Scientific Reports

Scientific Reports
Discovery Proteomics Defines Androgen-Regulated Glycoprotein Networks in Prostate Cancer Cells, as Well as Putative Biomarkers of Prostatic Diseases

Researchers discover that androgens elicited dose-dependent changes in the expression of glycoprotein networks related to cell growth and differentiation in PCa cells. 

Scientific Reports
CD8-Positive T Cells and CD204-Positive M2-like Macrophages Predict Postoperative Prognosis of Very High-Risk Prostate Cancer

This study investigated the clinical, pathological and immunological significance of the tumor immune microenvironment of very high-risk prostate cancer with seminal vesicle invasion.

Scientific Reports
A Phase II Study of Talimogene Laherparepvec for Patients With Inoperable Locoregional Recurrence of Breast Cancer

The local and systemic antitumor efficacy of T-VEC as monotherapy for inoperable locoregional recurrence of breast cancer with or without distant metastases was explored in this study.

Scientific Reports
Tunable Control of CAR T Cell Activity Through Tetracycline Mediated Disruption of Protein–Protein Interaction

This work shows how optimization of split-CAR structure affects function and adds a novel design allowing easy CAR inhibition through an FDA-approved small molecule.

Scientific Reports
Recurrence Monitoring for Ovarian Cancer Using a Cell Phone-Integrated Paper Device to Measure the Ovarian Cancer Biomarker HE4/CRE Ratio in Urine

The development of an at-home paper-based test to measure both HE4 and creatinine in one device was presented by researchers to increase recurrence detection. 

Scientific Reports
Photoplethysmography for Demarcation of Cutaneous Squamous Cell Carcinoma

Scientists present a video processing algorithm showing promising results encouraging further investigation to clarify how detailed distinctions can be made in cSCC. 

Scientific Reports
The Urinary Excretion of Epigenetically Modified DNA as a Marker of Pediatric ALL Status and Chemotherapy Response

Scientists investigated the role of epigenetic DNA modifications in childhood ALL diagnostics and therapy monitoring by analyzing the levels of 5-mdC oxidation products in the cellular DNA...

Scientific Reports
Prognostic Efficacy of the RTN1 Gene in Patients With Diffuse Large B-Cell Lymphoma

In this study, investigators examined the gene(s) that can reproducibly and robustly predict survival in patients with DLBCL.

Scientific Reports
Eukaryotic Initiation Factor 2 Signaling Behind Neural Invasion Linked With Lymphatic and Vascular Invasion in Pancreatic Cancer

Scientists observed a 128-patient cohort undergoing surgery for early-stage PDAC to clarify what changes occurred alongside PNI in PDAC.

Scientific Reports
Periostin Secreted by Activated Fibroblasts in Idiopathic Pulmonary Fibrosis Promotes Tumorigenesis of Non-Small Cell Lung Cancer

The effects of periostin secreted by fibroblasts derived from IPF lung on NSCLC cell proliferation were explored and researchers propose a possible new therapeutic strategy targeting periostin...

Scientific Reports
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