Skin Cancer

Skin Cancer

Bempegaldesleukin Plus Nivolumab in First-Line Metastatic Melanoma

This phase II cohort from PIVOT-02 study evaluates the CD122-preferential interleukin-2 pathway agonist bempegaldesleukin plus nivolumab in first-line metastatic melanoma.

Journal of Clinical Oncology
Immunotherapy Combo Checks Progression in Advanced Melanoma

Researchers have used two immunotherapy drugs to target and block different protein checkpoints, significantly increasing the time before melanoma progressed in new patients with...

Oncology Times - Latest Articles
PDCD1 Polymorphisms May Predict Response to Anti-PD-1 Blockade in Patients With Metastatic Melanoma

Investigators retrospectively analyze plasma DNA of patients with advanced melanoma treated with PD-1 antibodies, nivolumab or pembrolizumab, for five PD-1 genotype single nucleotide polymorphisms.

Frontiers in Immunology

High-Dose Interferon or Ipilimumab vs Pembrolizumab for High-Risk Resected Melanoma

Patients with high-risk melanoma who had a course of pembrolizumab had longer recurrence-free survival than patients who received either ipilimumab or high-dose interferon after surgery.

The ASCO Post
Ultrasound-Mediated Microbubble Destruction Inhibits Skin Melanoma Growth by Affecting YAP1 Translation Using Ribosome Imprinting Sequencing

In this study, tumor tissue samples are collected from 64 CMM patients.

Frontiers in Oncology
Health-Related Quality of Life With Adjuvant Pembrolizumab vs Placebo in Resected Stage III Melanoma

An analysis of this trial shows no clinically significant decline in health-related quality of life with adjuvant pembrolizumab vs placebo in resected high-risk stage III melanoma. 

The ASCO Post
Long-Term Outcomes in a Multicenter, Prospective Cohort Evaluating the Prognostic 31-Gene Expression Profile for Cutaneous Melanoma

Current guidelines for postoperative management of patients with stage I-IIA cutaneous melanoma do not recommend routine cross-sectional imaging...

JCO Precision Oncology
Patterns in the Development of Melanoma Across Body Sites

An international research team examined patterns in the development of melanoma in patients in Australia and the United Kingdom and shed light on possible relationships by anatomical site.

Cancer Therapy Advisor
Systemic Photoprotection in Skin Cancer Prevention: Knowledge Among Dermatologists

The aim of this study is to summarize the current state of knowledge of systemic photoprotection and to evaluate the knowledge and attitude of dermatologists regarding these treatments.

Checkpoint Inhibitor Therapy for Skin Cancer May be Safe in Patients With Asymptomatic COVID-19

An ongoing area of uncertainty during the SARS-CoV-2 pandemic is the safety of ICI therapy for cancer, and the theoretical possibility of exacerbated irAEs secondary to COVID-19 inflammatory pathol

Annals of Oncology
Anti-BRAF/Anti-MEK Targeted Therapies for Metastatic Melanoma Patients During the COVID-19 Outbreak: Experience From an Italian Skin Cancer Unit

Although melanoma has been increasing at a constant rate in the past few decades, mortality has been low, and only a small percentage of patients have developed metastatic disease.

Future Oncology
Construction and Validation of a Nomogram for Patients With Skin Cancer

Study investigators use patient data collected from the surveillance, epidemiology, and end results program database to construct and validate the model for clinical prediction of skin cancer.

Muffin Technique Micrographic Surgery for Non-Melanoma Skin Cancer

This study describes the implementation and the preliminary results of MTMS in an academic dermatology center.

Frontiers in Medicine
Bioactive Compounds for Skin Health

The present study draws attention to bioactive substances, i.e., vitamins, minerals, fatty acids, polyphenols, and carotenoids, with a particular focus on their effects on the condition of the skin

Sun Exposure During Water Sports: Do Elite Athletes Adequately Protect Their Skin Against Skin Cancer?

This study examines whether elite athletes in water sports take appropriate measures to protect their skin from the sun, and whether there are differences in this respect according to...

Repurposing of Drug Candidates for Treatment of Skin Cancer

This study aims to provide an updated overview of drugs’ repurposing to treat skin cancer and discuss future perspectives.

Frontiers in Oncology
Disease Risk Scores for Skin Cancers

Study investigators trained and validated risk prediction models for the three major types of skin cancer—basal cell carcinoma, squamous cell carcinoma, and melanoma—on a cross-sectional and longit

Treating Melanoma in Situ During a Pandemic with Telemedicine and a Combination of Imiquimod, 5-Fluorouracil, and Tretinoin

The recent COVID-19 pandemic has created a quandary for the physician in terms of evaluating and treating cutaneous skin cancers, particularly melanomas.

Dermatologic Therapy
Metastatic Cutaneous Squamous Cell Carcinoma Involving the Parotid Gland: Experience Outside of the Sun Belt

This study characterizes a subset of patients with metastatic head and neck cutaneous squamous cell carcinoma in a tertiary North American center and describe oncologic...

Skin Dendritic Cells in Melanoma Are Key for Successful Checkpoint Blockade Therapy

Immunotherapy with checkpoint inhibitors has shown impressive results in patients with melanoma, but still many do not benefit from this line of treatment.

Ultradeep Sequencing Differentiates Patterns of Skin Clonal Mutations Associated With Sun-Exposure Status and Skin Cancer Burden

In ultraviolet radiation–exposed skin, mutations fuel clonal cell growth.

Non-Invasive Skin Sampling of Tryptophan/Kynurenine Ratio in Vitro Towards a Skin Cancer Biomarker

Non-invasive topical sampling of Trp/Kyn can therefore serve as a promising concept for skin cancer diagnostics.

Scientific Reports
Novel Sunprotection Interventions to Prevent Skin Cancer

In Denmark, 16,500 cases of melanoma and keratinocyte cancers were registered in 2015, of which 90% could have been avoided by behavioral changes.

Novel Functions of CD147 in the Mitochondria Exacerbates Melanoma Metastasis

In this study, investigators showed that CD147 was translocated from the cell membrane to the mitochondria in advanced melanoma.

Optical Technologies for the Improvement of Skin Cancer Diagnosis

This paper reviews a variety of the optical modalities that have been used in the last years in order to improve non-invasive diagnosis of skin cancer...

Treatment of Non-melanoma Skin Cancers in the Absence of Mohs Micrographic Surgery

This study discusses the management of non-melanoma skin cancers in settings where Mohs micrographic surgery is not readily available.

A Brief Dermatology Curriculum in Skin Cancer Detection and Prevention to Improve Medical Student Knowledge and Confidence

While the incidence of skin cancers continues to rise, there remains a disproportionate lack of introductory training on skin cancer screening and identification of modifiable...

Immune Checkpoint Blockade in Advanced Cutaneous Squamous Cell Carcinoma: What Do We Currently Know in 2020?

This study focused on the differences between cSCC and cutaneous melanoma and their implications on therapy, summarize the current evidence on ICB for the treatment of...

International Journal of Molecular Sciences
pH-Responsive Nanostructures Based on Surface Active Fatty Acid-Protic Ionic Liquids for Imiquimod Delivery in Skin Cancer Topical Therapy

For topical treatment of skin cancer, the design of pH-responsive nanocarriers able to selectively release the drug in the tumor acidic microenvironment represents a reliable option for targeted de

Use of Skin Cancer Procedures, Medicare Reimbursement, and Overall Expenditures, 2012-2017

This cohort study describes recent trends in use and payment rates and in overall expenditure for skin cancer procedures in the Medicare Part B population in the United States.

Immune checkpoint inhibition therapy for advanced skin cancer in patients with concomitant hematological malignancy: a retrospective multicenter DeCOG study of 84 patients

The present study analyzed the ICI treatment outcome in advanced patients with skin cancer with a concomitant hematological malignancy.

A robust method for skin cancer diagnosis based on interval analysis

Early diagnosis of skin cancer from dermoscopy images significantly reduces the mortality due to this cancer. However, several reasons impact system precision. One important pr......


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