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Journal of Hematology & Oncology

Journal of Hematology & Oncology
Targeting the Metabolic Vulnerability of Acute Myeloid Leukemia Blasts With a Combination of Venetoclax and 8-Chloro-Adenosine

BCL‐2 inhibition through venetoclax targets acute myeloid leukemia blast cells and leukemic stem cells.

Journal of Hematology & Oncology
04/26/2021
Prostate Cancer and PARP Inhibitors: Progress and Challenges

In solid tumors, the first demonstration of an improvement in overall survival is provided by olaparib in patients with mCRPC harboring homologous recombination repair deficiencies.

Journal of Hematology & Oncology
03/29/2021
Novel Agents and Regimens for Hematological Malignancies: Recent Updates From 2020 ASH Annual Meeting

This study summarizes the latest updates on novel agents and regimens for hematological malignancies from the 2020 ASH annual meeting.

Journal of Hematology & Oncology
04/21/2021
Therapeutic Strategies in RET Gene Rearranged Non-Small-Cell Lung Cancer

The results from the LIBRETTO-001 and ARROW clinical trials demonstrate significant clinical benefits with selpercatinib and pralsetinib respectively, in NSCLC patients with RET gene fusions...

Journal of Hematology & Oncology
03/26/2021
Targeting Bruton Tyrosine Kinase Using Non-covalent Inhibitors in B Cell Malignancies

This review discusses the rationale for the use of non-covalent BTK inhibitors and the preclinical and clinical studies of non-covalent BTK inhibitors in B cell malignancies.

Journal of Hematology & Oncology
03/06/2021
Preclinical Evaluation of the Hsp90 Inhibitor SNX-5422 in Ibrutinib Resistant CLL

This study explores the efficacy of the Hsp90 inhibitor, SNX-5422, in CLL.

Journal of Hematology & Oncology
02/24/2021
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