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Frontiers in Immunology

Frontiers in Immunology
A Novel Germline Heterozygous BCL11B Variant Causing Severe Atopic Disease and Immune Dysregulation

Researchers work to classify germline BCL11B-dependent atopic disease as a novel primary atopic disorder.

Frontiers in Immunology
11/23/2021
Chimeric Antigen Receptor T Cells With Modified Interleukin-13 Preferentially Recognize IL13Rα2 and Suppress Malignant Glioma

Researchers examine the efficacy and safety of T cells containing a YYB-103 CAR that can preferentially bind to IL13Rα2 on MG cells.

Frontiers in Immunology
11/08/2021
SSTP1, a Host Defense Peptide, Exploits the Immunomodulatory IL6 Pathway to Induce Apoptosis in Cancer Cells

Researchers suggests that identification of the membrane targets for the promising anticancer HDPs might lead to the identification of new drugs for targeted therapy.

Frontiers in Immunology
11/19/2021
Identification and Validation of Immune-Related Gene for Predicting Prognosis and Therapeutic Response in Ovarian Cancer

Researchers investigated the ability to predict disease prognosis based on immune-related genes differentially expressed in the tumor microenvironment. 

Frontiers in Immunology
11/22/2021
Generation of an NFκB-Driven Alpharetroviral “All-in-One” Vector Construct as a Potent Tool for CAR NK Cell Therapy

Researchers find that in contrast to T cells, the inclusion of NFκB-responsive elements within the inducible promoter construct was essential for CAR-inducible expression of the transgene.

Frontiers in Immunology
11/03/2021
Pattern Recognition Receptors in Macrophages Possess Prognosis and Immunotherapy Potential for Melanoma

Researchers analyzed the correlations between PRR genes and the prognosis of many different cancers and found PRR genes highly positive corelated with the prognosis of SKCM. 

Frontiers in Immunology
11/09/2021
Prophylactic Tocilizumab Prior to Anti-CD19 CAR-T Cell Therapy for Non-Hodgkin Lymphoma

Anti-CD19 CAR-T cells have demonstrated activity against relapsed/refractory lymphomas.

Frontiers in Immunology
10/12/2021
Association Analyses of TP53 Mutation With Prognosis, Tumor Mutational Burden, and Immunological Features in Acute Myeloid Leukemia

Somatic mutations in AML patients were found using The Cancer Genome Atlas dataset and BeatAML dataset and then researchers identified the common mutant genes in the two cohorts. 

Frontiers in Immunology
10/21/2021
Integrative Characterization of the Role of IL27 In Melanoma Using Bioinformatics Analysis

Scientists work to uncover the multifaceted roles of IL27 and provide evidence for future cytokine-based immunotherapy against melanoma.

Frontiers in Immunology
10/18/2021
PTP4A3 Is a Prognostic Biomarker Correlated With Immune Infiltrates in Papillary Renal Cell Carcinoma

Scientists developed a comprehensive analysis across multiple databases to elucidate the role of PTP4A3 in ccRCC and pRCC & analyzed PTP4A3 and immune cell tumor infiltration (TIMER). 

Frontiers in Immunology
09/23/2021
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