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Cancers

Cancers
Small Extracellular Vesicle-Derived microRNAs Stratify Prostate Cancer Patients According to Gleason Score, Race and Associate with Survival of African American and Caucasian Men

Researchers determine the diagnostic and prognostic utility of sEV-associated miRs in identifying aggressive PCa in African American and Caucasian men.

Cancers
10/19/2021
Identification of Biochemical and Molecular Markers of Early Aging in Childhood Cancer Survivors

Scientists shed light on the mechanisms involved in C/RT-induced early aging, morbidities, and the risk of developing second tumors in CCS through a biochemical and molecular approach.

Cancers
10/18/2021
Targeting Ovarian Carcinoma With TSP-1:CD47 Antagonist TAX2 Activates Anti-Tumor Immunity

Study investigators aimed at providing an extensive molecular characterization of TAX2 mode of action, while evaluating its potential in ovarian cancer therapy.

Cancers
10/07/2021
RAS Mediates BET Inhibitor-Endued Repression of Lymphoma Migration and Prognosticates a Novel Proteomics-Based Subgroup of DLBCL Through Its Negative Regulator IQGAP3

Study investigators found that BET inhibitor JQ1 abrogated the amoeboid movement of DLBCL cells through a small GTPase-driven mechanism, including both restrained RAS signaling and...

Cancers
10/07/2021
Elevating CDCA3 Levels Enhances Tyrosine Kinase Inhibitor Sensitivity in TKI-Resistant EGFR Mutant Non–Small-Cell Lung Cancer

The aim of this study was to determine whether the protein CDCA3 might be a biomarker for TKI response in EGFR mutant lung cancer. 

Cancers
09/16/2021
Ovarian Cancer and Cancer Stem Cells—Cellular and Molecular Characteristics, Signaling Pathways, and Usefulness as a Diagnostic Tool in Medicine and Oncology

The current histological classification of ovarian tumors, their epidemiology, and the recent knowledge of ovarian CSCs, with particular emphasis on their molecular basis, are...

Cancers
08/19/2021
Development of Multidrug Resistance in Acute Myeloid Leukemia Is Associated with Alterations of the LPHN1/GAL-9/TIM-3 Signaling Pathway

Here, study investigators prove that latrophilin-1 expression also occurs in the myeloid blasts of patients newly diagnosed with myelodysplastic syndrome when ABCB1 is overexpressed.

Cancers
07/20/2021
Identification of a Novel Tumor Microenvironment Prognostic Signature for Advanced-Stage Serous Ovarian Cancer

In our study, investigators constructed a prognostic 11-gene signature for advanced serous ovarian cancer from tumor microenvironment-related genes through lasso regression. 

Cancers
07/03/2021
Prognostic Value of Tie2-Expressing Monocytes in Chronic Lymphocytic Leukemia Patients

In the current study, investigators observe an increased percentage of Tie2-expressing monocytes in CLL patients.

Cancers
06/05/2021
Impact of High-Dose Methotrexate on the Outcome of Patients With Diffuse Large B-Cell Lymphoma and Skeletal Involvement

Study investigators analyze the impact of adding high-dose methotrexate to standard chemotherapy on the outcome of patients with DLBCL and skeletal involvement.

Cancers
06/12/2021
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