Pediatric Oncology

Pediatric Oncology

Children With Cancer and COVID: Most Do Well, Which Ones Don't?

A new study that followed 131 children with cancer who were infected with SARS-CoV-2 shows that most (79%) did well and had only asymptomatic or mild disease.

'Remarkable' Results in Pediatric Acute Promyelocytic Leukemia

"Remarkable" results with a novel treatment regimen in pediatric acute promyelocytic leukemia have been reported by researchers at the National Cancer Institute.

Study Finds Unique Genomic and Molecular Features in Young Adult Patients With Cancer

Young adults diagnosed with cancer may require different treatments than those received by older patients, according to a systematic comparison of the genomes of 14 different types of cancers...

The ASCO Post

The Landscape of Coding RNA Editing Events in Pediatric Cancer

Researchers present a comprehensive analysis of RNA editing in pediatric cancer, yielding novel RNA editing events whose biological function should be investigated in future studies.

BMC Cancer
Personalized T Cell Immunotherapy for Pediatric Brain Tumors is One Step Closer to Becoming a Reality

Children's National Hospital experts developed a new approach that discovered unique proteins in an individual tumor's cells, to generate personalized T cells to target and kill tumors. 

Medical Xpress
Drug Used to Prolong Gestation Linked to Increased Cancer Risk in Offspring

A new study suggests children exposed in utero to 17 alpha-hydroxyprogesterone caproate may be at increased risk for cancer. 

CALCRL is a Marker of Stemness and an Independent Predictor of Outcome in Pediatric AML

Researchers investigate the prognostic impact of CALCRL expression in a cohort of 284 pediatric AML patients treated within the AAML03P1, AAML0531, and CCG-2961 trials.

Blood Advances
Heart Rate Variability and Psychosocial Symptoms in Adolescents and Young Adults With Cancer

A cross-sectional secondary analysis of baseline HRV and patient-centered psychosocial outcomes from a randomized trial among AYAs with cancer is presented. 

The Urinary Excretion of Epigenetically Modified DNA as a Marker of Pediatric ALL Status and Chemotherapy Response

Scientists investigated the role of epigenetic DNA modifications in childhood ALL diagnostics and therapy monitoring by analyzing the levels of 5-mdC oxidation products in the cellular DNA...

Scientific Reports
Loneliness Among Adolescents and Young Adults With Cancer During the COVID-19 Pandemic

Research investigates the prevalence of loneliness and factors associated with loneliness among AYAs with cancer during this pandemic.

Supportive Care in Cancer
CircRNF220, Not its Linear Cognate Gene RNF220, Regulates Cell Growth and is Associated With Relapse in Pediatric Acute Myeloid Leukemia

Researchers identified that circRNF220, a circRNA derived from the RING domain E3 ubiquitin ligase gene RNF220, was specifically upregulated in pediatric AML and was required for AML progression.

Molecular Cancer
Identification of Biochemical and Molecular Markers of Early Aging in Childhood Cancer Survivors

Scientists shed light on the mechanisms involved in C/RT-induced early aging, morbidities, and the risk of developing second tumors in CCS through a biochemical and molecular approach.

Risk-Based Treatment of Pediatric and Young Adult Synovial Sarcoma

Risk-based treatment of pediatric and young adult patients with synovial sarcoma produced favorable outcomes in those with nonmetastatic disease.

The ASCO Post
Incidence of Suicide Among Adolescent and Young Adult Cancer Patients

As the survival rates of cancer patients continue to increase, most cancer patients now die of non-cancer causes, this study characterizes suicide mortality among AYA patients in the US...

Cancer Cell International
Extracorporeal Photopheresis in Pediatric Chronic Graft vs Host Disease

ECP is a safe treatment approach for kids who have steroid-refractory cGVHD, while enabling high response rates but with further immunosuppressive treatment required for some patients.

Hematology Advisor
Characteristics of Genomically Targeted Single-Patient Use Requests for Pediatric Cancers

Scientists analyzed characteristics of genomically targeted single-patient use requests for investigational agents for the treatment of pediatric cancers.

The ASCO Post
Effects of Immersive Virtual Reality for Preventing and Managing Anxiety, Nausea and Vomiting Among Pediatric Cancer Patients Receiving Their First Chemotherapy

This exploratory trial aims to assess the feasibility of IVR as a relaxation & distraction intervention for reducing anxiety and CINV patients receiving their first chemotherapy.

SARS-CoV-2 in Children with Cancer or Following Haematopoietic Stem Cell Transplant

Research describes the severity and outcomes of SARS-COV-2 in children with cancer or following HSCT and identifies factors associated with severe disease.

European Journal of Cancer
A Systematic Analysis of Genetic Interactions and Their Underlying Biology in Childhood Cancer

Scientists present a robust pipeline that implements two statistical tests to detect with high confidence significantly co-occurring and mutually exclusive gene pairs.

Communications Biology
Factors Associated With Risk of Hearing Loss in Pediatric Patients Receiving Radiation and Chemotherapy

This study explores factors associated with an increased risk of hearing loss in pediatric patients receiving radiation therapy and chemotherapy for central nervous system and head and neck tumors.

The ASCO Post
Researchers ‘Extraordinarily Optimistic’ About Potential of CAR-T for Pediatric Brain Cancer

Scientists explore strategies to provide CAR T-cell therapy to treat advanced and high-risk brain and CNS tumors among younger patients.

Comparison of the Blood, Bone Marrow, and Cerebrospinal Fluid Metabolomes in Children with B-Cell Acute Lymphoblastic Leukemia

Scientists aim to create a resource that will accelerate ALL research by facilitating translation of findings from bone marrow and CSF.

Scientific Reports
A Supervised Exercise Intervention During Cancer Treatment for Adolescents and Young Adults—FiGHTING F!T

Scientists determine whether a 10-week individualised exercise intervention is associated with a reduction in the decline of physical fitness (V02peak) experienced by AYAs during cancer treatment..

DexaDays-2, Hydrocortisone for Treatment of Dexamethasone-Induced Neurobehavioral Side Effects in Pediatric Leukemia Patients

Researchers aim to replicate the NTR3280 trial results in a targeted larger sample before further implementing this intervention into standard of care.

BMC Pediatrics
Children With Cancer More Likely to Have Severe COVID-19 Illness

Data suggests that children with cancer who contracted COVID-19 developed more serious infections and had a greater likelihood of hospitalization or death than the general pediatric population.

Irinotecan Plus Doxorubicin Hydrochloride Liposomes for Relapsed or Refractory Wilms Tumor

Scientists retrospectively analyzed the efficacy and toxicity of the AI regimen in 16 patients with relapsed or refractory WT from July 2018 to September 2020.

Frontiers in Oncology
Effect of Concurrent Focal 22q11.22 Deletions and IKZF1 Alterations on Outcomes in Pediatric Patients With B-Cell ALL

Mangum et al find that focal deletions in chromosome 22q11.22 are associated with poor outcomes in pediatric patients with B-cell ALL with IKZF1 alterations.

The ASCO Post
Genetic Variant Linked to Hearing Loss in Children Treated With Chemotherapy

With significant advances in pediatric cancer care in recent decades, the 5-year survival rate for childhood cancer is now almost 80 percent.

Oncology Times - Latest Articles
Genetic Testing Options for Children With Rhabdomyosarcoma

In children with rhabdomyosarcoma, the presence of mutations in several genes, including TP53, MYOD1, and CDKN2A, appears to be associated with a more aggressive form...

Oncology Times - Latest Articles
Three-Platform Sequencing Provides Detailed Picture of Pediatric Cancers

A 3-platform sequencing approach allowed for identification and characterization of genetic drivers across a wide spectrum of pediatric cancers, according to a study published in Cancer Discovery.<

Cancer Therapy Advisor
Disparities Observed in Follow-up Care Among Young Adult Childhood Cancer Survivors

A research team examined gaps and disparities in lifelong follow-up among childhood cancer survivors, including taking a closer look at long-term follow-up care plans, specifically for...

The ASCO Post
Carboplatin Intensification for the Treatment of Pediatric High-Risk Medulloblastoma

In a COG phase III trial reported in JAMA Oncology, investigators found the addition of carboplatin to RT in pediatric patients with newly diagnosed high-risk medulloblastoma improved EFS...

The ASCO Post
More Children With High-Risk Brain Cancer Now Surviving

A study that used molecular testing to distinguish between subtypes of medulloblastoma has shown a significant improvement in survival for children with high-risk disease who underwent treatment...


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