Addition of Prime-Boost Vaccination Regimen to Atezolizumab in Soft-Tissue Sarcomas Expressing NY-ESO-1

Study investigators find that the addition of the heterologous prime-boost vaccination regimen CMB305 to atezolizumab did not improve survival outcomes in patients with STS expressing...

The ASCO Post
Relationship Between Ultrasound Features and Ki-67 Labeling Index of Soft Tissue Sarcoma

This study explores the relationship between ultrasound features and Ki-67 labeling index of soft tissue sarcoma.

Frontiers in Oncology
Proteomic Profiling of Soft Tissue Sarcomas With SWATH Mass Spectrometry

While large-scale genomic and epigenomic profiling of soft tissue sarcomas have been undertaken, proteomic analysis has thus far been limited.

Journal of Proteomics

Deep Learning for Diagnosis and Survival Prediction in Soft Tissue Sarcoma

Clinical management of soft tissue sarcoma is particularly challenging. Here, investigators use digital pathology and deep learning for diagnosis and prognosis prediction of STS.

Annals of Oncology
Radiation Therapy for Chemotherapy Refractory Gingival Myeloid Sarcoma

Study investigators present a single institution retrospective observational study of adult patients treated with palliative RT for chemotherapy refractory gingival myeloid sarcoma.

Frontiers in Oncology
Developing a Metabolic Therapy for Osteosarcoma

Tumor metabolism consists of a series of interconnected pathways that generate the amino acids, nucleotides, lipids, and cofactors required for cellular growth and proliferation, redox homeostasis.

Oncology Times - Latest Articles
Rechallenge With Multi-Targeted Tyrosine Kinase Inhibitors in Patients With Advanced Soft Tissue Sarcoma

This retrospective study investigates the efficacy and safety of multi-targeted TKI rechallenge in patients with advanced soft tissue sarcoma after the failure of previous TKI treatment.

Cancer Management and Research
Imaging Features and Radiologic-Pathologic Correlations of Inflammatory Pseudotumor-Like Follicular Dendritic Cell Sarcoma

This study aims to reveal the radiological characteristics of IPT-like FDCS by radiologic-pathologic correlation.

BMC Medical Imaging
The Feasibility Study of Hypofractionated Radiotherapy with Regional Hyperthermia in Soft Tissue Sarcomas

The recommended management of marginally resectable or unresectable soft tissue sarcomas is an attempt of neoadjuvant therapy.

Postradiation Fractures after Combined Modality Treatment in Extremity Soft Tissue Sarcomas

This literature reviews the mechanisms, risk factors, and treatment challenges associated with postradiation fractures in STS patients.

CD11c-CD8 Spatial Cross Presentation: A Novel Approach to Link Immune Surveillance and Patient Survival in Soft Tissue Sarcoma

With the concept of cellular cross presentation in mind, the present study supports the hypothesis that CD11c+ cells in direct cell-cell contact with CD8+ T cells within the primary tumor are...

Impact of Carbon Ion Radiotherapy on Inoperable Bone Sarcoma

This study analyzes the clinical outcomes and prognostic factors among patients with unresectable bone sarcoma who were treated with C-ion RT.

Integrated Analysis of lncRNA–miRNA–mRNA ceRNA Network and the Potential Prognosis Indicators in Sarcomas

This study identifies differentially expressed mRNAs, lncRNAs and miRNAs in sarcomas by comparing the gene expression profiles between sarcoma and normal muscle samples...

The Relationship Between the Expression of Ki-67 and the Prognosis of Osteosarcoma

Study investigators conduct an analysis using a meta-analysis and a TCGA dataset to estimate the value of Ki-67 expression in the prognosis of osteosarcoma.

BMC Cancer
Retroperitoneal Dendritic Cell Sarcoma

Interdigitating dendritic cell sarcoma is a rare sarcoma that originates from interdigitating dendritic cells in lymphoid tissue, the imaging characteristics of which are poorly defined.

Pulmonary Pleomorphic Carcinoma Mimicking Primary Sarcoma of the Neck

Study investigators describe the challenge in diagnosing an unusual and rapidly progressing case of pulmonary pleomorphic carcinoma.

HIV-Associated Cutaneous Kaposi's Sarcoma

This is a case report of cutaneous KS in a 31-year-old male with an unknown positive HIV status.

PDX-Derived Ewing’s Sarcoma Cells Retain High Viability and Disease Phenotype in Alginate Encapsulated Spheroid Cultures

Study investigators implement a 3D cell culture methodology based on encapsulation of PDX-derived ES cell spheroids in alginate and maintenance in agitation-based culture systems.

Diagnosis and Surgical Treatment of Primary Isolated Aggressive Lumbar Myeloid Sarcoma

The present case study aims to understand the diagnosis and surgical treatment of a rare primary isolated myeloid sarcoma of the lumbar spine...

BMC Musculoskeletal Disorders
V-Raf Murine Sarcoma Viral Oncogene Homolog B1 as a Prognostic Biomarker of Poor Outcomes in Esophageal Cancer Patients

This study investigates the protein expression of BRAF in esophageal cancer and determine its effect on patient outcomes.

BMC Gastroenterology
Efficacy of Pazopanib With or Without Gemcitabine in Patients With Anthracycline- and/or Ifosfamide-Refractory Soft Tissue Sarcoma

This study further examined the tolerability and efficacy of pazopanib and gemcitabine compared with pazopanib alone in pretreated soft tissue sarcoma. 

JAMA Oncology
Prognostic and Therapeutic Utility of Variably Expressed Cell Surface Receptors in Osteosarcoma

The current study seeks to validate previous expression patterns and evaluate whether these receptors offer prognostic and/or therapeutic value.

Identification of Tumor Microenvironment-Related Prognostic Genes in Sarcoma

The aim of the current study is to identify TME related gene signatures related to the prognosis of sarcoma by using the data from The Cancer Genome Atlas.

Frontiers in Genetics
Expression and Prognostic Significance of PDGF Ligands and Receptors Across Soft Tissue Sarcomas

As the level of expression and the prognosis of platelet-derived growth factor receptors and ligands in STS remain unclear, this study examines the topic.

Candidate Biomarkers for Specific Intraoperative Near-Infrared Imaging of Soft Tissue Sarcomas

This review searches the literature to find candidate biomarkers for soft tissue sarcomas, based on clinically used therapeutic antibodies.

Spindle Cell Sarcoma: A Rare Cause of a Spontaneous Pneumothorax

This study presents a case of an asymptomatic spontaneous pneumothorax in a 71‐year‐old never‐smoking woman. Her final diagnosis was a primary spindle cell sarcoma of the pleura. This case...

Development and Validation of an Immune Gene-Set Based Prognostic Signature for Soft Tissue Sarcoma

The present study aims to identify the prognostic value of immune-related genes in sarcoma and establish a prognostic signature based on IRGs.

BMC Cancer
Exploiting Gangliosides for the Therapy of Ewing’s Sarcoma and H3K27M-Mutant Diffuse Midline Glioma

Study investigators repurpose the existing drugs dinutuximab and eliglustat and investigated their potential to directly target or indirectly modulate the tumor cell-specific ganglioside GD2.

Lack of Electron Acceptors Contributes to Redox Stress and Growth Arrest in Asparagine-Starved Sarcoma Cells

This study investigates why the non-essential amino acid asparagine is important for cancer growth by examining metabolite composition in asparagine-deprived sarcoma cells compared to...

The Sarcoma Immune Landscape: Emerging Challenges, Prognostic Significance and Prospective Impact for Immunotherapy Approaches

This article gathers the available data on the specific immune tumor microenvironment of sarcoma and the immunotherapeutic strategies currently under investigation.

Low-Grade Fibromyxoid Sarcoma Incidentally Discovered as an Asymptomatic Mediastinal Mass

The most common anatomic locations of occurrence are the lower extremities, thorax, inguinal area, and upper limbs. Primary mediastinal sarcomas are even rarer. 

Immunotherapy for Sarcomas: New Frontiers and Unveiled Opportunities

This study discusses preclinical and clinical data highlighting how immunotherapy is being used in soft tissue sarcoma and bone sarcomas.

The Age-Related Impact of Surviving Sarcoma on Health-Related Quality of Life

An aim of this study is to compare HRQoL of each sarcoma survivor age group with an age- and sex-matched normative population sample.


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