Metalloproteinase Inhibition Reduces AML Growth, Prevents Stem Cell Loss, and Improves Chemotherapy Effectiveness

Metalloproteinase Inhibition Reduces AML Growth, Prevents Stem Cell Loss, and Improves Chemotherapy Effectiveness

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Results suggest that MMP inhibition could be a promising complementary therapy to reduce AML growth and limit HSPC loss and BM vascular damage caused by MLL-AF9 and possibly other AML subtypes.