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Genome Medicine

Genome Medicine
Multiscale Heterogeneity in Gastric Adenocarcinoma Evolution is an Obstacle to Precision Medicine

Using multiregional whole-exome sequencing, scientists investigate the effect of somatic evolution on intratumoral heterogeneity to shed light on the evolutionary biology of GC.

Genome Medicine
11/08/2021
Novel Temporal and Spatial Patterns of Metastatic Colonization From Breast Cancer Rapid-Autopsy Tumor Biopsies

Scientists collected 30 tumor samples over 3 timepoints, across 8 organs from a TNBC to comprehensively reconstruct the tumor’s evolution at subclonal resolution.

Genome Medicine
10/28/2021
Targeting CDC7 Potentiates ATR-CHK1 Signaling Inhibition Through Induction of DNA Replication Stress in Liver Cancer

Researchers use integrated bioinformatics and functional genetics approaches to study the therapeutic options for the use of ATR or CHK1 inhibitors in liver cancer.

Genome Medicine
10/18/2021
Molecular Features of Untreated Breast Cancer and Initial Metastatic Event Inform Clinical Decision-Making and Predict Outcome: Long-Term Results of ESOPE, a Single-Arm Prospective Multicenter Study

The genomic landscape of metastatic breast cancer has mostly been described in very advanced, pretreated disease, limiting the findings transferability to clinical use.

Genome Medicine
03/15/2021
Genetic and Functional Interaction Network Analysis Reveals Global Enrichment of Regulatory T Cell Genes Influencing Basal Cell Carcinoma Susceptibility

Study investigators set out to define background genetic factors that play a role in influencing BCC susceptibility via promoting or suppressing the effects of oncogenic drivers of BCC.

Genome Medicine
02/06/2021
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