X

Nature Communications

Nature Communications
Targeted PI3K/AKT-Hyperactivation Induces Cell Death in Chronic Lymphocytic Leukemia

Study investigators test the hypothesis that targeted hyperactivation of the phosphatidylinositol-3-phosphate/AKT-signaling pathway may be leveraged to trigger CLL cell death. 

Nature Communications
06/10/2021
Leukemia Stemness and Co-Occurring Mutations Drive Resistance to IDH Inhibitors in Acute Myeloid Leukemia

Allosteric inhibitors of mutant IDH1 or IDH2 induce terminal differentiation of the mutant leukemic blasts and provide durable clinical responses in approximately 40% of AML patients with...

Nature Communications
05/10/2021
PAX8 and MECOM Are Interaction Partners Driving Ovarian Cancer

Comprehensive genomic screens furthermore indicate an additional oncogenic role for PAX8 in renal and ovarian cancers.

Nature Communications
04/26/2021
A Clinical Transcriptome Approach to Patient Stratification and Therapy Selection in Acute Myeloid Leukemia

Study investigators develop and validate a clinical transcriptome-based assay for stratification of acute myeloid leukemia.

Nature Communications
04/30/2021
Targeting NSD2-Mediated SRC-3 Liquid–Liquid Phase Separation Sensitizes Bortezomib Treatment in Multiple Myeloma

This study finds that high steroid receptor coactivator-3 expression is correlated with relapse/refractory and poor outcomes in MM patients treated with bortezomib-based regimens.

Nature Communications
02/15/2021
A Pediatric Brain Tumor Atlas of Genes Deregulated by Somatic Genomic Rearrangement

The global impact of somatic structural variants on gene expression in pediatric brain tumors has not been thoroughly characterised.

Nature Communications
02/10/2021
Integrative Molecular Characterization of Sarcomatoid and Rhabdoid Renal Cell Carcinoma

Study investigators evaluate multiple clinical trial and real-world cohorts of S/R RCC to characterize their molecular features, clinical outcomes, and immunologic characteristics.

Nature Communications
02/05/2021
Subscribe to Nature Communications

source list reference

#7d60d9
#2694a4
#32a887
#85eb24
#352625
#4d4537
#d2093c
#8e3f1c
#76b6c3
#bfcfc8
#c61417
#67e25b
#efef71
#03cffc
#42fc9a
#cc529a
#c59445
#c8cc0c
#bf6be3
#e8085a
#97d1a0
#74e391
#eb6342
#b61f77
#a153ac
#e7f6e3
#6fc969
#9a8c2c
#a9c507
#2b9ab3
#e61923
#990677
#4a7bab
#89f67c
#49a21d
#2c990a
#d7da81
#f5ce42
#575662
#a60538
#49cde9
#c20fce
#d95d39
#eb5834