TIGIT is the Central Player in T-Cell Suppression Associated With CAR-T Cell Relapse in Mantle Cell Lymphoma

TIGIT is the Central Player in T-Cell Suppression Associated With CAR-T Cell Relapse in Mantle Cell Lymphoma

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To interrogate BA resistance mechanisms in MCL, we performed single-cell RNA sequencing on 39 longitudinally collected samples from 15 BA-treated patients, and multiplex cytokine profiling on 80 serial samples from 20 patients.