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Journal of Clinical Oncology

Journal of Clinical Oncology
Apalutamide in Patients With Metastatic Castration-Sensitive Prostate Cancer

The first interim analysis shows that apalutamide significantly improves OS and radiographic PFS in patients with mCSPC receiving ongoing androgen deprivation therapy.

Journal of Clinical Oncology
04/29/2021
Atezolizumab, Bevacizumab, and Chemotherapy for Newly Diagnosed Stage III or IV Ovarian Cancer

This study evaluates the addition of the humanized monoclonal PD-L1 antibody, atezolizumab, to platinum-based chemotherapy and bevacizumab in newly diagnosed stage III or IV ovarian cancer.

Journal of Clinical Oncology
04/23/2021
Neck Dissections Based on Sentinel Lymph Node Navigation Versus Elective Neck Dissections in Early Oral Cancers

This study aims to compare patients with early oral cavity squamous cell carcinoma treated with traditional elective neck dissection with those managed by sentinel lymph node biopsy using...

Journal of Clinical Oncology
04/20/2021
Palbociclib for Residual High-Risk Invasive HR-Positive and HER2-Negative Early Breast Cancer

About one third of patients with hormone receptor–positive, human epidermal growth factor receptor 2–negative breast cancer who have residual invasive disease after NACT will relapse...

Journal of Clinical Oncology
04/01/2021
HER2 Expression, Test Deviations, and Their Impact on Survival in Metastatic Gastric Cancer

The multicenter VARIANZ study aims to investigate the background of response and resistance to trastuzumab in mGC.

Journal of Clinical Oncology
03/25/2021
Long-Term Follow-Up of CD19-CAR T-Cell Therapy in Children and Young Adults With B-ALL

Study investigators conduct a phase I trial of autologous CD19.28ζ-CAR T cells in CAYAs with relapsed or refractory B-ALL.

Journal of Clinical Oncology
03/25/2021
Comparison of Radiation With or Without Concurrent Trastuzumab for HER2-Positive Ductal Carcinoma In Situ Resected by Lumpectom

The primary aim of the B-43 trial is to assess the efficacy of RT alone vs concurrent RT plus T in preventing recurrence of ipsilateral breast cancer in women with ductal carcinoma in situ.

Journal of Clinical Oncology
03/19/2021
Favorable Trisomies and ETV6-RUNX1 Predict Cure in Low-Risk B-Cell Acute Lymphoblastic Leukemia: Results From Children's Oncology Group Trial AALL0331

COG AALL0331 tests whether pegaspargase intensification on a low-intensity chemotherapy backbone would improve the CCR rate in a low-risk subset of children with standard-risk B-ALL.

Journal of Clinical Oncology
03/19/2021
Nivolumab and Ipilimumab as Maintenance Therapy in Extensive-Disease Small-Cell Lung Cancer

CheckMate 451, a double-blind phase III trial, evaluated nivolumab plus ipilimumab and nivolumab monotherapy as maintenance therapy following first-line chemotherapy for ED-SCLC.

Journal of Clinical Oncology
03/08/2021
Lenalidomide Plus R-CHOP Versus Placebo Plus R-CHOP in Previously Untreated Patients With ABC-Type Diffuse Large B-Cell Lymphoma

The goal of this study is to compare lenalidomide plus R-CHOP (R2-CHOP) with placebo/R-CHOP in previously untreated, ABC-type DLBCL.

Journal of Clinical Oncology
02/23/2021
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