Targeting GLUT1 in Acute Myeloid Leukemia to Overcome Cytarabine Resistance

Study investigators present a detailed structural and functional analysis of compounds that inhibit glucose transporters and sensitize AML cells for chemotherapy.

Lack of Activation-Induced Cytidine Deaminase Expression in in situ Follicular Neoplasia

The immunoglobulin heavy chain genes undergo class switch recombination and somatic hypermutation to produce a diverse repertoire of high affinity antibodies.

Outcomes After Late Bone Marrow and Very Early Central Nervous System Relapse of Childhood B-Acute Lymphoblastic Leukemia

Outcomes after relapse of childhood B-acute lymphoblastic leukemia are poor, and optimal therapy is unclear.

Clinical Significance of Occult Central Nervous System Disease in Adult Acute Lymphoblastic Leukemia

This study retrospectively evaluates the incidence of occult CNS disease and its impact on outcome in 240 adult patients with newly diagnosed ALL.

Differentiation Therapy of Myeloid Leukemia

AML is characterized by arrested differentiation, and agents that overcome this block are therapeutically useful, as shown by the efficacy of all-trans retinoic acid in...

SIRPαFc Treatment Targets Human Acute Myeloid Leukemia Stem Cells

Hematologic and solid tumors can upregulate expression of CD47, a self-marker that binds to SIRPα, an immunoglobulin superfamily receptor expressed on...

Measurable Residual Disease Monitoring Provides Insufficient Lead-Time to Prevent Morphological Relapse in the Majority of Patients with Core-Binding Factor Acute Myeloid Leukemia

Core-binding factor acute myeloid leukemia is characterized by t(8;21) or inv(16) and the fusion proteins RUNX1-RUNX1T1 and CBFB-MYH11.

FcγRIIb-BCR Coligation Inhibits B-cell Receptor Signaling in Chronic Lymphocytic Leukemia

Considering the major role of BCR in the pathogenesis of CLL and the activated nature of the leukemic cells, this study investigates whether FcγRIIb could regulate BCR signaling...

Genomic Arrays Identify High-Risk Chronic Lymphocytic Leukemia With Genomic Complexity

Complex karyotype identified by chromosome-banding analysis has been shown to have prognostic value in chronic lymphocytic leukemia.

Analysis of Retrotransposon Subfamily DNA Methylation Reveals Novel Early Epigenetic Changes in Chronic Lymphocytic Leukemia

While global hypomethylation of these elements has been widely reported in solid tumors, their epigenetic dysregulation is yet to be characterized in CLL, and...

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