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Scientific Reports

Scientific Reports
The Prognostic Relevance of HER2+ Gain in Metastatic Breast Cancer in the ChangeHER Trial

This study addresses the question if relevant differences exist between subjects who preserve the HER2 status and those who gain the HER2 positivity when relapsed. 

Scientific Reports
07/02/2021
Immunomodulatory Effects of Different Intravenous Immunoglobulin Preparations in Chronic Lymphocytic Leukemia

This study aims to evaluate the capacity of Pentaglobin and a standard IVIg preparation to affect leukemic and T cells from CLL patients.

Scientific Reports
06/21/2021
DNA-PK Inhibitor Peposertib Enhances p53-Dependent Cytotoxicity of DNA Double-Strand Break Inducing Therapy in Acute Leukemia

Study investigators examine the therapeutic potential of M3814 in combination with DSB-inducing agents in leukemia cells and a patient-derived tumor. 

Scientific Reports
06/09/2021
Skin Biopsies in Acute Myeloid Leukemia Patients Undergoing Intensive CT are Safe and Effect Patient Management

The aim of this study was to evaluate the diagnostic yield and safety of skin biopsies obtained from adult patients with AML during hospitalization for intensive chemotherapy.

Scientific Reports
06/07/2021
HGK Promotes Metastatic Dissemination in Prostate Cancer

In this study, investigators identify MAP4K4 as a relevant gene for metastasis in prostate cancer.

Scientific Reports
06/10/2021
Combination of Gene Set Signatures Correlates With Response to Nivolumab in Platinum-Resistant Ovarian Cancer

Based on a previous phase II clinical trial of anti-PD-1 antibody nivolumab for platinum-resistant ovarian cancer, investigators aim to identify the biomarkers predictive of response.

Scientific Reports
06/01/2021
Topical Arginase Inhibition Decreases Growth of Cutaneous Squamous Cell Carcinoma

This study demonstrates the therapeutic potential of transcutaneous arginase inhibition in cSCC.

Scientific Reports
05/24/2021
DC-SIGN Binding to Mannosylated B-cell Receptors in Follicular Lymphoma Down-Modulates Receptor Signaling Capacity

Investigators show that despite being of low-level, DC-SIGN induces a similar downstream transcriptional response to anti-IgM in primary FL cells, characterized by activation of pathways associated

Scientific Reports
06/03/2021
Prostate Cancer Risk Variants of the HOXB Genetic Locus

Study investigators examine the HOXB locus to define a potentially broader contribution to prostate cancer heritability.

Scientific Reports
05/31/2021
The Influence of High-Efficiency Particulate Air Filtration on Mortality Among Multiple Myeloma Patients Receiving Autologous Stem Cell Transplantation

Autologous stem cell transplantation continues to be the standard treatment for transplant-eligible multiple myeloma patients.

Scientific Reports
06/03/2021
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