Long-Term Safety Data Support Benefit-Risk Profile of NBTXR3 Plus Radiotherapy in Locally Advanced Soft Tissue Sarcoma

Treatment of LA-STS with the radio-enhancer NBTXR3 plus RT did not negatively impact quality of life or long-term morbidity, according to results of the phase 2/3 ACT.IN.SARC trial...

Cancer Therapy Advisor
Doxorubicin/Adriamycin Monotherapy or Plus Ifosfamide in First-Line Treatment for Advanced Soft Tissue Sarcoma

Researchers conducted a pooled analysis to comprehensively compare the efficacy and tolerability between AI and ADM in patients with previously untreated ASTS.

Frontiers in Oncology
Evaluating Thresholds to Adopt Hypofractionated Preoperative Radiotherapy as Standard of Care in Sarcoma

This research sought to understand the type and thresholds of clinical evidence required for experts to adopt hypofractionated RT as a standard-of-care option for patients with STS.


Bioinformatics Analysis of ZBTB16 as a Prognostic Marker for Ewing's Sarcoma

The purpose of this study was to identify novel biomarkers for the prognosis of Ewing's sarcoma based on bioinformatics analysis.

BioMed Research International
Phase II Study of Dacarbazine Given With Modern Prophylactic Anti-Emetics and Growth Factor Support to Patients With Metastatic, Resistant Soft Tissue, and Bone Sarcoma

Investigators hypothesized that administration of potent prophylactic anti-emetics and growth factors with dacarbazine would markedly reduce the proportion of patients who experience...

Rare Tumors
MYL2 as a Potential Predictive Biomarker for Rhabdomyosarcoma

The discovery of biomarker is expected to be the direction of targeted therapy, providing a new direction for the precise treatment of RMS.

TRIM8 Modulates the EWS/FLI Oncoprotein to Promote Survival in Ewing Sarcoma

This study provided a tractable strategy to therapeutically exploit oncogene overdose in Ewing sarcoma and potentially other fusion-TF-driven cancers.

Cancer Cell
Lenvatinib With Etoposide Plus Ifosfamide in Patients With R/R Osteosarcoma

Investigators determine the recommended phase 2 dose and antitumour activity of lenvatinib with etoposide plus ifosfamide in patients with refractory or relapsed osteosarcoma.

The Lancet Oncology
Clinical Outcomes of Frozen Autograft Reconstruction For the Treatment of Primary Bone Sarcoma in Adolescents and Young Adults

This study's purpose is to evaluate the clinical outcomes of the frozen autograft reconstruction focusing on skeletally mature adolescents and young adults ranging from 15 to 39 years of age.

Scientific Reports
Treatment Approaches Differ by Age Group in Extremity Soft Tissue Sarcoma

Young adults with extremity soft tissue sarcoma were more likely to receive chemotherapy and less likely to receive radiation compared with their older counterparts.

Cancer Therapy Advisor
New Guideline on Radiation Therapy for Soft Tissue Sarcoma in Adults

Recommendations outline optimal radiation dosing, techniques, and treatment planning for patients with localized, operable STS of the trunk and extremities, with a focus on...

Oncology Times - Latest Articles
Addition of Prime-Boost Vaccination Regimen to Atezolizumab in Soft-Tissue Sarcomas Expressing NY-ESO-1

Study investigators find that the addition of the heterologous prime-boost vaccination regimen CMB305 to atezolizumab did not improve survival outcomes in patients with STS expressing...

The ASCO Post
Relationship Between Ultrasound Features and Ki-67 Labeling Index of Soft Tissue Sarcoma

This study explores the relationship between ultrasound features and Ki-67 labeling index of soft tissue sarcoma.

Frontiers in Oncology
Proteomic Profiling of Soft Tissue Sarcomas With SWATH Mass Spectrometry

While large-scale genomic and epigenomic profiling of soft tissue sarcomas have been undertaken, proteomic analysis has thus far been limited.

Journal of Proteomics
Deep Learning for Diagnosis and Survival Prediction in Soft Tissue Sarcoma

Clinical management of soft tissue sarcoma is particularly challenging. Here, investigators use digital pathology and deep learning for diagnosis and prognosis prediction of STS.

Annals of Oncology
Radiation Therapy for Chemotherapy Refractory Gingival Myeloid Sarcoma

Study investigators present a single institution retrospective observational study of adult patients treated with palliative RT for chemotherapy refractory gingival myeloid sarcoma.

Frontiers in Oncology
Developing a Metabolic Therapy for Osteosarcoma

Tumor metabolism consists of a series of interconnected pathways that generate the amino acids, nucleotides, lipids, and cofactors required for cellular growth and proliferation, redox homeostasis.

Oncology Times - Latest Articles
Rechallenge With Multi-Targeted Tyrosine Kinase Inhibitors in Patients With Advanced Soft Tissue Sarcoma

This retrospective study investigates the efficacy and safety of multi-targeted TKI rechallenge in patients with advanced soft tissue sarcoma after the failure of previous TKI treatment.

Cancer Management and Research
Imaging Features and Radiologic-Pathologic Correlations of Inflammatory Pseudotumor-Like Follicular Dendritic Cell Sarcoma

This study aims to reveal the radiological characteristics of IPT-like FDCS by radiologic-pathologic correlation.

BMC Medical Imaging
The Feasibility Study of Hypofractionated Radiotherapy with Regional Hyperthermia in Soft Tissue Sarcomas

The recommended management of marginally resectable or unresectable soft tissue sarcomas is an attempt of neoadjuvant therapy.

Postradiation Fractures after Combined Modality Treatment in Extremity Soft Tissue Sarcomas

This literature reviews the mechanisms, risk factors, and treatment challenges associated with postradiation fractures in STS patients.

CD11c-CD8 Spatial Cross Presentation: A Novel Approach to Link Immune Surveillance and Patient Survival in Soft Tissue Sarcoma

With the concept of cellular cross presentation in mind, the present study supports the hypothesis that CD11c+ cells in direct cell-cell contact with CD8+ T cells within the primary tumor are...

Impact of Carbon Ion Radiotherapy on Inoperable Bone Sarcoma

This study analyzes the clinical outcomes and prognostic factors among patients with unresectable bone sarcoma who were treated with C-ion RT.

Integrated Analysis of lncRNA–miRNA–mRNA ceRNA Network and the Potential Prognosis Indicators in Sarcomas

This study identifies differentially expressed mRNAs, lncRNAs and miRNAs in sarcomas by comparing the gene expression profiles between sarcoma and normal muscle samples...

The Relationship Between the Expression of Ki-67 and the Prognosis of Osteosarcoma

Study investigators conduct an analysis using a meta-analysis and a TCGA dataset to estimate the value of Ki-67 expression in the prognosis of osteosarcoma.

BMC Cancer
Retroperitoneal Dendritic Cell Sarcoma

Interdigitating dendritic cell sarcoma is a rare sarcoma that originates from interdigitating dendritic cells in lymphoid tissue, the imaging characteristics of which are poorly defined.

Pulmonary Pleomorphic Carcinoma Mimicking Primary Sarcoma of the Neck

Study investigators describe the challenge in diagnosing an unusual and rapidly progressing case of pulmonary pleomorphic carcinoma.

HIV-Associated Cutaneous Kaposi's Sarcoma

This is a case report of cutaneous KS in a 31-year-old male with an unknown positive HIV status.

PDX-Derived Ewing’s Sarcoma Cells Retain High Viability and Disease Phenotype in Alginate Encapsulated Spheroid Cultures

Study investigators implement a 3D cell culture methodology based on encapsulation of PDX-derived ES cell spheroids in alginate and maintenance in agitation-based culture systems.

Diagnosis and Surgical Treatment of Primary Isolated Aggressive Lumbar Myeloid Sarcoma

The present case study aims to understand the diagnosis and surgical treatment of a rare primary isolated myeloid sarcoma of the lumbar spine...

BMC Musculoskeletal Disorders
V-Raf Murine Sarcoma Viral Oncogene Homolog B1 as a Prognostic Biomarker of Poor Outcomes in Esophageal Cancer Patients

This study investigates the protein expression of BRAF in esophageal cancer and determine its effect on patient outcomes.

BMC Gastroenterology
Efficacy of Pazopanib With or Without Gemcitabine in Patients With Anthracycline- and/or Ifosfamide-Refractory Soft Tissue Sarcoma

This study further examined the tolerability and efficacy of pazopanib and gemcitabine compared with pazopanib alone in pretreated soft tissue sarcoma. 

JAMA Oncology
Prognostic and Therapeutic Utility of Variably Expressed Cell Surface Receptors in Osteosarcoma

The current study seeks to validate previous expression patterns and evaluate whether these receptors offer prognostic and/or therapeutic value.


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