomes
11/18/2021
Cell-Morphodynamic Phenotype Classification With Application to Cancer Metastasis Using Cell Magnetorotation and Machine-Learning

Researchers define cell morphodynamics using a dynamic histology method which is based on multiplexed Cell Magneto-Rotation and Machine Learning. 

PLOS ONE
11/17/2021
FDA Grants Orphan Drug Status to Rivoceranib for Hepatocellular Carcinoma

The FDA granted orphan drug designation to rivoceranib, a small-molecule tyrosine kinase inhibitor that targets the VEGF receptor 2, for the treatment of hepatocellular carcinoma.

Healio
11/20/2021
Study Explores Efficacy & Safety of Tanezumab for Cancer Pain

New research suggests that subcutaneous tanezumab improved metastatic cancer-related bone pain when compared with placebo, according to data recently presented at the ESMO Congress 2021. 

Oncology Times - Latest Articles
11/20/2021
Aggrego Oncology - 11/25/21

In this week’s edition, Brian Van Tine, MD, Associate Professor of Medicine and Pediatrics at Siteman Cancer Center, shares headlines for updates in acute lymphoblastic leukemia, pediatric brain tumors, and prostate cancer. View the transcript here.

11/25/2021
Eligibility Criteria May Hinder Black Patients in Pancreatic Cancer Trials

A simulated pancreatic cancer clinical trial screening process found black patients are significantly more likely than White patients to be excluded from clinical trials... 

Oncology Times - Latest Articles
11/20/2021
Men and Women Differ in Their Refusal of Breast Cancer Treatments

Women with breast cancer are more likely than their male counterparts to refuse hormone therapy or surgery, according to a retrospective study published in Clinical Breast Cancer.

Cancer Therapy Advisor
11/23/2021
Newer Agents on the Horizon for Refractory or Relapsed DLBCL

Although treating patients with R/R DLBCL remains challenging, some newer therapies on the horizon offer promise including CAR T-cell therapy.

The ASCO Post
11/25/2021
TMPRSS4 Promotes Cancer Stem–Like Properties in Prostate Cancer Cells Through Upregulation of SOX2 by SLUG and TWIST1

Study authors investigated whether TMPRSS4 confers cancer stem–like properties to prostate cancer cells and characterized the underlying mechanisms.

Journal of Experimental & Clinical Cancer Research
11/22/2021
Exploration of the Tumor Mutational Burden as a Prognostic Biomarker and Related Hub Gene Identification in Prostate Cancer

Investigators examined the correlations of the tumor mutational burden with clinical prognosis and antitumor immunity in prostate cancer, and compared the gene sets of high-TMB and...

Technology in Cancer Research & Treatment
11/20/2021
CD8-Positive T Cells and CD204-Positive M2-like Macrophages Predict Postoperative Prognosis of Very High-Risk Prostate Cancer

This study investigated the clinical, pathological and immunological significance of the tumor immune microenvironment of very high-risk prostate cancer with seminal vesicle invasion.

Scientific Reports
11/18/2021
B7-H3 as a Target for CAR-T Cell Therapy in Skull Base Chordoma

Researchers generated B7-H3 targeted CAR-T-cells and tested their antitumor activities using patient derived tumor spheres.

Frontiers in Oncology
11/15/2021
FDA Grants Orphan Drug Designation to Dual-Target CAR-T for Advanced Multiple Myeloma

The FDA granted orphan drug designation to GC012F, a novel chimeric antigen receptor T-cell therapy for the treatment of relapsed or refractory multiple myeloma.

Healio
11/19/2021
Chimeric Antigen Receptor T Cells With Modified Interleukin-13 Preferentially Recognize IL13Rα2 and Suppress Malignant Glioma

Researchers examine the efficacy and safety of T cells containing a YYB-103 CAR that can preferentially bind to IL13Rα2 on MG cells.

Frontiers in Immunology
11/08/2021
TCR T-Cell Therapy Induces Response in Solid Cancers

Half of patients achieved objective response to an infusion of IMA203, an autologous TCR-T cell therapy that is gene-edited to express a T-cell receptor recognizing PRAME protein in tumor cells.

Healio
11/19/2021
Modified EASIX Score Predicts CRS and ICANS Before Severe Symptoms in Patients With B-Cell Malignancies

A modified version of the EASIX score, when calculated prior to and soon after CAR T-cell infusion, predicted severe CRS and ICANS before their occurrence. 

ASH Clinical News
11/01/2021
A Phase II Study of Talimogene Laherparepvec for Patients With Inoperable Locoregional Recurrence of Breast Cancer

The local and systemic antitumor efficacy of T-VEC as monotherapy for inoperable locoregional recurrence of breast cancer with or without distant metastases was explored in this study.

Scientific Reports
11/15/2021
Cold and Heterogeneous T Cell Repertoire is Associated With Copy Number Aberrations and Loss of Immune Genes in Small-Cell Lung Cancer

Researchers depict the immunogenomic ITH architecture of SCLC and compare these LS-SCLCs with localized NSCLCs to assess the impact of immunogenomic attributes on patient survival.

Nature Communications
11/17/2021
Maternal Deaths Among Patients With Cancer in the United States

A population-based analysis of maternal death among cancer patients was conducted in a modern cohort from the SEER database to characterize the risks of maternal deaths in cancer patients... 

Medicine
11/19/2021
Doxorubicin/Adriamycin Monotherapy or Plus Ifosfamide in First-Line Treatment for Advanced Soft Tissue Sarcoma

Researchers conducted a pooled analysis to comprehensively compare the efficacy and tolerability between AI and ADM in patients with previously untreated ASTS.

Frontiers in Oncology
11/22/2021
SSTP1, a Host Defense Peptide, Exploits the Immunomodulatory IL6 Pathway to Induce Apoptosis in Cancer Cells

Researchers suggests that identification of the membrane targets for the promising anticancer HDPs might lead to the identification of new drugs for targeted therapy.

Frontiers in Immunology
11/19/2021
CircTP63 Promotes Cell Proliferation and Invasion by Regulating EZH2 via Sponging miR-217 in Gallbladder Cancer

Scientists provided better understanding for the regulatory role of circRNAs in GBC progression to improve the diagnosis and therapies of GBC.

Cancer Cell International
11/17/2021
Efficacy and Safety of MIL60 Compared With Bevacizumab in Advanced or Recurrent Non-Squamous Non-Small Cell Lung Cancer

Researchers compared the efficacy, safety, and immunogenicity of MIL60 with reference bevacizumab as first-line treatment in patients with NSCLC in this phase 3, randomized, double-blind study.

EClinicalMedicine
11/19/2021