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Frontiers in Immunology

Frontiers in Immunology
One Stone, Two Birds: The Roles of Tim-3 in Acute Myeloid Leukemia

Targeting Tim-3 kills two birds with one stone by balancing the immune system and eliminating leukemia stem cells in AML.

Frontiers in Immunology
04/01/2021
The BCMA-Targeted Fourth-Generation CAR-T Cells Secreting IL-7 and CCL19 for Therapy of Refractory/Recurrent Multiple Myeloma

Study investigators construct the BCMA-targeted fourth-generation CAR-T cells expressing IL-7 and CCL19, and demonstrate that BCMA-7 × 19 CAR-T cells exhibit...

Frontiers in Immunology
03/05/2021
The Imbalance of Circulating Follicular T Helper Cell Subsets in Primary Sjögren’s Syndrome Associates With Serological Alterations and Abnormal B-Cell Distribution

This study investigates whether a change in the balance of circulating TFH subsets and follicular regulatory T cells could affect the distribution of B cells in pSS. 

Frontiers in Immunology
03/19/2021
Heat Shock Proteins in Lymphoma Immunotherapy

Immunotherapy harnessing the host immune system for tumor destruction revolutionized oncology research and advanced treatment strategies for lymphoma patients.

Frontiers in Immunology
03/18/2021
Interplay Between the Intestinal Microbiota and Acute Graft-Versus-Host Disease: Experimental Evidence and Clinical Significance

The current animal and human studies investigating the intestinal microbiota in aGVHD and the understanding of the influence and management of the microbiota in the clinic are reviewed herein.

Frontiers in Immunology
03/16/2021
Profiling Tissue and Biofluid miR-155-5p, miR-155*, and miR-146a-5p Expression in Graft vs Host Disease

In this study, investigators perform comprehensive expression profiling of miR-146a, miR-155, and miR-155* expression in aGvHD target tissue and biofluids and relate expression to post-HSCT outcome

Frontiers in Immunology
03/15/2021
Monogenic Immune Diseases Provide Insights Into the Mechanisms and Treatment of Chronic Graft-Versus-Host Disease

This review summarizes the evidence from these monogenic immune related diseases that provide insight into pathogenic pathways in chronic GvHD, rationales for current therapies and...

Frontiers in Immunology
02/04/2021
A T-Cell Surface Marker Panel Predicts Murine Acute Graft-Versus-Host Disease

This study investigates whether the detection of a combination of the expression of T-cell surface markers on peripheral blood CD8+ T-cells would improve the ability to predict aGvHD.

Frontiers in Immunology
01/29/2021
Potential Application of T-Follicular Regulatory Cell Therapy in Transplantation

This study discusses the current knowledge of T follicular regulatory cells and the role they play focusing on human diseases and transplantation.

Frontiers in Immunology
02/02/2021
A Phenomic Perspective on Factors Influencing Breast Cancer Treatment: Integrating Aging and Lifestyle in Blood and Tissue Biomarker Profiling

Understanding and managing heterogeneity in the clinical response exhibited by patients with breast cancer remains a challenge.

Frontiers in Immunology
02/01/2021
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