Journal of Clinical Oncology

Journal of Clinical Oncology
Immunogenicity and Reactogenicity of SARS-CoV-2 Vaccines in Patients With Cancer

Researchers correlate the immunogenicity and reactogenicity of current US FDA Emergency Use Authorization vaccines in a large cohort of approximately 1,000 patients enrolled in the CANVAX study.

Journal of Clinical Oncology
Metastatic Castration-Resistant Prostate Cancer Remains Dependent on Oncogenic Drivers Found in Primary Tumors

Scientists question if targeted sequencing of hormone-sensitive primary PC identify drivers of metastasis that are targetable in advanced CRPC. 

Journal of Clinical Oncology
Characterization of Non–Small-Cell Lung Cancers With MET Exon 14 Skipping Alterations Detected in Tissue or Liquid

Researchers explore METex14-altered NSCLC allowing granular description of diverse alterations activating MET. 

Journal of Clinical Oncology
Veliparib in Combination With Platinum-Based Chemotherapy for First-Line Treatment of Advanced Squamous Cell Lung Cancer

This phase III study investigates the efficacy and safety of poly (ADP-ribose) polymerase inhibitor veliparib in combination with conventional chemotherapy for advanced sqNSCLC.

Journal of Clinical Oncology
Radiotherapy Versus Inguinofemoral Lymphadenectomy as Treatment for Vulvar Cancer Patients With Micrometastases in the Sentinel Node

This study on Sentinel nodes in vulvar cancer investigated whether inguinofemoral RT is a safe alternative to inguinofemoral lymphadenectomy in vulvar cancer patients with a metastatic SN.

Journal of Clinical Oncology
Immunophenotype Rearrangement in Response to Tumor Excision May Be Related to the Risk of Biochemical Recurrence in Prostate Cancer Patients

The aim of this study is to examine the effect of tumor excision on immunophenotype rearrangements in peripheral blood and to elucidate if it is associated with biochemical recurrence...

Journal of Clinical Oncology
Phase I Study of Venetoclax Plus Daratumumab and Dexamethasone, With or Without Bortezomib, in Patients With Relapsed or Refractory Multiple Myeloma With and Without t(11;14)

This phase I study evaluates venetoclax with daratumumab and dexamethasone in patients with t(11;14) RRMM and VenDd with bortezomib in cytogenetically unselected patients with RRMM.

Journal of Clinical Oncology
Randomized Phase III Trial of Prophylactic Cranial Irradiation With or Without Hippocampal Avoidance for Small-Cell Lung Cancer

The key concern using hippocampal avoidance-prophylactic cranial irradiation in patients with SCLC is the incidence of brain metastasis within the hippocampal avoidance zone.

Journal of Clinical Oncology
Avapritinib Versus Regorafenib in Locally Advanced Unresectable or Metastatic GI Stromal Tumor

This study evaluates efficacy and safety of avapritinib versus regorafenib as third-line or later treatment in patients with unresectable or metastatic GIST.

Journal of Clinical Oncology
Bempegaldesleukin Plus Nivolumab in First-Line Metastatic Melanoma

This phase II cohort from PIVOT-02 study evaluates the CD122-preferential interleukin-2 pathway agonist bempegaldesleukin plus nivolumab in first-line metastatic melanoma.

Journal of Clinical Oncology
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