Pediatric Oncology

Pediatric Oncology

Pediatric Cancer Survivors at Risk for Opioid Misuse

Survivors of childhood cancers are at increased risk for prescription opioid misuse compared with their peers, a review of a claims database revealed.

Expert Panel–Endorsed Quality Measures for End-of-Life Care for Children With Cancer

There is currently no consensus on what quality end-of-life care for children with cancer looks like, or how to measure and deliver it; however, investigators recently assembled an expert panel...<

The ASCO Post
Heritability Genes Identified in Childhood Neuroblastoma

An important finding is that the heritability of pathogenic or likely pathogenic germline variants accounts for about 16% of neuroblastomas, whereas previous estimates were less than 10%.

The ASCO Post

Integration of Brentuximab Vedotin Into Front-Line Treatment for Pediatric Patients With High-Risk Hodgkin Lymphoma

Metzger et al finds that the integration of brentuximab vedotin into front-line treatment of pediatric patients with high-risk classical Hodgkin lymphoma results in avoidance of RT in many patients

The ASCO Post
Diet and Exercise Intervention May Increase Efficacy of Chemotherapy in Pediatric Patients With Leukemia

Research published by Orgel et al shows that restricting calories, reducing fat and sugar intake, and increasing physical activity may boost the effectiveness of chemotherapy for older children and

The ASCO Post
Safety and Family Satisfaction of a Home-Delivered Chemotherapy Program for Children With Cancer

Home chemotherapy programs for children with cancer are safe and feasible, and their impact on the quality of life has been reported in different countries.

Italian Journal of Pediatrics
The Utility of Verbal Therapy for Pediatric Cancer Patients and Survivors: Expressive Writing, Video Narratives, and Bibliotherapy Exercises

This literature review explores three promising avenues for verbal therapy in the pediatric oncology setting: expressive writing, video narratives, and bibliotherapy exercises.

Frontiers in Pediatrics
Impact of Pediatric Hypophosphatasia on Behavioral Health and Quality of Life

The effects of pediatric HPP on sleep, mood, regulation of attention and behavior, and other aspects of behavioral health have not been comprehensively studied.

Orphanet Journal of Rare Diseases
A Geospatiotemporal and Causal Inference Epidemiological Exploration of Substance and Cannabinoid Exposure as Drivers of Rising US Pediatric Cancer Rates

Prenatal cannabis exposure has been linked with several pediatric cancers which together comprise the majority of pediatric cancer types. 

BMC Cancer
Radiation Dose Evaluation of Pediatric Patients in CT Brain Examination

For the sake of radiation protection, study investigators have proposed to evaluate the dose and acquisition parameters delivered to their institution's pediatric patients to optimize the protocols

Scientific Reports
A Pediatric Brain Tumor Atlas of Genes Deregulated by Somatic Genomic Rearrangement

The global impact of somatic structural variants on gene expression in pediatric brain tumors has not been thoroughly characterised.

Nature Communications
Outcomes and Patterns of Relapse in Pediatric Medulloblastoma

Investigators found that time to relapse and postrelapse survival was associated with subgroup and that the majority of relapses involve conservation of the involved medulloblastoma subgroup.

The ASCO Post
A Case Series of Pediatric Survivors of Anaplastic Pleomorphic Xanthoastrocytoma

This study reports on 3 pediatric cases of anaplastic pleomorphic xanthoastrocytoma.

Cancer Care of Children, Adolescents and Adults With Autism Spectrum Disorders: Key Information and Strategies for Oncology Teams

This review details information on this heterogenous group of neurodevelopmental disorders, and recommendations /concrete tools for the enhanced oncological care of this vulnerable population of pa

Frontiers in Oncology
The Role of Cannabinoids as Anticancer Agents in Pediatric Oncology

This study details a comprehensive and critical review of what is known about the effects of cannabinoids on pediatric cancers...

Echocardiographic Myocardial Strain Analysis Describes Subclinical Cardiac Dysfunction After Craniospinal Irradiation in Pediatric and Young Adult Patients With Central Nervous System Tumors

Subclinical cardiac systolic dysfunction by GLS is present both early and late after CSI. 

CD79a Promotes CNS-Infiltration and Leukemia Engraftment in Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia

Central nervous system involvement remains a challenge in the diagnosis and treatment of acute lymphoblastic leukemia.

NTRK Fusions Identified in Pediatric Tumors: The Frequency, Fusion Partners, and Clinical Outcome

This study assesses the frequency, fusion partners, and clinical course in pediatric patients with NTRK fusion–positive tumors.


ASCO: Journal of Clinical Oncology: Table of Contents
Use of Antiangiogenic Therapies in Pediatric Solid Tumors

This review summarizes main antiangiogenic drugs, against which signaling pathways they are targeted, and the results that have been obtained from their use in pediatric patients.

Long-Term Treatment Outcomes of Children and Adolescents With Lymphoblastic Lymphoma Treated With Various Regimens

This study analyzes the outcomes of children and adolescents with LBL treated with various regimens.

Pediatric Hemato-Oncology Care Amid the COVID-19 Pandemic

The COVID-19 pandemic has created a parallel world of neglected non-COVID patients, especially, children with cancer and chronic blood disorders...

Targeted Sequencing to Identify Genetic Alterations and Prognostic Markers in Pediatric T-Cell Acute Lymphoblastic Leukemia

T-cell acute lymphoblastic leukemia is caused by the accumulation of multiple genetic alterations.

Scientific Reports
Gabapentin for Phantom Limb Pain After Amputation in Pediatric Oncology

This study aims to appraise the efficacy and safety of gabapentin for post-amputation phantom limb pain in pediatric oncology.

Outcomes After Late Bone Marrow and Very Early Central Nervous System Relapse of Childhood B-Acute Lymphoblastic Leukemia

Outcomes after relapse of childhood B-acute lymphoblastic leukemia are poor, and optimal therapy is unclear.

Targeting aurora kinases as a potential prognostic and therapeutical biomarkers in pediatric acute lymphoblastic leukaemia

The aim of this study was evaluated the mRNA expression profile of pediatric ALL patients and the efficacy of two AURKA and AURKB designed inhibitors in a...

Scientific Reports
Biomarker of Aggressive Childhood Cancer Discovered

Researchers discovered a new diagnostic marker that distinguishes a fast-growing type of the pediatric brain cancer medulloblastoma from a less-aggressive type.

Oncology Times - Latest Articles
Physical Activity for Pediatric Cancer Survivors: A Systematic Review of Randomized Controlled Trials

This study collates evidence and evaluates the effects of physical activity interventions on physical activity level among pediatric cancer survivors who had completed active cancer treatment.

Journal of Cancer Survivorship
Targeting Tumor-Associated Macrophages in the Pediatric Sarcoma Tumor Microenvironment

This review summarizes the mechanisms underlying TAM-facilitated immune evasion and tumorigenesis and discuss the potential therapeutic application of TAM-focused drugs in the...

Frontiers in Oncology
Vincristine-Induced Peripheral Neuropathy in Pediatric Oncology: A Randomized Controlled Trial Comparing Push Injections with One-Hour Infusions

This study examined children with cancer who receive vincristine chemotherapy as a one-hour infusion and compared them to children who received vincristine as a push injection.

CAR T cells for other pediatric non–B-cell hematologic malignancies

As CAR T-cell therapy has advanced in B-cell acute lymphoblastic leukemia, research is now underway to develop similar therapies for other lymphoid and myeloid malignancies for pediatric patients. 

Expression of Somatostatin Receptor Subtypes (SSTR-1–SSTR-5) in Pediatric Hematological and Oncological Disorders

This study aimed to investigate the expression of mRNA for SSTR subtypes in 15 pediatric hematological/oncological specimens by RT-PCR.

Biomarkers of cardiometabolic complications in survivors of childhood acute lymphoblastic leukemia

Survivors of childhood acute lymphoblastic leukemia are at higher risk of developing cardiometabolic complications.

Scientific Reports
Liquid Biomarkers for Pediatric Brain Tumors: Biological Features, Advantages and Perspectives

This review summarizes current knowledge on liquid biopsy markers and technologies in pediatric brain tumors, their advantages and drawbacks, as well as...

Improving Pediatric Neuro-Oncology Survival Disparities in the United States–Mexico Border Region: A Cross-Border Initiative Between San Diego, California, and Tijuana, Mexico

This study prospectively assessed clinicopathologic profiles, the extent of resection, progression-free survival, and overall survival in children with CNSTs at HGT from 2010 to 2017.

JCO Global Oncology
Role of implicit bias in pediatric cancer clinical trials and enrollment recommendations among pediatric oncology providers.

In the current study, the authors measured implicit bias training among pediatric oncology providers and exposure to implicit association tests. 

Candidemia in Children with Malignancies: Report from the Infection Working Group of the Hellenic Society of Pediatric Hematology-Oncology.

Candidemia is an important cause of morbidity and mortality especially in immunocompromised and hospitalized patients.

Journal of Fungi
Cutaneous manifestations in pediatric oncology patients.

The objective of this study was to evaluate the cutaneous findings in pediatric oncology patients receiving chemotherapy.

Pediatric Dermatology
Impact of the First Wave of COVID-19 on Pediatric Oncology and Hematology: A Report from the French Society of Pediatric Oncology.

The French society of pediatric oncology (SFCE) initiated a study to better describe COVID-19 in patients followed in French pediatric oncology and hematology wards.

Association between in-line filtration and Type I hypersensitivity reactions in pediatric oncology patients receiving intravenous etoposide.

The objective of this study was to describe hypersensitivity reactions with and without the use of in-line filters during intravenous etoposide therapy in pediatric oncology patients.

Pediatric Hematology and Oncology
Commonly Reported Adverse Events Associated With Pediatric Immunotherapy: A Systematic Review From the Children's Oncology Group.

The purpose of this systematic review was to review available evidence to: (a) identify commonly reported AEs associated with immunotherapy agents frequently used in...

Journal of Pediatric Oncology Nursing
Nurse-initiated protocols in the emergency department management of pediatric oncology patients with fever and suspected neutropenia: a scoping review protocol.

This study provides an overview of the existing evidence regarding nurse-initiated protocols in the emergency department management of pediatric oncology patients...

JBI evidence synthesis
Implications of Tumor Characteristics and Treatment Modality on Local Recurrence and Functional Outcomes in Children with Chest Wall Sarcoma: A Pediatric Surgical Oncology Research Collaborative Study.

Children with chest wall sarcoma require multimodal therapy including chemotherapy, surgery and/or radiation.

Annals of Surgery
Towards homogenization of total body irradiation practices in pediatric patients across SIOPE affiliated centers a survey by the SIOPE radiation oncology working group.

The study purpose was to evaluate clinical practices regarding TBI, such as fractionation, organ shielding and delivery techniques, among SIOPE affiliated radiotherapy centers.

Radiotherapy and Oncology
Changes in hair cortisol and self-reported stress measures following mindfulness-based stress reduction (MBSR): A proof-of-concept study in pediatric hematology-oncology professionals

Little data is available on the effect of mindfulness amongst pediatric hematology-oncology professionals.

Complementary Therapies in Clinical Practice
Emerging hyperthermia applications for pediatric oncology

This review summarizes the state of current applications of hyperthermia in pediatric oncology and discusses the use of hyperthermia in the context of other available treatments and promising pre-c

Advanced Drug Delivery Reviews
Custom Pediatric Oncology NGS Panel Identifies Somatic Mosaicism in Archival Tissue and Enhances Targeted Clinical Care

Disorders in the PIK3CA-related overgrowth spectrum due to somatic mosaicism are associated with segmental overgrowth of the body in conjunction with vascular, skeletal...

Pediatric Neurology
Pediatric CNS Tumor Patients Have Significantly Lower Requirement of Tissue Plasminogen Activator for Episodes of Central Venous Catheter Dysfunction Compared With Other Pediatric Oncology Patients: Results of a Population-based Cohort Study.

The goal of this study was to investigate the CVC experience and use of tPA for episodes of CVC dysfunction in pediatric patients with CNS tumors in comparison with other patients.

Journal of Pediatric Hematology Oncology
Platelet transfusion practice and platelet refractoriness for a cohort of pediatric oncology patients: A single-center study.

Platelet transfusions are an essential aspect of supportive care for pediatric oncology patients.

Pediatric Blood &amp
Evaluation of Inflammatory Biomarkers in Pediatric Hematology-Oncology Patients With Bloodstream Infection.

Bloodstream infection is a serious complication in pediatric hematology-oncology patients.

Journal of Pediatric Hematology Oncology
Incorporating Absolute Phagocyte Count With Absolute Neutrophil Count as a Measure for Safe Discharge for Pediatric Oncology Febrile Neutropenia: A Pilot Study.

Adequate bone marrow recovery is a discharge requirement after admission for febrile neutropenia in oncology patients, without specific threshold in consensus guidelines.

Journal of Pediatric Hematology Oncology
Socialization of Coping in Pediatric Oncology Settings: Theoretical Consideration on Parent-Child Connections in Posttraumatic Growth.

This theoretical article aims to summarize the results of studies relevant parental influence on coping with childhood cancer and provide implications for future research focused...

Frontiers in Psychology
Relationship-centered communication training for pediatric hematology/oncology providers to improve patient experience

This study evaluates the efficacy of this intervention to improve patient/family experience in healthcare encounters.

Authorea Preprints
Coping and Social Adjustment in Pediatric Oncology: From Diagnosis to 12 Months.

This study investigated the association between coping with cancer-related stress and problems in social adjustment across the first year after a pediatric cancer diagnosis.

Journal of Pediatric Psychology
Much is left unspoken: Self-reports from families in pediatric oncology.

The aim of this study was to explore how families in pediatric oncology experienced illness‐related information and communication with professionals and within the family.

Pediatric Blood &amp
Current challenges facing pediatric radiation oncology viewed through an economics lens.

Because cancer in children is relatively infrequent and the role of pediatric RT is limited, there are a small number of cases of children requiring RT in the US compared to the number of...

Pediatric Blood &amp
Impact of a Best Practice Prevention Bundle on Central Line-associated Bloodstream Infection (CLABSI) Rates and Outcomes in Pediatric Hematology, Oncology, and Hematopoietic Cell Transplantation Patients in Inpatient and Ambulatory Settings.

The authors sought to evaluate the influence of a standardized best practice CVC maintenance bundle on the burden of and risk factors for...

Journal of Pediatric Hematology Oncology
Validating an opioid prescribing algorithm in post-operative pediatric surgical oncology patients

The authors of this study developed an algorithm to decrease opioid prescriptions for pediatric oncology patients at discharge following surgery, based on a retrospective analysis to...

Journal of Pediatric Surgery
Development of an Integrative Care Program in a Pediatric Oncology Unit.

This article describes what needs be considered in implementing care practices, in this case an integrative care program consisting of anthroposophic treatments, in an ICU of a teaching hospital.

Complementary Medicine Research
Subcutaneous Analgesic System versus Epidural for Post-Operative Pain Control in Surgical Pediatric Oncology Patients

A surgeon-placed subcutaneous analgesic system may be able to provide equivalent pain control epidural analgesia for pediatric oncology patients undergoing open operations with...

Journal of Pediatric Surgery
Pharmacogenomics in Pediatric Oncology: Mitigating Adverse Drug Reactions While Preserving Efficacy

Cancer is the leading cause of death in American children older than year age.

Annual Review of Pharmacology and Toxicology
Guidance for Pediatric Hematology-Oncology (PHO) and Hematopoietic Stem Cell Transplant Services during COVID-19 Pandemic: A Consensus Statement by PHO Chapter of Indian Academy of Pediatrics

With the recent Pandemic of Covid-19 affecting more than 180 countries across the globe, services to children with blood disorders and cancers are likely to be affected.


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