JAMA Oncology

JAMA Oncology
Nivolumab Plus Ipilimumab vs Nivolumab for Previously Treated Patients With Stage IV Squamous Cell Lung Cancer

Combination therapy with nivolumab and ipilimumab is currently only indicated as first-line therapy in patients with advanced non–small-cell lung cancer.

JAMA Oncology
Effect of Celecoxib vs Placebo as Adjuvant Therapy on DFS Among Patients With Breast Cancer

This study examines if there is a benefit for patients who receive celecoxib as an addition to conventional therapy for women with ERBB2 (formerly HER2)–negative primary breast cancer.

JAMA Oncology
Association of Combination of Conformation-Specific KIT Inhibitors With Clinical Benefit in Patients With Refractory Gastrointestinal Stromal Tumors

This study seeks to answer the question: Is cotargeting the active and inactive conformations of KIT associated with clinical benefit in refractory GIST?

JAMA Oncology
Effect of Postoperative Radiotherapy for Patients With pIIIA-N2 Non–Small Cell Lung Cancer After Complete Resection and Adjuvant Chemotherapy

This study seeks to answer the question: can postoperative RT using modern techniques improve survival of patients with pIIIA-N2 NSCLC after complete resection and adjuvant chemotherapy?

JAMA Oncology
Association of Salpingectomy With Delayed Oophorectomy Versus Salpingo-oophorectomy With Quality of Life in BRCA1/2 Pathogenic Variant Carriers

This study seeks to answers the question: What is the menopause-related quality of life in carriers of the BRCA1/2 pathogenic variant after salpingectomy with delayed oophorectomy compared with the

JAMA Oncology
Tislelizumab Plus Chemotherapy vs Chemotherapy Alone as First-line Treatment for Advanced Squamous Non–Small-Cell Lung Cancer

Tislelizumab plus CT results in significant improvement of PFS and objective response rates compared with chemotherapy alone and demonstrated a manageable safety/tolerability profile.

JAMA Oncology
Efficacy of Reduced-Intensity Chemotherapy With Oxaliplatin and Capecitabine on Quality of Life and Cancer Control Among Older and Frail Patients With Advanced Gastroesophageal Cancer

This study aims to answer the question do older and/or frail patients with advanced gastroesophageal cancer benefit from less intensive palliative CT, and can a formal geriatric assessment assist..

JAMA Oncology
Comparison of Systemic Treatments for Metastatic Castration-Sensitive Prostate Cancer

This study seeks to answer the question surrounding the most effective systemic treatments for metastatic castration-sensitive prostate cancer.

JAMA Oncology
Evaluation of Safety of Stereotactic Body Radiotherapy for the Treatment of Patients With Multiple Metastases

Can ablative radiation schedules designed for single tumors be used when treating patients with 3 to 4 metastases or 2 metastases in close proximity to each other?

JAMA Oncology
Frequency of and Factors Associated With Nonmedical Opioid Use Behavior Among Patients With Cancer Receiving Opioids for Cancer Pain

This study examines the predictors for and frequency of the presence of nonmedical opioid use behavior in patients with cancer.

JAMA Oncology
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