Developing a Metabolic Therapy for Osteosarcoma

Tumor metabolism consists of a series of interconnected pathways that generate the amino acids, nucleotides, lipids, and cofactors required for cellular growth and proliferation, redox homeostasis.

Oncology Times - Latest Articles
Imaging Features and Radiologic-Pathologic Correlations of Inflammatory Pseudotumor-Like Follicular Dendritic Cell Sarcoma

This study aims to reveal the radiological characteristics of IPT-like FDCS by radiologic-pathologic correlation.

BMC Medical Imaging
Rechallenge With Multi-Targeted Tyrosine Kinase Inhibitors in Patients With Advanced Soft Tissue Sarcoma

This retrospective study investigates the efficacy and safety of multi-targeted TKI rechallenge in patients with advanced soft tissue sarcoma after the failure of previous TKI treatment.

Cancer Management and Research

The Feasibility Study of Hypofractionated Radiotherapy with Regional Hyperthermia in Soft Tissue Sarcomas

The recommended management of marginally resectable or unresectable soft tissue sarcomas is an attempt of neoadjuvant therapy.

Postradiation Fractures after Combined Modality Treatment in Extremity Soft Tissue Sarcomas

This literature reviews the mechanisms, risk factors, and treatment challenges associated with postradiation fractures in STS patients.

Impact of Carbon Ion Radiotherapy on Inoperable Bone Sarcoma

This study analyzes the clinical outcomes and prognostic factors among patients with unresectable bone sarcoma who were treated with C-ion RT.

CD11c-CD8 Spatial Cross Presentation: A Novel Approach to Link Immune Surveillance and Patient Survival in Soft Tissue Sarcoma

With the concept of cellular cross presentation in mind, the present study supports the hypothesis that CD11c+ cells in direct cell-cell contact with CD8+ T cells within the primary tumor are...

Integrated Analysis of lncRNA–miRNA–mRNA ceRNA Network and the Potential Prognosis Indicators in Sarcomas

This study identifies differentially expressed mRNAs, lncRNAs and miRNAs in sarcomas by comparing the gene expression profiles between sarcoma and normal muscle samples...

The Relationship Between the Expression of Ki-67 and the Prognosis of Osteosarcoma

Study investigators conduct an analysis using a meta-analysis and a TCGA dataset to estimate the value of Ki-67 expression in the prognosis of osteosarcoma.

BMC Cancer
Retroperitoneal Dendritic Cell Sarcoma

Interdigitating dendritic cell sarcoma is a rare sarcoma that originates from interdigitating dendritic cells in lymphoid tissue, the imaging characteristics of which are poorly defined.

Candidate Biomarkers for Specific Intraoperative Near-Infrared Imaging of Soft Tissue Sarcomas

This review searches the literature to find candidate biomarkers for soft tissue sarcomas, based on clinically used therapeutic antibodies.

Pulmonary Pleomorphic Carcinoma Mimicking Primary Sarcoma of the Neck

Study investigators describe the challenge in diagnosing an unusual and rapidly progressing case of pulmonary pleomorphic carcinoma.

HIV-Associated Cutaneous Kaposi's Sarcoma

This is a case report of cutaneous KS in a 31-year-old male with an unknown positive HIV status.

PDX-Derived Ewing’s Sarcoma Cells Retain High Viability and Disease Phenotype in Alginate Encapsulated Spheroid Cultures

Study investigators implement a 3D cell culture methodology based on encapsulation of PDX-derived ES cell spheroids in alginate and maintenance in agitation-based culture systems.

Diagnosis and Surgical Treatment of Primary Isolated Aggressive Lumbar Myeloid Sarcoma

The present case study aims to understand the diagnosis and surgical treatment of a rare primary isolated myeloid sarcoma of the lumbar spine...

BMC Musculoskeletal Disorders
V-Raf Murine Sarcoma Viral Oncogene Homolog B1 as a Prognostic Biomarker of Poor Outcomes in Esophageal Cancer Patients

This study investigates the protein expression of BRAF in esophageal cancer and determine its effect on patient outcomes.

BMC Gastroenterology
Identification of Tumor Microenvironment-Related Prognostic Genes in Sarcoma

The aim of the current study is to identify TME related gene signatures related to the prognosis of sarcoma by using the data from The Cancer Genome Atlas.

Frontiers in Genetics
Prognostic and Therapeutic Utility of Variably Expressed Cell Surface Receptors in Osteosarcoma

The current study seeks to validate previous expression patterns and evaluate whether these receptors offer prognostic and/or therapeutic value.

Efficacy of Pazopanib With or Without Gemcitabine in Patients With Anthracycline- and/or Ifosfamide-Refractory Soft Tissue Sarcoma

This study further examined the tolerability and efficacy of pazopanib and gemcitabine compared with pazopanib alone in pretreated soft tissue sarcoma. 

JAMA Oncology
Expression and Prognostic Significance of PDGF Ligands and Receptors Across Soft Tissue Sarcomas

As the level of expression and the prognosis of platelet-derived growth factor receptors and ligands in STS remain unclear, this study examines the topic.

Low-Grade Fibromyxoid Sarcoma Incidentally Discovered as an Asymptomatic Mediastinal Mass

The most common anatomic locations of occurrence are the lower extremities, thorax, inguinal area, and upper limbs. Primary mediastinal sarcomas are even rarer. 

Spindle Cell Sarcoma: A Rare Cause of a Spontaneous Pneumothorax

This study presents a case of an asymptomatic spontaneous pneumothorax in a 71‐year‐old never‐smoking woman. Her final diagnosis was a primary spindle cell sarcoma of the pleura. This case...

Development and Validation of an Immune Gene-Set Based Prognostic Signature for Soft Tissue Sarcoma

The present study aims to identify the prognostic value of immune-related genes in sarcoma and establish a prognostic signature based on IRGs.

BMC Cancer
Exploiting Gangliosides for the Therapy of Ewing’s Sarcoma and H3K27M-Mutant Diffuse Midline Glioma

Study investigators repurpose the existing drugs dinutuximab and eliglustat and investigated their potential to directly target or indirectly modulate the tumor cell-specific ganglioside GD2.

The Sarcoma Immune Landscape: Emerging Challenges, Prognostic Significance and Prospective Impact for Immunotherapy Approaches

This article gathers the available data on the specific immune tumor microenvironment of sarcoma and the immunotherapeutic strategies currently under investigation.

Lack of Electron Acceptors Contributes to Redox Stress and Growth Arrest in Asparagine-Starved Sarcoma Cells

This study investigates why the non-essential amino acid asparagine is important for cancer growth by examining metabolite composition in asparagine-deprived sarcoma cells compared to...

Immunotherapy for Sarcomas: New Frontiers and Unveiled Opportunities

This study discusses preclinical and clinical data highlighting how immunotherapy is being used in soft tissue sarcoma and bone sarcomas.

The Age-Related Impact of Surviving Sarcoma on Health-Related Quality of Life

An aim of this study is to compare HRQoL of each sarcoma survivor age group with an age- and sex-matched normative population sample.

Sarcoma Classification by DNA Methylation Profiling

This study demonstrates classification of soft tissue and bone tumors using a machine learning classifier algorithm based on array-generated DNA methylation data.

Immune Checkpoint Inhibitory Therapy in Sarcomas: Is There Light at the End of the Tunnel?

This study presents all the available published information from clinical trials about the results of using immune checkpoint blockade as a therapeutic agent in sarcomas.

Identification of Iron Metabolism-Related Gene Signatures for Predicting the Prognosis of Patients With Sarcomas

Study investigators construct two IMRG-based prognostic models that can effectively predict the OS and DFS of sarcoma patients.

Frontiers in Oncology
Immunological Status of Peripheral Blood is Associated With Prognosis in Patients With Bone and Soft-Tissue Sarcoma

The present study aims to clarify the immunological status of peripheral blood samples derived from patients with bone sarcoma and STS.

YAP/TAZ Inhibition Reduces Metastatic Potential of Ewing Sarcoma Cells

Study investigators test the effects of the potent YAP/TAZ/TEAD complex inhibitor verteporfin on EwS cell migration in vitro and on metastasis in vivo.

A Daily Diagnostic Multidisciplinary Meeting to Reduce Time to Definitive Diagnosis in the Context of Primary Bone and Soft Tissue Sarcoma

This study provides an evaluation of investigator's daily diagnostic multidisciplinary team meeting focusing on the improvement made to the diagnostic pathway and the overall impact on time...

Liver Transplantation in Locally Unresectable, Undifferentiated Embryonal Cell Sarcoma

This systematic review explores the practicality of liver transplantation as a viable option in the treatment armamentarium for locally advanced undifferentiated embryonal cell sarcoma.

Contrast-Enhanced Ultrasound Diagnosis of Prostatic Sarcoma

This study reports on a 64-year-old patient with PS and a 36-year-old patient with Ewing's sarcoma, both of whom were examined by contrast-enhanced ultrasonography before surgery.

Predicted CD4+ T Cell Infiltration Levels Could Indicate Better Overall Survival in Sarcoma Patients

The aim of this bioinformatics study is to explore the effect of TILs on sarcoma survival and genome alterations.

Systematic Profiling of Diagnostic and Prognostic Value of Autophagy-Related Genes for Sarcoma Patients

This study examined a systematic analysis of ARGs and their clinical significance in sarcoma patients. 

BMC Cancer
Intrapulmonary Solitary Fibrous Tumor With Adenofibromatous Pattern With Features of Pleomorphic High Grade Sarcoma

This study reports a case of an intrapulmonary SFT with an adenofibromatous pattern and areas with high grade histology resembling pleomorphic sarcoma.

A Prognostic Molecular Signature of N6-Methyladenosine Methylation Regulators for Soft-Tissue Sarcoma from The Cancer Genome Atlas Database

This study aims to identify the molecular signatures of N6-methyladenosine methylation regulators associated with patient prognosis using The Cancer Genome Atlas database.

Actual Long-Term Survival After Resection of Stage III Soft Tissue Sarcoma

This study aims to characterize the clinicopathological characteristics associated with actual long-term survival in patients with stage III soft tissue sarcoma.

BMC Cancer
Multimodal Risk-Adapted Treatment in Surgical Patients With Synovial Sarcoma: A Preoperative Nomogram-Guided Adjuvant Treatment Strategy

Study investigators established an effective preoperative nomogram to predict CSS and present a risk-adapted adjuvant treatment strategy in surgical patients with synovial sarcoma.

Will Virtual Multidisciplinary Team Meetings Become the Norm for Musculoskeletal Oncology Care Following the COVID-19 Pandemic?

Like with all cancers, multidisciplinary team meetings are the norm in bone and soft tissue tumour management too.

Efficacy of hyperthermic isolated limb perfusion in the treatment of locally recurrent high-grade soft tissue sarcoma of the extremities

This novel study compared the use of tumor necrosis factor-alpha and melphalan-based isolated limb perfusion to the standard treatment of locally recurrent soft tissue extremity sarcoma.

Eribulin as a first-line treatment for soft tissue sarcoma patients with contraindications for doxorubicin

This study retrospectively analyzed the efficacy and safety of first-line eribulin therapy for patients with advanced STS unable to receive doxorubicin.

Scientific Reports
Eltrombopag inhibits the proliferation of Ewing sarcoma cells via iron chelation and impaired DNA replication

There is an urgent need to identify novel therapies that will improve outcomes for children and adults with Ewing sarcoma tumors while also decreasing treatment-related toxicities.

BMC Cancer
Assessing immune infiltration and the tumor microenvironment for the diagnosis and prognosis of sarcoma

This study characterized infiltrating immune cells and analyze immune scores to identify the molecular mechanism of immunologic response to sarcomas.

Psychological adaptation and recovery in youth with sarcoma: a qualitative study with practical implications for clinical care and research

This study explored factors that play a role in psychological adaptation and recovery of young people with sarcoma.

BMJ Open
Continuous 14 Day Infusional Ifosfamide for Management of Soft-Tissue and Bone Sarcoma: A Single Centre Retrospective Cohort Analysis

This study describes the efficacy and toxicity profile of 14-day continuous infusional ifosfamide in adult and teenage young adult patients with relapsed or metastatic soft-tissue and bone sarcoma.

Unravelling the heterogeneity of soft tissue and bone sarcoma patients’ health-related quality of life: a systematic literature review with focus on tumour location

This review aims to unravel the heterogeneity of HRQoL of patients with sarcoma with regard to tumor location and to summarize the used measures in research.

Relationship between PDGFR expression and the response to pazopanib in intimal sarcoma of the pulmonary artery: A case report.

The present study reports findings related to two cases of PAIS with PDGF and VEGF expression following treatment with pazopanib.

Current Opinion in Clinical Nutrition and Metabolic Care
Incidence of radiation induced sarcoma attributable to radiotherapy in adults: A retrospective cohort study in the SEER cancer registries across 17 primary tumor sites.

Previous studies have noted the incidence of radiation-induced sarcomas but have not investigated the relative risk of developing RIS based on primary tumor organ disease site.

Cancer Epidemiology
A Fatal Case of Kaposi Sarcoma Immune Reconstitution Syndrome Complicated by Kaposi Sarcoma Inflammatory Cytokine Syndrome or Multicentric Castleman Disease

Kaposi sarcoma-associated herpesvirus or human herpesvirus 8 is the etiological agent for a heterogeneous group of human disorders. 

American Journal of Case Reports
GDF6-CD99 Signaling Regulates Src and Ewing Sarcoma Growth

This study reported the autocrine signaling mediated by growth and differentiation factor 6, a member of the bone morphogenetic protein family of cytokines, maintains...

Multi-omics analysis of copy number variations of RNA regulatory genes in soft tissue sarcoma

RNA regulatory genes were closely associated with tumorigenesis and prognosis in multiple tumors. Copy number variation is a frequent characteristic in soft tissue sarcomas.

Life Sciences
Primary cardiac synovial sarcoma: a clinicopathological, immunohistochemical, and molecular genetics study of five clinical cases.

Primary cardiac synovial sarcoma was an exceedingly rare tumor that less reported.

Cardiovascular Pathology
Targeted RNA expression profiling identifies high-grade endometrial stromal sarcoma as a clinically relevant molecular subtype of uterine sarcoma.

High-grade endometrial stromal sarcoma may harbor YWHAE-NUTM2A/B fusion, ZC3H7B-BCOR fusion, and BCOR internal tandem duplication.

Modern Pathology
Femoral Fracture in Primary Soft Tissue Sarcoma Treated with Intensity-Modulated Radiation Therapy with and Without Dose Constraints.

In the current study, the authors sought to evaluate the effect of radiation dose constraints on the rate of femoral fracture in a more contemporary cohort.

Annals of Surgical Oncology
Has the Outcome for Patients Who Undergo Resection of Primary Retroperitoneal Sarcoma Changed Over Time? A Study of Time Trends During the Past 15 years.

This study aimed to investigate changes in treatment strategy and outcome for patients with primary retroperitoneal sarcoma undergoing resection at referral centers during a recent period.

Annals of Surgical Oncology
Incidence of Kaposi Sarcoma in Sweden is Decreasing.

Using data from the Swedish Cancer Registry, this study examined the incidence rates and survival for Kaposi sarcoma in Sweden from 1993 to 2016.

Acta Dermato-venereologica
Identification of a survival-related signature for sarcoma patients through integrated transcriptomic and proteomic profiling analyses.

SARC represents a group of highly histological and molecular heterogeneous rare malignant tumors with poor prognosis. There are few proposed classifiers for predicting patient’s outcome.

Adrenal crisis and death following transarterial chemoembolization of sarcoma liver metastases.

A report on a case of a patient with metastatic sarcoma and adrenal insufficiency who underwent right hepatic artery chemoembolization to control his intrahepatic metastases.

Clinical Imaging
Radiotherapy is Associated With Improved Survival in Patients With Synovial Sarcoma Undergoing Surgery: A National Cancer Database Analysis

In this study, the authors sought to further analyze this association using a hospital-based data set where data on chemotherapy administration and surgical margin status are available.

Journal of Surgical Research
Evaluation of immune-biomarker expression in high-grade soft-tissue sarcoma: HLA-DQA1 expression as a prognostic marker.

The present study was performed to evaluate the expression of immune‑associated genes and to elucidate the association between these genes and the prognosis in high‑grade STS.

Experimental and Therapeutic Medicine
Paraneoplastic Pemphigus Associated with Bilateral Corneal Perforations in Follicular Dendritic Cell Sarcoma.

The study's purpose is to describe a case of PNP presenting as spontaneous bilateral corneal perforations in a patient with follicular dendritic cell sarcoma.

Ocular Immunology and Inflammation
Uterine sarcoma with posterior reversible encephalopathy syndrome associated with pazopanib.

The case objective is to report on a case of posterior reversible encephalopathy syndrome associated with pazopanib.

Journal of Clinical Pharmacy and Therapeutics
A case report of rare isolated Ewing sarcoma of left maxillary sinus

Ewing sarcoma is a malignant round cell neoplasm and categorized as part of family tumor (EFT).

The Egyptian Journal of Otolaryngology
Treatment Patterns and Distance to Treatment Facility for Soft Tissue Sarcoma of the Extremity

The impact that distance traveled to receive treatment has on treatments and outcomes among patients with STS of the extremity has yet to be thoroughly investigated.

Journal of Surgical Research
Assessment of Doxorubicin and Pembrolizumab in Patients With Advanced Anthracycline-Naive Sarcoma: A Phase 1/2 Nonrandomized Clinical Trial

In this nonrandomized phase 1/2 clinical trial of 37 patients with advanced sarcoma, the combination of doxorubicin and pembrolizumab was well tolerated.

JAMA Oncology
Nivolumab/Ipilimumab Established as New Standard in Frontline sRCC

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