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Journal of Experimental & Clinical Cancer Research

Journal of Experimental & Clinical Cancer Research
TMPRSS4 Promotes Cancer Stem–Like Properties in Prostate Cancer Cells Through Upregulation of SOX2 by SLUG and TWIST1

Study authors investigated whether TMPRSS4 confers cancer stem–like properties to prostate cancer cells and characterized the underlying mechanisms.

Journal of Experimental & Clinical Cancer Research
11/22/2021
Therapeutic Inhibition of GAS6-AS1/YBX1/MYC Axis Suppresses Cell Propagation and Disease Progression of Acute Myeloid Leukemia

Scientists find that GAS6-AS1 binds YBX1 to facilitate its interaction with MYC, resulting in transactivation of MYC and upregulation of IL1R1 and other known oncogenic transcripts from MYC... 

Journal of Experimental & Clinical Cancer Research
11/09/2021
Long Noncoding RNA SGO1-AS1 Inactivates TGFβ Signaling by Facilitating TGFB1/2 mRNA Decay and Inhibits Gastric Carcinoma Metastasis

Novel lncRNAs involved in the progression of GC were identified and explored for their regulatory mechanisms and clinical significance in GC.

Journal of Experimental & Clinical Cancer Research
10/28/2021
MYSM1 Inhibits Human Colorectal Cancer Tumorigenesis by Activating miR-200 Family Members/CDH1 and Blocking PI3K/AKT Signaling

New research suggests that MYSM1 might be a potential therapeutic and prognostic target for CRC.

Journal of Experimental & Clinical Cancer Research
10/27/2021
M6A Associated TSUC7 Inhibition Contributed to Erlotinib Resistance in Lung Adenocarcinoma Through a Notch Signaling Activation Dependent Way

 Researchers tentatively explored the supporting role of TUSC7 in cancer suppression, trying to establish the m6A correlated lncRNA functions in modulating the TKIs therapies resistance.

Journal of Experimental & Clinical Cancer Research
10/16/2021
Replication Catastrophe is Responsible for Intrinsic PAR Glycohydrolase Inhibitor-Sensitivity in Patient-Derived Ovarian Cancer Models

Scientists explore the use of a transcript-based biomarker, and provide insight into the design of future clinical trials of PARGi in patients with ovarian cancer.

Journal of Experimental & Clinical Cancer Research
10/16/2021
Mutant NPM1-Regulated lncRNA HOTAIRM1 Promotes Leukemia Cell Autophagy and Proliferation by Targeting EGR1 and ULK3

Scientists investigate the functional and mechanistic roles of the lncRNA HOTAIRM1 to improve the diagnosis and treatment of patients with NPM1-mutated AML.

Journal of Experimental & Clinical Cancer Research
10/06/2021
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