Genetic and Phenotypic Attributes of Splenic Marginal Zone Lymphoma

Study authors clarified the heterogeneity of SMZL by resolving different subgroups and their underlying genomic abnormalities, pathway signatures and microenvironment compositions...

Activated Natural Killer Cells Predict Poor Clinical Prognosis in High-Risk B- and T-Cell Acute Lymphoblastic Leukemia

Researchers outline the benefits of developing NK cell profiling as a diagnostic tool to predict clinical outcome in patients with ALL and underscore the clinical potential of allogeneic NK cells..

FoxO1-GAB1 Axis Regulates Homing Capacity and Tonic AKT Activity in Chronic Lymphocytic Leukemia

This study provided evidence that CXCR4/CD5 intraclonal subpopulations can be used to study the regulation of migration of CLL cells.

Low-Dose Decitabine Modulates T-cell Homeostasis and Restores Immune Tolerance in Immune Thrombocytopenia

In this study, investigators analyze the effect of decitabine on T-cell subpopulations in ITP in vitro and in vivo.

Dimethyl Fumarate Induces Ferroptosis and Impairs NF-κB/STAT3 Signaling in DLBCL

As a result of low glutathione and glutathione peroxidase 4 levels and high 5-lipoxygenase expression, DMF induces ferroptosis in GCB DLBCL.

KDM5 Inhibition Offers a Novel Therapeutic Strategy for the Treatment of KMT2D Mutant Lymphomas

KDM5 inhibition reverts the effects of KMT2D mutations by increasing levels of H3K4me3 and restoring expression of KMT2D-regulated genes.

Treatment Dependence of Prognostic Gene Expression Signatures in de novo Follicular Lymphoma

Study investigators evaluate the performance and treatment dependence of the published gene expression–based models in patients with first-line FL treated in the randomized, phase 3 GALLIUM study..

miR-29 Modulates CD40 Signaling in Chronic Lymphocytic Leukemia by Targeting TRAF4: An Axis Affected by BCR Inhibitors

miR-29 down-modulation in an intraclonal CLL subpopulation from immune niches allows for higher TRAF4 and increased CD40 responsiveness.

miR-15a/16-1 Deletion in Activated B Cells Promotes Plasma Cell and Mature B-Cell Neoplasms

Upon BCR antigen stimulation, follicular B cells undergo T-cell–dependent activation, whereas marginal zone and B1 B cells undergo mainly T-cell–independent activation.

Ivosidenib or Enasidenib Combined With Intensive Chemotherapy in Patients With Newly Diagnosed AML

Ivosidenib or enasidenib combined with induction and consolidation chemotherapy were both well tolerated in newly diagnosed mIDH1/2 AML.

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