Germline Mutations in Mitochondrial Complex I Reveal Genetic and Targetable Vulnerability in IDH1-Mutant Acute Myeloid Leukaemia

Germline Mutations in Mitochondrial Complex I Reveal Genetic and Targetable Vulnerability in IDH1-Mutant Acute Myeloid Leukaemia

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IDH1 mutation limits the flexibility for citrate utilization in the presence of impaired complex I activity to a degree that is not apparent in IDH2 mutant cells, exposing a mutation-specific...