Translational Oncology

Translational Oncology
High-Throughput Drug Screening Reveals Pyrvinium Pamoate as Effective Candidate Against Pediatric MLL-Rearranged Acute Myeloid Leukemia

Study investigators identify pyrvinium pamoate as a novel candidate drug effective against MLL-rearranged AML.

Translational Oncology
PRF1 is a Prognostic Marker and Correlated With Immune Infiltration in Head and Neck Squamous Cell Carcinoma

This study researches the correlations of PRF1 with clinical prognosis and tumor immune infiltration in head and neck squamous cell carcinoma.

Translational Oncology
Hypoxia-Induced Therapy Resistance: Available Hypoxia-Targeting Strategies and Current Advances in Head and Neck Cancer

This study provides an overview of three main strategies to target tumor hypoxia: HIF-inhibitors, hypoxia-activated prodrugs and anti-angiogenic agents, and summarizes the clinical advances...

Translational Oncology
Exosomal miR-193a and let-7g accelerate cancer progression on primary colorectal cancer and paired peritoneal metastatic cancer

This study confirmed the possibility of using this as a diagnostic and prognostic marker for colorectal cancer by measuring the expression levels of exosomal miR-193a and let-7g in blood.

Translational Oncology
Autoantibodies against tumor-associated antigens in sputum as biomarkers for lung cancer

This study provides the first evidence that sputum TAAbs could be used as biomarkers for the early detection of lung cancer.

Translational Oncology
Clinical significance and prognostic value of Porphyromonas gingivalis infection in lung cancer

This study analyzed the correlation between P. gingivalis infection and clinicopathological features and survival prognosis of patients with lung cancer.

Translational Oncology
Combination therapy: Future directions of immunotherapy in small cell lung cancer.

This review focused on the completed and ongoing trials of the combination therapy for immunotherapy of SCLC to find out the rational combination strategies which may improve the outcomes for SCLC.

Translational Oncology
Melatonin increases the chemosensitivity of diffuse large B-cell lymphoma cells to epirubicin by inhibiting P-glycoprotein expression via the NF-κB pathway.

Epirubicin is a first-line chemotherapeutic drug for the clinical treatment of DLBCL, but the overexpression of multidrug resistance transporter proteins, especially P-glycoprotein...

Translational Oncology
Anti-epidermal growth factor vaccine antibodies increase the antitumor activity of kinase inhibitors in ALK and RET rearranged lung cancer cells

This study investigated the effects of anti-EGF antibodies generated by vaccination, TKIs and combinations in EML4-ALK and CCDC6-RET NSCLC cell lines.

Translational Oncology
Emerging roles for HMGA2 in colorectal cancer.

In this review, the authors address the roles of HMGA2 in the oncogenic networks of CRC based on recent advances. 

Translational Oncology
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