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Recent Updates on the Significance of KRAS Mutations in Colorectal Cancer Biology

This literature covers the diverse nature of the effects of KRAS mutations on age-related CRC development.

Cells
03/17/2021
Association Between Inflammation and Function of Cell Adhesion Molecules Influence on Gastrointestinal Cancer Development

Gastrointestinal cancer is highly associated with inflammatory processes inducing the release of cytokines from cancer or immune cells, including interferons, interleukins...

Cells
01/04/2021
Mimicking Tumor Hypoxia in Non-Small Cell Lung Cancer Employing Three-Dimensional In Vitro Models

This review defines current knowledge in the field of tumor hypoxia in NSCLC, including biology, biomarkers, in vitro and in vivo studies and also hypoxia imaging and detection.

Cells
01/12/2021
Calreticulin—Multifunctional Chaperone in Immunogenic Cell Death: Potential Significance as a Prognostic Biomarker in Ovarian Cancer Patients

This study reviews the physiological functions of CRT and its involvement in the immunogenic cell death appearance in malignant disease.

Cells
01/11/2021
Targeting Chromatin Complexes in Myeloid Malignancies and Beyond: From Basic Mechanisms to Clinical Innovation

This review summarizes some of the current concepts on the role epigenetic modifiers in malignant chromatin states with a specific focus on myeloid malignancies and...

Cells
12/21/2020
NOTCH1 Signaling in Head and Neck Squamous Cell Carcinoma

Biomarker-driven targeted therapies are lacking for head and neck squamous cell carcinoma, which is common and lethal.

Cells
12/12/2020
Chronic Lymphocytic Leukemia-Induced Humoral Immunosuppression: A Systematic Review

The aim of the study was to review the available literature data on patients with CLL, with particular regard to the pathogenesis of the disease and the impact of...

Cells
11/02/2020
Molecular Mechanisms of Resistance to FLT3 Inhibitors in Acute Myeloid Leukemia: Ongoing Challenges and Future Treatments

Treatment of FMS-like tyrosine kinase 3 (FLT3)-internal tandem duplication (ITD)-positive acute myeloid leukemia remains a challenge despite the development of novel FLT3-directed...

Cells
11/17/2020
Update on Circulating Tumor Cells in Genitourinary Tumors with Focus on Prostate Cancer.

Current developments in the treatment of genitourinary tumors underline unmet clinical need for biomarkers to improve decision-making a challenging setting.

Cells
06/19/2020
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