Analysis of Rare Disruptive Germline Mutations in 2,135 Enriched BRCA-Negative Breast Cancers Excludes Additional High-Impact Susceptibility Genes

Analysis of Rare Disruptive Germline Mutations in 2,135 Enriched BRCA-Negative Breast Cancers Excludes Additional High-Impact Susceptibility Genes

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This study is the largest case-control analysis reported to date in enriched breast cancer cases, and better powered for discovery of a new rare high penetrance susceptibility gene than the largest reported case-control analysis to date of unselected breast cancers.