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Frontiers in Immunology

Frontiers in Immunology
Multi-Omics Profiling Identifies Risk Hypoxia-Related Signatures for Ovarian Cancer Prognosis

Hypoxia is a driver of the malignant progression in ovarian cancer, which results in poor prognosis.

Frontiers in Immunology
07/19/2021
γδ T Cells May Aggravate Acute GvHD Through CXCR4 Signaling After Allogeneic Hematopoietic Transplantation

The identification of immune cells that correlate with aGVHD is important and intriguing. To date, the involvement of innate-like γδ T cells in the pathogenesis of aGVHD is unclear. 

Frontiers in Immunology
07/14/2021
Identification and Validation of the Immune Regulator CXCR4 as a Novel Promising Target for Gastric Cancer

This study has determined the prognostic value of 11 immunomodulatory factors in gastric cancer.

Frontiers in Immunology
07/12/2021
Comprehensive Transcriptomic Analysis Reveals the Role of the Immune Checkpoint HLA-G Molecule in Cancers

The aim of this study is to systematically identify the roles of checkpoint HLA-G molecules across various types of cancer.

Frontiers in Immunology
07/01/2021
Inflammatory Pathophysiology as a Contributor to Myeloproliferative Neoplasms

In myelofibrosis, elevated levels of individual cytokines in plasma are adverse prognostic indicators: elevated IL-8/CXCL8, in particular, predicts risk of transformation of MF to secondary AML. 

Frontiers in Immunology
06/01/2021
PDCD1 Polymorphisms May Predict Response to Anti-PD-1 Blockade in Patients With Metastatic Melanoma

Investigators retrospectively analyze plasma DNA of patients with advanced melanoma treated with PD-1 antibodies, nivolumab or pembrolizumab, for five PD-1 genotype single nucleotide polymorphisms.

Frontiers in Immunology
06/09/2021
Study on the Immune Escape Mechanism of Acute Myeloid Leukemia With DNMT3A Mutation

Study investigators aim to explore the mechanism of immune escape in AML with DNMT3A mutation. 

Frontiers in Immunology
05/20/2021
Allogeneic Stem Cell Transplantation for Acute Myeloid Leukemia: Who, When, and How?

Allogeneic stem cell transplant represents a pivotally important treatment strategy in fit adults with AML because of its augmented anti-leukemic activity consequent upon dose intensification...

Frontiers in Immunology
05/03/2021
Metabolic Reprogramming of GMP Grade Cord Tissue Derived Mesenchymal Stem Cells Enhances Their Suppressive Potential in GvHD

Mesenchymal stem cells represent a promising therapeutic approach for the treatment of GvHD, but so far this strategy has had equivocal clinical efficacy. 

Frontiers in Immunology
05/04/2021
Natural Killer Cell Subpopulations and Inhibitory Receptor Dynamics in Myelodysplastic Syndromes and Acute Myeloid Leukemia

This study addresses NK cell maturation in bone marrow under three conditions: a normal developmental environment, during pre-leukemic state, and during leukemic transformation.

Frontiers in Immunology
04/27/2021
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