Pediatric Oncology

Pediatric Oncology

More Children With High-Risk Brain Cancer Now Surviving

A study that used molecular testing to distinguish between subtypes of medulloblastoma has shown a significant improvement in survival for children with high-risk disease who underwent treatment...

HER2-Specific CAR T-Cell Trial Addresses Pediatric Brain and Spinal Cord Tumors

The phase I BrainChild-01 trial is assessing the safety and efficacy of delivering repetitive doses of T cells into the brain or the cerebrospinal fluid of children and young adults with R/R tumors

The ASCO Post
Calaspargase Pegol vs Pegaspargase in Pediatric Acute Lymphoblastic Leukemia

Vrooman et al find that the novel pegylated asparaginase formulation calaspargase pegol given every 3 weeks is associated with similar serum asparaginase activity nadir values, survival outcomes...

The ASCO Post

Pediatric Treatment Options for Average-Risk Medulloblastoma

A national study suggests that children with average-risk medulloblastoma can receive a radiation boost to a smaller volume of the brain at the end of a 6-week course of radiation treatment and...<

Oncology Times - Latest Articles
Effects of FOXR2 Expression in Neuroblastoma

Schmitt-Hoffner et al find that FOXR2 expression is associated with poorer survival in neuroblastoma, identifying a subgroup of patients in addition to those with MYCN-amplified tumors...

The ASCO Post
Hypomethylating Agents in Children With Relapsed/Refractory AML

Hypomethylating agents also can serve as a bridge to transplant for children and young adults with relapsed or refractory acute myeloid leukemia.

Maternal and Perinatal Factors are Associated With Risk of Pediatric Central Nervous System Tumors and Poorer Survival After Diagnosis

Study investigators examine the association between these early-life factors, risk, and survival of pediatric CNS tumors, using data from one of the world’s largest and most diverse cancer...

Scientific Reports
Survival Benefit for Individuals With Constitutional Mismatch Repair Deficiency Undergoing Surveillance

Constitutional mismatch repair deficiency syndrome is a lethal cancer predisposition syndrome characterized by early-onset synchronous and metachronous multiorgan tumors.

Journal of Clinical Oncology
Pediatric Cancer Survivors at Risk for Opioid Misuse

Survivors of childhood cancers are at increased risk for prescription opioid misuse compared with their peers, a review of a claims database revealed.

Expert Panel–Endorsed Quality Measures for End-of-Life Care for Children With Cancer

There is currently no consensus on what quality end-of-life care for children with cancer looks like, or how to measure and deliver it; however, investigators recently assembled an expert panel...<

The ASCO Post
Heritability Genes Identified in Childhood Neuroblastoma

An important finding is that the heritability of pathogenic or likely pathogenic germline variants accounts for about 16% of neuroblastomas, whereas previous estimates were less than 10%.

The ASCO Post
Integration of Brentuximab Vedotin Into Front-Line Treatment for Pediatric Patients With High-Risk Hodgkin Lymphoma

Metzger et al finds that the integration of brentuximab vedotin into front-line treatment of pediatric patients with high-risk classical Hodgkin lymphoma results in avoidance of RT in many patients

The ASCO Post
Diet and Exercise Intervention May Increase Efficacy of Chemotherapy in Pediatric Patients With Leukemia

Research published by Orgel et al shows that restricting calories, reducing fat and sugar intake, and increasing physical activity may boost the effectiveness of chemotherapy for older children and

The ASCO Post
Safety and Family Satisfaction of a Home-Delivered Chemotherapy Program for Children With Cancer

Home chemotherapy programs for children with cancer are safe and feasible, and their impact on the quality of life has been reported in different countries.

Italian Journal of Pediatrics
A Geospatiotemporal and Causal Inference Epidemiological Exploration of Substance and Cannabinoid Exposure as Drivers of Rising US Pediatric Cancer Rates

Prenatal cannabis exposure has been linked with several pediatric cancers which together comprise the majority of pediatric cancer types. 

BMC Cancer
Radiation Dose Evaluation of Pediatric Patients in CT Brain Examination

For the sake of radiation protection, study investigators have proposed to evaluate the dose and acquisition parameters delivered to their institution's pediatric patients to optimize the protocols

Scientific Reports
Impact of Pediatric Hypophosphatasia on Behavioral Health and Quality of Life

The effects of pediatric HPP on sleep, mood, regulation of attention and behavior, and other aspects of behavioral health have not been comprehensively studied.

Orphanet Journal of Rare Diseases
A Pediatric Brain Tumor Atlas of Genes Deregulated by Somatic Genomic Rearrangement

The global impact of somatic structural variants on gene expression in pediatric brain tumors has not been thoroughly characterised.

Nature Communications
The Utility of Verbal Therapy for Pediatric Cancer Patients and Survivors: Expressive Writing, Video Narratives, and Bibliotherapy Exercises

This literature review explores three promising avenues for verbal therapy in the pediatric oncology setting: expressive writing, video narratives, and bibliotherapy exercises.

Frontiers in Pediatrics
Echocardiographic Myocardial Strain Analysis Describes Subclinical Cardiac Dysfunction After Craniospinal Irradiation in Pediatric and Young Adult Patients With Central Nervous System Tumors

Subclinical cardiac systolic dysfunction by GLS is present both early and late after CSI. 

A Case Series of Pediatric Survivors of Anaplastic Pleomorphic Xanthoastrocytoma

This study reports on 3 pediatric cases of anaplastic pleomorphic xanthoastrocytoma.

Cancer Care of Children, Adolescents and Adults With Autism Spectrum Disorders: Key Information and Strategies for Oncology Teams

This review details information on this heterogenous group of neurodevelopmental disorders, and recommendations /concrete tools for the enhanced oncological care of this vulnerable population of pa

Frontiers in Oncology
CD79a Promotes CNS-Infiltration and Leukemia Engraftment in Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia

Central nervous system involvement remains a challenge in the diagnosis and treatment of acute lymphoblastic leukemia.

Outcomes and Patterns of Relapse in Pediatric Medulloblastoma

Investigators found that time to relapse and postrelapse survival was associated with subgroup and that the majority of relapses involve conservation of the involved medulloblastoma subgroup.

The ASCO Post
NTRK Fusions Identified in Pediatric Tumors: The Frequency, Fusion Partners, and Clinical Outcome

This study assesses the frequency, fusion partners, and clinical course in pediatric patients with NTRK fusion–positive tumors.


ASCO: Journal of Clinical Oncology: Table of Contents
Use of Antiangiogenic Therapies in Pediatric Solid Tumors

This review summarizes main antiangiogenic drugs, against which signaling pathways they are targeted, and the results that have been obtained from their use in pediatric patients.

Targeted Sequencing to Identify Genetic Alterations and Prognostic Markers in Pediatric T-Cell Acute Lymphoblastic Leukemia

T-cell acute lymphoblastic leukemia is caused by the accumulation of multiple genetic alterations.

Scientific Reports
Gabapentin for Phantom Limb Pain After Amputation in Pediatric Oncology

This study aims to appraise the efficacy and safety of gabapentin for post-amputation phantom limb pain in pediatric oncology.

Pediatric Hemato-Oncology Care Amid the COVID-19 Pandemic

The COVID-19 pandemic has created a parallel world of neglected non-COVID patients, especially, children with cancer and chronic blood disorders...

Long-Term Treatment Outcomes of Children and Adolescents With Lymphoblastic Lymphoma Treated With Various Regimens

This study analyzes the outcomes of children and adolescents with LBL treated with various regimens.

Outcomes After Late Bone Marrow and Very Early Central Nervous System Relapse of Childhood B-Acute Lymphoblastic Leukemia

Outcomes after relapse of childhood B-acute lymphoblastic leukemia are poor, and optimal therapy is unclear.

Biomarker of Aggressive Childhood Cancer Discovered

Researchers discovered a new diagnostic marker that distinguishes a fast-growing type of the pediatric brain cancer medulloblastoma from a less-aggressive type.

Oncology Times - Latest Articles
The Role of Cannabinoids as Anticancer Agents in Pediatric Oncology

This study details a comprehensive and critical review of what is known about the effects of cannabinoids on pediatric cancers...


source list reference